Short-term effects of transcranial direct current stimulation on pain sensitivity, emotional and cognitive processes in non-suicidal self-injury: a randomised controlled trial by Runsen Chen, Yiheng Tu, Dennis Chong, Chang Lei, Diyang Qu, Yangyang Yi, Weijian Wu

“…For the secondary and additional outcomes, although there were initial improvements in joyful feelings and reductions in negative affect at 2 weeks post-intervention, these effects did not remain significant after multiple comparison corrections. Notably, reductions in rumination were statistically significant at both 1-week and 2-week follow-ups (1 week, padj=0.040; 2 weeks, padj=0.042). …”
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TCF12 enhances angiogenesis and affects sorafenib response in liver cancer via HIF-1α interaction by Yuanbin Chen, Xiaolong Wang, Jin Chen, Min Dai, Xinyue Zhang, Jie Yin, Xiao He

“…TCF12 promotes angiogenesis by stabilizing HIF-1α and modulates tumor sensitivity to sorafenib, highlighting its potential as a therapeutic target in liver cancer. …”
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Prevalence and genetic characteristics of Campylobacter jejuni from laying-hens in Hubei Province, China by Shichang Kuang, Zhaoyang Wang, Xiuzhong Hu, Zeyuan Dong, Chun Wang, Yuncai Xiao, Zili Li, Deshi Shi, Shaowen Li, Zutao Zhou

“…The most frequently occurring resistance genes were the gyrA (T86I) point mutation (95.14%), cmeR (95.14%), and tet(O) (95.14%). Notably, a robust correlation was discernibled between enrofloxacin resistance and the gyrA (T86I) point mutation, as well as between resistance to ceftriaxone and tilmicosin and the presence of the cmeR gene. …”
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Large Chengqi Decoction Improves Sepsis-Related Intestinal Damage by Inhibiting Inflammatory Response Through the HMGB1-TLR4 Signaling Pathway by Zhu Q, Pan Z, Li Z, Ye R, Zhuang Y, Yang M, Wang W, Pan J, Gao Q

“…In the LCD1 group, HMGB1 levels were notably higher at 3 and 5 days, accompanied by consistent TLR4 downregulation. …”
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Identification and development of KASP markers for genetic loci controlling plant height in bread wheat and evaluation their effects using near isogenic lines by Tao Li, Yanyan Tang, Zhengxi Lin, Baowei Chen, Jinghui Wang, Qiang Li, Furong Huang, Juanyu Zhang, Junjun Liang, Haili Zhang, Zehou Liu, Jun Li, Wuyun Yang, Guangbing Deng, Hai Long

“…Thus, the combination of QPh.cib-4B and QPh.cib-6A represents a promising genetic module with considerable potential for high-yield wheat breeding. …”
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App- and Wearable-Based Remote Monitoring for Patients With Myasthenia Gravis and Its Specialists: Feasibility and Usability Study by Maike Stein, Regina Stegherr, Pushpa Narayanaswami, David Legg, Meret Herdick, Andreas Meisel, Lea Gerischer, Sophie Lehnerer

“…In addition, communication between patients and physicians was facilitated through a chat module. Feasibility was evaluated by total adherence rates for completing PROMs within the app, alongside the collection of spirometry and wearable data. …”
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1.7 MV Tandem Accelerator Beam Tuning Optimization by JIANG Ran, LI Ailing, CUI Baoqun, TANG Bing, CHEN Haonan, WANG Yunfeng

“…During these trials, this paper not only scrutinized the algorithm’s performance but also implemented optimizations and enhancements based on empirical findings. These refinements notably elevate the optimization capabilities of the algorithm, culminating in an impressive beam transfer efficiency of 80%. …”
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Correlation between Serum Levels of Some Immunological Biomarkers and Severity of Idiopathic Immune Thrombocytopenia by Ola A. Hashim, Rawaa N. Alchalabi, Bassam F. Matti, Yaseen I. Mamoori

“…Immune regulatory molecules, including cytokines and immune checkpoint markers, play a vital role in modulating the inflammatory environment and immune tolerance. …”
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Intervening Non-Small-Cell Lung Cancer Progression by Cell Membrane Coated Platycodin D via Regulating Hsa-miR-1246/FUT9/GSK3β Pathway by Zheng S, Xie Z, Zhou Z, Wang S, Xin Y, Lin J, Cheng K, Lu T, Qi R, Guo Y

“…Furthermore, a homologous cell membrane-based PD delivery system was established to improve the biosafety and efficacy of PD in vivo.Results: Hsa-miR-1246 was upregulated by PD treatment, and functional experiments demonstrated that the miR-1246-mimic enhanced PD’s suppressive effects on NSCLC cell proliferation, colony formation, migration, and invasion, while the miR-1246-inhibitor abrogated these effects. Notably, dual-luciferase assays confirmed that hsa-miR-1246 directly targeted the 3’ untranslated regions (3’ UTRs) of Fucosyltransferase 9 (FUT9), modulating its expression. …”
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Therapeutic interventions aimed at cccDNA: unveiling mechanisms and evaluating the potency of natural products by Liyuan Hao, Liyuan Hao, Shenghao Li, Xiaoyu Hu

“…It meticulously elucidates the intricate molecular mechanisms through which these natural compounds modulate cccDNA activity, such as interfering with cccDNA formation, disrupting its epigenetic regulation, or inhibiting its transcriptional output. …”
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Physiological and Microbial Community Dynamics in Does During Mid-Gestation to Lactation and Their Impact on the Growth, Immune Function, and Microbiome Transmission of Offspring K... by Haidong Du, Kenan Li, Wenliang Guo, Meila Na, Jing Zhang, Jing Zhang, Renhua Na

“…These microbial communities may play a significant role in modulating the metabolism and immune responses of the offspring, thereby influencing their immune system development.…”
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Tripartite Motif-Containing 1 Influences the Prognosis of Cervical Cancer by Ge Zhang, Huan Chen, Yin Tao

“…The role of tripartite motif-containing 11 (TRIM11) in DNA repair may influence genomic stability in cervical cancer (CC) and modulate treatment response. This study aimed to analyze the expression and prognostic significance of TRIM11 in CC and across multiple cancer types (pan-cancer analysis). …”
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Probiotic efficacy and mechanism of a pigeon derived Ligilactobacillus salivarius strain in promoting growth and intestinal development of pigeons by Puze Zhao, Yumei Li, Yuwei Yang, Qingxing Xiao, Ziyi Zhang, Xiaoqing Hong, Hongyu Ni, Zhuxuan Xia, Kun Zhan, Sibao Yang, Yonghong Zhang

“…Transcriptomic profiling of the ileum revealed 1828 differentially expressed genes (DEGs) between CG and MG. Notably, DEGs involved in the MAPK signaling pathway, such as RAF1, PDGFRB, and ELK4, were significantly correlated with differential ileal bacteria, suggesting that modulation of intestinal flora can influence the expression of genes related to cell proliferation and differentiation in the ileum, which is potentially important in promoting the growth and development of pigeons.ConclusionLigilactobacillus salivarius S10 possesses the potential to be used as a probiotic for pigeons, which can influence the expression of gut development-related DEGs by regulating the intestinal flora, and further improve the growth performance of pigeons. …”
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Treatment With Schistosoma Japonicum Peptide SJMHE1 and SJMHE1-Loaded Hydrogel for the Mitigation of Psoriasis by Liu X, Wang S, Jiang Y, Luo X, Yang Y, Huo L, Ye J, Zhou Y, Yang Z, Du F, Dong L, Mao C, Wang X

“…Additionally, the effects of Poloxamer 407 (P407)-loaded SJMHE1 were evaluated in mice with IMQ-induced psoriasis through topical application.Results: Topical administration and subcutaneous injection of SJMHE1 alleviated psoriasis-like skin lesions, improved PASI scores, reduced epidermal thickness and dermal inflammatory cell infiltration, and decreased expression of Ki67, a marker of keratinocyte proliferation or differentiation. SJMHE1 modulated pro-inflammatory and anti-inflammatory cytokine expression in LPS-treated HaCaT cells, down-regulating NF-κB and STAT3 activation. …”
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Rhein Alleviates Cisplatin-Induced Acute Kidney Injury via Downregulation of NOX4-COX2/PGFS Signaling Pathway by Yuan X, Long L, Wang M, Chen W, Liang B, Xu L, Wang W, Li C

“…Molecular docking and MD simulations demonstrated Rhein’s robust binding stability with NOX4, COX2, and PGFS, indicating multi-target modulation. In vivo, Rhein attenuated CDDP-induced AKI by reducing plasma creatinine, renal KIM-1/NGAL expression, and suppressing tubular apoptosis and inflammation. …”
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The Mechanism of HPV-mediated DNA Methylation in the Promoter Region of Long-chain Non-coding RNA MAGI2-AS3 in the Occurrence and Development of Cervical Cancer by Jie Zhang, Qiong Xia, Qinghua Zhang

“…The influence of HPV infection on the malignant transformation of cervical epithelial cells is potentially mediated through the regulatory modulation of MAGI2-AS3 expression via DNA methylation.…”
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Calcium-dependent adhesion protein CDH18, a potential biomarker for prognosis in uterine corpus endometrial carcinoma by Xiaoxuan Tang, Shanxing Dang, Jie Qiu, Ruilan Zhou, Jing Ling, Limei Zhang, Xiaopeng Peng, Qingyun Li, Jin Liu, Wei Liao, Qingxiu Mei, Miao Xie, Yehong Sun, Jianmei Huang, Xuelian Du, Wencong Song

“…In the group with high CDH18 expression, the IC50 values for (5Z)-7-Oxozeaenol, AG-014699, CEP-701, Mitomycin C, PD-0325901, PD-0332991, PHA-665752, SL 0101-1, and SN-38 were notably elevated.ConclusionCDH18 is a novel promising biomarker in UCEC, uniquely associating tumor progression, immune modulation, and chemotherapy resistance, offering enhanced prognostic accuracy and guiding individualized therapeutic strategies for improved patient outcomes.…”
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Single-cell RNA sequencing reveals immune microenvironment niche transitions during the invasive and metastatic processes of ground-glass nodules and part-solid nodules in lung ade... by Yi-Feng Ren, Qiong Ma, Xiao Zeng, Chun-Xia Huang, Jia-Li Ren, Fang Li, Jia-Jing Tong, Jia-Wei He, Yang Zhong, Shi-Yan Tan, Hua Jiang, Long-Fei Zhang, Heng-Zhou Lai, Ping Xiao, Xiang Zhuang, Peng Wu, Li-Ting You, Wei Shi, Xi Fu, Chuan Zheng, Feng-Ming You

“…Results Diverse cellular compositions were observed in the tumor microenvironment (TME) during GGN– and PSN–LUAD invasion and metastasis. Notably, CXCL9 + and TREM2 + tumor-associated macrophages (TAMs) exhibited the most significant enrichment changes. …”
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Dietary Solid-state-fermentation product of Bacillus velezensis T23 alleviate hepatic steatosis, oxidative stress, gut barrier damage, and microbiota dysbiosis in juvenile genetica... by Qiang Hao, Rolf Erik Olsen, Einar Ringø, Qianwen Ding, Tsegay Teame, Yuanyuan Yao, Chao Ran, Yalin Yang, Zhen Zhang, Zhigang Zhou

“…Therefore, a 0.2 g/kg dose is suggested to supplement the diet of Nile tilapia to improve liver health and modulate the gut microbiota profile of the fish positively. …”
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CSF3 enhances the innate immune responses to ALV-J infections via NF-κB and interferon pathways by Junliang Xia, Weiding Chen, Chengxun Xu, Meihuizi Wang, Guodong Mo, Xiquan Zhang

“…Granulocyte colony-stimulating factor 3 (CSF3) is a cytokine that regulates hematopoiesis and modulates the proliferation and differentiation of immune cells. …”
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