MΦ macrophage – N0 neutrophil dialogue in the presence of TNF-α affects the endothelium by Sergiu-Marian VATAMANU, Monica ȚUCUREANU, Andreea MIHĂILĂ, Elena BUTOI, Anca FARKAS

“…This pro-inflammatory cytokine orchestrates a complex interplay between these immune cells, leading to the activation and recruitment of additional leukocytes, and the modulation of endothelial cell function, which collectively drive plaque formation and progression. …”
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Unveiling the therapeutic potential of natural products in Alzheimer’s disease: insights from in vitro, in vivo, and clinical studies by Nahida Aktary, Yerim Jeong, Seungji Oh, Yeju Shin, Yoonsoo Sung, Muntajin Rahman, Livia Ramos Santiago, Jinwon Choi, Han Gyeul Song, Fahrul Nurkolis, Rosy Iara Maciel Azambuja Ribeiro, Moon Nyeo Park, Bonglee Kim

“…Emerging evidence highlights the therapeutic potential of natural products, particularly herbal medicines, as versatile modulators of key pathogenic processes in AD. These compounds exert neuroprotective effects by mitigating oxidative stress, suppressing neuroinflammation, inhibiting tau hyperphosphorylation, and reducing amyloid-beta aggregation. …”
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P-26 EPIGENETIC MARKS IN PATIENTS WITH SUSTAINED VIRAL RESPONSE TO HCV AND RESIDUAL LIVER FIBROSIS ARE RESTORED BY PROLONGED-RELEASE PIRFENIDONE by Eira Cerda Reyes, Ricardo De la Rosa Bibiano, Ana Sandoval Rodriguez, Rebeca Rosas Campos, Rebeca Escutia Gutiérrez, Ángel Omar Vázquez Esqueda, Stefanny Cornejo Hernández, Alejandro Gutiérrez Átemis, Salvador Amezquita Pérez, Jorge Luis Poo, Gildardo Agustin Garrio Sanchez, Juan Ramón Aguilar, Juan Armendáriz Borunda

“…Conclusions: These findings indicate, for the first time, that PR-PFD treatment could exert therapeutic effects in Hispanic patients with residual fibrosis by modulating miRNA expression and methylation of specific CpG sites.…”
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Diversity and functional roles of endophytic and rhizospheric microorganisms in Ophioglossum vulgatum L.: implications for bioactive compound synthesis by Xian-Nv Long, Xian-Nv Long, Xian-Nv Long, Xing-Kai Zhang, Yue Wu, Shu-Shuang Tang, Tai-Xiong Zheng, Di Chen, Guan-Hua Cao, Guan-Hua Cao, Guan-Hua Cao, Xu-Hong Zhou, Sen He, Sen He, Sen He

“…These findings establish endophytic-rhizospheric microbiota as key biosynthetic modulators, proposing innovative approaches for enhancing phytochemical production through targeted microbial community manipulation.…”
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Pharmacokinetics and tissue distribution analysis of ginsenoside Rh3 in rats using a novel LC-MS/MS quantification strategy by Cong Hu, Cong Hu, Yuheng Wang, Yu Liu, Xiaojing Wang, Peifang Song, Hong Ma, Ling Yang, Ling Yang

“…The mechanism underlying its blood-brain barrier permeability warrants further investigation, potentially involving transporter-mediated uptake or modulation of barrier integrity. These findings provide a foundation for optimizing GRh3 dosing regimens and guiding future preclinical studies.…”
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Effects of chlorogenic acid on growth performance, immunity, antioxidant capacity, intestinal microbiota, and liver transcriptome in Mauremys mutica by Hongyao Zhang, Jingu Shi, Zike Yan, Mingzuo Gao, Kaijie Lin, Yutian Zhan, Yuhan Li, Jingzhen Liang, Shuyu Han

“…Transcriptomic analysis demonstrated that CGA significantly modulated liver gene expression, with the 200 mg/kg CGA group exhibiting the highest number of differentially expressed genes (DEGs). …”
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Multi-omics identification of a polyamine metabolism related signature for hepatocellular carcinoma and revealing tumor microenvironment characteristics by Yuexi Yu, Huiru Liu, Kaipeng Liu, Meiqi Zhao, Yiyan Zhang, Runci Jiang, Fengmei Wang

“…By employing unsupervised consensus clustering, AddModuleScore, single-sample gene set enrichment analysis (ssGSEA), and weighted gene co-expression network analysis (WGCNA), we identified polyamine metabolism-related genes at both the bulk RNA-seq and single-cell RNA-seq (scRNA-seq) levels. …”
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Indoleamine 2,3-dioxygenase 1-mediated immune suppressive status is positively associated with brain metastasis in patients with non-small cell lung cancer by Weiwei Chen, Li Yang, Victor Ho-fun Lee, Liangliang Xu, Lingyu Ma, Zhenghao Ye, Wanli Xu, Caining Zhao, Danyang Zheng, Karrie Mei-Yee Kiang, Stella Sun, Yuan Qu, Jiandong Zha, Dazhi Pang, Yan Zhang, Zhibing Liang, Wenchu Lin, Jinliang Zhang, Jitian Zhang, Min Luo, Zhiyuan Xu, Ding Li, Xiaoling Liang, Gilberto Ka-Kit Leung, Aya El Helali, Chiming Che, Feng-Ming (Spring) Kong

“…Here, we aimed to examine whether IDO1 activity is correlated with OS in NSCLC patients with brain metastasis (Bramet) and has negative effect on modulating the anti-tumor functions of immune cells. …”
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Honeybees fed D-galactose exhibit aging signs with changes in gut microbiota and metabolism by Guanzhou Zhou, Jiabin Hu, Mengqi Xu, Yiyuan Li, Ruqi Chang, Jiaqi Zeng, Wanyue Dan, Lihua Peng, Zikai Wang, Gang Sun, Fei Pan, Yunsheng Yang

“…These phenotypic changes were associated with microbial dysbiosis characterized by Lactobacillus enrichment and diminished butyrate levels. Notably, sodium butyrate supplementation extended the honeybees’ lifespan and improved their learning and memory abilities damaged by D-galactose. …”
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Lactobacillus salivarius metabolite succinate enhances chicken intestinal stem cell activities via the SUCNR1-mitochondria axis by Danni Luo, Minyao Zou, Xi Rao, Mingping Wei, Lingzhi Zhang, Yuping Hua, Lingzi Yu, Jiajia Cao, Jinyi Ye, Sichao Qi, Huanan Wang, Yuling Mi, Caiqiao Zhang, Jian Li

“…The activity of intestinal stem cells (ISCs) can be modulated by Lactobacillus, which subsequently affects the mucosal absorptive capacity. …”
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Association studies for leaf rust resistance earmark differential genomic regions for silicon (Si) responsiveness in bread wheat (Triticum aestivum L.) by Prashanth Babu, Manjunath Prasad, R. Nirmalaruban, Sudhir Kumar, Rajbir Yadav, Manjeet Kumar, Kiran B. Gaikwad, Naresh Kumar Bainsla, S. Bhaskar Reddy, Nasreen Saifi, Amit Kumar Mazumder, Meda Alekya, Gaurav Kaushik, Palaparthi Dharamteja, Meghashri S. Patil, Shiv Kumar Singh, Dunna Vijay, Ranjeet Ranjan Kumar

“…It plays a significant role in enhancing photosynthetic efficiency, modulating hormonal balance, and activating defence mechanisms through regulating antioxidant systems and expressing defence-related genes, leading to increased stress tolerance and improved yield. …”
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Bikaverin as a molecular weapon: enhancing Fusarium oxysporum pathogenicity in bananas via rhizosphere microbiome manipulation by Honglin Lu, Suxia Guo, Yongbao Yang, Zhihao Zhao, Qingbiao Xie, Qiong Wu, Changjun Sun, Hongli Luo, Bang An, Qiannan Wang

“…Secondary metabolites are critical tools employed by pathogens to interact with their environment and modulate host–pathogen dynamics. Bikaverin, a red-colored polyketide pigment produced by several Fusarium species, has been studied for its pharmacological properties, but its ecological roles and impact on pathogenicity remain unclear. …”
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Beyond gold: the chemoenhancing mechanism and therapeutic potential of auranofin in melanoma by Xiaofeng Wang, Yingnan Liu, Wuqiong Zhang, Zhongda Li, Su Li, Jiaxin Chen, Qi Li, Xiaoman Suo, Yanqiao Zeng, Guofang Zhang, Yang Li

“…Conclusions: This study underscores the chemosensitizing potential of AF in overcoming multidrug resistance in cancer therapy through redox modulation. The molecular mechanism of action underlying AF on TrxR1 demonstrated the unique binding configuration that impedes the reduction of Trx by TrxR1 and instigates an apoptotic response in cancer cells. …”
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High genetic relatedness between multidrug resistant bacteria before and after the 2022 invasion of Ukraine by Francois Lebreton, Viacheslav Kondratiuk, Valentyn Kovalchuk, Niels Pfennigwerth, Ting L. Luo, Brendan T. Jones, Nadiia Fomina, Frieder Fuchs, Jörg B. Hans, Jessica Eisfeld, Ana Ong, Sören Gatermann, Jason W. Bennett, Patrick Mc Gann

“…For all, the mobile genetic elements associated with carbapenemase carriage were fully characterized. Notably, post-invasion ST-773 and ST-1047 P. aeruginosa had a signature of host adaptation with multiple loss-of-function mutations in the quorum-sensing regulator LasR, known to modulate immune responses and provide survival advantages in animal models of infection. …”
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Genetic diversity of the Duffy antigen/receptor for chemokines gene and its susceptibility to zoonotic malaria in non-human primates and Indonesian populations by Dendi H. Permana, Puji B. S. Asih, Dwi A. Suryandari, Elsa H. Murhandarwati, Isfanda Isfanda, Ismail E. Rozi, Lepa Syahrani, Farah N. Coutrier, Hannie Kartapradja, Hairul Afzan, Najdah Hidayah, Din Syafruddin

“…Three genotypic forms – FYA, FYB, and FYA/FYB – were observed in human populations, with FYA being predominant in Kalimantan and Sulawesi. Notably, individuals with the FYA allele in Aceh, a region with high P. knowlesi incidence, were less likely to have an infection, suggesting a potential protective role. …”
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Integrated plasma metabolomic and proteomic analysis uncover the effects and mechanisms of isotretinoin in severe acne by Manqi Xia, Manqi Xia, Jing Zhang, Jing Zhang, Yang Hu, Ziyan Chen, Ziyan Chen, Yanan Ke, Yanan Ke, Shujuan Zhang, Shujuan Zhang, Zeen Yang, Zeen Yang, Xin Tian, Xin Tian, Jingyao Liang, Jingyao Liang, Yumei Liu, Yumei Liu

“…Additionally, 36 differentially expressed proteins (DEPs) were identified in patients before and after isotretinoin treatment. Notably, downregulation of acyl-CoA synthetase long-chain family member 4 (ACSL4) suggests a potential therapeutic mechanism for isotretinoin, while upregulation of monoacylglycerol O-acyltransferase 2 (MOGAT2) may mediate the elevation of blood lipids and the correction of some abnormal lipids. …”
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Integration of multi-omics data to unveil the molecular landscape and role of piRNAs in early-onset colorectal cancer by Siyun Zhou, Lili Yu, Jianhui Zhao, Qian Xiao, Jing Sun, Lijuan Wang, Yuan Zhou, Yadong Lu, Malcolm G Dunlop, Evropi Theodoratou, Honghe Zhang, Kefeng Ding, Xue Li

“…Integrative transcriptomic and DNA methylation analyses identified six EOCRC-specific molecules, including PIWIL1. Notably, PIWIL1 was mainly expressed in epithelial cells, with lower expression in EOCRC versus LOCRC. …”
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Delivery of miR-26a-5p by Subcutaneous Adipose Tissue-Derived Extracellular Vesicles Alleviates Acute Lung Injury in Mice Through CHUK/NF-κB Pathway by Xie Y, Ran L, Yue C, Wang C, Chen F, Su Y, Qin Y, Zhang Q, Liu J, Du N, Zhang L, Jiang Y, Liu G

“…These findings provide mechanistic insights into the role of SAT-EVs in immune modulation and suggest their potential as a therapeutic strategy for ARDS.Keywords: adipose tissue-derived extracellular vesicles, inflammation, CHUK, acute respiratory distress syndrome, miR-26a-5p…”
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MiR-147b-3p promotes osteogenesis by targeting NDUFA4 and PI3K/AKT pathway by Yuanyuan Guo, Kai Shen, Zhijie Li, Changchun Niu, Yang Luo

“…Growing evidence suggests that microRNAs (miRNAs) play a crucial role in bone homeostasis by regulating osteoblast differentiation, bone metabolism, and remodeling processes. Notably, miR-147b-3p has been found to be downregulated in OVCF; however, its specific role in osteogenic regulation remains largely unknown. …”
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A combination of four Toxoplasma gondii nuclear-targeted effectors protects against interferon gamma-driven human host cell death by Brittany Henry, Aubrey J. Phillips, L. David Sibley, Alex Rosenberg

“…This disruption is crucial in preventing premature egress of the parasite and host cell death. Notably, this phenotype is exclusive to human cells, highlighting the intricate and unique mechanisms T. gondii employs to modulate host responses in the human cellular environment.…”
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