The role and machine learning analysis of mitochondrial autophagy-related gene expression in lung adenocarcinoma by Binyu Wang, Di Liu, Danfei Shi, Xinmin Li, Yong Li

“…Subsequently, Weighted Gene Co-expression Network Analysis (WGCNA) was conducted to classify DEGs into modules. …”
Get full text

Identification of MMP14 and MKLN1 as colorectal cancer susceptibility genes and drug-repositioning candidates from a genome-wide association study by Dabin Yun, Jung-Ho Yang, Jin-ah Sim, Minjung Kim, Ji Won Park, Seung Yong Jeong, Aesun Shin, Sun-Seog Kweon, Nan Song

“…Furthermore, post-GWAS analysis was conducted. Drug-repositioning candidates were identified using a pre-trained deep neural network and the druggability assessment tool. …”
Get full text

Importance of the early visual cortex and the lateral occipito-temporal cortex for the self-hand specific perspective process by Yuko Okamoto, Ryo Kitada, Takanori Kochiyama, Motohide Miyahara, Hiroaki Naruse, Norihiro Sadato, Hidehiko Okazawa, Hirotaka Kosaka

“…We conducted a functional magnetic resonance imaging experiment where 29 participants observed their own or someone else's hand from first- and third-person perspectives. …”
Get full text

GWAS and transcriptome analyses unravel ZmGRAS15 regulates drought tolerance and root elongation in maize by Dongmei Wang, Xuyang Liu, Guanhua He, Kailiang Wang, Yongxiang Li, Honghui Guan, Tianyu Wang, Dengfeng Zhang, Chunhui Li, Yu Li

“…Additionally, through co-expression network analysis (WGCNA), we identified five modules significantly associated with the leaf relative water content (RWC) under drought treatment. …”
Get full text

Multiomic analysis of the synthetic pathways of secondary metabolites in tobacco leaves at different developmental stages by Zhijun Tong, Kun Yang, Xuejun Chen, Fei Xu, Xueyi Sui, Yujie Huang, Shenyun Zhu, Enhui Shen, Sanling Wu, Longjiang Fan, Bingguang Xiao

“…The findings offer novel molecular insights into the mechanisms underlying leaf quality formation and establish a theoretical framework for functional studies of candidate genes, reinforcing the utility of N. tabacum as a model species for secondary metabolism research and breeding innovation.…”
Get full text

CCT8 drives colorectal cancer progression via the RPL4-MDM2-p53 axis and immune modulation by Yangyang Teng, Hao Lin, Zijian Lin, Xichen Li, Yejiao Ruan, Binhui Pan, Jinlin Ge, Yuesheng Zhu, Daopo Lin, Qingji Ying, Zhenzhai Cai, Xuanping Xia

“…Immunohistochemistry was performed to examine CCT8 distribution in CRC tissues and adjacent non-tumor tissues. Functional assays, including CCK-8, transwell, wound-healing, and flow cytometry, were conducted using DLD-1 and HCT116 cell lines to assess the effects of CCT8 on cell proliferation, migration, invasion, and apoptosis. …”
Get full text

Genetic Alterations in War-Related Post-Traumatic Stress Disorder: A Systematic Review by Amir Hossein Rajabi, Samaneh Zafarabadi, Kimia Jazi, Maryam Moghbel Baerz, Omid Bahrami, Gelareh Azarinoush, Pardis Habibi, Negar Azami, Shahram Paydar

Get full text

Exploring nutritional supplement use for countering respiratory tract infections through an X (formerly Twitter)-based survey by Rajeev K. Singla, Himel Mondal, Shailja Singla, Ronita De, Sahar Behzad, Mihnea-Alexandru Găman, Siva Sai Chandragiri, Merisa Cenanovic, Jayanta Kumar Patra, Jennifer R. Depew, Hemanth Kumar Boyina, Abdulkadir Yusif Maigoro, Soojin Lee, Omar M. Atrooz, Gitishree Das, Fabien Schultz, Emad Mohamed Abdallah, Hitesh Chopra, Jamil Ahmad, Rupesh K. Gautam, Sourav S. Patnaik, Bey Hing Goh, Smith B. Babiaka, Sharad Vats, Michael P. Okoh, Atallah F. Ahmed, Ankit Kumar Dubey, Ronan Lordan, Parasuraman Aiya Subramani, Amit Kumar Singh, José M. Alvarez-Suarez, Dinesh Kumar Chellappan, Shravan Kumar Paswan, Prabhakar Semwal, Johra Khan, Sadeeq Sheshe, Neeraj Kumar Sethiya, Tomasz M. Karpiński, Muhammad Riaz, Zahra Emam-Djomeh, Girish Kumar Gupta, Reecha Madaan, Suresh Kumar, Neeraj Choudhary, Salvatore Parisi, Harald Willschke, Vasil Pirgozliev, Rehab A. Rayan, Valentin Ritschl, Shaikat Mondal, Gokhan Zengin, Pritt Verma, Bhupinder Kapoor, Monica Gulati, Gareeballah Osman Adam Balla, Dan Khoa Le, Valeria Pittalà, Amr El-Demerdash, Garba M. Khalid, Jesus Simal-Gandara, Qushmua E. Alzahrani, Gian Luigi Russo, Kiran R. Kharat, Anupam Bishayee, Dongdong Wang, Ilkay Erdogan Orhan, Hammad Ullah, Michael Heinrich, Bikash Baral, Nikolay T. Tzvetkov, Andy Wai Kan Yeung, João M.L. Dias-Ferreira, Scarlett Perez Olea, Yugal Kishore Mohanta, Azazahemad A. Kureshi, Claudiu T. Supuran, Neeraj Rani, Rohit Gundamaraju, Eoghan Joseph Mulholland, Sara Di Lonardo, Albena T. Dinkova-Kostova, Elena González-Burgos, Lucian Hritcu, Pravin Badhe, Abhilasha Singh, Fuad Al-Rimawi, Antoni Sureda, Rambod Abiri, Nady Braidy, Lorenz Kapral, A.N. Abdullahi, Christhian Delfino Villanueva Medina, Helen Sheridan, Massimo Lucarini, Alessandra Durazzo, Francesca Giampieri, Davide Barreca, Witkowska Anna Maria, José Carlos Andrade, Carmela Fimognari, Faizan Akram, Aleksei Tikhonov, Maurizio Battino, Akolade R. Oladipupo, Mila Emerald, Thomas Efferth, Said Amrani, Javier Echeverría, Anna Maria Louka, Surya Kant Tripathi, Bernd L. Fiebich, Nour Eddine Es-Safi, Shafaat Yar Khan, Vivek P. Chavda, Muhammad Asim Masoom Zubair, Samrina Hussain, Muhammad Fasih Ur Rahman, Joy Odimegwu, Jaroslaw Olav Horbanczuk, Hari Prasad Devkota, Alejandro Cifuentes, Rupinder Sodhi, Antonello Santini, Ourlad Alzeus G. Tantengco, Sandeep Ramchandra Pai, Ananda Kumar Chettupalli, Sebastian Granica, Nikola M. Stojanović, Devesh Tewari, Vineet Mittal, Vandana Garg, Mohammad Akhlaquer Rahman, Rajan Logesh, Ioana Berindan-Neagoe, Rohit Sharma, Artur Jóźwik, Maima Matin, Emil D. Parvanov, Nina Strzałkowska, Farhan Bin Matin, Olena Litvinova, Jivko Stoyanov, Monika Michalczuk, Bogumila Zima-Kulisiewicz, Okyaz Eminaga, Awanish Mishra, Nishat Jahan, Joanna Bensz, Tanuj Joshi, Aman Upaganlawar, Kiran Patni, Aleksandra Zielińska, Dalibor Hrg, Artur Stolarczyk, Olga Adamska, George Perry, Michał Ławiński, Agnieszka Kamińska, Mario Štefanović, Bodrun Naher Siddiquea, Sara Frazzini, Luciana Rossi, Marek Wieczorek, Michel Edwar Mickael, Leif-Alexander Garbe, Atanas G. Atanasov, Bairong Shen

Get full text

Study protocol of sustaining home palliative care for patients with Heart Failure (HF) and their family caregivers in rural Appalachia: a mixed methods randomized clinical trial by Ubolrat Piamjariyakul, Stephanie Young, Angel Smothers, Sijin Wen, R. Osvaldo Navia, George Sokos, Ann E. Hendrickson, Peggy Fink, Diana Niland, Matthew Hottle, Angelo C. Giolzetti, Carol E. Smith

“…Data collection for both groups was conducted at baseline and at 3, 6, 9, and 12 months. …”
Get full text

Uncovering potential biomarkers of endometriosis: transcriptomic and single-cell analysis by Yuqiu Liu, Guanwen Gao, Guanwen Gao, Guanwen Gao, Wei Tian, Qingfeng Lv, Degao Liu, Degao Liu, Changzhong Li, Changzhong Li

“…Functional analyses, immune infiltration profiling, and the construction of regulatory networks further elucidated the mechanisms through which these biomarkers may influence EMS. …”
Get full text

Analysis of Alternative Splicing Events and Identification of Key Genes in <i>Brassica napus</i> Leaves Infected by <i>Leptosphaeria biglobosa</i> by Xinning Ma, Lin Yuan, Jiuru Huangfu, Mengjiao Yan, Chen Guo, Lili Zhao, Hongxia Sun, Xiaoqing Jia, Ziqin Li, Haiyan Huangfu

“…Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed to elucidate the biological functions of differentially spliced genes at various time points, while Weighted Gene Co-expression Network Analysis (WGCNA) was used to identify key modules and hub genes. …”
Get full text

A bioinformatic analysis to systematically unveil shared pathways and molecular mechanisms underlying monkeypox and its predominant neurological manifestations by Amir Hossein Barjasteh, Hanieh Latifi, Ali Sepehrinezhad, Ali Sepehrinezhad

“…Pathway analysis was performed using WikiPathways, and cell-type-specific enrichment was conducted using Enrichr. Additionally, we predicted functional microRNAs using mirTarbase and identified potential drug candidates via the Stitch database. …”
Get full text

Immune Regulation and Disulfidptosis in Atherosclerosis Influence Disease Progression and Therapy by Wei Lu, Zhidong Zhang, Gang Qiao, Gangqiang Zou, Guangfeng Li

“…A diagnostic risk score model was developed and rigorously tested through Receiver Operating Characteristic analysis. To illustrate the functional impact of CTSC on the regulation of plaque formation and SMC viability, both in vitro and in vivo experimental investigations were conducted. …”
Get full text

How do various strategies for returning residues change microbiota modulation: potential implications for soil health by Nan Jiang, Nan Jiang, Zhenhua Chen, Zhenhua Chen, Yi Ren, Shichang Xie, Zimeng Yao, Zimeng Yao, Dongqi Jiang, Yulan Zhang, Yulan Zhang, Lijun Chen, Lijun Chen

“…Finally, through analyzing the correlation network among indices that exhibited active responses to residue additions, potential indicators for functional changes in response to residue additions were identified. …”
Get full text

Spatio-temporal dynamics of sound-induced vestibular processing: insights from stereo-EEG recordings by Michele Terzaghi, Piergiorgio d'Orio, Ivana Sartori, Veronica Pelliccia, Flavia Maria Zauli, Silvia Colnaghi, Valter Rustioni, Fausto Caruana, Maria Del Vecchio, Maurizio Versino, Pietro Avanzini

“…Numerous functions rely on the activation of the vestibular system, resulting in widespread activation of cortical brain regions. …”
Get full text

Pan-cancer analysis reveals TRA16 as a master regulator of human carcinogenesis by Yanyan Zhu, Yike Gao, Xiaoqing Huang, Bowang Chen, Bowang Chen, Xinyi Wang, Ying Wu, Jian Sun, Xiaoyun Huang, Xiaoyun Huang

“…Understanding TRA16’s involvement in cancer biology could uncover novel regulatory mechanisms and potential therapeutic targets.MethodsWe conducted a comprehensive pan-cancer analysis of TRA16 expression and function across multiple human malignancies. …”
Get full text

EGCG attenuated spinal cord injury by inhibiting ferroptosis via activation of HMOX1 expression and suppression of HIF-1 signaling pathway by Han Yang, Fei Ye, Liuxu Chen, Linyu Yang, Jianping Kang

“…Component-Target-Disease networks were constructed with Cytoscape software, and inter-target interactions were analyzed using the String database. …”
Get full text

Constitutive model of metal rubber material considering plastic accumulation behavior by FENG Zhipeng, YANG Fang, FU Hailong, AI Shigang, WANG Yue, YUAN Liangyang

“…Metal rubber, as a novel functional material characterized by its unique three-dimensional reticulated porous structure, has demonstrated significant application value in aerospace engine mounts, aircraft landing gear buffer systems, satellite vibration damping devices, and precision vibration isolation systems for intelligent equipment, owing to its exceptional energy dissipation capacity, remarkable temperature resistance, and excellent environmental adaptability. …”
Get full text

Prostate cancer and metabolic syndrome: exploring shared signature genes through integrative analysis of bioinformatics and clinical data by Maomao Guo, Sudong Liang, Zhenghui Guan, Jingcheng Mao, Zhibin Xu, Wenchao Zhao, Hao Bian, Jianfeng Zhu, Jiangping Wang, Xin Jin, Yuan Xia

“…Comprehensively bioinformatics analyses, including functional enrichment, LASSO, and random forest algorithms, coupled with receiver operating characteristic (ROC) and precision recall curve (PRC) analyses were conducted. …”
Get full text

Exploring ENPP5 as a diagnostic biomarker for sepsis: a comprehensive bioinformatics analysis by Jiamin Gao, Yanjun Li, Jinping Huang, Cailing Wei, Jieling Chen, Aichun Huang, Ningmei Liu, Yibo Lu, Shixiong Yang

“…This study aims to identify markers associated with biological functions to offer new strategies for sepsis diagnosis. …”
Get full text