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1841
Harnessing AlphaFold to reveal hERG channel conformational state secrets
Published 2025-07-01“…Remarkably, AlphaFold not only predicts inactivation mechanisms of the hERG channel that prevent ion conduction but also uncovers novel molecular features explaining enhanced drug binding observed during inactivation, offering a deeper understanding of hERG channel function and pharmacology. …”
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1842
MMPW-Net: Detection of Tiny Objects in Aerial Imagery Using Mixed Minimum Point-Wasserstein Distance
Published 2024-11-01“…Firstly, we introduce a light backbone-heavy neck architecture, named the Global Context Self-Attention and Dense Nested Connection Feature Extraction Network (GC-DN Network), which efficiently extracts and fuses multi-scale features of the target. …”
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1843
Genome-wide analysis of m6A-modified circRNAs in the mouse model of myocardial injury induced by obstructive sleep apnea
Published 2025-04-01“…GO analyses and KEGG analyses were conducted to predict the potential functions of these m6A-modified circRNAs. …”
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1844
Meanings of family under the perspective of parents of adolescent students
Published 2014-06-01“…Eight themes emerged: Structure, values and meanings of family; Roles and functions of family members; Family and school; Family dynamics and the health-disease process in the family; Affective bonds and family relationships; Strategies for family functioning; Feelings and support network; Adolescence and the adolescent in the family. …”
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1845
Placental Vimentin Expression in Preeclampsia and Gestational Diabetes Mellitus
Published 2024-04-01“…A semiquantitative measurement was done between groups by comparing the Vimentin signal and significance was calculated. Network construction and pathway enrichment analysis were conducted using Cytoscape (v3.10.1) and ShinyGO, respectively. …”
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1846
eHealth interventions for chronic pain: Protocol for a systematic review and meta-analysis
Published 2025-12-01“…A network meta-analysis (NMA) will be conducted to compare different eHealth modalities and identify which features contribute most to positive outcomes. …”
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1847
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1849
Machine-learning based optimizing the neutronic and thermal-hydraulic performance in a VVER-1000 mixed-core as well as fuel burnup assessment
Published 2025-06-01“…The reactor core of a functioning power plant usually contains hundreds of fuel assemblies. …”
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1850
Identification of Exposed Submarine Cable Status based on Optimized VMD-GAF-MCNN for Multi Sensor Fusion
Published 2025-06-01“…The training set is used to train the network, while the test set verifies the network's effectiveness in identifying the exposed state of the submarine cable.…”
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1851
Building electrical consumption patterns forecasting based on a novel hybrid deep learning model
Published 2025-06-01“…A comparative analysis was conducted against benchmark models, including the generalized regression neural network (GRNN) and adaptive neuro-fuzzy inference system (ANFIS), to validate the efficacy of the proposed approach. …”
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1852
The Silk Road as a Skilled Practice: taking the two tea roads as cases
Published 2025-06-01“…The Silk Road, an ancient network of trade and cultural exchange, has been a subject of significant scholarly interest, particularly in China, Russia, and Mongolia. …”
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1853
Novel insights into the molecular mechanisms of sepsis-associated acute kidney injury: an integrative study of GBP2, PSMB8, PSMB9 genes and immune microenvironment characteristics
Published 2025-03-01“…We used differentially expressed genes (DEGs) and weighted gene co-expression network analysis (WGCNA) to identify characteristic genes associated with SA-AKI and conducted enrichment analyses. …”
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1854
Identification of unique biomarkers for proliferative diabetic retinopathy with tractional retinal detachment by proteomics profiling of vitreous humor
Published 2025-04-01“…By employing bioinformatics tools for GO and KEGG pathway annotation, as well as conducting protein-protein interaction(PPI) network analysis, we investigated the functional enrichment of proteins in the TRD vitreous and their associated pathways. …”
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1855
Freely Selective Analog and Digital Resistive Switching Behavior of In2Se3 Devices for Storage and Neuromorphic Applications
Published 2025-06-01“…Reconfigurable logic functions and an artificial neural network (ANN) with outline learning accuracy (≈89%) for handwritten digit recognition are achieved. …”
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1856
Acupuncture treatment of vascular cognitive impairment through peripheral nerve stimulation pathway: a scoping review
Published 2025-04-01“…A comprehensive search of databases, including PubMed, Web of Science, MEDLINE, and Embase, was conducted, including 79 studies on acupuncture interventions for VCI. …”
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1857
EPAS1 amplifies asthma pathogenesis through JAK2/STAT3-mediated ferroptosis and inflammation
Published 2025-03-01“…Additionally, immune cell infiltration in asthma patients was analyzed using the Immune Cell AI database in relation to ferroptosis-related genes. Functional experiments at the cellular level were conducted to assess the effects of key genes on cell viability, inflammation, and ferroptosis. …”
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1858
E-learning course for creating descriptions of information about occupations
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1859
RNA-Seq analysis reveals the long noncoding RNAs associated with immunity in wild Myotis myotis bats
Published 2025-04-01“…Our network analysis revealed significant variation in immune status among a subset of individuals, potentially due to pathogenic conditions. …”
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1860
Multi-feature fusion RFE random forest for schizophrenia classification and treatment response prediction
Published 2025-03-01“…Initially, we computed multiple features, such as regional homogeneity, fractional amplitude of low-frequency fluctuations, and functional connectivity. Subsequently, the RFE-RF method was employed to conduct SZ classification. …”
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