GENERATION OF NEW REGULATORY T CELLS AND INCREASED IL-10 LEVELS IN SYSTEMIC SCLEROSIS PATIENTS TREATED WITH AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION by M Santana-Gonçalves, PB Santis, PD Forti, K Malmegrim, MC Oliveira

“…This suggests that AHSCT can modulate the inflammatory milieu and improve immunoregulatory mechanisms, contributing to the clinical improvements observed in these patients.…”
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The Resistin/TLR4/miR-155-5p axis: a novel signaling pathway in the onset of hypothalamic neuroinflammation by Marianne Prévost, Delphine Crépin, Sarah Al Rifai, Ghislaine Poizat, Mélanie Gonçalves, Femke van Barneveld, Rozhina Shadpay, Karim Taouis, Laure Riffault, Yacir Benomar, Mohammed Taouis

“…Notably, intracerebroventricular administration of resistin led to the upregulation of miR-155-5p in a TLR4-dependent manner. …”
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Urinary glyphosate, selenium status, and their impact on mortality: Evidence from NHANES 2013–2018 by Pei-Lun Chu, Ching-Chung Hsiao, Ta-Chen Su, Chikang Wang, Chien-Yu Lin

“…However, the interplay between glyphosate exposure and selenium status remains poorly understood in epidemiological studies, particularly regarding selenium's role in modulating the mortality risk associated with glyphosate exposure in nationally representative populations. …”
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Effects and mechanisms of trifolin on attenuating hypertension-induced vascular smooth muscle cell proliferation and collagen deposition in vivo and in vitro by Aling Shen, Meizhu Wu, Zhi Guo, Farman Ali, Jinkong Wu, Hong Chen, Ying Cheng, Dawei Lian, Jun Peng, Min Yu, Keji Chen

“…Trifolin treatment attenuated the elevation of blood pressure, the proliferation and collagen deposition of VSMCs, and modulated multiple signaling pathways, including PI3K/Akt pathway. …”
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Transcutaneous Spinal Stimulation Combined with Locomotor Training Improves Functional Outcomes in a Child with Cerebral Palsy: A Case Study by Darryn Atkinson, Kristen Barta, Fabian Bizama, Hazel Anderson, Sheila Brose, Dimitry G Sayenko

“…This non-invasive technique delivers electrical stimulation over the spinal cord, leading to the modulation of spinal sensorimotor networks. TSS has been used in combination with AB-LT and has been shown to improve muscle activation patterns and enhance motor recovery. …”
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Transcriptome Analysis Reveals the Molecular Mechanisms for Mycorrhiza-Enhanced Drought Tolerance in Maize by Regulating the Ca²⁺ Signaling Pathway by Qiaoming Zhang, Wenjing Yang, Miaomiao Wang, Junwei Chen, Zhaoran Zhang, Yanan Wei, Qingshan Chang, Minggui Gong

“…This study provides insightful perspectives on how AMF-induced modulation of gene expression within the Ca²⁺ signaling pathway can enhance the drought tolerance of mycorrhizal maize in the future.…”
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The extracellular matrix protein type I collagen and fibronectin are regulated by β-arrestin-1/endothelin axis in human ovarian fibroblasts by Ilenia Masi, Flavia Ottavi, Valentina Caprara, Danila Del Rio, Martina Kunkl, Francesca Spadaro, Valerio Licursi, Loretta Tuosto, Anna Bagnato, Laura Rosano’

“…Both receptors are implicated, evident from inhibitory effects after ETAR or ETBR antagonist treatments and notably with bosentan, a dual antagonist, in vitro and in vivo. …”
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Hesperidin facilitating gastrointestinal motility by “Gut-brain axis” and “SCF/C-Kit signaling pathways” by Yunfei Li, Xinying Zhou, Yusong Du, Mingyuan An, Shasha Wan, Zewei Sun, Qingzhen Zhong

“…Notably, basal diet supplemented with 150mg/Kg hesperidin demonstrates superior efficacy.…”
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Uncovering the neural basis of risk preferences in cooperative Dyads: A fNIRS study by Qianlan Yin, Jing Wen, Shuo Chen, Tianya Hou, Ying Liu, Danni Yang, Guorui Liu, Peiqi Shi, Wei Dong

“…Inter-brain synchrony showed significance during outcome periods characterized by positive feedback, notably being higher within the ''Risky&Risky'' group. …”
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Integrative physiological and transcriptomic analysis provides insights on the molecular basis of ABA-enhanced drought tolerance in pear (Pyrus betulaefolia) by Guo-Ling Guo, An-Ran Luo, Yun-Hui Tan, Rui-Kang Yuan, Ting-Yue Luo, Pan-Pan Ma, Jun-Yu Zhan, Piao Han, Li Liu, Wei Heng, Zhenfeng Ye, Sheng Yang, Bing Jia

“…The results showed that while drought caused severe leaf water loss and damage, applying ABA at 50 µM and 100 µM dramatically amended the phenomenon, as indicated by the markedly increased relative water content, and notably decreased relative electrolyte leakage and malondialdehyde content. …”
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Pattern Recognition in Dried Milk Droplets Using Lacunarity and Deep Learning by Josías N. Molina-Courtois, Yaquelin Josefa Aguilar Morales, Luis Escalante-Zarate, Mario Castelán, Yojana J. P. Carreón, Jorge González-Gutiérrez

“…The key innovation is the addition of NaCl, which modulates crystallization to enhance structural differentiation and facilitate the classification of milk types and detection of adulteration. …”
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Analysis of molecular mechanisms of the development of experimental diabetes in Wistar rats under conditions of intermittent hypoxia by T. V. Ivanenko

“…The Nkx2-1 genes, Pik3r1, and Slc14a2 in rats subjected to experimental diabetes displayed notably reduced protein expression activity. Hypoxic training demonstrated an impact on mitigating the expression of the Nkx2-1 protein, which suggests that it might affect the mitochondrial muscle respiratory chain, modulate insulin signaling, and potentially rectify molecular deficiencies associated with diabetic nephropathy. …”
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Visnagin treatment attenuates DSS-induced colitis by regulating inflammation, oxidative, stress, and mucosal damage by Vemula Sravathi, Madhuri Doppalapudi, Ravi Kumar Yadala, Anilkumar Banothu, Vijaya Kumar Anumolu, Hanuman Donga Durga Veera, Bhaskar Debbarma

“…Immunohistochemical analysis showed strong positive immunoreactivity for NF-κB, COX-2, NLRP3 and TNF-α in DSS group, which wa notably reduced in VIS-treated groups. Additionally, VIS improved intestinalbarrier integrity by upregulating occluding expression. …”
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Investigating the mechanisms by which low NAT1 expression in tumor cells contributes to chemo-resistance in colorectal cancer by Zheng Yuan, Kai Fang, Xinsheng Miao, Yan Zhang, Menghui Gu, Wei Xu, Hao Li, Dawei Zhu, Jiahui Zhou, Jian Sun, Xinhua Gu

“…Conclusion Our study underscores the multifaceted role of NAT1 in modulating chemo-sensitivity, cellular metabolism, and angiogenesis in CRC. …”
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Effect of Spatial Variations in Floodplain Vegetation on Bed Shear Stress Distribution by REN Chun-ping, YANG Fan, ZHANG Yuan-yuan, WANG Hong-fei

“…To account for the effects of vegetation, a vegetation module was incorporated into the hydrodynamic model. …”
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Regulatory roles of an sRNA derived from the 5´ UTR and sequence internal to lapA in Pseudomonas aeruginosa PAO1 by Xiaojuan Tan, Jingjing Xiao, Qianqian Liu, Ting Yang, Dandan Feng, Ruyi Zheng, Liping Luo, Xi Cheng, Dongsheng Du, Minghui Li, Jinwei Zhou, Guoping Zhu

“…This study highlights the role of LapS in modulating P. aeruginosa virulence during phosphate-depleted stress.…”
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Effects of Lacticaseibacillus paracasei K56 on perceived stress among pregraduate students: a double-blind, randomized, placebo-controlled trial by Yiran Guan, Ruixin Zhu, Wen Zhao, Langrun Wang, Li You, Zhaozhong Zeng, Qiuyue Jiang, Zeyang Zhu, Jiayu Gou, Qi Zhang, Jie Guo, Keji Li, Liang Zhao, Yixuan Li, Pengjie Wang, Bing Fang, Weilian Hung, Jian He, Liwei Zhang, Ran Wang, Jingjing He

“…Moreover, taking probiotics K56 could modulate the pressure-induced changes in gut microbiota composition, particularly by increasing the beneficial bacteria (Lacticaseibacillus and Lacticaseibacillus paracasei), while suppressing suspected pathogenic bacteria (Shieglla and Escherichia_coli). …”
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Bisphenol B restrains rat leydig cell function via H3K27me3/H3K9me3 histone modifications by Jiayi He, Huiqian Zhang, Hehua Quan, Qingyuan Wang, Congcong Wen, Yiyan Wang, Yang Zhu, Ren-Shan Ge, Xiaoheng Li

“…BPB could potentially hinder the growth and function of Leydig cells by modulating H3K27me3 and H3K9me3. The findings of the study indicate the involvement of histone methylation (H3K27me3) in BPB-induced steroidogenic dysfunction, emphasizing the correlation between histone modifications and male reproductive toxicity.…”
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Integrative multi-omics and bioinformatics analysis of the effects of BaiRui YuPingFeng Powder on intestinal health in broilers by Haonan Xu, Fang Zhang, Yan Che, Yu Cui, Qisheng Yao, Yueqin Guan, Hao Chen, Hao Chen, Hao Chen, Yuying Huang

“…Compared to the CON group, ATB treatment increased the abundance of Faecalibacterium and Lachnospiraceae_unclassified but reduced Ruminococcaceae_unclassified and Firmicutes_unclassified. Notably, dietary TCYP supplementation maintained gut microbiota profiles similar to the CON group, demonstrating its stabilizing effect on microbial community structure in broilers. …”
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Therapeutic Effects of Fire Needling Acupuncture on Pain Relief and Cartilage Protection in MIA-Induced Knee Osteoarthritis Rats: The Role of Macrophage Polarization in Synovium an... by Wei J, Yang X, Ge X, Zhao L, Liu X, Zhang J, Zhou J, Zhang C, Li W, Li Z, Lyu T, Wang Y, Yuan F, Liu L, Li B

“…The therapeutic mechanism may involve modulation of synovial macrophage polarization and subchondral bone angiogenesis. …”
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