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    Divalent Metal Ion Transport across Large Biological Ion Channels and Their Effect on Conductance and Selectivity by Elena García-Giménez, Antonio Alcaraz, Vicente M. Aguilella

    Published 2012-01-01
    “…Electrophysiological characterization of large protein channels, usually displaying multi-ionic transport and weak ion selectivity, is commonly performed at physiological conditions (moderate gradients of KCl solutions at decimolar concentrations buffered at neutral pH). …”
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    The Pseudomonas aeruginosa Tse4 toxin assembles ion-selective and voltage-sensitive ion channels to couple membrane depolarisation with K+ efflux. by Jessica Rojas-Palomino, Carmen Velázquez, Jon Altuna-Alvarez, Amaia González-Magaña, Maialen Zabala-Zearreta, Matthias Müller, María Queralt-Martín, Antonio Alcaraz, David Albesa-Jové

    Published 2025-06-01
    “…Our results show that Tse4 spontaneously incorporates into lipid monolayers and forms multi-ionic channels in planar bilayers, with either ohmic conduction or diode-like rectifying currents and a preference for cations over anions. …”
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