Colorectal cancer-infiltrating NK cell landscape analysis unravels tissue-resident PD-1+ NK cells in microsatellite instability tumors by Valentina Obino, Chiara Giordano, Simona Carlomagno, Chiara Setti, Marco Greppi, Matteo Bozzo, Silvia Pesce, Silvia Pesce, Elisa Ferretti, Elisa Ferretti, Simona Candiani, Simona Candiani, Letizia Muccio, Enrico Ciferri, Tania Buttiron Webber, Agnese Solari, Fulvia Ortolani, Laura Paleari, Matteo Clavarezza, Andrea Barberis, Marco Filauro, Nicoletta Provinciali, Nicoletta Provinciali, Mariangela Rutigliani, Emanuela Marcenaro, Emanuela Marcenaro, Andrea DeCensi, Andrea DeCensi, Mariella Della Chiesa, Mariella Della Chiesa, Simona Sivori, Simona Sivori

“…., KIR, NKG2A and TIM-3) were significantly enriched in tumor compared to tumor-free tissue, and an increase in PD-1+ NK cells was observed in tumors compared to peripheral blood and tumor-free tissue, indicating TME-induced modulation. Notably, tumor-associated PD-1+ NK cells characterized MSI rather than MSS CRC. …”
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Enhanced Anti-Melanoma Activity of Nutlin-3a Delivered via Ethosomes: Targeting p53-Mediated Apoptosis in HT144 Cells by Arianna Romani, Giada Lodi, Fabio Casciano, Arianna Gonelli, Paola Secchiero, Giorgio Zauli, Olga Bortolini, Giuseppe Valacchi, Daniele Ragno, Agnese Bondi, Mascia Benedusi, Elisabetta Esposito, Rebecca Voltan

“…Furthermore, nutlin-3a-loaded ethosomes successfully modulated two p53-regulated proteins involved in survival/apoptosis, with up to a 2.5-fold increase in membrane TRAIL-R2 and up to an 8.2-fold decrease in Notch-1 (Notch intracellular domain, NICD) protein expression. …”
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Leveraging Machine Learning and Genetic Risk Scores for the Prediction of Metabolic Syndrome in Children with Obesity by Concepción M. Aguilera, Mireia Bustos-Aibar, Augusto Anguita-Ruiz, Álvaro Torres-Martos, Gloria Bueno, Rosaura Leis, Jesús Alcalá-Fernández

“…Results: Strong associations were observed between each genetic risk score and its corresponding phenotypic biomarker. Notably, certain scores related to obesity and high-density lipoprotein levels exhibited significant interactions with environmental factors, such as sedentary lifestyle, modulating disease effects. …”
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Research on the effect of LAMP1 in the development and progression of ccRCC and its potential mechanism with LC3C-mediated autophagy by Xiongbao Wang, Xiongbao Wang, Xiongbao Wang, Liang Fang, Liang Fang, Lixiang Xiao, Guangxin Zhong, Minghao Han, Bingshen Wang, Juchao Ren, Yuanwei Zang, Yuanwei Zang

“…LAMP1 expression remained unchanged during autophagy modulation but decreased with LC3C knockdown and vice versa. …”
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Immunogenic cell death-related biomarkers in heart failure probed by transcriptome and single-cell sequencing by Haoyue Wang, Haoyue Wang, Dongdong Wu, Dongdong Wu, Gangfei Han, Gangfei Han, Jingjing Yan, Zehui Wang, Xing He, Xing He, Yuxiang Chen, Yuxiang Chen, Yan Wang, Qinghua Han, Qinghua Han, Qinghua Han

“…These biomarkers were notably correlated with CD8 T cells and M2 macrophages. …”
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Corticostriatal glutamate‐mediated dynamic therapeutic efficacy of electroacupuncture in a parkinsonian rat model by Xinxin Jiang, Min Sun, Yitong Yan, Yanhua Wang, Xinyu Fan, Jing Wei, Ke Wang, Peirong Liang, Zirui Wang, Jihan Wang, Xiaomin Wang, Jun Jia

“…Results Chronic EA stimulation resulted in a gradual and long‐lasting alleviation of motor symptoms, independent of nigrostriatal dopamine (DA) restoration. Notably, EA stimulation modulated corticostriatal spine plasticity and reduced excessive glutamate transmission in PD model rats. …”
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Meta-analysis of the synergistic effect of traditional Chinese medicine compounds combined with conventional Western medicine in the treatment of osteoporosis by Huan Jin, Huan Jin, Cai Huang, Yan Zhang, Ying Dong, Qi Xiong, Di Wang, Di Wang, Ziyi He, Ziyi He, Lin Shen, Chen Ma, Zixian Wang, Lingfeng Zeng, Bo Shuai

“…Notably, Procollagen I N-Terminal Propeptide (P1NP) levels remained unchanged (P = 0.63), indicating differential targeting of bone formation pathways. …”
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Human menstrual blood-derived stem cells secreted ECM1 directly interacts with LRP1α to ameliorate hepatic fibrosis through FoxO1 and mTOR signaling pathway by Yangxin Fang, Lin Chen, Yin Yuan, Sining Zhou, Jiamin Fu, Qi Zhang, Ning Zhang, Yuqi Huang, Yifei Li, Li Yuan, Lijun Chen, Charlie Xiang

“…Abstract Background Human menstrual blood-derived stem cells (MenSCs), a major class of mesenchymal stem cells (MSCs), modulate intercellular signals via paracrine factors. …”
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Comparative transcriptome analysis of bovine blastocysts reveals specific effects of the oocyte source and the environments during maturation and early embryo development by Mohammad Bozlur Rahman, Eva Held-Hoelker, Mohammed Saeed-Zidane, Franca Rings, Dessie Salilew-Wondim, Dawit Tesfaye, Ahmed Gad, Samuel Gebremedhn, Ernst Tholen, Karl Schellander, Christine Große-Brinkhaus, Michael Hoelker

“…In addition, the insights gained from this study could inform future strategies to improve the quality of embryos in in vitro production systems through the targeted modulation, either enhancement or inhibition, of specific genes or pathways.…”
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Co-Highly Expressed SLC17A9 and KCNH1 as Potential Prognostic Biomarkers and Therapeutic Targets in Clear Cell Renal Cell Carcinoma by Zongpan Ke, Zhiwang Tang, Deyun Shen, Yixun Liu, Yawei Shu, Xiangyu Mu, Zexuan Li, Ping Xiang, Bing Zhong, Xuechun Hu, Ruoyun Tan, Jun Xiao

“…Background: The vesicular nucleotide transporter Solute Carrier Family 17 Member 9 (SLC17A9) has recently been recognized as a significant modulator of oncogenic pathways, with its elevated expression levels being closely linked to the aggressiveness of clear cell renal cell carcinoma (ccRCC). …”
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Prognostic and immunological implications of cathepsin Z overexpression in prostate cancer by Junyue Tao, Junyue Tao, Junyue Tao, Yiding Chen, Yiding Chen, Yiding Chen, Xiaokang Bian, Xiaokang Bian, Xiaokang Bian, Tingting Cai, Tingting Cai, Tingting Cai, Changhao Song, Changhao Song, Changhao Song, Chaozhao Liang, Chaozhao Liang, Chaozhao Liang, Zongyao Hao, Zongyao Hao, Zongyao Hao, Jialing Meng, Jialing Meng, Jialing Meng, Qintao Ge, Qintao Ge, Jun Zhou, Jun Zhou, Jun Zhou

“…BackgroundRecent studies have underscored the potential involvement of cathepsin Z (CTSZ) in modulating the progression of diverse tumor types. Nevertheless, its specific role in prostate cancer (PCa) remains insufficiently understood. …”
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ISG15 as a Potent Immune Adjuvant in MVA-Based Vaccines Against Zika Virus and SARS-CoV-2 by Juan García-Arriaza, Michela Falqui, Patricia Pérez, Rocío Coloma, Beatriz Perdiguero, Enrique Álvarez, Laura Marcos-Villar, David Astorgano, Irene Campaña-Gómez, Carlos Óscar S. Sorzano, Mariano Esteban, Carmen Elena Gómez, Susana Guerra

“…One such molecule is interferon-stimulated gene 15 (ISG15), a key modulator of antiviral immunity that acts both through ISGylation-dependent mechanisms and as a cytokine-like molecule. …”
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Down-regulation of serum SIRT6 levels is associated with an increased risk of chronic intestinal inflammation in children exposed to airborne particulate matter and polycyclic arom... by Tengyang Huang, Xijin Xu, Shuqin Chen, Zhiping Liu, Yu Huang, Xia Huo, Guangcan Chen

“…SIRT6, a histone deacetylase, modulates inflammation by suppressing NF-κB signaling, but its role in mitigating e-waste pollutant-induced childhood enteritis remains unclear. …”
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Novel Inhibitory Actions of Neuroactive Steroid [3α,5α]-3-Hydroxypregnan-20-One on Toll-like Receptor 4-Dependent Neuroimmune Signaling by Alejandro G. Lopez, Venkat R. Chirasani, Irina Balan, Todd K. O’Buckley, Makayla R. Adelman, A. Leslie Morrow

“…The endogenous neurosteroid (3α,5α)-3-hydroxypregnan-20-one (3α,5α-THP) modulates inflammatory and neuroinflammatory signaling through toll-like receptors (TLRs) in human and mouse macrophages, human blood cells and alcohol-preferring (P) rat brains. …”
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Endo 180 participates in collagen remodeling of the periodontal ligament during orthodontic tooth movement by Liyuan Chen, Danqing He, Zixin Li, Shengjie Cui, Min Yu, Zimo Zhao, Yuetong Chen, Jiayi Song, Nan Jiang, Huajie Yu, Yan Liu

“…Conclusion Force-induced Endo180 expression modulates collagen remodeling in PDL during OTM by upregulating COL III and downregulating COL I. …”
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Identification of glycolysis-related gene signatures for prognosis and therapeutic targeting in idiopathic pulmonary fibrosis by Han Gao, Zhongyi Sun, Xingxing Hu, Weiwei Song, Yuan Liu, Menglin Zou, Menglin Zou, Minghui Zhu, Zhenshun Cheng, Zhenshun Cheng, Zhenshun Cheng

“…Notably, AURKA, MERTK, and CXCR4 were associated with pathways linked to fibrosis progression and represent potential therapeutic targets. …”
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The role of gut microbiota in traditional Chinese medicine processing: A general review by Rui-Rui Qiao, Ya-Long Chen, Ya-Ya Bai, An-Dong Dong, Rui Tian, Ya-Jun Shi, Chong-Bo Zhao, Peng Zhao, Jing Sun, Qiao Zhang, Yu-Ping Tang

“…Leveraging advancements in high-throughput technologies, GM has become a prominent focus within the realm of Traditional Chinese Medicine (TCM). Notably, Chinese herbal remedies exhibit the capacity to modulate GM dysbiosis by influencing its structural and composition. …”
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Supplementation of Yupingfeng polysaccharides in low fishmeal diets enhances intestinal health through influencing the intestinal barrier, immunity, and microflora in Macrobrachium... by Mingyang Liu, Mingyang Liu, Cunxin Sun, Cunxin Sun, Qunlan Zhou, Qunlan Zhou, Pao Xu, Pao Xu, Aimin Wang, Xiaochuan Zheng, Xiaochuan Zheng, Bo Liu, Bo Liu

“…However, YPF supplementation notably improved these parameters, with the greatest improvement observed at a 1000 mg/kg dosage. …”
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Effector T cells under hypoxia have an altered transcriptome similar to tumor-stressed T cells found in non-responsive melanoma patients by Ahmad A Tarhini, Zhihua Chen, Dongliang Du, Joshua Davis, Justin C Boucher, Katarzyna A Rejniak, Jose A Guevara-Patino, Timothy I Shaw, Alyssa Obermayer, Mate Z Nagy, Lourdes B Plaza-Rojas, Elena Kostenko, Anna L Austin, Awino Maureiq E Ojwang'

“…Background In the tumor microenvironment (TME), hypoxia stands as a significant factor that modulates immune responses, especially those driven by T cells. …”
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CCN5 negatively regulates TGF-β-induced endometriosis associated fibrosis through Wnt/β-catenin signaling via Smad3-dependent mechanism by Mian Liu, Yi Gong, Hong Cai, Rui Hua, Hong Li, Zhe Wang, Yao Zhou, Yanlin Ma, Song Quan

“…We evaluated the impact of CCN5 modulation on the activation of the TGF-β/Smad and Wnt/β-catenin signaling pathways in primary HESCs subjected to TGF-β stimulation. …”
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