Establishment of a two-dimensional PCR method for simultaneous detection of nine sexually transmitted disease pathogens: insights into coinfection rates and epidemiological trends... by Shuang Yao, Jun Zhang, Lili Pan, Yang Yu, Guanghua Luo

“…The significant linkage between U. parvum/U. urealyticum, M. hominis, and HPV infection suggests potential synergistic mechanisms influencing HPV persistence or progression. Notably, the predominance of HPV 52 and increased prevalence of genotypes 53, 6, 11, 42, 43, and 61 in STDP-infected individuals highlight how pathogen co-infections may modulate HPV genotype distribution. …”
Get full text

Cognitive and behavioral benefits of 2′-fucosyllactose in growing mice: the roles of 5-hydroxytryptophan and gut microbiota by Liuying Zhu, Zhiyi Zhang, Ting Luo, Hongyan Li, Zeyuan Deng, Jing Li, Liufeng Zheng, Jinqiang Liao, Minghui Wang, Bing Zhang

“…The findings suggest that 2′-FL contribute to cognitive development in growing mice, potentially by modulating gut microbiota and enhancing 5-HT levels in the brain. …”
Get full text

Human umbilical cord mesenchymal stem cell-derived exosomes enhance follicular regeneration in androgenetic alopecia via activation of Wnt/β-catenin pathway by Aiqing Yu, Yujun Zhang, Saifeng Zhong, Zhizhen Yang, Mingming Xie

“…Notably, high levels of two microRNAs, miR-21-5p and let-7b-5p, were identified within hUCMSC exosomes. …”
Get full text

Exploring the potential benefits of areca nut extract in animal production: a review by Zhuying Liu, Zhuying Liu, Xiaolong Wang, Lixin Wen, Lixin Wen

“…This review focuses on the biological activities of areca nut extract, particularly its antioxidant, anti-inflammatory, antiparasitic, antibacterial, and microbiota-modulating effects, which collectively contribute to its potential role as a feed additive for enhancing animal health and performance.Key findings indicate that areca nut extract can promote livestock productivity by accelerating growth, enhancing immune responses, and reducing disease incidence. …”
Get full text

A Review on Pre-, In-Process, and Post-Synthetic Strategies to Break the Surface Area Barrier in g-C₃N₄ for Energy Conversion and Environmental Remediation by Mingming Gao, Minghao Zhao, Qianqian Yang, Lan Bao, Liwei Chen, Wei Liu, Jing Feng

“…This review systematically examines controllable synthesis methodologies for high-SSA g-C<sub data-eusoft-scrollable-element="1">3</sub>N<sub data-eusoft-scrollable-element="1">4</sub>, analyzing how SSA amplification intrinsically modulates band structures, extends carrier lifetimes, and boosts catalytic efficiencies. …”
Get full text

Positive feedback regulation between RpoS and BosR in the Lyme disease pathogen by Sajith Raghunandanan, Raj Priya, Gaofeng Lin, Fuad Alanazi, Andrew Zoss, Elise Warren, Philip Stewart, X. Frank Yang

“…Specifically, mutation or deletion of rpoS significantly reduced BosR levels, whereas artificial induction of rpoS resulted in a dose-dependent increase in BosR levels. Notably, RpoS does not affect bosR mRNA levels but instead modulates the turnover rate of the BosR protein. …”
Get full text

Diagnostic Value Investigation and Bioinformatics Analysis of miR-31 in Patients with Lymph Node Metastasis of Colorectal Cancer by Wu-wen Zhang, Xin-liang Ming, Yuan Rong, Chao-qun Huang, Hong Weng, Hao Chen, Jun-mei Bian, Fu-bing Wang

“…We next identified seven hub genes via module analysis; of these, TNS1 was most likely to be the target of miR-31 and had significant prognostic value for CRC patients. …”
Get full text

Decoding a novel non-enzymatic protein acetylation mechanism in sperm that is essential for fertilizing potential by María Iniesta-Cuerda, Jan Nevoral, Dario Krapf, Julián Garde, Ana Josefa Soler-Valls, Marc Yeste

“…Conclusion This study provides novel evidence for the occurrence of non-enzymatic acetylation in sperm, linked to the modulation of α-tubulin acetylation levels and motility during capacitation. …”
Get full text

Alpha EEG Spectral Characteristics in the Parieto-Occipital lobe of Elderly Patients with Chronic Insomnia and Mild Cognitive Impairment by GUO Zhenxing, BAI Linxin, ZHANG Lin, GAO Jiahui, RAO Ting, LIU Zhizhen

“…Moreover, Parieto-Occipital lobe alpha spectral power can modulate cognitive function in this population.…”
Get full text

SUMOylation of TP53INP1 is involved in miR-30a-5p-regulated heart senescence by Yi-Xiang Hong, Chan Wu, Jing-Zhou Li, Fei Song, Yu Hu, Yue Han, Yi-Jie Mao, Wei-Yin Wu, Yan Wang, Gang Li

“…This study identified miR-30a-5p as a crucial modulator of heart senescence and revealed that the miR-30a-5p–TP53INP1–p53 axis is essential for heart and cardiomyocyte aging.…”
Get full text

Exosomal miR-125b-5p derived from mesenchymal stromal/stem cell enhances anti-PD-1 therapy in mouse colon cancer model by Mengmeng Jiang, Jia Liu, Shengquan Hu, Xueqin Yan, Yongkai Cao, Zhengzhi Wu

“…Conclusions In summary, our findings suggest that exosomal miR-125b-5p derived from MSC exerts prominent potential in advancing anti-PD-1 therapy by modulating tumor immune environment. This property of miR-125b-5p may be therapeutically harnessed in human cancers to enhance the efficacy of immunotherapy. …”
Get full text

Association of placental mitochondrial DNA mutations on infant negative affectivity: modifying effects of maternal lifetime stress and infant sex by Agathe M. de Pins, Hsiao-Hsien Leon Hsu, Rosalind J. Wright, Kelly J. Brunst

“…This is the first study connecting placental mitochondrial DNA mutations with infant temperament in a diverse population, revealing sex-specific and stress-modulated effects.…”
Get full text

Psychophysiological Acute Effects of Functional Neurology Intervention on Vestibulo-Ocular Reflex Dysfunction by Guillermo Escribano-Colmena, Jorge Rey-Mota, Ana Isabel Beltrán-Velasco, Vicente Javier Clemente-Suárez

“…Specifically, the intervention led to marked enhancements in pain tolerance, cortical arousal, and handgrip strength, and notably, an increased tolerance to VOR cancellation stimuli, indicating improved vestibular control. …”
Get full text

Indigo alleviates psoriasis through the AhR/NF-κB signaling pathway: an in vitro and in vivo study by Yu Lin, Lihong Yang, Dongxiang Wang, Haiqing Lei, Yuelin Zhang, Wen Sun, Jing Liu

“…Its mechanism of action is likely linked to the modulation of the AhR/NFκB signaling pathway.…”
Get full text

Biofilm matrix regulation by Candida glabrata Zap1 under acidic conditions: transcriptomic and proteomic analyses by Bruna Gonçalves, Diana Priscila Pires, Liliana Fernandes, Miguel Pacheco, Tiago Ferreira, Hugo Osório, Ana Raquel Soares, Mariana Henriques, Sónia Silva

“…In this study, we reveal that Zap1 regulates the matrix of C. glabrata acidic biofilms and analyzed the modulation of their transcriptome (by microarrays) and matrix proteome (by LC-MS/MS) by Zap1. …”
Get full text

Semantic classification of Indonesian consumer health questions by Raniah Nur Hanami, Rahmad Mahendra, Alfan Farizki Wicaksono

“…One key component of such a system could be a module for classifying the semantic type of a question. …”
Get full text

A telomere-associated molecular landscape reveals immunological, microbial, and therapeutic heterogeneity in colorectal cancer by Yinmeng Zhang, Jiawei Fan, Jiahui Zhao, He Zhu, Yan Xia, Hong Xu

“…Conversely, these tumors demonstrated increased susceptibility to MAPK pathway inhibitors, such as Selumetinib and Trametinib. Notably, TELscore also served as a robust predictor of immunotherapy response, which was validated in the IMvigor210 cohort. …”
Get full text

Engineering n-Type and p-Type BiOI Nanosheets: Influence of Mannitol on Semiconductor Behavior and Photocatalytic Activity by Shuo Yang, Wenhui Li, Kaiyue Li, Ping Huang, Yuquan Zhuo, Keyan Liu, Ziwen Yang, Donglai Han

“…In this study, the pivotal role of mannitol in modulating the semiconductor characteristics of BiOI nanomaterials is underscored, particularly in promoting the n-type to p-type transition and enhancing photocatalytic efficiency. …”
Get full text

Metabolomic Profiling of Erector Spinae Plane Block for Breast Cancer Surgery by Ekin Guran, Ozan Kaplan, Serpil Savlı, Cigdem Sonmez, Lutfi Dogan, Suheyla Unver

“…In conclusion, we think that ESP block, which provides adequate analgesia, is an acceptable approach in terms of modulating immune responses in breast cancer surgery.…”
Get full text

Identification of cancer cell-intrinsic biomarkers associated with tumor progression and characterization of SFTA3 as a tumor suppressor in lung adenocarcinomas by Yu Zhao, Chengcheng Zhou, Ling Zuo, Haoming Yan, Yuhan Gu, Hong Liu, Guiping Yu, Xiaorong Zhou

“…Furthermore, our study revealed that a progressive decrease in SFTA3 expression in cancer cells was correlated with tumor advancement. Notably, the serum levels of SFTA3 significantly decreased in patients with LUAD, suggesting its potential utility in liquid biopsy for LUAD diagnosis. …”
Get full text