Gene expression profiling in pure neural leprosy: insights into pathogenesis and diagnostic biomarkers by Mariana Martins de Athaide, Thyago Leal-Calvo, Tatiana Pereira Da Silva, Thabatta Leal Silveira Andrezo Rosa, Helen Ferreira, Bernardo Miguel de Oliveira Pascarelli, Ana Caroline Siquara de Sousa, Marcia Rodrigues Jardim, Marcia Rodrigues Jardim, Marcia Rodrigues Jardim, Marcia Rodrigues Jardim, Marcia Rodrigues Jardim, Roberta Olmo Pinheiro, Roberta Olmo Pinheiro, Roberta Olmo Pinheiro

“…Moreover there is no a specific treatment to control neural damage. Transcriptomic profiling may reveals unique gene expression changes in PNL nerves, shedding light on immune response and pathogenesis. …”
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Vitamin and zeatin treatments promote colchicine-induced haploid chromosome doubling in maize by Chen Chen, Yuling Zhang, Chenxu Liu, Jinlong Li, Jiuran Zhao, Yuandong Wang, Shaojiang Chen

“…These results provide novel insights in exploring the molecular responses to antimitotic reagents at both the transcriptomic and metabolomic levels. …”
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Human transcriptional signature of protection after Plasmodium falciparum immunization and infectious challenge via mosquito bites by Marie Mura, Burook Misganaw, Aarti Gautam, Tanisha Robinson, Sidhartha Chaudhury, Neha Bansal, Andrew J. Martins, John Tsang, Rasha Hammamieh, Elke Bergmann-Leitner

“…The current study expands our previous cellular and serological profiling of vaccine-induced responses to a whole parasite malaria vaccine. The irradiated sporozoite model was chosen as it is considered the most effective vaccine against malaria. …”
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Time-course RNA-seq analysis of upland cotton (Gossypium hirsutum L.) responses to Southern root-knot nematode (Meloidogyne incognita) during compatible and incompatible interactio... by Sameer Khanal, Pawan Kumar, Mychele B. da Silva, Rippy Singh, Nelson Suassuna, Don C. Jones, Richard F. Davis, Peng W. Chee

“…Results Using time-course RNA-seq analyses across nematode developmental phases, we uncovered transcriptomic events—both genome-wide and within QTL intervals—underlying defense responses during compatible interactions (with Cocker 201, a susceptible line) and incompatible interactions (with M-120 RNR, a resistant line). …”
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Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy. by Chloe I Bloom, Christine M Graham, Matthew P R Berry, Katalin A Wilkinson, Tolu Oni, Fotini Rozakeas, Zhaohui Xu, Jose Rossello-Urgell, Damien Chaussabel, Jacques Banchereau, Virginia Pascual, Marc Lipman, Robert J Wilkinson, Anne O'Garra

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Comparative transcriptome analysis in two contrasting genotypes for Sclerotinia sclerotiorum resistance in sunflower. by Mingzhu Zhao, Bing Yi, Xiaohong Liu, Dexing Wang, Dianxiu Song, Enyu Sun, Liangji Cui, Jingang Liu, Liangshan Feng

“…A total of 10151 and 7439 differentially expressed genes (DEGs) were detected in DS and DR genotypes, respectively. Most of DEGs were enriched in cell wall organisation, protein kinase activity, hormone, transcription factor activities, redox homeostasis, immune response, and secondary metabolism. …”
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TRANSCRIPTOMIC ANALYSIS OF MELANOMA CELLS EXTRACTED FROM DIFFERENT SITES OF THE PRIMARY TUMOR by M. B. Aksenenko, A. V. Komina, N. V. Palkina, A. S. Averchuk, Yu. A. Rybnikov, Yu. A. Dyhno, T. G. Ruksha

“…Treatment of malignant tumors requires an individual approach to choose the most appropriate treatment regimen.The purpose of the study was to evaluate differences in melanoma tissue samples obtained from different parts of one patient’s primary tumor at the transcriptomic level.Material and Methods. …”
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Transcriptomic Analysis of <i>Trachinotus ovatus</i> Under Flow Velocity Stress by Jing Zhang, Xixi Liu, Jiayue Dai, Sufang Niu, Xuefeng Wang, Baogui Tang

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Investigating the Effect of Microcystins on the Transcriptomics of Hepatopancreas in Penaeus vannamei Using Reverse-Gavage by Haiqing YUAN, Rongsheng JIN, Baoran WANG, Daiqiang CHEN, Shuangyong ZHANG, Zhiqiang CHANG

“…Microcystin-LR (MC-LR) is the most prevalent and highly toxic variant. MC-LR is toxic to aquatic organisms and impacts terrestrial organisms and human health in several ways. …”
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Transcriptome Remodeling and Adaptive Preservation of Muscle Protein Content in Hibernating Black Bears by Vadim B. Fedorov, Arthur Garreau, Øivind Tøien, Brian M. Barnes, Anna V. Goropashnaya

“…ABSTRACT Hibernation is an energy‐saving adaptation associated with physical inactivity. In contrast to most mammals, hibernating bears demonstrate limited loss of muscle mass and protein content over the prolonged periods of immobility and fasting during winter. …”
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Transcriptomic profiles reveal hormonal regulation of sugar-induced stolon initiation in potato by Xiaoqing Wang, Kaifeng Zheng, Tiancang Na, Guangji Ye, Shengcheng Han, Jian Wang

“…Abstract Potato (Solanum tuberosum L.) is one of the world’s most important non-cereal food crops, with stolon development playing a crucial role in determining tuber yield. …”
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Multi-tissue transcriptomic characterization of endogenous retrovirus-derived transcripts in Capra hircus by Ming-Di Li, Ming-Di Li, Hu-Rong Li, Shao-Hui Ye

“…They showed strong co-expression with their proximal gene OAS1 and TMPRSS2, indicating the impact of activated proximal gene expression on nearby ERVs.ConclusionWe generated ERV transcriptomes across goat tissues, and identified ERVs activated in response to different physiological and pathological conditions.…”
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Combining transcriptomic and metabolomic insights into carbohydrate utilization by Ruminiclostridium papyrosolvens DSM2782 by Mengcheng You, Zhenxing Ren, Letian Ye, Qiuyun Zhao, Ziyi Liu, Houhui Song, Chenggang Xu

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Spatial Transcriptomic Signatures of Early Acute T Cell–mediated Rejection in Kidney Transplants by Minji Kang, BS, Haeyoon Kwon, Jeongin Song, BS, Yunyoung Jang, BS, Seung Hee Yang, PhD, Seung-Min Cha, BS, Ji Hwan Moon, PhD, Yong Chul Kim, MD, PhD, Hyun Je Kim, MD, PhD

“…Although T cell–directed immunosuppressive drugs effectively contain graft rejection in most patients, a notable proportion still experiences acute T cell–mediated rejection (TCMR). …”
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Characteristics of transcriptome and chromatin accessibility in the peripheral blood after acute hypoxia exposure by Kuo Zeng, Pei-ru Yuan, Jin-feng Xuan, Lai-xi Zhao, Xiao-na Li, Jun Yao, Dong Zhao

“…Abstract Background Human responses and acclimation to the environmental stresses of high altitude and low oxygen are multifaceted and regulated by multiple genes. …”
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Transcriptomic atlas reveals organ-specific disease tolerance in sickle cell mice by Anne Grunenwald, Julie Peliconi, Julien Lavergne, Margot Revel, Elodie Voilin, Tania Robe-Rybkine, Gilles Crambert, Jordan D. Dimitrov, Olivier Blanc-Brude, Lubka T. Roumenina

“…Inflammation and myeloid cell signatures were omnipresent in resting HbSS organs, with the liver being the most affected. The injection of heme triggered a robust inflammatory response in HbAA mice. …”
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Cross-species transcriptome-wide meta-analysis of anterior cruciate ligament rupture by Livia Beccacece, Stefano Pallotti, Yiyun Li, Jie Huang, Leonardo Pasotti, Valerio Napolioni

“…Results A positive correlation in expression was observed between human and the other three species (r2 = 0.177–0.305, p-value ≤ 2.7 × 10− 113), identifying 210 genes as the most consistently up- and down-regulated in response to ACL rupture (p-adjusted ≤ 1.27 × 10− 23). …”
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Evaluation and Interpretation of Transcriptome Data Underlying Heterogeneous Chronic Obstructive Pulmonary Disease by Seokjin Ham, Yeon-Mok Oh, Tae-Young Roh

“…Our extensive evaluation of COPD transcriptome data could provide guidelines for analyzing heterogeneous gene expression profiles and classifying potential candidate genes that are responsible for the pathogenesis of COPD.…”
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Deciphering the transcriptomic landscape of systemic lupus erythematosus-associated pulmonary arterial hypertension by Yutong Li, Junyan Qian, Xiaoyue Deng, Leyao Ma, Qizhi Yuan, Qian Wang, Zhuang Tian, Xiaofeng Zeng, Xinzhuang Yang, Jiuliang Zhao, Mengtao Li

“…In contrast, the subgroup with moderate inflammation displayed the most pronounced PAH symptoms. Further disease enrichment analysis revealed that, beyond the dysregulated inflammatory pathways, patients with the most severe PAH exhibited distinct pathogenic transcriptomic profiles that disrupted vascular smooth muscle homeostasis, a critical component of vascular health. …”
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Transcriptome sequencing of Codonopsis pilosula and identification of candidate genes involved in polysaccharide biosynthesis. by Jian Ping Gao, Dong Wang, Ling Ya Cao, Hai Feng Sun

“…<h4>Background</h4>Codonopsis pilosula (Franch.) Nannf. is one of the most widely used medicinal plants. Although chemical and pharmacological studies have shown that codonopsis polysaccharides (CPPs) are bioactive compounds and that their composition is variable, their biosynthetic pathways remain largely unknown. …”
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