Targeted Isolation of ω-3 Polyunsaturated Fatty Acids from the Marine Dinoflagellate <i>Prorocentrum lima</i> Using DeepSAT and LC-MS/MS and Their High Activity in Promoting Microg... by Chang-Rong Lai, Meng-Xing Jiang, Dan-Mei Tian, Wei Lu, Bin Wu, Jin-Shan Tang, Yi Zou, Song-Hui Lv, Xin-Sheng Yao

“…Collectively, our study suggests that FA18:4 (<b>7</b>) modulates microglial function in vitro, indicating its potential to exert neuroprotective effects.…”
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Emerging cytokines contribute to the clinical manifestation of carotid artery plaque formation and stability in patients with diabetes by Zhongqing Xu, James Healy, Wenhui Dong, JingJing Ding, Xiaoyi Shen, Xianzhen Feng, Jun Zhou, Rajesh Puranik, Brett D. Hambly, Shisan Bao

“…Emerging evidence implicates members of the interleukin-1 family—particularly IL-36, IL-37, and IL-38—in the modulation of inflammatory responses in diabetic and non-diabetic vascular disease. …”
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Impact of Fluxapyroxad and Mefentrifluconazole on Microbial Succession and Metabolic Regulation in Rice Under Field Conditions by Changpeng Zhang, Nan Fang, Chizhou Liang, Xiangyun Wang, Yanjie Li, Hongmei He, Xueping Zhao, Yuqin Luo, Jinhua Jiang

“…Residual dissipation followed first-order kinetics, with half-lives (T_1/2) spanning 10.83–21.00 d (FXP) and 23.10–57.76 d (MFZ). Notably, MFZ exhibited prolonged persistence in brown rice (T_1/2 = 57.76 d), though final residues (0.031 ± 0.001 μg/g FXP; 0.011 ± 0.0003 μg/g MFZ) remained below regulatory limits (China: 1 mg/kg; CAC: 5 mg/kg). …”
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Targeting B-raf/MEK signaling in melanocytic carcinoma using HPLC-MS/MS characterized metabolites from Valeriana wallichii Rhizome by Charushila V. Balikai, Raviraj M. Kulkarni, Kiran Thabaj, Shankar Gharge, Rohini S. Kavalapure, Shyam S. Desai

“…High-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) profiling of the ultrasonication-assisted hydroalcoholic extract identified key phytoconstituents, notably chlorogenic acid and quinic acid. Network pharmacology analysis linked these metabolites to critical signaling pathways involved in skin cancer progression, particularly the MAPK, PI3K-Akt, and Ras pathways. …”
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Phytochemical Profiling of Processed Açaí Pulp (<i>Euterpe oleracea</i>) Through Mass Spectrometry and Its Protective Effects Against Oxidative Stress in Cardiomyocytes and Rats by Jefferson Romáryo Duarte da Luz, Eder Alves Barbosa, Rubiamara Mauricio de Sousa, Maria Lúcia de Azevedo Oliveira, Marcela Fabiani Silva Dias, Ingrid Reale Alves, Gisele Custódio de Souza, Elenilze Figueiredo Batista Ferreira, Carla Guzmán-Pincheira, Maria das Graças Almeida, Gabriel Araujo-Silva

“…The antioxidant capacity and modulation of oxidative stress by industrially processed açaí pulp extract from the Amazon (APEA) and its major anthocyanins, cyanidin 3-glucoside (C3G) and cyanidin-3-O-rutinoside (C3R), were evaluated as potential strategies for preventing cardiovascular diseases. …”
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Endoplasmic reticulum adenylate transporter activity affects amino acid metabolism under photorespiratory conditions by Jieni Li, Yuxin Song, Xin Luan, Yajun Gou, Tao Xie, Yu Hong, Na Liu, Yao Su, Xueli Fu, Tianxiu Zhong, Shu Chen, Yuexiong Zhang, Gang Qin, Xiang-Qian Zhang

“…Furthermore, knockout of ER-ANT1 marginally impacted the transcription of genes governing core enzymes in photorespiration, but notably upregulated BOU expression that encodes a putative mitochondrial glutamate transporter and AGAT1 that encodes an alanine:glyoxylate aminotransferase gene. …”
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Effects of the <i>Agrobacterium rhizogenes rolC</i> Gene Insertion on Secondary Metabolites Profile and In Vitro Biological Activity of <i>Acmella oleracea</i> (L.) R.K. Jansen by Priscilla Paola Bettini, Martina Imbesi, Patrizia Bogani, Valentina Maggini, Filippo Firenzuoli, Fabio Firenzuoli, Domenico Trombetta, Antonella Smeriglio

“…LC−DAD−ESI−MS analysis identified a diverse metabolite profile, with AP being notably rich in flavonoids (48.65%) and alkylamides (32.43%), including spilanthol. …”
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Steroid hormones and influence of therapeutic drugs in Chinese postmenopausal rheumatoid arthritis patients by Ying-ying Zhang, Ying-ying Zhang, Na Yang, Na Yang, Hua-yong Zhang, Jia-jia Ge, Si-min Yan, Si-min Yan, Dan Han, Dan Han, Qian-ye Qiu, Wei-hong Ge, Wei-hong Ge, Qing Shu, Qing Shu

“…This was accompanied by profound alterations in estrogen metabolism, notably a hyperactivated 2-hydroxylation pathway and depleted 16-hydroxylation metabolites (FDR&lt;0.001). …”
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Transcriptomic analysis of melatonin-mediated drought stress response genes in alfalfa during germination period by Xiaoxia Zhang, Wenxuan Zhu, Zirui Liu, Xiangling Ren, Yingao Li, Guomin Li, Jingzhuo Wang, Xiaoyan Zhu, Yinghua Shi, Chengzhang Wang, Defeng Li, Hao Sun

“…This suggests that MT mitigates drought stress by modulating the expression of genes associated with energy supply and antioxidant capacity. …”
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A dual program for CRP-mediated regulation in bacterial alarmone (p)ppGpp by Li Zhao, Shi-Yu Zhou, Yu Fu, Jin-Long Shen, Bin-Cheng Yin, Di You, Bang-Ce Ye

“…A model was created in which cAMP-CRP and (p)ppGpp cooperate to dynamically modulate the efficiency of transcriptional–translational coordination responses to stress. …”
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Molecular cloning of TPM3 gene in qinchuan cattle and its effect on myoblast proliferation and differentiation by Juntao Guo, Jianfang Wang, Ke Zhang, Zhimei Yang, Bingzhi Li, Yueting Pan, Hengwei Yu, Shengchen Yu, Sayed Haidar Abbas Raza, Belete Kuraz Abebea, Linsen Zan

“…This protein demonstrated high conservation across species while displaying a predominant α-helix secondary structure despite being an unstable acidic protein. Notably, a noticeable increase in TPM3 expression was observed in the longissimus dorsi muscle and myocardium of calves and adult cattle. …”
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In vitro study on the osteoimmunological potential of magnesium implants (WE43MEO) by Sabrin Aydin, Ana Prates Soares, Heilwig Fischer, Raphael Silvan Knecht, Alexander Kopp, Katharina Schmidt-Bleek, Max Heiland, Carsten Rendenbach

“…PEO surface modification did not further enhance osteogenic differentiation. Notably, WE43 implants elicited a minimal inflammatory response in RAW264.7 murine macrophages, indicating good biocompatibility. …”
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Pan-cancer analysis identifies CLEC12A as a potential biomarker and therapeutic target for lung adenocarcinoma by Desheng Zhou, Yachao Cui, Tianxiang Liang, Zhenpeng Wu, Haiping Yan, Yingchang Li, Wenguang Yin, Yunen Lin, Qiang You

“…Abstract C-type lectin domain family 12 member A (CLEC12A) is a type II transmembrane glycoprotein widely expressed in innate immune cells, where it plays a crucial role in immune modulation and has been implicated in cancer progression. …”
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Interaction between post-tumor inflammation and vascular smooth muscle cell dysfunction in sepsis-induced cardiomyopathy by Rui Liu, Lina Jia, Lin Yu, Detian Lai, Qingzhu Li, Bingyu Zhang, Enwei Guo, Kailiang Xu, Qiancheng Luo

“…BackgroundSepsis-induced cardiomyopathy (SIC) presents a critical complication in cancer patients, contributing notably to heart failure and elevated mortality rates. …”
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GPR43 regulates mitochondrial apoptosis through the cyclophilin D pathway in Alzheimer’s disease by Xiaoqin Wang, Shijing Wu, Zhangjing Deng, Mengyu Yan, Dandan Wang, Maojun Yang, Fuxing Zhong, Jiaqi Song, Lihua Chen, Yingxi Chen, Qi Tian, Weihua Yu, Yang Lü

“…Notably, GPR43 downregulated CypD protein levels, which are linked to mitochondrial permeability transition pore (mPTP) channels, thereby inhibiting apoptosis. …”
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Pyruvate kinase M2 activation maintains mitochondrial metabolism by regulating the interaction between HIF-1α and PGC-1α in diabetic kidney disease by Jimin Park, Young Su Joo, Bo Young Nam, Gyuri Kim, Jung Tak Park, Tae-Hyun Yoo, Shin-Wook Kang, Seung Hyeok Han

“…Conclusion Our study highlights the role of PKM2 activation in restoring impaired mitochondrial metabolism and function by modulating HIF-1α and PGC-1α interactions in DKD.…”
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Multi-Omics Analyses Uncover the Mechanism Underlying Polyploidization-Enhanced Steviol Glycosides Biosynthesis in <i>Stevia rebaudiana</i> by Juan Liu, Jiaxue Wang, Mingjia Chen, Wenna Meng, Anping Ding, Miao Chen, Rongping Ding, Mingpu Tan, Zengxu Xiang

“…Overall, our results indicate the presence of a regulatory circuit orchestrated by polyploidization, which recruits beneficial rhizosphere microbes and modulates the expression of genes associated with SG biosynthesis, ultimately enhancing the SG content in stevia. …”
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Recombinant serralysin metalloproteases D enhances the intracellular replication of infectious bovine rhinotracheitis virus by Longfei Yan, Yanran Li, Jiancheng Qi, Li Ren, Xueke Zhou, Liping Gou, Zhicai Zuo

“…In this study, we investigated the role of recombinant serralysin-like protease D (rSPD) in modulating IBRV infection in Madin-Darby bovine kidney (MDBK) cells. …”
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Dravet syndrome: novel insights into SCN1A-mediated epileptic neurodevelopmental disorders within the molecular diagnostic-therapeutic framework by Guirui Zhang, Guirui Zhang, Shupeng Huang, Mingzhen Wei, Yongmo Wu, Zhengyi Xie, Jin Wang, Jin Wang, Jin Wang

“…Additionally, novel molecules such as the Nav1.1-selective agonist Hm1a and 5HT2BR receptor modulators offer new avenues by remodeling neuronal electrophysiology and neurotransmitter homeostasis. …”
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A Novel Ashwagandha (<i>Withania somnifera</i>) Formulation Mitigates Sleep Deprivation-Induced Cognitive Impairment and Oxidative Stress in a Rat Model by Besir Er, Busra Ozmen, Emre Sahin, Cemal Orhan, Nurhan Sahin, Abhijeet A. Morde, Muralidhara Padigaru, Kazim Sahin

“…All doses improved antioxidant enzyme activity and memory performance, while AE 8.0% doses notably increased serotonin (19% for SD + A3 and 33% for SD + A4) and dopamine levels (40% for SD + A3 and 50% for SD + A4). …”
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