GRK5 as a Novel Therapeutic Target for Immune Evasion in Testicular Cancer: Insights from Multi-Omics Analysis and Immunotherapeutic Validation by Congcong Xu, Qifeng Zhong, Nengfeng Yu, Xuqiang Zhang, Kefan Yang, Hao Liu, Ming Cai, Yichun Zheng

“…<b>Methods:</b> Consensus clustering analysis was conducted to delineate immune subtypes, while weighted gene co-expression network analysis (WGCNA), least absolute shrinkage and selection operator (LASSO) regression, and support vector machine (SVM) algorithms were employed to evaluate the potential efficacy of anti-tumor immunotherapy. …”
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Peculiarities of Modeling a Specialized Computing System by G. A. Zvonareva, D. S. Buzunov

“…The method is based on the joint use of the developed simulation model, which describes in detail the functioning of the system of the considered class in time, taking into account conflict situations arising during parallel processing of information, and experimentally obtained individual time characteristics of the system.Materials and methods. …”
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Identification of RNA binding protein genes associated with colorectal cancer by bioinformatics analysis by Rong-Chao He, Haibo Wang, Jun He, Hou-Dong Wang, Zhong Shen

“…Protein–protein interaction (PPI) network analysis revealed key modules involving 394 nodes, highlighting their functional interconnectivity. …”
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Single-cell RNA sequencing technology was employed to construct a risk prediction model for genes associated with pyroptosis and ferroptosis in lung adenocarcinoma by Longfei Ji, Binyu Wang, Danfei Shi, Weiyun Shen, Xinmin Li, Yong Li

“…We conducted high-resolution clustering analysis on the GSE189357 single-cell dataset, constructed a protein interaction network, and established a prognostic model in conjunction with iron death related genes. …”
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Circulating Plasma Proteins as Biomarkers for Immunotherapy Toxicity: Insights from Proteome-Wide Mendelian Randomization and Bioinformatics Analysis by Liansha Tang, Wenbo He, Handan Hu, Jiyan Liu, Zhike Li

“…Systems biology approaches including tissue-specific expression profiling, pathway enrichment, and protein interaction network analysis revealed spatial and functional drivers of irAE pathogenesis. …”
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An Analysis of the Gene Expression Associated with Lymph Node Metastasis in Colorectal Cancer by Hongjie Yang, Jiafei Liu, Peishi Jiang, Peng Li, Yuanda Zhou, Zhichun Zhang, Qingsheng Zeng, Min Wang, Luciena Xiao Xiao, Xipeng Zhang, Yi Sun, Siwei Zhu

“…The data sets of CRC patients were collected through the Cancer Gene Atlas database; the differentially expressed genes (DEGs) associated with CRC lymph node metastasis were screened; a protein–protein interaction (PPI) network was constructed; the top 20 hub genes were selected; the Gene Ontology functions and the Kyoto Encyclopedia of Genes and Genomes pathways were enriched and analyzed. …”
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Failure or success of self-organizing teams in long-term care organizations: an integrative systematic literature review on the role of the organization structure by Laura Harkema, Dirk Vriens, Lander Vermeerbergen, Debby Gerritsen, Patrick Vermeulen

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Identification of therapeutic targets in lung adenocarcinoma using Mendelian randomization and multi-omics by Yue Li, Keru Ma, Hao Wang, Zongying Liu, Zhuying Li

“…Functional interactions were explored via protein–protein interaction network analysis, while single-cell analyses were employed to determine cell-specific expression patterns and differentiation trajectories. …”
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Implementing a chatbot to promote hereditary breast & ovarian cancer genetic screening in women’s health: identifying barriers and facilitators to screening adoption by Easton N. Wollney, Shireen Madani Sims, Luisel J. Ricks-Santi, Elizabeth Eddy, Daniel Wiesman, Carla L. Fisher

“…We conducted in-depth, semi-structured interviews with 17 women (nine adopted the screen, eight did not). …”
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Identification and validation of hub genes associated with biotic and abiotic stresses by modular gene co-expression analysis in Oryza sativa L. by Izreen Izzati Razalli, Muhammad-Redha Abdullah-Zawawi, Rabiatul Adawiah Zainal Abidin, Sarahani Harun, Muhamad Hafiz Che Othman, Ismanizan Ismail, Zamri Zainal

“…Over-representation analysis was conducted to determine the functional association of each gene module with stress-related processes and pathways. …”
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LEGAL BASIS FOR THE ACTIVITIES OF THE ECONOMIC SECURITY BUREAU AS AN AGENCY RESPONSIBLE FOR ENSURING THE FINANCIAL SECURITY OF THE STATE by Andrii Borovyk, Nataliia Derevianko, Oleksandr Shyra

“…In particular, these challenges include: staff shortages; insufficient employee qualifications; inefficient functioning; lack of adequate funding for the ESB's activities; imperfect implementation of analytical functions; lack of a network of territorial divisions; lack of tools for criminal prosecution of persons supplying raw materials from Russia; uncertainty regarding the ESB's interaction with taxpayers for the purpose of verifying information outside the scope of criminal proceedings; resistance from businesses and the public. …”
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Transcriptomic Profiling Reveals Regulatory Pathways of Tomato in Resistance to Verticillium Wilt Triggered by VdR3e by Xiao Wang, Qian Tan, Xiyue Bao, Xinyue Gong, Lingmin Zhao, Jieyin Chen, Lei Liu, Ran Li

“…We confirmed that VdR3e triggers immune responses in the parents of IVF6384 plants and conducted transcriptome sequencing between male and female IVF6384 plants after VdR3e infiltration to analyze the potential regulatory network response to VdR3e. …”
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Allergic bronchopulmonary aspergillosis as an initial manifestation of cystic fibrosis: Diagnostic and therapeutic implications in the era of CFTR modulators by Georgia Mitropoulou, MD, Zisis Balmpouzis, MD, Aurelia Oberhansli-Wavre, MD, Michael Morris, PhD, Sylvain Blanchon, MD, Alain Sauty, MD, Angela Koutsokera, MD, PhD

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Security monitoring via sound analysis and voice identification with artificial intelligence by Balabanova Ivelina, Sidorova Kristina, Georgiev Georgi

“…Successful correct recognition of the test voice profiles on access and security personalization with a quantitative equivalent of 100.0 % accuracy was achieved in the Linear transfer function for Cascade-Forward Neural Networks. The proposed method and the synthesized neural models in the research can be used as units and modules in access control systems with biometric diagnostics and intelligent recognition of employees in company departments to electronically store classified information and physical access control.…”
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Identification of PANoptosis related biomarkers to predict hepatic ischemia‒reperfusion injury after liver transplantation by Zhihong Chen, Junwei Zhang, Lei Zhang, Yaoge Liu, Ting Zhang, Xinting Sang, Yiyao Xu, Xin Lu

“…Differential expression analysis, weighted gene coexpression analysis, and protein interaction network analysis were used to identify candidate biomarkers. …”
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Integrating smartwatch-based out-of-hospital cardiac arrest detection into resuscitation systems: a focus group study of community responder perspectives by Marijn Eversdijk, Babette J.W. van der Eerden, Dick L. Willems, Willem J. Kop, Mirela Habibović, Marieke A.R. Bak

“…Methods: Four semi-structured focus group discussions (FGDs) were conducted with 15 community responders in the Netherlands, recruited through the national cardiac arrest emergency network. …”
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Lipid profile in the aqueous humor of diabetic macular edema patients by Mengru Su, Mengru Su, Qinglu Song, Ruiwen Cheng, Ye Zhang, Xinghong Sun, Xinghong Sun, Feng Jiang, Qinghuai Liu

“…Additionally, correlation network analysis, community classification, and functional enrichment analysis were performed on the differential lipids. 90 lipid compounds were identified, encompassing a range of 13 lipid categories. …”
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Pollination-driven modulation of amino acid biosynthesis in plum: A multi-omics approach by Lijun Deng, Binshu Yuan, Xiaojun Jin, Yingying Xu, Yuhuan Feng, Xuan Zhang, Hui Zhang, Bo Xiong, Xun Wang, Guochao Sun, Mingfei Zhang, Siya He, Ling Liao, Zhihui Wang

“…However, few studies have been conducted on the effects of various pollinated cultivars on amino acid biosynthesis in plum fruit. …”
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Educational component of digital competence of researchers and academic staff: the results of a statement experiment by Mintii Iryna, Vakaliuk Tetiana

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Effects of Carbon Nitride Combined with Chitosan on Lipid Metabolism of Salmonella Typhimurium by Yanyan WANG, Xingning XIAO, Jian LI, Jiele MA, Xiaoping DONG, Zhengkai YI, Qiaoming LOU, Wen WANG

“…In addition, lipid metabolomics was employed to investigate the bactericidal process by examining several metabolite functions and regulatory networks associated with bacterial lipid metabolism. …”
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