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  1. 2381
  2. 2382

    Comprehensive Analysis Reveals the Potential Diagnostic Value of Biomarkers Associated With Aging and Circadian Rhythm in Knee Osteoarthritis by Hao Li, Yuze Yang, Bo Li, Jiaju Yang, Pengyu Liu, Yuanpeng Gao, Min Zhang, Guangzhi Ning

    Published 2025-03-01
    “…We then performed Gene Set Enrichment Analysis (GSEA) to investigate the pathways associated with the selected biomarkers, conducted immune infiltration analysis, built a competing endogenous RNA (ceRNA) network, and performed molecular docking studies. …”
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  3. 2383

    Explore the Ultra-High Density Urban Waterfront Space Form: An Investigation of Macau Peninsula Pier District via Point of Interest (POI) and Space Syntax by Yue Huang, Yile Chen, Junxin Song, Liang Zheng, Shuai Yang, Yike Gao, Rongyao Li, Lu Huang

    Published 2025-05-01
    “…The distribution of life service facilities basically overlaps with the high-density residential area, forming an obvious “living circle + community unit” structure with clear spatial boundaries. (3) Commercial and transportation facilities form a “functional axis belt” organizational structure along the main road, with the Rua das Lorchas—Rua do Almirante Sérgio axis as the skeleton, constructing a “functional transmission chain”. (4) The spatial system of the Macau Peninsula pier district has transformed from a single center to a multi-node, network-linked structure. …”
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  4. 2384

    Meta-analysis of muscle transcriptome data identifies key genes influencing intramuscular fat content in pigs by Yan Wang, Jiahao Wang, Yanhui Zhao, Xihui Sheng, Xiaolong Qi, Lei Zhou, Jianfeng Liu, Chuduan Wang, Jianliang Wu, Yongchun Cao, Kai Xing

    Published 2025-08-01
    “…To identify key genes affecting IMF content, we performed a meta-analysis of the differential expression results from the 10 datasets using MetaVolcanoR. Subsequently, we conducted protein-protein interaction network analysis, Gene Ontology and Kyoto encyclopedia of genes and genomes functional enrichment analysis, and quantitative trait locus (QTL) analysis on the DEGs. …”
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  5. 2385

    Integrated Cytological, Physiological, and Comparative Transcriptome Profiling Analysis of the Male Sterility Mechanism of ‘Xinli No.7’ <i>Pear</i> (<i>Pyrus</i> sp.) by Hao Li, Xiangyü Li, Yüjia Luo, Quanhui Ma, Zhi Luo, Jiayuan Xuan, Cuiyun Wu, Fenfen Yan

    Published 2025-06-01
    “…A core transcriptome-mediated MS network was proposed, implicating accelerated ROS generation and dysregulated tapetal programmed cell death. …”
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  6. 2386

    Explaining the Comprehensive Human-To-Human Marketig System in the Health Tourism Industry by Ali Pourang, Meysam Shirkhodaie, Mahmood Yahyazadeh far, Mohsen Alizadeh San, Masoomeh Tavangar

    Published 2025-03-01
    “…Specific recommendations include: Identifying and integrating soft institutions to support the system’s functions. Conducting institutional mapping to analyze the current state of health tourism stakeholders. …”
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    Article
  7. 2387

    SARS-CoV-2 infection-induced immunity reduces rates of reinfection and hospitalization caused by the Delta or Omicron variants by Marc-Antoine de La Vega, Efstathia Polychronopoulou, Ara XIII, Zhe Ding, Tong Chen, Qixing Liu, Jiaming Lan, Marie-Edith Nepveu-Traversy, Hugues Fausther-Bovendo, Mohammed F. Zaidan, Gary Wong, Gulshan Sharma, Gary P. Kobinger

    Published 2023-12-01
    “…During a pandemic, effective vaccines are typically in short supply, particularly at onset intervals when the wave is accelerating. We conducted an observational, retrospective analysis of aggregated data from all patients who tested positive for SARS-CoV-2 during the waves caused by the Delta and Omicron variants, stratified based on their known previous infection and vaccination status, throughout the University of Texas Medical Branch (UTMB) network. …”
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  8. 2388

    A new method for predicting essential proteins based on participation degree in protein complex and subgraph density. by Xiujuan Lei, Xiaoqin Yang

    Published 2018-01-01
    “…Identification of essential proteins from protein-protein interaction (PPI) networks can be applied to pathway analysis and function prediction, furthermore, it can contribute to disease diagnosis and drug design. …”
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  9. 2389
  10. 2390

    Novel cuproptosis metabolism-related molecular clusters and diagnostic signature for Alzheimer’s disease by Fang Jia, Wanhong Han, Shuangqi Gao, Jianwei Huang, Wujie Zhao, Zhenwei Lu, Wenpeng Zhao, Zhangyu Li, Zhanxiang Wang, Ying Guo

    Published 2024-10-01
    “…This study developed a novel molecular clustering based on cuproptosis-related genes and constructed a signature for AD patients.MethodsThe differentially expressed cuproptosis-related genes (DECRGs) were identified using the DESeq2 R package. The GSEA, PPI network, GO, KEGG, and correlation analysis were conducted to explore the biological functions of DECRGs. …”
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  11. 2391

    Genome-wide identification, tissue expression pattern, and salt stress response analysis of the NAC gene family in Thinopyrum elongatum by Jilin Sun, Xiaokuo Cui, Jiaqi Zhang, Fansen Meng, Jiangong Li, Shenghui Zhou, Changai Wu, Peng Zhou, Silong Sun, Long Han

    Published 2025-05-01
    “…Comparative genomic analysis identified significant syntenic conservation between TeNACs and wheat NAC genes. Protein interaction network prediction indicated intricate functional associations among TeNAC proteins. …”
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  12. 2392

    New biomarkers of Kawasaki disease identified by gingival crevicular fluid proteomics by Xue Fan, Ying Li, Yuehao Xu, Jianqing Lin, Xin Guo, Jinwen Liao, Mingguo Xu

    Published 2025-05-01
    “…DEPs were identified and subjected to functional enrichment analysis using KEGG and GO. Protein–protein interaction (PPI) analysis was conducted for all detected DEPs. …”
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  13. 2393

    Identification of CENPM as a key gene driving adrenocortical carcinoma metastasis via physical interaction with immune checkpoint ligand FGL1 by Cunru Zou, Yu Zhang, Chengyue Liu, Yaxin Li, Congjie Lin, Hao Chen, Jiangping Hou, Guojun Gao, Zheng Liu, Qiupeng Yan, Wenxia Su

    Published 2025-01-01
    “…Methods Weighted gene co‐expression network analysis (WGCNA) and functional enrichment analysis were conducted to identify ACC metastasis‐related genes. …”
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  14. 2394

    Effect of black soldier fly (Hermetia illucens) larvae meal and oil on the performance, biochemical profile, intestinal health and gut microbial dynamics in laying hens by Samiullah Khan, Xiaoli Shi, Renlian Cai, Zhao Shuai, Wei Mao, Ibrar Muhammad Khan, Ayman A. Swelum, Jianjun Guo

    Published 2024-12-01
    “…The inclusion of BSF meal and oil enriched the functional network of several pathways, including ascorbate and aldarate metabolism, D-arginine and D-ornithine metabolism, and fatty acid metabolism, highlighting the positive effects of BSF larvae meal and oil on the chicken gut microbiota. …”
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  15. 2395
  16. 2396
  17. 2397

    Genomic Architecture of <i>AP2</i>/<i>ERF</i> Superfamily Genes in Marigold (<i>Tagetes erecta</i>) and Insights into the Differential Expression Patterns of <i>AP2</i> Family Gene... by Hang Li, Guoqing Chen, Shirui Hu, Cuicui Liu, Manzhu Bao, Yanhong He

    Published 2025-05-01
    “…These findings suggest that <i>AP2</i> family genes may collaborate with <i>MADS-box</i> and <i>CYC2</i> genes in regulating the characteristic floral architecture of marigold, establishing a foundation for future functional studies and molecular breeding efforts to enhance ornamental and agricultural traits in this economically important plant.…”
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  18. 2398

    Genome-Wide Identification and Expression Analysis of <i>NAC</i> Gene Family Members in Seashore Paspalum Under Salt Stress by Xuanyang Wu, Xiaochen Hu, Qinyan Bao, Qi Sun, Pan Yu, Junxiang Qi, Zixuan Zhang, Chunrong Luo, Yuzhu Wang, Wenjie Lu, Xueli Wu

    Published 2024-12-01
    “…Furthermore, the protein interaction network predicted that <i>PvNAC73</i> interacts with proteins such as <i>BZIP8</i> and <i>DREB2A</i> to form a major regulatory hub. …”
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  19. 2399

    Constructing a tumor immune microenvironment-driven prognostic model in acute myeloid leukemia using bioinformatics and validation data by Amir Abbas Navidinia, Ali Keshavarz, Bentol Hoda Kuhestani Dehaghi, Reza Khayami, Najibe Karami, Vahid Amiri, Mehdi Allahbakhshian Farsani

    Published 2025-07-01
    “…Differentially expressed genes (DEGs) between high/low immune score groups were identified, followed by functional enrichment, protein-protein interaction (PPI) network analysis for selecting the hub-DEGs with the highest degree scores, and univariate Cox regression to pinpoint prognostic genes. …”
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  20. 2400

    Advancements in Herpes Zoster Diagnosis, Treatment, and Management: Systematic Review of Artificial Intelligence Applications by Dasheng Wu, Na Liu, Rui Ma, Peilong Wu

    Published 2025-06-01
    “…AI applications were analyzed across three domains: (1) diagnosis, where mobile deep neural networks, convolutional neural network ensemble models, and mixed-scale attention-based models have improved diagnostic accuracy and efficiency; (2) treatment, where machine learning models, such as deep autoencoders combined with functional magnetic resonance imaging, electroencephalography, and clinical data, have enhanced treatment outcome predictions; and (3) management, where AI has facilitated case identification, epidemiological research, health care burden assessment, and risk factor exploration for postherpetic neuralgia and other complications. …”
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