Association between a low–carbohydrate diet and macronutrient intake with the gut microbiome, and their interaction with dyslipidemia among Korean adults by Sangwon Chung, Ji-Hee Shin, Jung-Ha Kim, Ki Bae Kim, Young-Do Nam, Mi Young Lim

“…Abstract Background The prevalence of dyslipidemia has increased in recent years; however, it remains a modifiable condition through diet and gut microbiome modulation. Yet, evidence from population-based studies remains limited. …”
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Dissecting PTPN7‐driven aggressiveness in IDH‐wildtype astrocytomas: multi‐omics, clinical validation, and spatial transcriptomics for prognostic insights by Tung Liu, Yu-Chieh Lin, Pei-Chi Chang, Dueng-Yuan Hueng, Yao-Feng Li

“…Conclusion This study positions PTPN7 as a prognostic biomarker and immune modulator in gliomas, particularly IDH‐wildtype astrocytomas. …”
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Linkage of living microbial biomass, function, and necromass to soil organic carbon storage along a chronosequence of Larix principis-rupprechtii plantation in North China by Mengyun Yang, Xiaomeng He, Jingfei Liang, Qiang Liu, Lihua Fu, Xiaodong Cui, Shaohui Huang, Haoan Luan

“…The partial least squares path model highlighted that SOC stocks were primarily regulated by MRC, while the microbial community altered SOC stability by modulating exo-enzyme activities.DiscussionThese results offered novel insights into elucidating the coupling connections between microbial attributes and SOC sequestration during forest development in northern China.…”
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Developing a novel aging assessment model to uncover heterogeneity in organ aging and screening of aging-related drugs by Yingqi Xu, Maohao Li, Congxue Hu, Yawen Luo, Xing Gao, Xinyu Li, Xia Li, Yunpeng Zhang

“…Additionally, drug screening identified Fostamatinib, Ranolazine, and Metformin as potential modulators of multi-organ aging, with mechanisms involving key pathways such as longevity regulation and circadian rhythm. …”
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Analysis of the Potential Link Between Dermatomyositis and Cancer by Guo J, Lei T, Yu X, Wang P, Xie H, Jian G, Zhang Q, Qing Y

“…Immune infiltration analysis revealed diverse immune cell populations in DM patients, with significant correlations between central genes and these immune cells. MIF levels were notably elevated in various tumors and correlated with the prognosis of specific cancers. …”
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Exploring T-cell metabolism in tuberculosis: development of a diagnostic model using metabolic genes by Shoupeng Ding, Chunxiao Huang, Jinghua Gao, Chun Bi, Yuyang Zhou, Zihan Cai

“…Results The analysis revealed significant immunological alterations in TB patients, characterized by markedly elevated monocyte/macrophage populations (p < 0.001) accompanied by reduced T and NK cell counts. Notably, LTBI cases demonstrated an intermediate CD4+/CD8+ T-cell ratio, indicative of dynamic immune homeostasis. …”
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Overcoming therapeutic resistance in driver-negative NSCLC: Immunomodulatory mechanisms and clinical efficacy of Camrelizumab-chemotherapy combination in a real-world cohort by Yan Ge, Yang Zhao

“…Multivariate Cox regression confirmed the PFS benefit (adjusted HR = 0.51, 95% CI 0.29–0.89, P = 0.018). Notably, patients with early progression on prior chemotherapy regimens (resistant phenotype) demonstrated meaningful clinical benefit from the addition of immunotherapy. …”
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Suramin blocked hCAP18/LL-37-induced macrophage recruitment and M2 polarization to enhance the therapeutic efficacy of 1,25(OH)2D3 against hepatocellular carcinoma in vitro and in... by Huidan Zhang, Wenjing Xie, Wenliang Duan, Xueli Yuan, Yaxin Yang, Qin Chen, Yiqiang Zhu, Yuqing Chen

“…Suramin, a potent LL-37 inhibitor, abrogated these immunosuppressive effects by blocking LL-37 internalization, restoring M1 polarization and suppressing Akt/mTOR and STAT3 pathways. Notably, 1,25(OH)2D3/suramin combination therapy synergistically inhibited HCC proliferation, colony formation, and invasion in vitro. …”
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Phytochemical Characterization and Assessment of the Wound Healing Properties of Three Eurasian Propolis by Elisabetta Miraldi, Alessandro Giordano, Giorgio Cappellucci, Federica Vaccaro, Marco Biagi, Giulia Baini

“…Propolis also suppressed IL-1β release in fibroblasts, although its impact on TNF-α was inconclusive. Notably, co-treatment upregulated IL-8 in monocytes, suggesting a potential immunomodulatory role. …”
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Survival benefit of radical prostatectomy in bone metastatic prostate cancer stratified by disease characteristics: A SEER-based retrospective analysis. by Xinxing Zhang, Yuxuan Wang

“…<h4>Conclusion</h4>Survival benefits of RP in de novo bone metastatic prostate cancer are modulated by disease characteristics, with attenuated effects in advanced/high-grade disease. …”
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Targeting inflammatory macrophages with hyaluronan tetrasaccharide: effects on fibroblast collagen degradation and synthesis by Eiko Uno, Florence Kim, Mihoko Yoshino, Yasunari Sato, Masao Hashimoto, Kenji Watanabe, Yoichi Mizukami, Jun Muto

“…These findings indicate that HA4 holds promise as a molecule for mitigating inflammation-induced collagen degradation by modulating macrophage activity in photoaged skin.…”
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Dietary bile acids alleviate dextran sulfate sodium-induced enteritis in juvenile leopard coral grouper (Plectropomus leopardus) by Shengpeng Wang, Longting Zhang, Jie Huang, Qingcong Fu, Dingqian Guo, Yujie Gao

“…Microbial diversity analysis through 16S rRNA sequencing indicated that dietary bile acids notably increased the abundance of Firmicutes and Candidatus-Arthromitus. …”
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Identification of biomarkers associated with energy metabolism in hypertrophic cardiomyopathy and exploration of potential mechanisms of roles by Songyan Cai, Tianying Jin, Mintong Liu, Qingyuan Dai

“…Subsequently, the identified DEGs were intersected with key module genes in Weighted gene co-expression network analysis (WGCNA) and energy metabolism related genes (EMRGs) to identify DE-EMRGs. …”
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Spectrum of γ-Secretase dysfunction as a unifying predictor of ADAD age at onset across PSEN1, PSEN2 and APP causal genes by Sara Gutiérrez Fernández, Cristina Gan Oria, Dieter Petit, Wim Annaert, John M. Ringman, Nick C. Fox, Natalie S. Ryan, Lucía Chávez-Gutiérrez

“…Our findings also support the development of therapeutic strategies modulating γ-secretase across different genetic ADAD forms and potentially more broadly in AD.…”
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Growth hormone combined with estrogen improves intrauterine adhesion fibrosis by downregulating endometrial microbial citraconic acid to target β-catenin protein by Yuhua Zeng, Yanfei Yang, Fei Zeng, Qing Feng

“…Biochemical serum analysis showed that the combined therapy upregulated key reproductive hormone levels. Notably, the combined application of rrGH and estrogen partially restored GH receptor levels. …”
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miR-374-5p inhibits osteogenesis by targeting PTEN/PI3K/AKT signaling pathway by Guangning Long, Fen Liu, Hongmeng Cheng, Jun Guo, Pei Wang, Yunfei Luo, Zhihua Li, Fei Tong

“…Conclusion Our findings indicate that miR-374-5p inhibits osteogenesis in rat osteoblasts by targeting PTEN and modulating the PI3K/AKT signaling pathway.…”
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Synthesis of Zinc Oxide-Doped Carbon Dots for Treatment of Triple-Negative Breast Cancer by Wang M, Lan S, Song M, Zhang R, Zhang W, Sun X, Liu G

“…We confirmed the biosafety and potent anti-cancer efficacy of CDs/ZnO in inhibiting TNBC progression by disrupting malignant cell behaviors through modulation of the MAPK signaling pathway.Keywords: zinc, carbon dots, triple-negative breast cancer, MAPK signaling pathway…”
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Assessing the selective impact of histone modifying drugs on adenoid cystic carcinoma cells and their stem cell counterparts by Carolina Emerick, Luan César Silva, Yeejin Jang, Pablo A. Vargas, Cristiane H. Squarize, Rogerio M. Castilho

“…Conclusion These findings demonstrate that CSCs and non‑CSCs respond differently to epigenetic modulation, suggesting that personalized combination therapies targeting both subpopulations may be necessary to improve treatment outcomes for ACC. …”
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Antiviral activity of Scutellaria baicalensis Georgi Extract against Getah virus in vivo and in vitro by Baoling Liu, Yuling Wang, Lina Shao, Yuanhang Chen, Zhiwen Xu, Zhiwen Xu, Ling Zhu, Ling Zhu

“…Mechanistically, the antiviral activity of ESG appears to be mediated, at least in part, through the modulation of E2 protein expression.…”
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Computational drug discovery of phytochemical alkaloids targeting the NACHT/PYD domain in the NLRP3 inflammasome by Nilay Singh, Promila Sharma, Manoj K. Pal, Ragini Kahera, Himani Badoni, Kumud Pant, Neetu Sharma, Bhawana Bhist

“…This computational approach predicted ligands that may modulate inflammatory proteins and support host immunity. …”
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