<i>OsVPS16</i> Deficiency Enhances Salinity Tolerance in Rice by Regulating Ion Homeostasis, Antioxidant Activity, and Stress-Responsive Gene Expression by Juan Liu, Mingming Tang, Yun Lu, Huimin Yan, Yang Liu, Yongrun Cao, Xiaohua Song, Qiuyuan Liu, Xin Ji

“…Collectively, comprehensive physiological and molecular analyses demonstrated that the loss of <i>OsVPS16</i> improves rice salt tolerance through multiple mechanisms, including the regulation of K⁺/Na⁺ homeostasis, the modulation of antioxidant enzyme activities, and the transcriptional reprogramming of stress-responsive genes. …”
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Repetitive prefrontal tDCS activates VTA dopaminergic neurons, resulting in attenuation of Alzheimer’s Disease-like deficits in Tg2576 mice by Maria Luisa De Paolis, Gilda Loffredo, Paraskevi Krashia, Livia La Barbera, Annalisa Nobili, Emma Cauzzi, Lucy Babicola, Matteo Di Segni, Roberto Coccurello, Stefano Puglisi-Allegra, Emanuele Claudio Latagliata, Marcello D’Amelio

“…Given these findings, interventions capable of directly modulating VTA activity and augmenting DA release, despite the ongoing neurodegeneration, may hold therapeutic potential for mitigating DA-related deficits in AD. …”
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Prognostic implications of the interaction between intratumoral microbiome and immune response in gastric cancer by Sifan Liu, Lingyu Qi, Lu Dong, Wenjing Sun, Siying Liu, Peng Li, Nan Zhang

“…ABSTRACT Gastric cancer (GC) prognosis is significantly influenced by intratumoral microbiomes, which modulate host–immune interactions. This study analyzed data from the The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases to identify immune genes associated with GC prognosis and conducted prognostic immune subtypes. …”
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Key determinants of the chemo-sensitizing activity of novel Telmisartan derivatives by Maximilian Gebhart, Christian A. Elvert, Anna M. Schoepf, Alexandra Scheiber, Stefan Schwaiger, Cornelia A. Karg, Ronald Gust, Stefan Salcher

“…A promising approach involves Telmisartan (1)-based cell death modulators, which may help overcome TKI resistance. …”
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Ten-year survival outcomes of concurrent chemoradiotherapy with or without adjuvant chemotherapy for locoregionally advanced nasopharyngeal carcinoma in the IMRT era: A retrospecti... by Wang-Jian Li, Li-Ting Ling, Yue Yao, Kai-Qing Tan, Bo-Lin Zhu, Li-Qing Zhou, Song Qu, Ling Li, Ying Guan, Ling-Hui Pan, Xiao-Dong Zhu, Zhong-Guo Liang

“…Objective: To evaluate 10-year survival outcomes of intensity-modulated radiotherapy (IMRT)-era locoregionally advanced nasopharyngeal carcinoma (NPC) treated with concurrent chemoradiotherapy (CCRT) ± adjuvant chemotherapy (AC), and assess the impact of AC on survival in high-risk and low-risk patients. …”
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SREBF1-mediated SND1 transcriptional activation promotes prostate cancer progression via MTDH interaction through the SESN2/AMPK/mTOR axis by Yijie Tang, Yufan Ying, Xueyou Ma, Jiahe Yi, Zixiang Liu, Yuqing Wu, Shen Lin, Xuan Shu, Zhixiang Qi, Jindan Luo, Xiangyi Zheng, Jiangfeng Li, Liping Xie, Ben Liu

“…Mechanistically, SND1 interacts with MTDH and promotes SESN2 mRNA degradation, modulating PCa progression through the AMPK/mTOR pathway.…”
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Comprehensive Bioinformatics Analyses and Experimental Validation of the Cell Cycle Related Protein SAPCD2 as a New Biomarker and Potential Therapeutic Target in Pancreatic Cancer by Liu Y, Li B, Ke L, Luo T, Wu H, Lin J, Deng Y, Huang X, Xu L, Liu Y, Qi J

“…However, no comprehensive study has explored its expression and regulation, discussed its role in tumor prognosis and immune modulation, along with therapy response in pan-cancer until now.Methods: SAPCD2 expression was analyzed using data from The Cancer Genome Atlas database (TCGA) and Human Protein Atlas (HPA) database. …”
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Early expression of osteopontin glycoprotein on the ocular surface and in tear fluid contributes to ocular surface diseases in type 2 diabetic mice. by Ananya Datta, Xin Yi Li, Manshul Nagpaul

“…However, its specific roles in modulating ocular surface dynamics and immune responses in diabetes remain unexplored. …”
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Exploring the Mechanism of Qinzhuliangxue Mixture for Treating Skin Lesions in Atopic Dermatitis: Insights from Network Pharmacology and Experimental Validation by Qiao Y, Yin H, Zhang H, He Q, Li Y, Sun L, Wang J, Li X, Koh WX, Pottakorn A, Chu Z, Xiang Y

“…Moreover, the levels of serum IgE, TSLP, and IL-4 in the QZLX group were notably lower than those in the Model group (P < 0.05). …”
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Deciphering the structural and dynamic effects of SHP2-E76 mutations: mechanistic insights into oncogenic activation by Humaira Rafiq, Lu Han, Ashfaq Ur Rehman, Pei He, Ali Saber Abdelhameed, Eman S. G. Hassan, Hongxia Fu, Abdul Wadood, Junjian Hu

“…This regulation is achieved through the release of intramolecular autoinhibition and the modulation of several signaling pathways, including the signaling cascade of Ras-MAPK. …”
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Biomarker-Driven Pharmacokinetics and Efficacy of Polymyxin B in Critically Ill Patients with XDR-GN Pneumonia by Wei Zuo, Qianlin Wang, Longxiang Su, Jiaxin Yu, Hongwei Fan, Qiang Fu, Yun Long, Bo Zhang

“…The AUC_ss,0–24h metric was identified as a robust predictor of clinical efficacy, with an optimal cutoff value of 77.27 h·µg/mL. Notably, 48.15% of patients achieved the target AUC_ss,0–24h range of 50–100 h·µg/mL, with 76.95% of these patients attaining treatment success. …”
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Amino acid insertion in the Meq protein of Marek’s disease virus, an avian oncogenic herpesvirus, accelerates tumorigenesis by Jumpei Sato, Shiro Murata, Yoshinosuke Motai, Shwe Yee Win, Hikari Seo, Shunsuke Yamagami, Naoya Maekawa, Tomohiro Okagawa, Satoru Konnai, Kazuhiko Ohashi

“…RNA-seq analysis revealed that similar genes were modulated in tumor lesions of chickens infected with vRB-1B_Meq or vRB-1B_L-Meq. …”
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Identification and Validation of Epithelial Cell Centre Regulatory Transcription Factors in the Gastric Cancer Microenvironment by Su G, Wang J, Liu S, Fu X, Li Y, Pan G

“…They may contribute to GC progression by modulating the tumour’s immune microenvironment.Keywords: PROX1, EPAS1, GC, tumour microenvironment, transcription factor, cell communication…”
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Comparative Genomic Analysis of Tigecycline Resistance Development in Clinical Acinetobacter baumannii Isolates by Li X, Liu J, Zhang X, Li J, Xuan L, Yuan S, Li J, Sun Y, Du X

“…All three patients had received tigecycline therapy before the emergence of tigecycline resistance. Notably, in one patient, resistance developed 21 days after discontinuing tigecycline treatment. …”
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The impact of bilberry extract combined with docosahexaenoic acid on the expression of Chrnb4 gene in the sclera of myopic guinea pigs by Mei-hong Zhu, Qian Wen, Tai-nan Lin, Yun Gao, Xiao-ting Liu, Jing-hua Lin, Miao Lin, Qiao-mei Shi

“…After 12 weeks of therapeutic intervention, the combined treatment group showed marked improvements in ocular parameters, with refraction measuring –2.46 ± 0.92 D and axial length reduced to 9.94 ± 1.10 mm. Notably, ChT and CVI increased by 8.7 and 15.6%, respectively, compared to the LIM group (P &lt; 0.05). …”
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Effects of Bacillus licheniformis on the water quality, growth performance and bacterial community in Penaeus vannamei aquaculture system by Yi Zheng, Yi Zheng, Yingzi Wu, Shuling Tang, Junpeng Li, Lingyu Fan, Wenjin He

“…In water, Aurantimicrobium was the predominant genus in both groups, with the PB group showing a notably lower relative abundance. In the shrimp intestines, the CK group was dominated by Gemmobacter and Fluviicola, while Aurantimicrobium prevailed in the PB group. …”
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Influence of substrate bias on the properties of CrAlN wear-resistant coating prepared by arc/magnetron composite technology by Xiaoyan NIU, Mingze LIU, Guoqiang DONG, Yujiang WANG, Haoliang TIAN

“…In addition, substrate bias, a key process parameter, was found to affect particle activity and sputtering yield, thereby modulating element distribution in the coating and coating properties. …”
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Solar-thermoelectric mobile storage system integrated with electric vehicles for reducing postharvest and microbial losses in agro produce transportation by Lalith Pankaj Raj Nadimuthu, Kirubakaran Victor, Mohit Bajaj, Vojtech Blazek, Lukas Prokop

“…Despite these strengths, Indian agriculture continues to encounter critical bottlenecks—most notably, post-harvest losses in fruits, which are estimated to range between 6.02% and 15.05%. …”
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IL-10/STAT5 axis suppresses miR-140 to upregulate B7-H4 expression in RAW264.7 cells by Dandan Zhu, Guo Chen, Guo Chen, Pei Shen, Weiliang Fan, Chuxin Ji, Yinong Duan, Wenxi Gao, Wenxi Gao

“…B7-H4 is a critical immune checkpoint molecule that modulates T cell activation and exerts immunosuppressive effects. …”
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Determination of the Roles of <i>H. pylori</i> Outer Membrane Virulence Factors and Pyroptosis-Associated NLRP3, ASC, Caspase-1, Gasdermin D, IL-1β, and IL-18 in Ulcer and Gastriti... by Yaren Buyukcolak-Cebeci, Emel Timucin, Sumeyye Akcelik-Deveci, Nesteren Mansur-Ozen, Tuana Aydinlar, Arzu Tiftikci, Sinem Oktem-Okullu

“…These results underscore the critical role of <i>H. pylori</i> virulence determinants in modulating pyroptosis and suggest that understanding this relationship may pave the way for developing targeted therapeutic strategies to mitigate <i>H. pylori</i>-associated pathologies.…”
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