Tumour-associated macrophage infiltration differs in meningioma genotypes, and is important in tumour dynamics by Ting Zhang, Claire L. Adams, Gyorgy Fejer, Emanuela Ercolano, Jonathan Cutajar, Juri Na, Felix Sahm, C. Oliver Hanemann

“…Results Our findings revealed significant differences in the immune infiltration patterns associated with specific genotypes and methylation classes, especially M2-like TAMs. Notably, the 3D spheroid models more closely replicated the TME observed in parental tissues compared to traditional 2D monolayer cultures, offering a superior platform for immune infiltration studies. …”
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Whole-brain spatial distribution of serine incorporator 2 mRNA in adult C57BL/6 J mice by Tianlang Ke, Ruilan Yang, Zewen Tan, Liping Cao, Xuemei Liu

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Harnessing miRNA dynamics in HIV-1-infected macrophages: Unveiling new targeted therapeutics using systems biology by R. Harshithkumar, Mollina Kaul, Madhuri Chandane-Tak, Nikhat J. Siddiqi, Abdul Malik, Abdul Arif Khan, Anupam Mukherjee

“…This study aims to explore the impact of HIV-1 infection on macrophage microRNA (miRNA) expression profiles using a systems biology approach to uncover the potential role of miRNAs in modulating macrophage functionality and identify key miRNA targets that may serve as therapeutic avenues. …”
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PRMT5 deficiency in myeloid cells reprograms macrophages to enhance antitumor immunity and synergizes with anti-PD-L1 therapy by Jian Cao, Yongyu Chen, Bingqian Zhou, Shiyu Chen, Zheyi Chen, Yiren Huang, Lisong Shen, Yingxia Zheng

“…Macrophages are crucial modulators of both innate and adaptive immune responses, and their differentiation into tumor-associated macrophages is critical in shaping the TME. …”
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Multiomics approach reveals the comprehensive interactions between nutrition and children’s gut microbiota, and microbial and host metabolomes by Mingyu Zhu, Qi Wang, Yan Yang, Xiaobing Liu, Jiawen Zhang, Guanghao Li, Wenqing Liu, Xuesong Xiang, Juanjuan Chen

“…Abstract The gut microbiome can modulate nutrient metabolism to produce many metabolites interacting with the host. …”
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Antioxidant and Anticancer Mechanisms of Unique Polyphenols in <i>Camellia ptilophylla</i>: Focus on Gallocatechin-3,5-di-O-gallate and 1,2,4,6-Tetra-O-galloyl-β-D-glucopyranose by Langhua Zhou, Sen Lu, Xiong Gao, Zhongzheng Chen, Yuanyuan Zhang, Weixia Zhong, Fuming Zhu, Bin Li, Xiaorong Lin

“…Mechanistic studies revealed that these polyphenols modulated antioxidant defenses and reactive oxygen species homeostasis via targets like fibroblast growth factor 2, telomerase reverse transcriptase, matrix metalloproteinase 9, and ATP-binding cassette subfamily G member 2, inducing oxidative stress and mitochondrial apoptosis to inhibit carcinogenesis. …”
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CD22 blockade exacerbates neuroinflammation in Neuromyelitis optica spectrum disorder by Wenjun Zhang, Yali Han, Huachen Huang, Yue Su, Honglei Ren, Caiyun Qi, Jinyi Li, Huaijin Yang, Jing Xu, Guoqiang Chang, Wenjin Qiu, Qiang Liu, Ting Chang

“…In this study, we investigated to what extent and by what mechanisms CD22 may modulate microglial activity, neuroinflammation and CNS lesion formation. …”
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Aspergillusidone G Exerts Anti-Neuroinflammatory Effects via Inhibiting MMP9 Through Integrated Bioinformatics and Experimental Analysis: Implications for Parkinson’s Disease Inter... by Fangfang Ban, Longjian Zhou, Zhiyou Yang, Yayue Liu, Yi Zhang

“…The analysis of network pharmacology suggested that Asp G’s anti-PD potential might be attributed to its modulation of inflammation. The data from nitric oxide (NO) detection, qRT-PCR, and Western blot confirmed that Asp G dose-dependently inhibited lipopolysaccharide (LPS)-stimulated NO production, with 40 μM Asp G suppressing 90.54% of the NO burst compared to the LPS group, and suppressed the overproduction of inflammatory-related factors in LPS-induced BV2 cells. …”
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Cbl-b inhibitor NX-1607 activates MAPK/ERK signaling pathway and enhances T-cell activation by Ting Yu, Li Jia, Wenting Zhu, Shan Lu, Yongliang Zhang, Benjin Liu, Shanshan Song, Xubin Bao, Zehong Miao, Jinxue He

“…Backgroud: The E3 ubiquitin ligase casitas B lymphoma-b (Cbl-b) is pivotal in modulating immune responses by attenuating T-cell activation and cytokine production. …”
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Lysinibacillus sphaericus exposure impedes Anopheles dirus’s oviposition via downregulating vitellogenin by Shasha Yu, Zhilong Liu, Jing Wang, Hong Zheng, Shiqian Han, Feifei Zheng, Dan Zheng, Caizhi Zhao, Xin Li, Tingting Liu, Xuesen Yang, Ying Wang

“…This study offers novel insights into the interaction between L. sphaericus and its mosquito host and identifies potential molecular targets for controlling mosquito population density by modulating oviposition behavior. Graphical Abstract…”
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Hippo/YAP signaling pathway in colorectal cancer: regulatory mechanisms and potential drug exploration by Lingqiu Zhang, Lingqiu Zhang, Lingqiu Zhang, Lingqiu Zhang, Fan Zhang, Fan Zhang, Fan Zhang, Fan Zhang, Fan Zhang, Haimei Liang, Haimei Liang, Haimei Liang, Haimei Liang, Xiangling Qin, Xiangling Qin, Xiangling Qin, Xiangling Qin, Yuemi Mo, Yuemi Mo, Yuemi Mo, Yuemi Mo, Shiyi Chen, Shiyi Chen, Shiyi Chen, Shiyi Chen, Jinling Xie, Jinling Xie, Jinling Xie, Jinling Xie, Xiaotao Hou, Xiaotao Hou, Xiaotao Hou, Xiaotao Hou, Jiagang Deng, Jiagang Deng, Jiagang Deng, Jiagang Deng, Jiagang Deng, Erwei Hao, Erwei Hao, Erwei Hao, Erwei Hao, Zhengcai Du, Zhengcai Du, Zhengcai Du, Zhengcai Du

“…This review aims to comprehensively synthesize recent advances in the regulatory mechanisms of the Hippo/YAP pathway and critically evaluate its therapeutic implications, including emerging clinical interventions and epigenetic modulation.MethodsA systematic literature review was conducted to synthesize mechanistic studies, translational research, and clinical trials involving the Hippo/YAP pathway in CRC. …”
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The protein kinases family in fungi: adaptability, virulence and conservation between species by Emanoelle La Santrer, Cláudia Barbosa Assunção, Thiago Miguelito Navarro de Camargo, Izabella Rodrigues, Sabrina Sidney Campolina, Edgar Lacerda de Aguiar, Thiago de Souza Rodrigues, Rachel Basques Caligiorne

“…In Cryptococcus neoformans, GCN2 emerges as the sole kinase responsible for eIF2α phosphorylation, a unique role in modulating translational responses to environmental and host-induced stressors. …”
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Identification of biomarkers and immune microenvironment associated with pterygium through bioinformatics and machine learning by Li-Wei Zhang, Ji Yang, Hua-Wei Jiang, Hua-Wei Jiang, Xiu-Qiang Yang, Ya-Nan Chen, Wei-Dang Ying, Ying-Liang Deng, Min-hui Zhang, Hai Liu, Hong-Lei Zhang

“…Additionally, we utilized weighted correlation network analysis (WGCNA) to select module genes and applied Random Forest (RF) and Support Vector Machine (SVM) algorithms to identify pivotal feature genes influencing pterygium progression. …”
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A Ralstonia solanacearum effector regulates plant cell death by disrupting the homeostasis of the BPA1-ACD11 complex by Bingbing Xue, Yan Zhou, Yongxiao Xie, Xiaocheng Huang, Jinye Zhang, Yang Zhang, Wenyan Zhong, Jinjia Zhao, Dehong Zheng, Lifang Ruan

“…Our study reveals a novel mechanism by which an effector inhibits ETI and, for the first time, highlights the critical role of protein abundance in its function.IMPORTANCER. solanacearum infects major economic crops, notably tomato, potato, and tobacco, leading to substantial yield reductions and economic losses. …”
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Filtered and unfiltered lipoaspirates reveal novel molecular insights and therapeutic potential for osteoarthritis treatment: a preclinical in vitro study by Alissa Behn, Saskia Brendle, Saskia Brendle, Marianne Ehrnsperger, Marianne Ehrnsperger, Magdalena Zborilova, Thomas M. Grupp, Thomas M. Grupp, Joachim Grifka, Joachim Grifka, Nicole Schäfer, Susanne Grässel, Susanne Grässel

“…Nanofat also elevated secretion of complement components and TIMPs in both cell types. Notably, our results revealed no significant differences in cellular effects between sSVF filtered using the Adinizer® and Lipocube™ Nano systems, as well as compared to unfiltered sSVF.DiscussionHere, we provide first insights into how autologous nanofat therapy may ameliorate OA by enhancing chondrocyte proliferation and synoviocyte migration while modulating inflammatory and pain-related factors. …”
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The mechanism of Guanxin Qiwei dropping pills target Dubosiella to improve atherosclerosis by Yuanhong Liao, Yuanhong Liao, Jun Li, Jun Li, Yuxin Li, Jing Liu, Jing Liu, Tingting Chen, Jingkun Lu, Hongxia Li, Qian Zhang, Qian Zhang, Yuewu Wang, Yuewu Wang

“…In terms of gut microbiota modulation, high-dose GXQW treatment promoted the abundance of Bacteroidota and decreased Firmicutes, particularly the Dubosiella genus within Firmicutes. …”
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<i>SIRT5</i> Regulates Lipid Deposition in Goat Preadipocytes via PI3K-Akt and MAPK Signaling Pathways by Haiyang Li, Wenli Yao, Changheng Yang, Wenyang Zhang, Yong Wang, Yaqiu Lin, Zhanyu Du, Changhui Zhang, Lian Huang, Ming Zhang, Huaigong Fan, Jiangjiang Zhu, Hua Xiang

“…In conclusion, our findings demonstrated that <i>SIRT5</i> may modulate intramuscular fat deposition in goats through PI3k-Akt and MAPK signaling pathways. …”
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Genome-wide characterization of monoacylglycerol lipase (MAGL) gene family in soybean and functional analysis of GmMAGLs in storage lipid metabolism and drought resistance by Haiqing Jing, Yan Sun, Bicheng Wang, Juhua Ma, Kun Wan, Zhanqian Li, Yali Zhou, Runzhi Li, Haiping Zhang, Jinai Xue

“…Particularly, 6 GmMAGL genes (GmMAGL1/3/4/6/8/12) showed significant modulation in response to drought stress in roots and leaves of soybean seedlings. …”
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Helminth Seropositivity Inversely Correlated with Th1 and Th17 Cytokines and Severe COVID-19 by Brice Armel Nembot Fogang, Julia Meyer, Linda B. Debrah, Michael Owusu, George Agyei, Derrick Adu Mensah, John Boateng, Jubin Osei Mensah, Ute Klarmann-Schulz, Sacha Horn, Inge Kroidl, Ezekiel Bonwin Ackah, Richard O. Phillips, Augustina Sylverken, Alexander Y. Debrah, Achim Hoerauf, Tomabu Adjobimey

“…In comparison, mild and moderate patients had helminth seropositivity rates of 43.8% and 34.5%, respectively, which were 1.4 and 1.8 times lower than those of the asymptomatic group, respectively. Notably, the two severe COVID-19 cases investigated were seronegative for all three of the helminths tested. …”
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Depression like-behavior and memory loss induced by methylglyoxal is associated with tryptophan depletion and oxidative stress: a new in vivo model of neurodegeneration by Md. Samsuzzaman, Seong-Min Hong, Jae Hyuk Lee, Hyunjun Park, Keun-A Chang, Hyun-Bum Kim, Myoung Gyu Park, Hyeyoon Eo, Myung Sook Oh, Sun Yeou Kim

“…Additionally, MGO reduced the cell count in the DG, CA1, and CA3 hippocampal regions and modulated TPH2 levels in the brain. Notably, co-treatment with MGO and Trp mirrored the effects observed after Trp-null treatment in neurons, including reduced TPH1 and TPH2 levels and inhibition of neuronal outgrowth. …”
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