The Potential Biological Roles and Clinical Significance of Anaphase-Promoting Complex Subunit 1 in Colorectal Cancer by Yi Chen MD, Yu-Xing Tang MD, Da-Tong Zeng MD, Jia-Ying Wen MD, Yan-Ting Zhan MD, Dong-Ming Li MD, Rong-Quan He MD, Zhi-Guang Huang MD, Yu-Zhen Chen MD, Qiu-Yu Wei MD, Gang Chen PhD, Yu-Lu Tang MD, Hui Li MD

“…It also incorporated evidence from immune infiltration analysis, functional enrichment analysis, and weighted gene co-expression network analysis to explore the biological behaviour of ANAPC1 in CRC. …”
Get full text

DEVELOPMENT OF THE METHODS FOR RESOURCE REALLOCATION IN CLOUD COMPUTING SYSTEMS by Viacheslav Davydov, Daryna Hrebeniuk

“…The goal of the work is to increase the efficiency of available resources usage in cloud computing systems (such as RAM, disk space, CPU, network) by developing the model for adaptive management of resource reallocation. …”
Get full text

Continued Implementation and Use of a Digital Informal Care Support Platform Before and After COVID-19: Multimethod Study by Nikita Sharma, Christian Wrede, Sofia Bastoni, Annemarie Braakman-Jansen, Lisette van Gemert-Pijnen

“…ObjectiveThis study aimed to (1) identify technology developers’ lessons learned from the continued implementation of Caren during COVID-19 and (2) examine pre-post COVID-19 changes in usage behavior and support functionality use of Caren. MethodsA focus group with developers of the Caren platform (N=3) was conducted to extract implementation lessons learned. …”
Get full text

Integrative Analysis of Arachidonic Acid Metabolism in the Pathogenesis and Immune Dysregulation of Psoriasis by Hou M, Sun Y

“…Differentially expressed genes were identified, and functional enrichment analyses were performed. Weighted gene co-expression network analysis (WGCNA) and machine learning techniques were employed to identify psoriasis associated AAM genes. …”
Get full text

Influence of Pregnancy on Whole-Transcriptome Sequencing in the Mammary Gland of Kazakh Mares by Zhenyu Zhang, Zhixin Lu, Xinkui Yao, Linling Li, Jun Meng, Jianwen Wang, Yaqi Zeng, Wanlu Ren

“…Additionally, this study constructed a competing endogenous RNA (ceRNA) regulatory network based on the differentially expressed genes (|log₂FC| > 1, FDR < 0.05), offering a novel perspective for revealing the functional regulation of the mammary gland. …”
Get full text

Identification of glucocorticoid-related genes in systemic lupus erythematosus using bioinformatics analysis and machine learning. by Yinghao Ren, Weiqiang Chen, Yuhao Lin, Zeyu Wang, Weiliang Wang

“…We also constructed an RNA-binding protein (RBP)-mRNA network and conducted drug sensitivity analysis along with molecular docking studies.…”
Get full text

BSCL2 and CDK5 are two genes associated with circadian rhythm disturbance in Parkinson’s disease by Dongdong Chen, Qingqing Huang, Ming Ye

“…We first performed differential gene expression analysis on the GSE20163 dataset to identify differentially expressed genes (DEGs). We then conducted weighted gene co-expression network analysis on this dataset to select the most significant modules (turquoise modules) and took the intersection of the two to obtain crossover genes (85 genes), which were functionally enriched in the Disease Ontology (DO), Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG). …”
Get full text

Neutrophil extracellular trap is an important connection between hemodialysis and acute myocardial infarction by Yue Yang, Yuan-yuan Jiao, Zheng Zhang, Li Zhuo, Wen-ge Li

“…Receiver operating characteristic curves and gene set enrichment analyses were used to explore the characters and biological function of hub genes, networks were used for candidate identification of transcription factor (TF), microRNA (miRNA), and drug. …”
Get full text

Social frailty in community-dwelling older adults: a scoping review by Cuiting Huang, Wachiranun Sirikul, Nida Buawangpong

“…Results The findings revealed that social frailty is a complex, multidimensional phenomenon determined by physical function decline, cognitive impairment, and depression. …”
Get full text

Staying hooked: effective science engagement and communication in recreational fisheries by Pablo Pita, Sean Tracey, Robert Arlinghaus, Robert Arlinghaus, Eneko Bachiller, Filipa Pinho-Duarte, Keno Ferter, Filipe Henriques, Filipe Henriques, Samantha Hook, Kieran Hyder, Alejo Irigoyen, María P. Jiménez, María P. Jiménez, Martín Laporta, Martín Laporta, Adam M. Lejk, Eoin Leonard, Hans Jakob Olesen, Freya Palmer, Mišo Pavičić, João Pontes, Marta Pujol-Baucells, Marta Pujol-Baucells, Zachary Radford, Mafalda Rangel, William Roche, Hannah Rudd, Diarmuid Ryan, Valerio Sbragaglia, Jules Selles, Catarina N. S. Silva, Christian Skov, Harry V. Strehlow, Stephen Taylor, Pedro Veiga, Leonardo A. Venerus, Paul Venturelli, David Vertegaal, Marc Simon Weltersbach, Martin Wiech, Alexander Winkler

Get full text

Development and use of a cognitive system model for solving problems of purposeful behavior by A. A. Solodov, V. M. Trembach

“…Subsystems were formed in the form of separate functional formations-multi-agent systems.…”
Get full text

Identification of ubiquitination-related key biomarkers and immune infiltration in Crohn’s disease by bioinformatics analysis and machine learning by Wei Chen, Zeyan Xu, Haitao Sun, Wen Feng, Zhenhua Huang

“…This study aimed to explore the functional roles of ubiquitination-related genes in CD. …”
Get full text

Key gene screening and diagnostic model establishment for acute type a aortic dissection by Yue Pan, Zhiming Yu, Xiaoyu Qian, Xuesong Zhang, Qun Xue, Weizhang Xiao

“…Functional enrichment and immunoinfiltration analyses were performed to explore biological pathways and immune cell interactions. …”
Get full text

Effect of PTGES3 on the Prognosis and Immune Regulation in Lung Adenocarcinoma by Wenyan Jiang, Qiong Wei, Haiqin Xie, Dandan Wu, Haiyan He, Xuedong Lv

“…Thereafter, survival analysis was conducted using the R software, Gene Expression Profiling Interactive Analysis 2 (GEPIA2), and Kaplan–Meier Plotter. …”
Get full text

Identification of Therapeutic Targets for Hyperuricemia: Systematic Genome-Wide Mendelian Randomization and Colocalization Analysis by Na Chen, Leilei Gong, Li Zhang, Yali Li, Yunya Bai, Dan Gao, Lan Zhang

“…Summary-data-based MR (SMR) analysis and Bayesian colocalization were used to assess causality. In addition, we conducted phenome-wide association studies, protein network construction, and enrichment analysis of significant targets to evaluate their biological functions and potential side effects. …”
Get full text

PCK1 as a potential hub gene in distinguishing lactate metabolism between rheumatoid arthritis and osteoarthritis by Pengfei Xin, Shaoqiang Pei, Nanshan Ma, Lianbo Xiao

“…In vitro experiments were conducted to assess the effects of PCK1 on lactate secretion and cellular functions in RA-FLS. …”
Get full text

Methods of Calculating the Indexes of Intellectual Capital of Organizations by V. A. Korzhak

“…Competitive functioning at the micro and macro levels of businesses in different industries creates the need to make changes in the assessment of the impact on the performance of companies of tangible and intangible assets, leading to an increase in the value of both products and companies. …”
Get full text

Transcriptome and Endogenous Hormones Reveal the Regulatory Mechanism of Flower Development in <i>Camellia azalea</i> by Jian Xu, Fan Yang, Ruimin Nie, Wanyue Zhao, Fang Geng, Longqing Chen

“…These DEGs were further analyzed for functional enrichment using the GO and KEGG databases. …”
Get full text

A Deep Learning Method for Inversing 3D Temperature Fields Using Sea Surface Data in Offshore China and the Northwest Pacific Ocean by Xiangyu Wu, Mengqi Zhang, Qingchang Wang, Xidong Wang, Jian Chen, Yinghao Qin

“…Control experiments are conducted to explore the impact of different input variables, labels, and loss functions on the reconstruction results. …”
Get full text

Cannabinoids: Do they alleviate pain in cancer patients? by Magdalena Waśniowska, Magdalena Bujak, Wenancjusz Stołowski, Adrianna Czyżnikiewicz, Justyna Stadler-Szajda, Dominika Prystacka-Szar, Dagmara Neska, Jakub Siemko, Filip Grabowski, Natalia Rulewska

“…This review centers on the endocannabinoid system (ECS), a sophisticated network of cell signals that is essential for controlling a number of physiological and pathological functions, including the feeling of pain. …”
Get full text