Preclinical models of mitochondrial dysfunction: mtDNA and nuclear-encoded regulators in diverse pathologies by Dalia M. Miller, Stephen L. Archer, Stephen L. Archer, Stephen L. Archer, Kimberly J. Dunham-Snary, Kimberly J. Dunham-Snary

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Mitochondrial echoes in the bloodstream: decoding ccf-mtDNA for the early detection and prognosis of hepatocellular carcinoma by Yu-De Chu, Wei-Ting Chen, Wey-Ran Lin, Ming-Wei Lai, Chau-Ting Yeh

“…This review provides a comprehensive overview of the origins, biological significance, and clinical applicability of ccf-mtDNA in HCC, and explores emerging interest in mitochondrial DNA encapsulated in extracellular vesicles as a novel diagnostic tool. …”
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A Successful Approach to Extracted Human mtDNA and Amplify some Genes from FFPE Samples by Nisreen Abdulkadhim Hanoush, Ahmed E.Dhamad

“…To extract mtDNA, the Geneaid gSYNCTM DNA kit (cat#GS100) was used with fifty breast cancer tissues (block). …”
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MtDNA depletion influences the transition of CD44 subtypes in human prostate cancer DU145 cells by Xiaoran Li, Mantas Grigalavicius, Yaqing Li, Xiaoli Li, Yali Zhong, Ruixia Huang, Dandan Yu, Viktor Berge, Mariusz Adam Goscinski, Gunnar Kvalheim, Jahn M Nesland, Zhenhe Suo

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Application of rapid clinical exome sequencing technology in the diagnosis of critically ill pediatric patients with suspected genetic diseases by Xuejun Ouyang, Dazhi Chi, Yu Zhang, Tian Yu, Qian Zhang, Lei Xu, Victor Wei Zhang, Bin Wang

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Corrigendum: Application of rapid clinical exome sequencing technology in the diagnosis of critically ill pediatric patients with suspected genetic diseases by Xuejun Ouyang, Dazhi Chi, Yu Zhang, Tian Yu, Qian Zhang, Lei Xu, Victor Wei Zhang, Bin Wang

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Corrigendum: Corrigendum: Application of rapid clinical exome sequencing technology in the diagnosis of critically ill pediatric patients with suspected genetic diseases by Xuejun Ouyang, Dazhi Chi, Yu Zhang, Tian Yu, Qian Zhang, Lei Xu, Victor Wei Zhang, Bin Wang

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Protective role of mitophagy on microglia-mediated neuroinflammatory injury through mtDNA-STING signaling in manganese-induced parkinsonism by Yang Lu, Liang Gao, Yuqing Yang, Dihang Shi, Zhipeng Zhang, Xiaobai Wang, Ying Huang, Jie Wu, Jia Meng, Hong Li, Dongying Yan

“…Abstract Manganese (Mn), the third most abundant transition metal in the earth’s crust, has widespread applications in the emerging field of organometallic catalysis and traditional industries. …”
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Characterization of Some Commercially Important Octopus (Mollusca: Cephalopoda) from Indonesian Waters using Mitochondrial DNA Cytochrome Oxidase Sub-Unit I (Mt-DNA COI) by Nenik Kholilah, Norma Afiati, Subagiyo Subagiyo

“…This study therefore aimed to determine the species of octopus based on phylogenetic analysis of mt-DNA COI. Octopuses were collected from nine different locations throughout Indonesia, i.e., Anambas, Bangka-Belitung, Cirebon, Karimunjawa, Tuban, Lombok, Buton, Wakatobi and Jayapura. …”
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Lipid nanoparticle delivery of the CRISPR/Cas9 system directly into the mitochondria of cells carrying m.7778G>T mutation in MtDNA (mt-Atp8) by Kaede Norota, Sen Ishizuka, Misa Hirose, Yusuke Sato, Masatoshi Maeki, Manabu Tokeshi, Saleh M. Ibrahim, Hideyoshi Harashima, Yuma Yamada

“…RNP-MITO-Porter is expected to contribute significantly to the clinical application of mitochondrion-targeted gene therapy.…”
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The quality and detection limits of mitochondrial heteroplasmy by long read nanopore sequencing by Barbara Slapnik, Robert Šket, Klementina Črepinšek, Tine Tesovnik, Barbara Jenko Bizjan, Jernej Kovač

“…Abstract This study evaluates long-read and short-read sequencing for mitochondrial DNA (mtDNA) heteroplasmy detection. 592,315 bootstrapped datasets generated from two single-nucleotide mismatched ultra-deep sequenced mtDNA samples were used to assess basecalling error and accuracy, limit of heteroplasmy detection, and heteroplasmy detection across various coverage depths. …”
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Reassessing leatherback turtle lineages and unveiling the first evidence of nuclear mitochondrial DNA in sea turtles by Wesley D. Colombo, Juliana de Freitas Justino, Ana Carolina Barcelos, Sibelle Torres Vilaça, Larissa Pavanelli, Sarah M. Vargas

“…However, this hypothesis may be influenced by nuclear mitochondrial DNA segments (NUMTs), which could have been misamplified as true mtDNA. NUMTs are sequences that have migrated from the mitochondrial genome to the nuclear genome and can co-amplify with mtDNA, potentially leading to erroneous phylogenetic interpretations. …”
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Inhibition of the ATP synthase c subunit ameliorates HDM/LPS-induced inflammatory responses in asthmatic bronchial epithelial cells by blocking the mPTP-mtDNA-cGAS-STING axis by Decai Wang, Chao Liu, Chen Bao, Jiannan Hu, Ziling Li, Xinyue Ma, Yunfei Zhu, Shuyun Xu

“…Clinical trial number Not applicable.…”
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Typing of Echinococcus multilocularis by Region-Specific Extraction and Next-Generation Sequencing of the mitogenome by Franziska Rachel, Franziska Rachel, Christine Luttermann, Dirk Höper, Franz Josef Conraths, Johannes Dapprich, Pavlo Maksimov

“…For the capture and sequencing of large (several kb) genomic regions of E. multilocularis and other applications, this method can be very helpful.…”
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Application of mitochondrial genomes to species identification and evolution by Bingpeng Xing, Liangyu Lin, Qiong Wu

“…This review examines the application of mtDNA in tracing evolutionary history, elucidating phylogenetic relationships, and understanding mechanisms of species divergence. …”
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Recent advances and applications of mitochondria in tumors and inflammation by Hui Liu, Mengmeng Pan, Yumeng Li, Zhen Huang, Hanying Li, Chenguang Zhang, Chunlei Guo, Hui Wang

“…This review discusses the relationship between mitochondria (including mitochondrial metabolism and mitophagy) and tumors, and the relationship between mtDNA and inflammation, as well as its clinical application in inflammatory diseases. …”
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Single-cell mitochondrial DNA sequencing: Methodologies and applications by Guoqiang Zhou, Zhenglong Gu, Jin Xu

“…This review aims to provide a comprehensive overview of current single-cell mtDNA sequencing methodologies and their applications in advancing our understanding of mitochondrial genetics.…”
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Population-genetics analysis of the brown trout broodstock in the “Panjica” hatchery (Serbia) and its conservation applications by Veličković Tijana, Snoj Aleš, Bravničar Jernej, Simić Vladica, Šanda Radek, Vukić Jasna, Barcytė Dovilė, Stanković David, Marić Saša

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Protocol to test the efficacy and safety of frequent applications of skin electrical stimulation for Leber hereditary optic neuropathy: a single-arm, open-label, non-randomised pro... by Sotaro Mori, Yusuke Murai, Kaori Ueda, Mari Sakamoto, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura, Takayuki Nagai, Fumio Takano

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Populations of the Australian Saltmarsh Mosquito Aedes vigilax Vary Between Panmixia and Temporally Stable Local Genetic Structure by Thomas L. Schmidt, Nancy Endersby‐Harshman, Toby Mills, Rahul Rane, Gunjan Pandey, Chris Hardy, Leon Court, Cameron Webb, Brendan Trewin, Brett Neilan, Ary A. Hoffmann

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