SDR42E1 modulates vitamin D absorption and cancer pathogenesis: insights from an in vitro model by Nagham Nafiz Hendi, Nagham Nafiz Hendi, Georges Nemer, Georges Nemer

“…ConclusionThese findings establish SDR42E1 as a key modulator of vitamin D-related pathways and highlight its potential as a therapeutic target for addressing vitamin D deficiency and associated pathologies, including cancer.…”
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Flavonoid Glycosides and Phenolic Acids from Inula Oculus-Christi Modulate Membrane Organization and Provide Antioxidant Protection by Ralitsa Veleva, Tanya Topouzova-Hristova, Aneliya Kostadinova, Dayana Benkova, Antoaneta Trendafilova, Viktoria Ivanova, Veselina Moskova-Doumanova, Kirilka Mladenova, Jordan Doumanov, Vesela Yordanova, Galya Staneva

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Thermomorphic pneumatic metamaterials: numerous and robust shape-locking under temperature modulation through 4D printing by Yafei Wang, Wei Cai, Jingyi Zhang, Weijia Guo, Biyun Qi, Yuheng Liu, Weimin Huang, Haibao Lu, Xueyong Wei, Richard Fu, Zhen Ding

“…We present a series of examples demonstrating complex multi-shape transformations modulated by temperature, supported by finite element simulations. …”
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Fucoidan alleviates high sucrose-induced metabolic disorders and enhances intestinal homeostasis through modulation of Notch signaling by Jian Liu, Weiqiang Xia, Qifang Wu, Ya Zhang, Yu Wu, Boyang Li, Fangyu Chen, Xueting Du, Siya Wu, Yue Yang, Yitian Gao, Mingjiang Wu, Laijin Su, Haibin Tong

“…Furthermore, we assessed the modulation of larval intestinal homeostasis by FUC, focusing on the regulation of Notch signaling. …”
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Tangeretin Suppresses Fumonisin Production by Modulating an NmrA- and HSCARG-like Protein in <i>Fusarium verticillioides</i> by Liuqing Wang, Wenlei Zhai, Dongmei Jiang, Nan Jiang, Jiaqi Yan, Haoyun Jiang, Meng Wang

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Isatidis root polysaccharides ameliorates post-weaning diarrhea by promoting intestinal health and modulating the gut microbiota in piglets by Miao Zhou, Zenghao Yan, Deqin Wang, Chuyuan Li, Leli Wang, Rui Li, Jie Yin, Yulong Yin

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Vitamin D ameliorates prediabetic cardiac injure via modulation of the ErbB4/ferroptosis signaling axis by Yufan Miao, Yujing Zhang, Luoya Zhang, Hao Chen, Lulu Tang, Wenjie Li, Chenxi Gu, Lili Lang, Xing Li, Xing Li, Hanlu Song, Hanlu Song

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Berberine inhibits colorectal liver metastasis via modulation of TGF-β in a cecum transplant mouse model by Yong-Hwi Kang, Jing-Hua Wang, Jin-Seok Lee, Seung-Ju Hwang, Nam-Hun Lee, Chang-Gue Son

“…Berberine treatment also notably lowered the levels of inflammatory cytokines (TGF-β, TNF- α, IL-6 and IL-1β) in the blood. …”
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Nanoengineered-based delivery systems to modulate CD4+ T cell responses in cancer: emerging paradigms in cancer immunotherapy by Nekhat Shahreen, Anukrati Agnihotri, Asfi Rizwan, Faizul Hasan, Mohd Danish Ansari, Zarif Mohamed Sofian, Nur Akmarina B. M. Said, Kenneth K. W. To, Syed Mahmood, Syed Mahmood, Syed Mahmood, Syed Mahmood

“…Notably, MHC II-coated nanoparticles expanded antigen-specific CD4+ T-cells, while mRNA nano vaccines activated CD4+ and CD8+ responses.ConclusionNovel drug delivery systems provide a versatile platform for precise CD4+ T-cell modulation in cancer therapy, enhancing antitumor responses while reducing toxicity. …”
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HJURP modulates cell proliferation and chemoresistance via the MYC/TOP2A transcriptional axis in gastric cancer by Xu Li, Xu Li, Xiwen Li, Yanlin Ren, Ling Wang, Zehao Mao, Shikun Gao, Shikun Gao, Peng Ma, Junjie Chen, Junjie Chen

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Injectable platelet-mimicking silk protein-peptide conjugate microspheres for hemostasis modulation and targeted treatment of internal bleeding by Yajun Shuai, Yu Qian, Meidan Zheng, Chi Yan, Jue Wang, Peng Wang, Jie Wang, Chuanbin Mao, Mingying Yang

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Tendomodulin in pan-cancer analysis: exploring its impact on immune modulation and uncovering functional insights in colorectal cancer by Jingfeng Chen, Qin Hu, Cong Zhang, Aiqi Zhao, Bihua Guan, Yifan Wang, Min Zhang, Xia Li, Biao Chen, Lulu Zeng, Minjiang Chen, Bing Wu, Jianping Wang, Yang Yang, Jiansong Ji

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Gut microbiota modulates lung gene expression and metabolism to aid SD rats in adapting to low-pressure hypoxia by Zheng Chen, Shatuo Chai, Yuxia Ding, Kaiyue Pang, Tanqin Dong, Dongwen Dai, Jianmei Wang, Shuxiang Wang, Shujie Liu

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Fenaminosulf Promotes Growth and Gall Formation in <i>Zizania latifolia</i> Through Modulation of Physiological and Molecular Pathways by Chaohong Ding, Ruifang Ma, Liqiu Wang, Xinyan Lan, Limin Chen, Jinxing Zhu, Lailiang Wang

“…Key pathways related to plant-pathogen interaction, phenylpropanoid biosynthesis, and hormone signal transduction were significantly modulated. Notably, FM treatment suppressed key immune-related genes, including <i>Xa21</i> and <i>PBL19</i>, potentially reducing plant resistance and facilitating gall formation. …”
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Neutral Sodium Humate Modulates Growth, Slaughter Traits, Antioxidant Status, and Gut Health in Yellow-Feathered Broilers by Junran Lv, Mingzhu Cen, Benkuan Li, Xin Feng, Hongyu Cai, Huihua Zhang

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Guanxinning attenuates diabetic myocardial ischemia–reperfusion injury by targeting oral Fusobacterium nucleatum and modulating PTEN signaling by Yiwen Li, Yiwen Li, Qian Xu, Yanfei Liu, Longkun Liu, Wenting Wang, Mengmeng Zhu, Jing Cui, Hongjun Yang, Yue Liu

“…Correspondingly, cardiac tissues from diabetic mice exhibited reduced expression of PTEN, consistent with pathway activation. Notably, F. nucleatum exposure elevated plasma levels of specific anti–F. nucleatum IgG antibodies and appeared to influence the host PI3K pathway through modulation of phenylalanine metabolism.ConclusionGXN may alleviate DMIRI by targeting F. nucleatum and PTEN related pathways, offering new insights into microbiota-based cardio protection.…”
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The role of PSMC4 in non-small cell lung cancer: implications for prognosis, diagnosis, and immune microenvironment modulation by Lili Zhu, Yuanjun Li, Yunfei Xu, Yunfei Xu, Jian Lei

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Enhancing Akkermansia growth via phytohormones: a strategy to modulate the gut-bone axis in postmenopausal osteoporosis therapy by Zhiqi Zhao, Yixuan Deng, Li Li, Liying Zhu, Xin Wang, Haibiao Sun, Xiaoqiong Li, Xiaoqiang Han, Jinjun Li

“…Akkermansia has the capacity to not only augment bone mass and alleviate strength deterioration via extracellular vesicles, but it also influences bone metabolism by diminishing inflammation and modulating lipid metabolism. Notably, no significant changes in the gut microbiota were observed in the Deno group, which may be attributed to the differences in the method of administration, as Deno was administered via subcutaneous injection rather than gavage. …”
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CLCF1 contributes to high-glucose-induced EndMT by modulating JAK2/STAT3 signaling by Rongrong Deng, Kaiying He, Qicai You, Wenkai Zhang, Xuezhen Ma, Xiaochun Zhou, Yuke Kong, Jianqin Wang

“…Conclusion These findings demonstrate that CLCF1 mediates HG-induced EndMT in HRGECs via modulation of the JAK2/STAT3 pathway. This indicates that the CLCF1/JAK2/STAT3 signaling axis plays a role in the pathogenesis of DKD.…”
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First evidence of an anxiety-like behavior and its pharmacological modulation in a molluscan model organism, Lymnaea stagnalis by Veronica Rivi, Pierfrancesco Sarti, Istvan Fodor, Zsolt Pirger, Joris M. Koene, Luca Pani, Anuradha Batabyal, Ken Lukowiak, Johanna Maria Catharina Blom, Fabio Tascedda, Cristina Benatti

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