Can the 3rd Hour Value of 100 g Oral Glucose Tolerance Test Be Ignored in the Diagnosis of Gestational Diabetes Mellitus? by Mehmet Metin Altay, Serdinç Özdoğan, Aytaç Tohma, Sertaç Esin, Okyar Erol, Orhan Gelişen, Melih Akkuş, Sinan Karadeniz

“…For the 100 g OGTT fasting plasma glucose cut-off value was 105 mg/dl, 1 hour cut-off value was 190 mg/dl, 2 hour cut-off value was 165 mg/dl and 3 hour cut-off value was 145 mg/dl. Patients with 2 or more values above the cut-off level were diagnosed as GDM. …”
Get full text

Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease by Thomas F Baumert, Charlotte Bach, Patrick Pessaux, Catherine Schuster, Frank Jühling, Sarah C Durand, Yujin Hoshida, Fabien Zoulim, Atish Mukherji, Naoto Fujiwara, Marine A Oudot, Armando Andres Roca Suarez, Michel L Tremblay, Barbara Testoni, Joachim Lupberger, Romain Parent, Laurent Mailly, Nassim Dali-Youcef, Emanuele Felli, Maria Saez-Palma, Julien Moehlin, Alessia Virzì, Nicolas Brignon, Eugenie Schaeffer, Romain Martin, Laura Meiss-Heydmann, Zakaria Boulahtouf, Lea Girard, Emma Osswald, Carole Jamey, Daniel Brumaru, Bhuvaneswari Koneru

“…We further validated PTPRD as a STAT3 phosphatase in the liver, acting as a regulator of peroxisomal fatty acid metabolism. During MASH, low PTPRD led to increased liver steatosis in Ptprd+/− mice and a pronounced unfolded protein response, which impacts insulin signalling. …”
Get full text

Inflamed immune phenotype predicts favorable clinical outcomes of immune checkpoint inhibitor therapy across multiple cancer types by Jeanne Shen, Sergio Pereira, Chan-Young Ock, Yung-Jue Bang, Seulki Kim, Sehhoon Park, Se-Hoon Lee, George A Fisher, Young Kwang Chae, Yoon-La Choi, Jin-Haeng Chung, Tony S K Mok, Leeseul Kim, Jun-Eul Hwang, Gahee Park, Sanghoon Song, Seunghwan Shin, Yoojoo Lim, Wonkyung Jung, Heon Song, Hyojin Kim, Taebum Lee, Sukjun Kim, Chang Ho Ahn, Seokhwi Kim, Ben W Dulken, Stephanie Bogdan, Maggie Huang, Chiyoon Oum, Siraj M. Ali

“…However, it is challenging to define the IIP in an objective and reproducible manner during manual histopathologic examination. Here, we investigate artificial intelligence (AI)-based immune phenotypes capable of predicting ICI clinical outcomes in multiple solid tumor types.Methods Lunit SCOPE IO is a deep learning model which determines the immune phenotype of the tumor microenvironment based on TIL analysis. …”
Get full text

High quality genome assembly of the brown hare (Lepus europaeus) with chromosome-level scaffolding by Michell, Craig, Collins, Joanna, Laine, Pia K., Fekete, Zsófia, Tapanainen, Riikka, Wood, Jonathan M. D., Goffart, Steffi, Pohjoismäki, Jaakko L. O.

“…The genome was assembled using 25X PacBio HiFi sequencing data and scaffolded utilizing a Hi-C chromosome structure capture approach. …”
Get full text

Risk factors analysis and prediction model establishment of acute kidney injury after heart valve replacement in patients with normal renal function by Xiaofan Huang, Xiaofan Huang, Xiangyu Sun, Jiangang Song, Yongqiang Wang, Jindong Liu, Jindong Liu, Yu Zhang, Yu Zhang

“…BackgroundThe study aimed to develop a risk prediction model through screening preoperative risk factors for acute kidney injury (AKI) after heart valve replacement in patients with normal renal function.MethodsA total of 608 patients with normal renal function who underwent heart valve replacement from November 2013 to June 2022 were analyzed retrospectively. The Lasso regression was used to preliminarily screen potential risk factors, which were entered into the multivariable logistic regression analysis to identify preoperative independent risk factors for postoperative AKI. …”
Get full text

Prevalence of signs and symptoms of temporomandibular disorders (TMD) in a sample of medical students in Erbil city by Dilan Burhan Yousif, Zana Qadir Omer

“…According to Helkimo clinical dysfunction index temporomandibular disorder was more prevalent among females and those who had a degree of anxiety. …”
Get full text

Association of blood cadmium and physical activity with mortality: A prospective cohort study by Yilin Chen, Cien Zhen, Lin Zeng, Hongliang Feng, Jinyu Wang, Qi Yong H. Ai, Sizhi Ai, Jihui Zhang, Yannis Yan Liang, Huachen Xue, Yujing Zhou

“…Restricted cubic spline analyses were employed to investigate the nonlinear relationships between blood cadmium and PA levels and mortality risks. During a median follow-up of 7.6 years, a total of 2002 (9.89 %) all-cause deaths occurred, of which 581 (2.87 %) participants were due to cardiovascular disease (CVD) and 498 (2.46 %) died of cancer. …”
Get full text

Electrodermal activity and skin temperature characteristics related to stress and depression: A 4-week observational study of office workers by Yuki Ishikawa, Tatsuki Sugio, Kiko Shiga, Keisuke Izumi, Kazumichi Minato, Momoko Kitazawa, Sayaka Hanashiro, Ryo Takemura, Hiroyuki Uchida, Taishiro Kishimoto

“…Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9), and stress was assessed using the 10-item version of the Perceived Stress Scale (PSS-10). …”
Get full text

Development of an expectation management intervention for patients with Long COVID: A focus group study with affected patients. by Manuel Funk, Max Reinke, Bernd Löwe, Petra Engelmann

“…Patients' response to the presented vicious circle of fear and a behavior change exercise was mixed. Modifications to the manual were made in response to patients' feedback.…”
Get full text

Longitudinal Survey of Astrovirus infection in different bat species in Zimbabwe: Evidence of high genetic Astrovirus diversity by Chidoti, Vimbiso, De Nys, Hélène, Abdi, Malika, Mashura, Getrude, Pinarello, Valérie, Chiweshe, Ngoni, Matope, Gift, Guerrini, Laure, Pfukenyi, Davies, Cappelle, Julien, Mwandiringana, Ellen, Missé, Dorothée, Gori, Elizabeth, Bourgarel, Mathieu, Liégeois, Florian

“…Pooled and individual faecal sampling methods were used for this study, with collection dates ranging from June 2016 to July 2021. …”
Get full text

The Effect of Knowledge, Education, Income, and Marriage Age on Iron Deficiency Anemia in Pregnant Women in Taiz City-Yemen by Lamia A. S. Ali, Hermanto Tri Joewono, Widati Fatmaningrum, Riyadh A. S. Thabit, Hebah H. M. Almothana, Fardous G. Alsoufi, Aya Ali Abdullah, Tasnim Mohammed Al-Qadhi, Suha Ali Al Hajj, Samar A. A. Ahmed, Sarah A. D. Alselwi, Habib Thabet, Haitham T. S. Mohammed, Linda Andriani

“…A simple random selection procedure is used to choose six of Taiz City's 10 primary healthcare facilities.101 pregnant women between the ages of 18 and 42 took part in the study. …”
Get full text

Diagnosis and Treatment of Gastroesophageal Reflux Disease (Clinical Guidelines of the Russian Gastroenterological Association, Russian Scientific Medical Society of Internal Medic... by V. T. Ivashkin, A. S. Trukhmanov, I. V. Maev, O. M. Drapkina, M. A. Livzan, A. I. Martynov, T. L. Lapina, A. V. Paraskevova, D. N. Andreev, O. P. Alexeeva, S. A. Alekseenko, A. Yu. Baranovsky, O. V. Zayratyants, O. Yu. Zolnikova, O. B. Dronova, I. L. Kliaritskaia, N. V. Korochanskaya, Yu. A. Kucheryavyy, S. N. Mammaev, M. F. Osipenko, S. S. Pirogov, E. A. Poluektova, D. E. Rumyantseva, R. G. Sayfutdinov, O. A. Storonova, Yu. P. Uspenskiy, I. B. Khlynov, V. V. Tsukanov, A. A. Sheptulin

“…The main groups of medications used in the treatment of GERD are proton pump inhibitors (PPIs), potassium-competitive acid blockers (P-CABs), alginates, antacids, and prokinetics. …”
Get full text

Serum calprotectin and renal function decline in ANCA-associated vasculitides: a post hoc analysis of MAINRITSAN trial by Xavier Romand, Benjamin Terrier, Athan Baillet, Philippe Gaudin, Loic Guillevin, Christian Pagnoux, Minh Vu Chuong, Marie Hélène Paclet

“…A significantly higher risk of relapse was observed in proteinase 3- AAV patients with an increase of serum calprotectin levels (OR 5.6 (95% CI 1.0 to 31.2), p=0.03).Conclusion An increase in serum calprotectin by month 6 compared with inclusion during remission-maintenance therapy in AAV was associated with a higher risk of renal function decline in the following 12 months.Trial registration number NCT00748644.…”
Get full text

The motives for seeking dental health services in a sample of children attending a College of Dentistry Erbil, Iraq. by Alla Mahmud Mustafa, Heran Ibrahim Hassan, Fighan Jalal Huseen

“…The chi-square test was used to find any statistical association between the variables. …”
Get full text

Dynamic 19F-MRI of pulmonary ventilation in lung transplant recipients with and without chronic lung allograft dysfunction by Mary A. Neal, PhD, Saskia Bos, MD, PhD, Charlotte W. Holland, MRCP, Kieren G. Hollingsworth, Gerard Meachery, FRCP, Arun Nair, MD, FRCP, James L. Lordan, FRCP, Andrew J. Fisher, FRCP, PhD, Peter E. Thelwall, PhD

“…FEV1 (% of baseline) negatively correlated with ventilation during wash-in, most strongly for the periphery (r = −0.844, p = 0.0021). …”
Get full text

Caveolin Gene, a Possible Risk Factor for Metabolic Syndrome in Humans: A Systematic Review and Meta-Analysis by Mohadeseh Arefian, Sadegh Mazaheri-Tehrani, Maryam Yazdi, Roya Kelishadi

“…With future studies focusing on the matter, this gene can be used as a screening tool for metabolic health to detect individuals with a higher genetic susceptibility to metabolic syndrome.…”
Get full text

Verbal fluency and semantic association deficits in children with in birth nonprogressive neuromuscular diseases by Maria Koriakina, Maria Koriakina, Olga E. Agranovich, Ioannis Ntoumanis, Maxim Ulanov, Isak B. Blank, Anna Shestakova, Evgeny Blagovechtchenski

“…Mainly, MD children produced fewer words during verbal fluency tasks and demonstrated reduced semantic associations. …”
Get full text

The Impact of Cementing Techniques on Implant Longevity in Relation to Keel Length in Persona and NexGen Knee Arthroplasty: A Comprehensive Study by Arash Sharafat Vaziri, MD, Mohammad Naghi Tahmasebi, MD, Hoseinali Hadi, MD, Sina Javidmehr, MD, Sohrab Keyhani, MD, Zahra Vahdati, MD, Hossein Nematian, MD, Yalda Farahmand, MD

“…The revision rate for early (during the first 24 months) aseptic loosening was 4.6% in the conventionally cemented Persona group. …”
Get full text

Prenatal malaria exposure and risk of adverse birth outcomes: a prospective cohort study of pregnant women in the Northern Region of Ghana by Akbar Fotouhi, Masud Yunesian, Hawawu Hussein, Mansour Shamsipour, Mohammad Sadegh Hassanvand, Percival Delali Agordoh, Mashoud Alabi Seidu

“…After adjusting for newborn admissions to the neonatal intensive care unit, parity, maternal age and glucose-6-phosphate dehydrogenase, women who were exposed to malaria during the third trimester of pregnancy had 2.02 times (95% CI 1.36 to 2.99) higher odds of premature delivery. …”
Get full text

Outcomes of the toxic hepatites caused by alcohol surrogates by I. Yu. Pirogova, I. Yu. Ponomareva, S. P. Sinitsyn, Ye. P. Samokhina, A. S. Gorbunova, Ye. Yu. Startseva, V. S. Chulkov, T. F. Kondrat'yeva

“…Within the first month of disease 16 (20%) patients died of liver failure, during following period – 13 patients (19%). Calculation of MELD index and Hy's Law showed their low informative value at this group of patients, R index in 78% of cases indicated mixed lesion and did not affect prognosis. …”
Get full text