A Cross-Tissue Transcriptome-Wide Association Study Reveals Novel Susceptibility Genes for Diabetic Kidney Disease in the FinnGen Cohort by Menghan Liu, Zehua Li, Yao Lu, Pingping Sun, Ying Chen, Li Yang

“…These genes converge on immune modulation, steroid biosynthesis, DNA repair, and transcriptional regulation—processes central to DKD pathogenesis. …”
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Klebsiella pneumoniae-derived extracellular vesicles impair endothelial function by inhibiting SIRT1 by Xinxin Li, Jinghua Cui, Zanbo Ding, Ziyan Tian, Yiming Kong, Linghai Li, Yang Liu, Wen Zhao, Xueying Chen, Han Guo, Zhengshuo Cui, Xinwei Li, Jing Yuan, Huina Zhang

“…Bacterial extracellular vesicles (BEVs) released by Gram-negative bacteria modulate host cell functions by delivering bacterial components to host cells. …”
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Radiation induced dermatitis by increasing triglyceride levels to induce autophagy and inhibit the PI3K/Akt/mTOR signaling pathway by Yafang Hong, Hongdan Guan, Yunhao Chen, Yao Wang, Junjian Lin, Ying Wang, Yang Zhang, Rong Zheng, Xingchen Ding, Zihan Zhou, Benhua Xu

“…Methods Data were collected from 248 patients with locally advanced HNC treated with intensity-modulated radiation therapy (IMRT). Clinical characteristics and blood profiles prior to RT were collected. …”
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Dynamics of oxylipin biosynthesis in systemic inflammation: insights from a large animal model of endotoxemia by Madison N. Myers, Miguel Chirivi, Jose M. dos Santos Neto, Jair Parales-Girón, Lynn C. Worden, Adam L. Lock, G. Andres Contreras

“…Our study provides novel insights into both systemic and adipocyte-specific OXL dynamics during endotoxemia and highlights their potential as biomarkers and therapeutic targets for modulating inflammation.…”
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Patchoulene epoxide mitigates colitis and hepatic damage induced by dextran sulfate sodium by regulating the colonic microbiota and purine metabolism by Liping Chen, Lili Xie, Lifen Wang, Xueli Zhan, Zhenjian Zhuo, Zhenjian Zhuo, Susu Jiang, Lei Miao, Xinxin Zhang, Weiming Zheng, Tzu-Ming Liu, Jing He, Yuhong Liu

“…Furthermore, PAO corrected the colon metabolic disturbance in UC mice by modulating the purine metabolism, notably increasing the abundance of deoxyadenosine, adenosine and guanine in UC mice.ConclusionsThe therapeutic effect of PAO on UC and liver injury was mainly attributed to its regulation of colonic microbiota and purine metabolism. …”
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Profiling HIV1-host protein–protein interaction networks in patient-derived exosome proteins: impact on pathophysiology and innate immune pathways by Noor Fatima, Mirza Sarwar Baig, Aman Haider Rizvi, Alisha Arzoo, Manu Sharma, Md Shahadab, Aditya Arya, Ayan K. Das, Vineeta Vijay Batra, Keshar Kunja Mohanty, Md Anzar Alam, Ejaj Ahmad, Shakir Ali, Angamuthu Selvapandiyan, Mairaj Ahmed Ansari

“…Notably, CDH5, ENO1, OGT, and TRAF6 were shared among these pathways, BioGRID version 4.4 showed that HIV-1 Gag, Gag-pol, Env, and Nef proteins interact with 196, 162, 158, and 80 human proteins, respectively, associated with different innate immune response pathways. …”
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E74‐like ETS transcription factor 3 expression and regulation in human intervertebral disc by María González‐Rodríguez, Djedjiga Ait Eldjoudi, Alfonso Cordero‐Barreal, Mariam Farrag, María Varela‐García, Clara Ruiz‐Fernández, Carlos Torrijos‐Pulpón, Francisca Lago, Lucía García‐Caballero, Yousof Farrag, Javier Conde‐Aranda, Jesus Pino, Oreste Gualillo

“…Thus, we aim to explore, for the first time, the expression, modulation, and the role of ELF3 in human IVD cells. …”
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Mechanosensory Piezo2 regulated by gut microbiota participates in the development of visceral hypersensitivity and intestinal dysmotility by Haonan Zheng, Yuzhu Chen, Siqi Lu, Zuojing Liu, Yinchao Ma, Cunzheng Zhang, Yiming Zhang, Jindong Zhang, Chang Liu, Ming Chu, Fei Pei, Shuangjiang Liu, Liping Duan

“…However, it remains unclear whether Piezo2 is modulated by the gut microbiota, thus contributing to the development of visceral hypersensitivity and gut dysmotility. …”
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Integrated multiomics analysis identifies PHLDA1+ fibroblasts as prognostic biomarkers and mediators of biological functions in pancreatic cancer by Rui Wang, Rui Wang, Guan-Hua Qin, Guan-Hua Qin, Yifei Jiang, Fu-Xiang Chen, Fu-Xiang Chen, Zi-Han Wang, Zi-Han Wang, Lin-Ling Ju, Lin Chen, Da Fu, En-Yu Liu, Su-Qing Zhang, Wei-Hua Cai

“…A 7-gene mCAF-associated risk model was constructed using advanced machine learning algorithms, and the biological significance of PHLDA1 was validated through co-culture experiments and pan-cancer analyses.ResultsOur multiomics analysis revealed that the novel 7-gene model (comprising USP36, KLF5, MT2A, KDM6B, PHLDA1, REL, and DDIT4) accurately predicts patient survival, immunotherapy response, and TME status. Notably, PHLDA1 was uniquely overexpressed in CAFs and correlated with the activation of key protumorigenic pathways, including EMT, KRAS, and TGF-β, underscoring its central role in modulating the crosstalk between CAFs and malignant ductal cells. …”
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Probiotic <i>Lactobacillus johnsonii</i> Reduces Intestinal Inflammation and Rebalances Splenic Treg/Th17 Responses in Dextran Sulfate Sodium-Induced Colitis by Hao-Yu Liu, Shicheng Li, Kennedy Jerry Ogamune, Peng Yuan, Xinyu Shi, Wael Ennab, Abdelkareem A. Ahmed, In Ho Kim, Ping Hu, Demin Cai

“…Transcriptomic analysis of the spleen revealed that N5 mediated the downregulation of inflammatory pathways, including the IL-17 and TNF signaling pathways, as well as the HIF-1 signaling pathway, and modulated the metabolic pathway of oxidative phosphorylation. …”
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Unraveling gut microbiome alterations and metabolic signatures in hereditary transthyretin amyloidosis by Hanyu Li, Zeyuan Wang, Shan He, Xinyue Zhao, Qingyang Wu, Yueshen Sun, Yue Fan, Xiaomin Hu, Zhuang Tian, Shuyang Zhang

“…Significant disparities were observed in both the serum metabolome and gut microbiome of individuals with hATTR when compared to healthy controls. Notably, the serum levels of gamma-aminobutyric acid (GABA) and taurine were markedly decreased in the hATTR group, with the most pronounced reduction in those exhibiting hATTR-related cardiac amyloidosis. …”
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Glaesserella parasuis infection triggers endoplasmic reticulum stress-mediated pyroptosis via PERK/eIF2α/ATF4 axis and metabolic reprogramming in porcine alveolar macrophages by Weili Feng, Yu Han, Wanyun Zhang, Lei Wu, Ao Zhou, Liangyu Shi, Jing Zhang

“…By contrast, pyroptosis was characterised by activation of the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, Caspase-1 cleavage, and gasdermin D (GSDMD)-mediated membrane pore formation. Notably, infection provoked endoplasmic reticulum (ER) stress through the PERK/eIF2α/ATF4/CHOP pathway, as evidenced by ER expansion, ribosomal detachment, and mitochondrial damage. …”
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The Cecal Distribution of Microalgal Pigments in Rats: Do Carotenoids and Chlorophylls Play a Pharmacobiotic Role? by Tatiele Casagrande do Nascimento, Patrícia Acosta Caetano, Marcylene Vieira da Silveira, Luiz Eduardo Lobo, Uashington Da Silva Riste, Mariany Costa Deprá, Maria Rosa Chitolina Schetinger, Cristiano Ragagnin de Menezes, Roger Wagner, Eduardo Jacob-Lopes, Leila Queiroz Zepka

“…Notably, 300 µg·kg⁻¹bw·d⁻¹ significantly increased <i>Bifidobacterium</i> and <i>Lactobacillus</i> populations. …”
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<i>Cis</i>-Palmitoleic Acid Regulates Lipid Metabolism via Diacylglycerol Metabolic Shunting by Wenwen Huang, Bei Gao, Longxiang Liu, Qi Song, Mengru Wei, Hongzhen Li, Chunlong Sun, Wang Li, Wen Du, Jinjun Shan

“…Notably, DAG(36:3, 18:1–18:2) emerged as a potential biomarker for HFD-aggravated metabolic dysregulation. …”
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Non-immune targeting of CXCR3 compromises mitochondrial function and suppresses tumor growth in glioblastoma by Travis Yui Hei Chan, Bo Chen, Wanjun Tang, Henry Hei Chan, Yogesh K. H. Wong, Ethan C. L. Wong, Junbo Liao, Anson Cho-Kiu Ng, Jenny Sum Yee Wong, Gilberto Ka-Kit Leung, Karrie M. Kiang

“…This was further supported by our findings that CXCR3 would localize to the mitochondrial membrane, and that inhibition of CXCR3 would lead to mitochondrial depolarization and increased reactive oxygen species production. Notably, activation of phosphorylated-STAT3 rescued cell viability in CXCR3-depleted cells, suggesting that CXCR3 may modulate mitochondrial function through a STAT3-dependent mechanism, consistent with the known functional role of STAT3 in maintaining mitochondrial redox balance. …”
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Dietary resistant starch protects against post-antibiotic intestinal damage by restoring microbial homeostasis and preserving intestinal barrier function in meat duck by Simeng Qin, Yifeng Zhu, Gang Tian, Martin Blomberg Jensen, Keying Zhang, Xuemei Ding, Shiping Bai, Jianping Wang, Yue Xuan, Qiufeng Zeng

“…Resistant starch (RS) is recognized as a nutritional strategy that supports gut and overall host health by modulating gut microbiota. To directly assess the effects of RS on gut microbiota and its role in improving intestinal barrier function in meat ducks, this study first established an antibiotic-induced microbial dysbiosis model, which was characterized by reduced gut microbial diversity, intestinal dysfunction, and an inflammatory outburst following antibiotic exposure. …”
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Effects of Dietary Additives on Nitrogen Balance, Odor Emissions, and Yolk Corticosterone in Laying Hens Fed Low-Protein Diets by Ju-Yong Song, Yun-Ji Heo, Jina Park, Hyun-Kwan Lee, Yoo Bhin Kim, Byung-Yeon Kwon, Da-Hye Kim, Kyung-Woo Lee

“…Branched-chain fatty acids tended to be higher in all laying hens fed low-CP diets, irrespective of feed additives. Notably, low vs. standard protein diets tended to increase yolk corticosterone levels, which is an indicator of stress responses in chickens. …”
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The short-chain fatty acid receptors Gpr41/43 regulate bone mass by promoting adipogenic differentiation of mesenchymal stem cells by Friederike Behler-Janbeck, Anke Baranowsky, Timur A. Yorgan, Michelle Y. Jaeckstein, Anna Worthmann, Marceline M. Fuh, Karthikeyan Gunasekaran, Gisa Tiegs, Michael Amling, Thorsten Schinke, Joerg Heeren

“…Overall, these data indicate that acetate regulates bone architecture via SCFA-Gpr41/43 signaling by modulating the osteogenic versus adipogenic differentiation of mesenchymal stem cells.…”
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Baseline-dependent network reactivity to visual input in children with autism spectrum disorder: a magnetoencephalography study by Tetsu Hirosawa, Tetsu Hirosawa, Daiki Soma, Masuhiko Sano, Masafumi Kameya, Yuko Yoshimura, Yuko Yoshimura, Sumie Iwasaki, Sanae Tanaka, Mitsuru Kikuchi, Mitsuru Kikuchi

“…Graph theoretical analyses quantified the clustering coefficient (C), characteristic path length (L), and small-worldness (SW) to evaluate network organization.ResultsBoth groups exhibited increased alpha-band clustering coefficients under EO. Notably, baseline (DR) graph metrics predicted EO-induced changes, with higher initial values associated with smaller subsequent increases. …”
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Astrocytic NLRP3 cKO mitigates depression-like behaviors induced by mild TBI in mice. by Hui-Tao Miao, Jun Wang, Jing-Jing Shao, Rong-Xin Song, Wen-Guang Li, Jian-Kai Sun, Shi-Yan Jia, Dong-Xue Zhang, Xiao-Ming Li, Jian-Yong Zhao, Li-Min Zhang

“…Our prior research suggests that Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)-related neuroinflammation, modulated by glial cells such as astrocytes, is likely to play a crucial role in the progression of anxiety and cognitive dysfunction. …”
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