Exploring the Association Between Human Blood Metabolites and Autism Spectrum Disorder Risk: A Bidirectional Mendelian Randomization Study by Wenhua Li, Suya Ma, Yunong Tian

“…Additionally, metabolic pathway and network pharmacology analyses were conducted to explore potential mechanisms. …”
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Decoding the Tissue-Specific Profiles of Bioactive Compounds in <i>Helvella leucopus</i> Using Combined Transcriptomic and Metabolomic Approaches by Qian Zhou, Xusheng Gao, Junxia Ma, Haoran Zhao, Dan Gao, Huixin Zhao

“…Pathway enrichment analysis highlighted tissue-specific metabolic pathways, including riboflavin metabolism, pantothenate and CoA biosynthesis, and terpenoid backbone biosynthesis, as key contributors to the unique functional properties of the cap and stipe. A detailed biosynthetic pathway network further illustrated how these pathways contribute to the production of crucial bioactive and nutritional compounds, such as sterols, alkaloids, linoleic acid derivatives, glycerophospholipids, and amino acids, in each tissue. …”
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Computational nanobody design through deep generative modeling and epitope landscape profiling by Liyun Huo, Tian Tian, Yanqin Xu, Qin Qin, Xinyi Jiang, Qiang Huang

“…The nanobody-enriched epitopes showed strong overlap with known functional regions, suggesting potential biological activity. …”
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Computational Neuroscience’s Influence on Autism Neuro-Transmission Research: Mapping Serotonin, Dopamine, GABA, and Glutamate by Victoria Bamicha, Pantelis Pergantis, Charalabos Skianis, Athanasios Drigas

“…Neurotransmitters play a crucial role in the function of brain cells, enhancing synaptic conduction and signal transmission. …”
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Implementation of MF block in CNN for advanced REB fault diagnosis by M. Pandiyan, Narendiranath Babu T.

“…Using the Balance Cross-Entropy (BCE) loss function for training has helped the model optimize prediction accuracy by minimizing the difference between the actual class and the predicted class probabilities. …”
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Expression profiles and bioinformatic analysis of circular RNA in rheumatic heart disease: potential hsa_circ_0001490 and hsa_circ_0001296 as a diagnostic biomarker by Xiaoliang Chen, Lina Chen, Li Bi, Shunying Zhao, Xiaoyan Hu, Ni Li, Linwen Zhu, Guofeng Shao

“…Bioinformatics analysis was used to predict the target miRNA and analyze the co-expressed mRNA to construct a circRNA–miRNA-mRNA regulatory network. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were conducted to predict the potential functions of the differentially expressed genes and RHD-related pathways.ResultsFour circRNAs were selected from circRNA microarray data. qRT-PCR confirmed that hsa_circ_0001490 and hsa_circ_0001296 were significantly upregulated in RHD plasma (4.28-fold, P &lt; 0.001; 5.24-fold, P &lt; 0.001, respectively). …”
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Identification of potential druggable targets for endometriosis through Mendelian randomization analysis by Peng Chen, Xin Wei, Xiao-Ke Li, Yi-Hang Zhou, Yi-Hang Zhou, Qi-Fang Liu, Ling Ou-Yang

“…We applied a range of validation techniques, including reverse causality detection, phenotype scanning, Bayesian co-localization (BC) analysis, and external validations to substantiate our findings. Additionally, we conducted a protein-protein interaction (PPI) network as well as functional enrichment analyses to unveil potential associations among target proteins.ResultsMR analysis revealed that a decrease of one standard deviation (SD) in plasma R-Spondin 3 (RSPO3) level had a protective effect on EM (OR = 1.0029; 95% confidence interval (95% CI): 1.0015–1.0043; P = 3.2567e-05; Bonferroni P &lt; 5.63 × 10−5). …”
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Exploring the mechanism of Bu Zhong Yi Qi Tang in the treatment of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) based on network pharmacology and molecular docking by Pengfei Zhou, Yang Xuan, Zaisheng Zhu, Han Wu, Yang Hu, Liangyou Chen, Qianya Zhou

“…Overlapping targets between BZYQT and CP/CPPS were analyzed using the STRING database to construct a protein-protein interaction (PPI) network. Key targets were further subjected to Gene Ontology (GO) functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. …”
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Activity and mechanism of naringin in the treatment of post-infectious cough by Yinghan Chen, Dong Wang, Meng Song, Weiqi Pan, Wenda Guan, Zifeng Yang, Shan Zhong

“…PPI (Protein–Protein Interaction) networks for disease-related targets were constructed using STRING and Cytoscape 3.10.1. …”
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Comparing Strategies for Optimal Pumps as Turbines Selection in Pressurised Irrigation Networks Using Particle Swarm Optimisation: Application in Canal del Zújar Irrigation Distric... by Mariana Akemi Ikegawa Bernabé, Miguel Crespo Chacón, Juan Antonio Rodríguez Díaz, Pilar Montesinos, Jorge García Morillo

“…This study assesses the use of PATs in pressurised irrigation networks for recovering wasted hydraulic energy, employing the particle swarm optimisation (PSO) algorithm for PAT sizing based on two single-objective functions. …”
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NDAWL-PINN: a new non-dimensionalization and multi-task learning approach for efficient training of physics-informed neural networks to solve the shallow water equations by Xin Qi, Dawei Zhang, Fan Wang, Wuxia Bi, Mingda Lu

“…Furthermore, a comparative analysis is conducted between the solutions obtained using NDAWL-PINN and those from the original PINN, which relies on manual fine-tuning of loss functions. …”
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A Federated Learning-Based Framework for Accurately Identifying Human Activity in the Environment by Nwadher Suliman Al-Blihed, Dina M. Ibrahim

“…The deep learning models used were Convolutional Neural Network (CNN), Residual Network (ResNet), and Long Short-Term Memory (LSTM), and the performance measures used to evaluate these FL models were the Loss function and Accuracy. …”
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Glutamate-bound NMDARs arising from in vivo-like network activity extend spatio-temporal integration in a L5 cortical pyramidal cell model. by Matteo Farinella, Daniel T Ruedt, Padraig Gleeson, Frederic Lanore, R Angus Silver

“…These effects were also observed in a passive model where all the non-synaptic voltage-gated conductances were removed. Our results show that glutamate-bound NMDA receptors arising from ongoing network activity can provide a powerful spatially distributed nonlinear dendritic conductance. …”
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Sarcopenia diagnosis using skeleton-based gait sequence and foot-pressure image datasets by Muhammad Tahir Naseem, Na-Hyun Kim, Haneol Seo, JaeMok Lee, Chul-Min Chung, Sunghoon Shin, Chan-Su Lee

“…Second, we performed experiments on the foot-pressure dataset using the ResNet-18 and spatiotemporal graph convolutional network (ST-GCN) models on the skeleton dataset to classify normal and abnormal gaits due to sarcopenia. …”
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Comparative Analysis of Short-Term and Long-Term Clinical Efficacy of Mesenchymal Stem Cells from Different Sources in Knee Osteoarthritis: A Network Meta-Analysis by Qi Xin Ding, Xu Wang, Tian Shu Li, Yue Fang Li, Wan Yue Li, Jia Huan Gao, Yu Rong Liu, WeiSheng Zhuang

“…The results of the network meta-analysis showed the following: short-term functional improvement (the indexes were evaluated after 6 months of follow-up) (WOMAC total score: bone marrow-derived MSC (BMMSC) vs. adipose-derived MSC (ADMSC) (mean difference (MD) = −20.12, 95% confidence interval (CI) −125.24 to 42.88), umbilical cord-derived MSC (UCMSC) (MD = −7.81, 95% CI −158.13 to 74.99); WOMAC stiffness: BMMSC vs. …”
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Integrated single-cell analysis reveals the regulatory network of disulfidptosis-related lncRNAs in bladder cancer: constructing a prognostic model and predicting treatment respons... by Jiafu Xiao, Jiafu Xiao, Jiafu Xiao, Wuhao Liu, Wuhao Liu, Wuhao Liu, Jianxin Gong, Jianxin Gong, Jianxin Gong, Weifeng Lai, Weifeng Lai, Weifeng Lai, Neng Luo, Neng Luo, Neng Luo, Yingfan He, Junrong Zou, Junrong Zou, Zhihua He, Zhihua He, Zhihua He

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Understanding the effectiveness and underlying mechanisms of lifestyle modification interventions in adults with learning disabilities: a mixed-methods systematic review by Dikshyanta Rana, Sophie Westrop, Nishant Jaiswal, Evi Germeni, Arlene McGarty, Louisa Ells, Phillippa Lally, Michael McEwan, Craig Melville, Leanne Harris, Olivia Wu

“…The network meta-analysis was conducted on all weight management outcomes listed above. …”
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Laboratory diagnostics performance in Uganda: A survey of test availability and constraints by Noel Namuhani, Suzanne Namusoke Kiwanuka, Martha Akulume, Simeon Kalyesubula, William Bazeyo, Angela Nakanwagi Kisakye

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Comparative Efficacy and Safety of Different Tenecteplase Doses With Alteplase in Acute Ischemic Stroke: A Systematic Review With Pairwise and Network Meta‐Analysis to Determine th... by Muhammad Hassan Waseem, Zain ul Abideen, Muhammad Haris Khan, Muhammad Fawad Tahir, Marium Khan, Hafsa Arshad Azam Raja, Ameer Haider Cheema, Sania Aimen, Muhammad Arslan Tariq, Javed Iqbal

“…Additionally, R version 4.3.2 and the “netmeta” package were used to conduct a network meta‐analysis for various dosages of the two thrombolytic drugs. …”
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Association patterns of work-family balance, perceived stress and turnover intentions among female medical workers in China (2022–2023): integration network and pathway analysis by Yin Lin, Jia li

“…A network analysis and path analysis of the data were conducted through R software and the PROCESS macro in SPSS. …”
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