A dynamic co-expression approach reveals Gins2 as a potential upstream modulator of HNSCC metastasis by Nasibeh Khayer, Samira Shabani, Maryam Jalessi, Mohammad Taghi Joghataei, Frouzandeh Mahjoubi

“…Abstract Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer that is notably associated with a high risk of lymph node metastasis, a major cause of cancer mortality. …”
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Mycobacterium tuberculosis specific protein Rv1509 modulates osteoblast and osteoclast differentiation via TLR2 signaling by Pan Liu, Jiezhong Deng, Yusheng Yang, Wenxi Bai, Shengtao Dong, Zehua Zhang

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PNMA1 is a novel immune modulator and therapeutic target in hepatocellular carcinoma linked to bile acid metabolism by Hongyu Chu, Yuezhan Shan, Chengwei Jiang, Yumin Zhong, Zijing Liu, Xuedong Fang, Zhaoying Yang

“…Furthermore, PNMA1 is a pivotal HCC biomarker and therapeutic target with a focus on cancer progression, immune modulation, and bile acid metabolism.…”
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Anaesthetics modulate tumour necrosis factor α: effects of L-carnitine supplementation in surgical patients. Preliminary results. by Giovanna Delogu, Claudio De Simone, Giuseppe Famularo, Alessandra Fegiz, Francesca Paoletti, Emilio Jirillo

“…During in vitro experiments the authors found that anaesthetics modulate the production of TNFα by peripheral blood mononuclear cells. …”
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Exogenous strigolactones modulate antioxidant metabolism via CsD27 to enhance drought tolerance in tea plants by Jingyue Shen, Jingyue Shen, Manni Tong, Qingyun Yuan, Lizhi Long, Yuanzhi Shi

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Synergistic modulation of gut microbiota and mindfulness-based interventions in schizophrenia: Integrating neurotransmitter regulation and multimodal therapeutic strategies by Izabela Zajkowska, Patrycja Niczyporuk, Aleksandra Giba, Kamila Iłendo, Wiktor Królikiewicz, Rafał Marecki, Aleksandra Kicman

“…In parallel, MBIs, including Mindfulness-Based Stress Reduction (MBSR) and Mindfulness-Based Cognitive Therapy (MBCT), promote improvements in emotional regulation, cognitive function, and neuroplasticity through the modulation of neurophysiological pathways, notably by attenuating amygdala reactivity and heightening prefrontal cortex engagement. …”
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Coenzyme Q10 modulates the immunity by enhancing mononuclear macrophage, NK cell activity, and regulating gut microbiota by Yajun Liang, Yang Han, Ling Xiao, Yupeng Su, Tongen Bao, Xia Ji, Longgang Jia, Jing Zhang

“…However, the intrinsic mechanism of CoQ10 on immunity, and the relationship to the gut microbiota have not been elucidated.MethodsHere, we conducted a series of in vivo experiments with the aim of comprehensively exploring the effect of CoQ10 on both cellular and humoral immune functions, and on gut microbiota communities in mice.ResultsCoQ10 showed negligible impact on both mouse body weight fluctuations and tissue indices, but enhanced the mouse body immunity by elevating the carbon clearance ability and natural killer (NK) cellular viability. 16S rRNA gene sequencing revealed that administration of CoQ10 modulated the structure and composition of the gut microbiota in mice, notably by enhancing the abundance of Lactobacillus, Limosilactobacillus, and decreasing the abundance of Paramuribaculum species.DiscussionThis work makes a contribution to the application of CoQ10 as an immunomodulator in the biological, pharmaceutical and health care product industries.…”
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The role of bioactive compounds in coconut water-herb fermentation: formation of biological nanoparticles and their application in the modulation of intestinal microbiota by Sofi Nabila, Arie Srihardyastutie, Aulanni’am, Tri Ardiyati

“…The findings suggest that this fermented product has significant potential as a nutraceutical for intestinal microbiota modulation and immune system enhancement.…”
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Quarter-Wave Plate Meta-Atom Metasurfaces for Continuous Longitudinal Polarization Modulation of Hybrid Poincaré Sphere Beams by Yunxiao Li, Quanhong Feng, Gongzheng Fang, Haonan Sun, Xingyi Fan, Zhenghao Liu, Hao Wang, Yuexu Si, Shuhao Si, Xuran Li, Chen Cheng

“…Quarter-wave plate (QWP) metasurfaces provide a novel approach for generating three-dimensional (3D) hybrid-order Poincaré sphere (HyOPS) beams and enabling longitudinal polarization modulation, owing to their unique spin-decoupling properties. …”
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Orbital-Scale Modulation of the Middle Miocene Third-Order Eustatic Sequences from the Northern South China Sea by Haichun Xu, Nan Wu, Xinyan Xu, Bo Yu, Ke Xu

“…We constructed an absolute astronomical time scale anchored at the HJF’s top boundary (10.221 ± 0.4 Ma), identifying 6 third-order sequences through detailed analysis. Notably, 18 long-eccentricity cycles (405 kyr) and distinctive 1.2-Myr obliquity modulation signals were detected in the stratigraphic record. …”
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Gut microbiota and their metabolites ameliorate acute and chronic colitis in mice via modulating Th17/Treg balance by Dongyue Li, Huiling Tao, Xin Tan, Hao Ling, Yue Lu, Huichao Zhang, Sok Theany, Hongyu Xu

“…Notably, butyrate synergistically enhances microbial therapeutic effects, providing experimental evidence for personalized modulation of gut ecosystems in inflammatory bowel disease management.…”
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BAG2 Inhibits Cervical Cancer Progression by Modulating Type I Interferon Signaling through Stabilizing STING by Shijie Yao, Siming Chen, Anjin Wang, Ziyan Liang, Xuelian Liu, Yang Gao, Hongbing Cai

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Targeting S100A9 attenuates social dysfunction by modulating neuroinflammation and myelination in a mouse model of autism by Hong Gong, Yao Lu, Shi-Long Deng, Ke-Yi Lv, Jing Luo, Yi Luo, Zhu-Lin Du, Ling-Feng Wu, Tian-Yao Liu, Xia-Qing Wang, Jing-Hui Zhao, Lian Wang, Mei-Ling Xia, Dong-Mei Zhu, Li-Wei Wang, Xiao-Tang Fan

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Xiaoyao San ameliorates maternal inflammation-induced neurobehavioral deficits by modulating the microbiota-gut-brain axis in offspring by Chunqiao Lin, Chunqiao Lin, Jiushuang Zhu, Lu Zhang, Lijie Shi, Zhuoting Zhong, Xiuwen Xia, Weijun Ding, Youjun Yang

“…Notably, B. uniformis was identified as a key microbial mediator capable of recapitulating XYS-mediated neurophysiological improvements through metabolic regulation.ConclusionThis study elucidates XYS as a multi-target therapeutic agent that coordinately modulates gut microbial ecosystems, amino acid homeostasis, and neurotransmitter homeostasis. …”
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Enhancing DOX efficacy against NSCLC through UDCA-mediated modulation of the TGF-β/MAPK autophagy pathways by Ying Li, Helian Zhao, Zhoumin Shen, Yao Zheng, Yuanyuan Jiang, Ying Song, Yimin Cai

“…This study, through a rigorous methodological framework, elucidates UDCA’s capacity to inhibit NSCLC cellular proliferation and induce apoptosis, thereby significantly amplifying DOX’s chemotherapeutic efficacy. Notably, the co-administration of UDCA and DOX was observed to attenuate DOX-induced autophagy via the modulation of the TGF-β/MAPK signaling axis, a pathway pivotal in mediating cellular survival and autophagic mechanisms. …”
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Choline metabolism modulates cyclic-di-GMP signaling and virulence of Pseudomonas aeruginosa in a macrophage infection model by Yachun Zhou, Yu Zhang, Xiangke Duan, Tian Zhou, Anmin Ren, Yinyue Deng, Lin Zhong, Lei Liu, Yingfeng Huang, Weidong Zheng, Dongjing Liu, Liang Yang

“…Conclusion Our study showed that P. aeruginosa Cho metabolism not only interferes host nutritional immunity, but also directly affect multiple virulence phenotypes through modulation of c-di-GMP signaling.…”
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Fumarate and nitrate reduction regulator (FNR) modulates hypermucoviscosity and virulence in hypervirulent Klebsiella pneumoniae through anaerobic adaptation by Yidan Xu, Ruolan Guo, Ruomei Wang, Zhe Su, Yulu Wu, Chengbin Xie, Pinjia Wang

“…This study demonstrates that FNR modulates the HMV phenotype and virulence of the hvKP strain NTUH-K2044 under anaerobic conditions. …”
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Interstitial fluid flow in an engineered human lymph node stroma model modulates T cell egress and stromal change by Jennifer H. Hammel, Abhinav Arneja, Jessica Cunningham, Maosen Wang, Sophia Schumaecker, Yamilet Macias Orihuela, Tochukwu Ozulumba, Jonathan M. Zatorski, Thomas J. Braciale, Chance John Luckey, Rebecca R. Pompano, Jennifer M. Munson

“…Overall, we demonstrate that interstitial flow is an essential consideration in the lymph node for modulating LN stroma morphology, T cell migration, and inflammation.…”
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Non-temperature environmental drivers modulate warming-induced 21st-century permafrost degradation on the Tibetan Plateau by Fu Ziteng, Wu Qingbai, Chen Anping, Wang Luyang, Jiang Guanli, Gao Siru, Yun Hanbo, Chen ji

“…Our findings underscore the crucial role of non-temperature variables in modulating permafrost responses to climate change, which is important for refining projections of carbon, nutrient, and water cycling and for safeguarding critical infrastructures in the TP and other permafrost regions.…”
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Taming of trinitromethyl-oxadiazole to access high density and high oxygen balance via a dual modulation strategy by Jinya Zhang, Teng Fei, Jingwei Meng, Jinxiong Cai, Lei Zhang, Siping Pang, Chunlin He

“…In this work, an effective dual modulation strategy involving both molecular isomerization and crystal morphology control was employed to design and optimize trinitromethyl-oxadiazole with improved comprehensive performance. …”
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