Amygdala Neurodegeneration: A Key Driver of Visual Dysfunction in Parkinson's Disease by Asier Erramuzpe, Ane Murueta‐Goyena, Antonio Jimenez‐Marin, Marian Acera, Sara Teijeira‐Portas, Rocío Del Pino, Tamara Fernández‐Valle, Ibai Diez, Unai Sainz‐Lugarezaresti, Naroa Ibarretxe‐Bilbao, Unai Ayala, Maitane Barrenechea, Alberto Cabrera‐Zubizarreta, Jesús Cortés, Juan Carlos Gómez‐Esteban, Iñigo Gabilondo

“…Voxel‐level associations between gray matter volume and visual outcomes were used to define a visual impairment region (visualROI). Functional connectivity of the visualROI with brain networks was analyzed. …”
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Landscape of the immune infiltration and identification of molecular diagnostic markers associated with immune cells in patients with kidney transplantation by Zhangxiao Xu, Xun Sun, Xiaobo Ma, Bo Tao, Jian Wu, Yunpeng He, Yuan Zhao, Hexiang Mao, Jie Yang, Dehui Jiang, Lijun Wang, Chao Song

“…Moreover, infiltrating immune cell-related genes were identified using weighted gene co-expression network analysis (WGCNA), and enrichment analysis was conducted to observe their biological functions. …”
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Comparative analysis of differentially expressed genes in breast cancer across Asian and European populations: insights into molecular pathways and biomarkers by Prabhu Meganathan, Sharvari Sawant, Shreshta Reddy

“…Functional enrichment was conducted using Enrichr-KG and GeneMANIA to explore pathway associations. …”
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A cross-tissue transcriptome-wide association study reveals GRK4 as a novel susceptibility gene for COPD by Guanglei Chen, Yaxian Jin, Cancan Chu, Yuhao Zheng, Changfu Yang, Yunzhi Chen, Xing Zhu

“…Although genome-wide association studies (GWAS) have identified several loci associated with COPD susceptibility, the specific pathogenic genes underlying these loci, along with their biological functions and roles within regulatory networks, remain unclear. …”
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Subthalamic Nucleus Oscillatory Characteristics in Meige, Cervical Dystonia and Generalized Dystonia by Zhu Guan‐Yu, Yin Zi‐Xiao, Chen Ying‐Chuan, Timon Merk, Thomas Binns, Ma Ruo‐Yu, Du Ting‐Ting, Liu Yu‐Ye, Xie Hu‐Tao, Shi Lin, Yang An‐Chao, Meng Fan‐Gang, Wolf‐Julian Neumann, Andrea A. Kühn, Zhang Jian‐Guo

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Multi-omics analysis uncovers the transcriptional regulatory mechanism of magnesium Ions in the synthesis of active ingredients in Sophora tonkinensis by Zhu Qiao, Peng-Cheng Zhou, Zhan-Tao Fan, Fan Wei, Shuang-Shuang Qin, Jing Wang, Ying Liang, Ling-Yun Chen, Kun-Hua Wei

“…Abstract Magnesium (Mg) plays a pivotal role as an essential component of plant chlorophyll and functions as a critical coenzyme. However, research exploring the regulatory mechanisms of magnesium ions on the synthesis of secondary metabolites is still in its early stages. …”
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CYLD as a key regulator of myocardial infarction-to-heart failure transition revealed by multi-omics integration by Jingya Xu, Jingya Xu, Zhonghua Dong, Zhaodong Li, Xuan Wang, Xuan Wang

“…Our multistep analytical pipeline included weighted gene coexpression network analysis (WGCNA) to map interacting genes, machine learning algorithms for robust classification, functional annotation via Kyoto Encyclopedia of Genes and Genomes (KEGG) to explore biological pathways, CIBERSORT correlation analysis linking hub genes with immune cell states, transcriptional regulation profiling of key hubs, and single-cell sequencing to assess the functional relevance of these hubs.ResultsOur findings revealed that 413 DEGs were significantly different between MI and HF. …”
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ER stress-driven unfolded protein response fuels aging-related tumor aggressiveness in gliomas by Xiaodong Shao, Shaolei Guo, Jia Yang, Junjie Dai, Kaihua Cao, Xia Cai, Tianshi Song, Shun Yao, Umar Raza, Kun Chen

“…Differential gene and protein expression, functional annotation and pathway enrichment, gene set enrichment, network construction, CRSISPR-based functional dependency, transcription factor prediction, correlation, clinical association and survival analyses were conducted to identify, develop and validate endoplasmic reticulum (ER) stress-driven unfolded protein response (UPR) as key aging-related molecular mechanism driving tumor aggressiveness in gliomas. …”
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Research hotspots and frontiers of vagus nerve stimulation in stroke: a bibliometric analysis by Mingyue Liu, Mengya Liu, Bohan Zhang, Mingzhu Fang, Ke Chen, Yishen Zhang, Qian Wang, Chunyan Tian, Liang Wu, Zhe Li, Zhe Li

“…CiteSpace and the Bibliometrix package in R software were used to generate knowledge maps and conduct a bibliometric analysis. This analysis focused on publication output, geographic distribution, institutional involvement, author and co-cited author networks, journal and co-cited journal relationships, co-cited references, and keyword trends.ResultsDuring the study period, 316 publications on VNS in stroke were identified, authored by 1,631 researchers from 1,124 institutions across 172 countries or regions. …”
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Impact of <i>Ectropis grisescens</i> Warren (Lepidoptera: Geometridae) Infestation on the Tea Plant Rhizosphere Microbiome and Its Potential for Enhanced Biocontrol and Plant Healt... by He Liu, Wei Chen, Xiaohong Fang, Dongliang Li, Yulin Xiong, Wei Xie, Qiulian Chen, Yingying You, Chenchen Lin, Zhong Wang, Jizhou Wang, Danni Chen, Yanyan Li, Pumo Cai, Chuanpeng Nie, Yongcong Hong

“…The root-associated microbiome significantly influences plant health and pest resistance, yet the temporal dynamics of its compositional and functional change in response to <i>Ectropis grisescens</i> Warren (Lepidoptera: Geometridae) infestation remain largely unexplored. …”
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Bioinformatics Analysis Identifies Lipid Droplet‐Associated Gene Signatures as Promising Prognostic and Diagnostic Models for Endometrial Cancer by Vijayalakshmi N. Ayyagari, Miao Li, Paula Diaz‐Sylvester, Kathleen Groesch, Teresa Wilson, Ejaz M. Shah, Laurent Brard

“…Model performance was evaluated using ROC curves and support vector machine (SVM) classification. Functional enrichment and protein–protein interaction (PPI) network analyses were conducted to assess the biological relevance of the identified genes. …”
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Deciphering Immunometabolic Landscape in Rheumatoid Arthritis: Integrative Multiomics, Explainable Machine Learning and Experimental Validation by Dong Q, Wu J, Zhang H, Chen X, Xu X, Chen J, Shi C, Luo L, Zhang D

“…Explainable machine learning, PPI network analysis, and qPCR jointly identified four hub genes (PFN1, SRP14, S100A11, and SAP18). …”
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Pharmacological mechanisms of probenecid for SARS-CoV-2 and RSV co-infection: findings of system pharmacology, molecular docking, molecular dynamics simulation, and structure–activ... by Junbin Hong, Zhendong Guo, XiaoMei Huang, Peng Wu, Xinying Chen, Xiaoyi Liu, Jinghua Yang, Yanni Lai

“…Therefore, as one probable molecular candidate for the co-infection with SARS-CoV-2 and RSV, probenecid was researched in this exploration.MethodsUsing systems pharmacology and bioinformatics, we characterized the targets associated with probenecid for the treatment of SARS-CoV-2/RSV co-infection, focusing on their biological functions, mechanisms and binding activities. To further validate these findings, we conducted molecular docking, MD simulations, electrostatic potential mapping, and SAR analysis to explore the binding interactions between probenecid and the identified core targets.ResultsWe identified 141 targets that overlapped with the co-infection and probenecid, and used these shared targets to construct a protein-protein interaction (PPI) network. …”
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Control over biopower in cognitive and surveillance capitalism by Stanković-Pejnović Vesna

“…Power can achieve an effective command over the entire life of the population only when it becomes an integral, vital function that every individual embraces and reactivates of his or her own accord. …”
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Social Confrontation with Menstruation: A Feminist Ethnography of Menstrual Experience among Female Instagram Users by Rana Mohammad Taghinejad Esfahani, Majid Movahed, Halimeh Enayat, Aliyar Ahmadi

“…Instagram as a social network that offers a free and visual platform plays a crucial role in dismantling socio-cultural taboos. …”
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Electric-stimulated controllable synaptic GaN nanodevice for neuromorphic computing by Jianya Zhang, Jiamin Li, Liubin Yang, Yiping Shi, Zhiyang Liu, Jiyou Liu, Yibin Wang, Rui Xu, Yukun Zhao

“…Based on experimental conductance, the simulated three-layer neural network could achieve a stable recognition accuracy of 95% after just 13 training cycles. …”
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Identification and Validation of circDOCK1/miR-138-5p/GRB7 Axis for Promoting Breast Cancer Progression by Zhang Y, Yang M, Wang Y, Zhao J, Lee PY, Ma Y, Qu S

“…The expression level of circDOCK1 in breast cancer specimens was measured using qRT-PCR. Functional rescue experiments were conducted to explore the role of circDOCK1/miR-138-5p/GRB7 axis in breast cancer cells. …”
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MAFF mitigates oxidative stress and pyroptosis in cardiopulmonary bypass-induced myocardium injury by Lei Yuan, Duo Wang, Yale Su, Long Yuan, Mixia Li, Dongdong Zheng, Cuilin Zhu, Hulin Piao, Yong Wang, Zhicheng Zhu, Dan Li, Tiance Wang, Kexiang Liu

“…Through systematic validation, we identified the most representative hub gene. Subsequent functional studies, including gene knockdown and overexpression experiments, were conducted to elucidate its role and underlying mechanisms in oxidative stress-induced cardiomyocyte injury.ResultsIntegrated bioinformatics analysis and experimental validation identified MAFF as the most differentially expressed hub gene between pre- and post-CPB conditions. …”
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Integrated Transcriptomic Analysis of Liver and Muscle Tissues Reveals Candidate Genes and Pathways Regulating Intramuscular Fat Deposition in Beef Cattle by Siwei Wang, Tingting Liu, Peng Peng, Yurong Fu, Shaoqing Shi, Shuang Liang, Xi Chen, Kun Wang, Rongyan Zhou

“…A “liver–muscle” regulatory network of IMF deposition was built to illustrate the tissues’ interaction. …”
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Identification of lactylation-related biomarkers in osteoporosis from transcriptome and single-cell data by Jiafeng Peng, Hongxing Zhang, Huaize Wang, Ting Jiang, Minglei Gao, Xingfu Ma, Yingzong Xiong, Yingchun Li, Ran Xu, Junchen Zhu

“…Subsequently, nomograms, functional enrichment analyses, immune infiltration analyses, regulatory network construction, drug prediction, and molecular docking were performed to characterize the functional and clinical significance of the biomarkers. …”
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