Multi-omics identification of a polyamine metabolism related signature for hepatocellular carcinoma and revealing tumor microenvironment characteristics by Yuexi Yu, Huiru Liu, Kaipeng Liu, Meiqi Zhao, Yiyan Zhang, Runci Jiang, Fengmei Wang

“…Further analysis revealed significant differences in clinical features, biological functions, mutation profiles, and immune cell infiltration between high-risk and low-risk groups. …”
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Norcantharidin inhibits TOP2A expression via H3K27me3 mediated epigenetic regulation to alleviate the progression of hepatocellular carcinoma by Ruibing Wu, Hengye Yuan, Yuehua Wang, Xianggang Gou, Wanhua Hou, Zhongzheng Zhou, Xinran Wang, Xiuling Deng, Changshan Wang, Haisheng Wang, Jia Yan, Jia Yan

“…Functional characterization revealed that NCTD significantly attenuated HCC cell proliferation and induced G2/M phase cell cycle arrest through disruption of the TOP2A-p53 signaling axis. …”
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Assessing the prognostic and therapeutic value of cuproptosis-related genes in colon adenocarcinoma patients by Zhanhui Ye, Yixian Song, Mengqing Zhu, Fuying Zheng, Wenjie Qin, Wenjie Qin, Xue Li, Pei Wang, Zihua Li, Kequan Chen, Aimin Li

“…Using the Weighted Gene Co-expression Network Analysis (WGCNA) method, we identified the gene module most strongly linked to cuproptosis and conducted functional enrichment analysis to explore the roles of genes within this module in COAD tumorigenesis. …”
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In-vitro and in-vivo assessment of biocompatibility and efficacy of ostrich eggshell membrane combined with platelet-rich plasma in Achilles tendon regeneration by Omid Koohi-Hosseinabadi, Reza Shahriarirad, Amireza Dehghanian, Laleh Amini, Sajjad Barzegar, Afrooz Daneshparvar, Omid Alavi, Seyedeh-Parvin Khazraei, Saba Hosseini, Ali Arabi Monfared, Roya Khorram, Nader Tanideh, Soheil Ashkani-Esfahani

“…Despite advancements in tendon injury repair techniques, outcomes remain suboptimal due to inferior tissue quality and functionality. Tissue engineering offers a promising avenue for tendon regeneration, with biocompatible scaffolds playing a crucial role. …”
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Identification and validation of three diagnostic autophagy-related genes associated with advanced plaques and immune cell infiltration in carotid atherosclerosis based on integrat... by Tiegen Huang, Chen Su, Quanli Su, Yali Nie, Zhenni Xiao, Yao Tang, Jiahao Wang, Xiaotian Luo, Yixin Tang

“…Protein-protein interaction (PPI) network was constructed with the DE-ATGs to identify the key CAS-related DE-ATGs. …”
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GNSS Precipitable Water Vapor Prediction for Hong Kong Based on ICEEMDAN-SE-LSTM-ARIMA Hybrid Model by Jie Zhao, Xu Lin, Zhengdao Yuan, Nage Du, Xiaolong Cai, Cong Yang, Jun Zhao, Yashi Xu, Lunwei Zhao

“…To address these challenges, this paper proposes a hybrid model combining the improved complete ensemble empirical mode decomposition with adaptive noise (ICEEMDAN), autoregressive integrated moving average (ARIMA), and long short-term memory (LSTM) networks. Enhanced by local mean optimization and adaptive noise regulation, the ICEEMDAN algorithm effectively suppresses pseudo-modes and minimizes residual noise, enabling its decomposed intrinsic mode functions (IMFs) to more accurately capture the multi-scale features of GNSS-PWV. …”
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Prognostic value and immunotherapy analysis of immune cell-related genes in laryngeal cancer by Sen Zhang, Jianrui Pan, Huina Guo, Xiaoya Guan, Chenxu Yan, Lingling Ji, Xiansha Wu, Hui Huangfu

“…Key genes were identified through the intersection of differentially expressed genes (DEGs) between normal and LC samples and module genes derived from weighted gene co-expression network analysis (WGCNA), followed by functional enrichment analysis. …”
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Multi-omic biomarkers associated with multiple sclerosis: from Mendelian randomization to drug prediction by Wei Yang, chenglin Liu, Zhenhua Li, Miao Cui

“…This approach allowed us to explore the functions of key genes and the mechanisms of co-morbidity associated with the disease. …”
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The Effect of Weed Control with Pre-Emergence Herbicides on the Yield Level of Mung Bean Yield by Cailing Jing, Junying Wang, Yonghong Wu, Yufan Zhou, Huijun Zhu, Yaowen Zhang, Shuqi Dong, Xiaorui Li, Juan Zhao, Junli Cao, Xiangyang Yuan, Xi’e Song

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Comparative analysis of microwave indices for freeze/thaw state monitoring and adaptive thresholding implications by Zhicheng Yang, Tianjie Zhao, Qingfeng Wang, Lihua Peng, Youhua Ran, Yu Bai, Jingyao Zheng, Panpan Yao, Zhiqing Peng, Jinbiao Zhu, Xiaokang Kou, Yuei-An Liou, Jiancheng Shi

“…This study systematically evaluated eight individual indicators—including soil liquid water content indices (Normalized Polarization Ratio, NPR; Modified Polarization Ratio, MPR; Quasi-Emissivity, QE; Normalized Frequency Difference Index, NFDI) derived from SMAP and AMSR2 satellite data, and surface soil temperature indices (TbV6.9, TbV10.65, TbV18.7, TbV36.5)—along with their 16 combinations. The evaluation was conducted across six soil moisture and temperature networks spanning the Tibetan Plateau (Maqu, Naqu, Pali, Shiquan River, SMN-WDL) and Inner Mongolian Plateau (SMN-SDR), utilizing both the Threshold - based Algorithm (TA) and Discriminant Function Algorithm (DFA). …”
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M6A-Methylated circRAPGEF5 drives lung adenocarcinoma progression and metastasis via IGF2BP2/NUP160-mediated autophagy suppression by Liqun Ling, Tianqi Hu, Chenkang Zhou, Yingjie Dai, Lijuan Hu, Yuxin Chen, Zhaoting Hu, Kate Huang, Jie Chen, Yumin Wang

“…This study systematically investigates the functional interplay within the RBP-circRNA-autophagy network in LUAD pathogenesis. …”
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The Decision-Making Experience of Self-Management Behaviors in Home Peritoneal Dialysis for Patients with Diabetic Nephropathy: A Qualitative Study Using the Theory of Planned Beha... by Song Z, Xiao Y, Su Y, Qin G, Yang J

“…The TPB was applied to formulate the interview themes and provide information for the Interpretative Phenomenological Analysis (IPA) method used.Results: A total of 3 themes and 7 sub-themes were summarized, namely attitude towards behavior, where physical and mental perception affects the decision-making attitude (the positive feedback of improved physical function strengthens the decision-making attitude; the two-way influence of emotions catalyzes the decision-making attitude); subjective norm, where social factors drive the decision-making belief (the behavioral outcomes of peers transform the decision-making belief; the continuity of medical and nursing services consolidates the decision-making belief; the motivation of social feedback stimulates the decision-making belief); perceived behavioral control, where self-perception influences the decision-making intention (positive self-efficacy motivates the decision-making intention; the limitation of external resources restricts the decision-making intention).Conclusion: For the management of home PD in patients with DKD, efforts can be made to improve patients’ decision-making in self-management of home PD by strengthening the positive feedback of psychological experiences in behavioral decision-making, exploring digital peer support platforms and social support networks for such patients to improve the mechanism of patients’ active participation in decision-making within social support networks, and improving the community support system from multiple dimensions such as incorporating relevant policies into assessment criteria, coordinating funds through multiple channels, enhancing the capabilities of community medical and nursing teams, and encouraging doctor-patient shared decision-making, thereby exploring and constructing a community assistance model for the management of home PD in patients with DKD.Keywords: diabetic kidney disease, home peritoneal dialysis, Self-management, theory of planned behavior, qualitative research…”
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Barriers and Facilitators to Adherence to Exercise-Based Cardiac Rehabilitation Among Coronary Artery Disease Patients: A Scoping Review by Zhao X, Zhang S, Zhang F, Wu X, Zhang Z, Liu Y, Jiang J, Li Z, Li S, Zheng S, Yang X, Ju X, Li H, Gong L, Kong D

“…These factors were mapped onto the Behaviour Change Wheel, and the APEASE criteria were applied to determine appropriate intervention functions. Finally, Behaviour Change Techniques were matched to these intervention functions.Results: Seventeen studies were included, identifying multiple core domains of the Theoretical Domains Framework influencing EBCR adherence. …”
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Transcriptome sequencing and Mendelian randomization analysis identified biomarkers related to neutrophil extracellular traps in diabetic retinopathy by Linlin Hao, Songhong Wang, Lian Zhang, Lian Zhang, Jie Huang, Yue Zhang, Xuejiao Qin

“…Additional analysis, including nomogram construction, gene set enrichment analysis, drug prediction and molecular docking, were performed to investigate the functions and molecular mechanisms of the key genes. …”
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SREBF1, a target gene of multiple sclerosis and coronary heart disease: based on mendelian randomization study by Linqin Du, Yangyang Cui, Yang Zhou, Ofe Eugene Kwaku, Xuefeng Ding, Lang Zeng, Shikang Li, Lijuan Xiong, Yonghong Zhang, Peng Zhou, Kun Wang, Rongchuan Yue

“…Enrichment analyses and protein-protein interaction studies were used to elucidate biological functions associated with these genes. We included colocalization analysis and summary data-based Mendelian randomization (SMR) method for further screening of core genes to obtain target genes.Finally, we investigated how these genes might affect health by conducting a phenome-wide MR analysis. …”
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Use of Digital Health Technologies for Dementia Care: Bibliometric Analysis and Report by Hebatullah Abdulazeem, Israel Júnior Borges do Nascimento, Ishanka Weerasekara, Amin Sharifan, Victor Grandi Bianco, Ciara Cunningham, Indunil Kularathne, Genevieve Deeken, Jerome de Barros, Brijesh Sathian, Lasse Østengaard, Frederique Lamontagne-Godwin, Joost van Hoof, Ledia Lazeri, Cassie Redlich, Hannah R Marston, Ryan Alistair Dos Santos, Natasha Azzopardi-Muscat, Yongjie Yon, David Novillo-Ortiz

“… BackgroundDementia is a syndrome that compromises neurocognitive functions of the individual and that is affecting 55 million individuals globally, as well as global health care systems, national economic systems, and family members. …”
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Transcriptome analysis of insecticide resistance mechanisms in field populations of the bean flower thrips, Megalurothrips usitatus (Bagnall) by Hongyi Cao, Jiangjiang Yuan, Yanran Wan, Yingxi Tang, Xiaobin Zheng, Jing Wang, Kanghua Qian, Jiuming Feng, Sirui Chen, Youjun Zhang, Qingjun Wu

“…To evaluate insecticide susceptibility and the role of detoxification enzyme involvement, resistance monitoring and enzyme activity assays were conducted. RNA sequencing (RNA-seq) and weighted gene co-expression network analysis (WGCNA) techniques validated key gene functions. …”
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Multidimensional analysis suggests that ZNF433 is a promising biomarker for the diagnosis and prognosis of human cancers by Lingyu Xie, Lingyu Xie, Xin Zeng, Xin Zeng, Hui Luo, Hui Luo, Bin Xie, Xuefeng Wang, Nan Wu, Junrong Zou, Junrong Zou, Junrong Zou, Guoxi Zhang, Guoxi Zhang, Guoxi Zhang, Xiaofeng Zou, Xiaofeng Zou, Xiaofeng Zou, Hui Xu, Hui Xu, Hui Xu

“…Functional enrichment and protein interaction network analyses were also performed to explore its potential involvement in cancer-related pathways.ResultsOur findings revealed that ZNF433 is significantly downregulated in most cancer types, with stage-dependent expression patterns observed in KIRC and KIRP. …”
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Bioinformatics-based screening and validation of PANoptosis-related biomarkers in periodontitis by Qing Sun, Qing Sun, JinYue Hu, JinYue Hu, RuYue Wang, RuYue Wang, ShuiXiang Guo, ShuiXiang Guo, GeGe Zhang, GeGe Zhang, Ao Lu, Ao Lu, Xue Yang, Xue Yang, LiNa Wang, LiNa Wang

“…Protein-protein interaction (PPI) networks of these PRGs were constructed using the STRING database and visualized with Cytoscape. …”
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Genome‐wide siRNA library screening identifies human host factors that influence the replication of the highly pathogenic H5N1 influenza virus by Guangwen Wang, Li Jiang, Jinliang Wang, Qibing Li, Jie Zhang, Fandi Kong, Ya Yan, Yuqin Wang, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Liling Liu, Zhigao Bu, Hualan Chen, Chengjun Li

“…Together, our genome‐wide siRNA library screening unveiled a panorama of host cellular networks engaged in the regulation of highly pathogenic H5N1 influenza virus replication, which may provide potential targets and strategies for developing novel antiviral countermeasures.…”
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