Flexibility in PAM recognition expands DNA targeting in xCas9 by Kazi A Hossain, Lukasz Nierzwicki, Modesto Orozco, Jacek Czub, Giulia Palermo

“…Furthermore, xCas9 enhances DNA binding to alternative PAM sequences during the early evolution cycles, while favouring binding to the canonical PAM in the final evolution cycle. …”
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Betaine enhances SCAPs chondrogenic differentiation and promotes cartilage repair in TMJOA through WDR81 by Meiyue Wang, Zejie Wu, Xiaoyu Zheng, Yishu Huang, Yizhou Jin, Jiaxin Song, Wanzhen Lei, Hua Liu, Riyue Yu, Haoqing Yang, Runtao Gao

“…The chondrogenic differentiation potential was assessed using Alcian Blue staining, Sirius Red staining and the main chondrogenic markers. …”
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Deep learning and hyperspectral features for seedling stage identification of barnyard grass in paddy field by Siqiao Tan, Qiang Xie, Wenshuai Zhu, Yangjun Deng, Lei Zhu, Xiaoqiao Yu, Zheming Yuan, Zheming Yuan, Yuan Chen, Yuan Chen

“…Detection of barnyard grass before the four-leaf stage is critical for effective control measures. However, due to their striking visual similarity, separating them from rice seedlings at early growth stages is daunting using traditional visible light imaging models. …”
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How do serum cytokine levels change in myocarditis and inflammatory dilated cardiomyopathy relative to healthy individuals? A protocol for a systematic review and meta-analysis by Romuald Wojnicz, Piotr Lewandowski, Maciej Baron, Marcin A Rojek, Marcin Goławski, Karol Krystek, Magdalena Żegleń, Pascal Zytkiewicz, Jakub Kancerek, Klaudia Gabriela Lis, Jakub Warecki, Jakub Kufel, Kamila Kuśpiel

“…Meta-analyses will be used to summarise serum levels of each cytokine if possible. …”
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Exogenous nitric oxide relieves iron-inhibitory effect on wheat seed germination by Shuqian Shi, Zhe Zhang, Rongrong Ma, Yihui Tao, Ziling Wang, Yingli Yang

“…Notably, Fe and PTIO treatments reduced the germination potential, germination rate, germination index, and vitality index of wheat seeds during the early and late germination stages. Additionally, Fe and PTIO treatments reduced endogenous NO levels, increased starch, sucrose, and soluble sugar contents, induced oxidative stress, suppressed antioxidant enzymes, and downregulated nitrate reductase, NO synthase, and amylase activities. …”
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Vertical distribution of ice nucleating particles over the boreal forest of Hyytiälä, Finland by Z. Brasseur, J. Schneider, J. Lampilahti, V. Vakkari, V. Vakkari, V. A. Sinclair, C. J. Williamson, C. J. Williamson, C. Xavier, C. Xavier, D. Moisseev, D. Moisseev, M. Hartmann, P. Poutanen, M. Lampimäki, M. Kulmala, T. Petäjä, K. Lehtipalo, K. Lehtipalo, E. S. Thomson, K. Höhler, O. Möhler, J. Duplissy

“…This study focuses on aircraft measurements conducted during spring 2018 above the boreal forest of Hyytiälä, Finland. …”
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The role of starting knee angle in squat jump force-velocity profiles: interactions with subjects’ strength levels and imputed push-off distance by Xuelin Qin, Beibei Liu, Ruolin Tang, Yan Liu, Amador García-Ramos, Amador García-Ramos

“…IntroductionThis study investigated whether differences in the force-velocity (F-v) profile obtained using Samozino’s method during squat jumps (SJ) performed at varying knee angles are influenced by subjects’ strength levels and the push-off distance (HpO) used in the analysis.MethodsTwenty-one resistance-trained men were classified as stronger (n = 10) or weaker (n = 11) based on the external load required to achieve a 10 cm SJ height. …”
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Associations of daily steps and step intensity with peripheral arterial disease in Chinese community-dwelling older women by Chenfei Li, Litao Du, Xiangli Xue, Na Zhao, Qiang He, Si Chen, Xianliang Zhang

“…Multivariate logistic regression was used to investigate associations of step variable with PAD. …”
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CORRELATION BETWEEN KNEE OSTEOARTHRITIS (OA) GRADE AND BODY MASS INDEX (BMI) IN OUTPATIENTS OF ORTHOPAEDIC AND TRAUMATOLOGY DEPARTMENT RSUD DR. SOETOMO by Lukas Widhiyanto, Andre Triadi Desnantyo, Lilik Djuari, Maynura Kharismansha

“…Populations in this study were taken from the outpatients of Orthopaedic and Traumatology Department RSUD Dr. Soetomo during August until November 2015. After statistic test using Spearman correlation test was done, the result was p=0,822. …”
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Advanced glycation end products and risk of mortality in patients with cirrhosis: a prospective cohort study by Mohsen Shaygan Tabar, Maryam Nilghaz, Azita Hekmatdoost, Fereshteh Pashayee-Khamene, Zeinab Mokhtari, Sara Karimi, Saleheh Ahmadzadeh, Mehdi Saberifiroozi, Behzad Hatami, Zahra Yari

“…To determine the incidence of mortality in the quartiles of dietary AGEs, cox regression models were used with the adjustment of potential confounding variables. …”
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In vitro study on the inhibitory effect of various essential oils against murine coronavirus mouse hepatitis virus A-59 replication by Karelle Contant, Shiv Shankar, Monique Lacroix

“…Methods: In the present study, 32 EOs were screened in vitro against MHV-A59 on DBT cells using plaque assay. EOs in emulsions were applied at their maximum noncytotoxic concentrations to MHV-A59 after penetration of the viruses into the host cells for 1 h during intracellular virus replication. …”
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Quality of reporting in abstracts of clinical trials using physical activity interventions: a cross-sectional analysis using the CONSORT for Abstracts by Angélica Trevisan De Nardi, Leony Morgana Galliano, Nórton Luís Oliveira, Daniel Umpierre

“…RCTs published in 9 exercise science journals and 2 general medicine journals during 2019 were eligible. Two researchers conducted study selection and, thereafter, assessment of the abstracts using a form comprising 16 items based on CONSORT for Abstracts. …”
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Soil Carbon Characteristics of a Fluvisol Affected by Aggregates from Two Tillage and Crop Regimes by Emmanuel Onweremadu, Frank Akamigbo, Chigozie Asiabaka

“…Sci. Environ. Manage. June, 2012, Vol. 16 (2)174 - 179…”
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Integrated multi-omics analysis reveals the underlying molecular mechanism for the neurotoxicity of triclosan in zebrafish by Shasha Zhao, Yuhang Ling, Baohua Zhang, Danting Wang, Limei Sun

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Continuous follow-up intervention of a low-salt diet to control blood pressure among older people with hypertension in rural Indonesia by Ivana Aprilia Pehopu, Andi Masyitha Irwan, Elly Lilianty Sjattar, Sakul Changmai, Noor Azah Abd Aziz

“…In the intervention group, blood pressure decreased and remained stable during the first and second months. The statistical tests for the intervention group showed significant changes in both systolic blood pressure (p = 0.000) and diastolic blood pressure (p = 0.000). …”
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A Study on Performance and Reusability of Certified and Uncertified Face Masks by Haebum Lee, Seojeong Kim, HungSoo Joo, Hee-joo Cho, Kihong Park

“…Monodisperse and polydisperse sodium chloride particles were used as test aerosols. Except for the uncertified mask filter, PM2.5 removal efficiency was > 90%. …”
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Efficiency of a macroroughness block ramp in reducing the impact of low-head dams on riverine fish dispersion by Tomanova Sylvie, Courret Dominique, Richard Sylvain, Mercier Olivier, Guillemin Axel, Labedan Mathilde, Sagnes Pierre

“…However, their in situ efficiency has not been evaluated yet. Here, we used Radio Frequency Identification (RFID) telemetry to monitor during two years the displacement of eleven fish species, on such a macroroughness ramp located on a tributary of the Loire River in France. …”
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Post-traumatic arthritis: overview on pathogenic mechanisms and role of inflammation by Roberta Ramonda, Leonardo Punzi, Anna Scanu, Francesca Oliviero, Roberto Luisetto, Paola Galozzi, Marta Favero

“…At the present time, intra-articular injection of IL-1 receptor antagonist is the only anticytokine approach that has been used in a human study of PTA. Despite the fact that knowledge in this area has increased in the past years, the identification of more specific disease markers and new therapeutic opportunities are needed.…”
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Functional Outcome by Evaluation of DASH Score on Drop Hand Patient Treated with Jones’ Tendon Transfer: A Retrospective Study by Tito Sumarwoto, Seti Aji Hadinoto, Adhitya Indra Pradhana

“…Conclusions: Surgical intervention for drop hand due to radial nerve palsy using the Jones tendon transfer technique yielded a satisfactory functional outcome based on the DASH score.…”
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A comparative performance analysis of machine learning models for compressive strength prediction in fly ash-based geopolymers concrete using reference data by Muhammad Kashif Anwar, Muhammad Ahmed Qurashi, Xingyi Zhu, Syyed Adnan Raheel Shah, Muhammad Usman Siddiq

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