A meta-analysis of MHC diversity in Pan troglodytes verus by Christelle Vangenot, Alicia Sanchez‑Mazas

“…The MHC genes play a key role in the immune responses and are located on the short arm of chromosome 6. …”
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Genome-Wide Identification and Expression Pattern Analysis of Nuclear Factor Y B/C Genes in <i>Pinus koraiensis</i>, and Functional Identification of <i>LEAFY COTYLEDON 1</i> by Xiuyue Xu, Xin He, Qun Zhang, Ling Yang

“…The nuclear factor Y (NF-Y) transcription factor is widely involved in various plant biological processes, such as embryogenesis, abscisic acid signaling, and abiotic stress responses. This study presents a comprehensive genome-wide identification and expression profile of transcription factors NF-YB and NF-YC in <i>Pinus koraiensis</i>. …”
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Nuclear hormone receptors control fundamental processes of human fetal neurodevelopment: Basis for endocrine disruption assessment by Katharina Koch, Kevin Schlüppmann, Saskia Hüsken, Louisa Merit Stark, Nils Förster, Stefan Masjosthusmann, Jördis Klose, Arif Dönmez, Ellen Fritsche

“…Most receptor agonists modulated KNDPs at concentrations in the range of physiologically relevant hormone concentrations. …”
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Identification and Characterization of Lipid Droplet-Associated Protein (LDAP) Isoforms from Tung Tree (<i>Vernicia fordii</i>) by Alyssa C. Clews, Payton S. Whitehead, Lingling Zhang, Shiyou Lü, Jay M. Shockey, Kent D. Chapman, John M. Dyer, Yang Xu, Robert T. Mullen

“…Lipid droplets (LDs) are cytoplasmic organelles responsible primarily for the storage of neutral lipids, such as triacyclglycerols (TAGs). …”
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Epigenome profiling reveals distinctive regulatory features and cis-regulatory elements in pepper by Hongji Yang, Guorong Yu, Zhidong Lv, Tonghui Li, Xi Wang, Ying Fu, Zhangsheng Zhu, Guangjun Guo, Hang He, Ming Wang, Guochen Qin, Feng Liu, Zhenhui Zhong, Yan Xue

“…Abstract Background Pepper (Capsicum annuum) is one of the earliest and most widely cultivated vegetable crops worldwide. …”
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Amblyostatin-1, the first salivary cystatin with host immunomodulatory and anti-inflammatory properties from the Neotropical tick Amblyomma sculptum, vector of Brazilian spotted fe... by Wilson Santos Molari, Mohamed Amine Jmel, Mohamed Amine Jmel, Josiane Betim Assis, Alan Frazão-Silva, Júlia Moura Bernardi, Gretta Huamanrayme, José María Medina, Eliane Esteves, Solange Cristina Antão, Gabriel Cerqueira Alves Costa, Aparecida Sadae Tanaka, Aparecida Sadae Tanaka, Andréa Cristina Fogaça, Andréa Cristina Fogaça, Zdenek Franta, Lucas Tirloni, Michalis Kotsyfakis, Michalis Kotsyfakis, Anderson Sá-Nunes, Anderson Sá-Nunes

“…Thus, this study aims to describe and characterize the most expressed member of the cystatin family identified in Amblyomma sculptum salivary transcriptome, named Amblyostatin-1. …”
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Clinical significance of plasma-free amino acids and tryptophan metabolites in patients with non-small cell lung cancer receiving PD-1 inhibitor: a pilot cohort study for developin... by Akihiko Kawahara, Tetsuro Sasada, Koichi Azuma, Hidenobu Ishii, Norikazu Matsuo, Takaaki Tokito, Tomoaki Hoshino, Yohei Miyagi, Huihui Xiang, Tomoyuki Tagami, Rika Kasajima, Yumiko Kato, Sachise Karakawa, Shinya Kikuchi, Akira Imaizumi, Kenta Murotani

“…From the transcriptome analysis in PBMCs, this multivariate model was significantly correlated with the gene signatures related to immune responses, such as CD8 T-cell activation/proliferation and proinflammatory immune responses, and 12 amino acid-related genes were differentially expressed between the high-risk and low-risk groups.Conclusions The multivariate model with PFAAs and metabolites in plasma might be useful for stratifying patients who will benefit from PD-1 inhibitors.…”
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The CCL5/CCR5/SHP2 axis sustains Stat1 phosphorylation and activates NF-κB signaling promoting M1 macrophage polarization and exacerbating chronic prostatic inflammation by Chen Jin, Fei Zhang, Hailang Luo, Boyang Li, Xue Jiang, Christopher J. Pirozzi, Chaozhao Liang, Meng Zhang

“…Results Our analysis identified CCL5 as one of the most prominently elevated cytokines in CP-LS patients. …”
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Titanium nanotubes modulate immunophenotyping and cytokine secretion of T cells via IL-17A: a bioinformatic analysis and experimental validation by Jingju Yin, Jingju Yin, Jingju Yin, Jingju Yin, Yunyang Liao, Yunyang Liao, Yunyang Liao, Yunyang Liao, Shaofeng Liu, Shaofeng Liu, Shaofeng Liu, Shaofeng Liu, Bangwei Che, Hanghang Zhu, Hanghang Zhu, Bingbing Yang, Bingbing Yang, Bingbing Yang, Bingbing Yang, Bin Shi, Bin Shi

“…Magnetic bead sorting of CD3+ T cells and transcriptome sequencing were performed to explore the signaling pathways and key immune factors that may influence the related immune responses.ResultsBioinformatics analysis showed that healthy peri-implant tissues were enriched by the most of T-cell subtypes. …”
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Variability in Chromosome 1 of Select Moroccan Pyrenophora teres f. teres Isolates Overcomes a Highly Effective Barley Chromosome 6H Source of Resistance by Jinling Li, Nathan A. Wyatt, Ryan M. Skiba, Gayan K. Kariyawasam, Jonathan K. Richards, Karl Effertz, Sajid Rehman, Zhaohui Liu, Robert S. Brueggeman, Timothy L. Friesen

“…We then generated a new reference quality genome assembly of parental isolate MorSM40-3 with annotation supported by deep transcriptome sequencing of infection time points. The annotation identified candidate genes predicted to encode small, secreted proteins, one or more of which are likely responsible for overcoming the CIho5791 resistance. …”
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Effects of heterologously overexpressing Manihot esculenta Crantz MeNRT2.6 gene in Arabidopsis thaliana on nitrogen utilization efficiency by Min ZHAI, Yingjie CAO, Chenyu LIN, Pingjuan ZHAO, Wenbin LI, Xiaoling YU, Wenbin LIAO, Mengbin RUAN, Liangping ZOU, Zhuang LI

“…Its promoter sequence contains stress- and hormone-responsive cis-elements. MeNRT2.6 protein was localized to the cell membrane. …”
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H1‐0 is a specific mediator of the repressive ETV6::RUNX1 transcriptional landscape in preleukemia and B cell acute lymphoblastic leukemia by Vera H. Jepsen, Andrea Hanel, Daniel Picard, Rigveda Bhave, Rebecca Hasselmann, Juha Mehtonen, Julian Schliehe‐Diecks, Carla‐Johanna Kath, Vithusan Suppiyar, Yash Prasad, Katerina Schaal, Jia‐Wey Tu, Nadine Rüchel, Ersen Kameri, Nan Qin, Herui Wang, Zhengping Zhuang, Rabea Wagener, Lena Blümel, Tobias Lautwein, Daniel Hein, David Koppstein, Gesine Kögler, Marc Remke, Sanil Bhatia, Merja Heinäniemi, Arndt Borkhardt, Ute Fischer

“…Taken together, our data identify H1‐0 as a key regulator of the ETV6::RUNX1+ transcriptome and indicate that the addition of Quisinostat may be beneficial to target non‐responsive or relapsing ETV6::RUNX1+ BCP‐ALL.…”
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Traffic-related ultrafine particles influence gene regulation in olfactory mucosa cells altering PI3K/AKT signaling by Laura Mussalo, Alexey M. Afonin, Tana Zavodna, Zdenek Krejcik, Katerina Honkova, Claire Fayad, Muhammad Ali Shahbaz, Juho Kalapudas, Elina Penttilä, Heikki Löppönen, Anne M Koivisto, Tarja Malm, Jan Topinka, Pasi Jalava, Riikka Lampinen, Katja M. Kanninen

“…These data were combined with previously published transcriptomics analysis (mRNA) to construct an mRNA-miRNA-DNAmet-integrative network. …”
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Engineering exosomes from fibroblast growth factor 1 pre-conditioned adipose-derived stem cells promote ischemic skin flaps survival by activating autophagy by Xuanlong Zhang, Xiaoqiong Jiang, Huiming Deng, Gaoxiang Yu, Ningning Yang, Abdullah Al Mamun, Feifei Lian, Tianling Chen, Haijuan Zhang, Yingying Lai, Jiayi Huang, Shi Xu, Fuman Cai, Xiaokun Li, Kailiang Zhou, Jian Xiao

“…FGF1 was co-incubated with adipose stem cells, and ultracentrifugation was applied to extract FEXO. Transcriptome sequencing analysis was used to determine the most effective microRNA in FEXO. …”
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Multi-omics analysis reveals the role of ribosome biogenesis in malignant clear cell renal cell carcinoma and the development of a machine learning-based prognostic model by Zhouzhou Xie, Zhouzhou Xie, Shansen Peng, Shansen Peng, Jiongming Wang, Jiongming Wang, Yueting Huang, Yueting Huang, Xiaoqi Zhou, Xiaoqi Zhou, Guihao Zhang, Guihao Zhang, Huiming Jiang, Huiming Jiang, Kaihua Zhong, Kaihua Zhong, Lingsong Feng, Lingsong Feng, Nanhui Chen, Nanhui Chen

“…BackgroundClear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer, marked by high molecular heterogeneity and limited responsiveness to targeted or immune therapies. …”
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Genome-wide association study on salt tolerance of core germplasm resources in watermelon by YUAN Gaopeng, ZHAO Yanlong, SUN Dexi, GAO Bowen, LI Weihua, SHI Mingkun, ZHANG Jingyu, ZHU Yingchun

“…It is worth noting that in category I, Cla97C08G145130 (mannan endo-1, 4-beta-mannosidase 1-like, ManA1) showed the most significant changes, and increased by 255.82 and 7.80 times in salt-sensitive and salt-tolerant materials, respectively. …”
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The impact of genomic variation on protein phosphorylation states and regulatory networks by Jan Grossbach, Ludovic Gillet, Mathieu Clément‐Ziza, Corinna L Schmalohr, Olga T Schubert, Maximilian Schütter, Julia S P Mawer, Christopher A Barnes, Isabell Bludau, Matthias Weith, Peter Tessarz, Martin Graef, Ruedi Aebersold, Andreas Beyer

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Spatial regulation of CD8+ T cells at the HLA-E-NKG2A axis drives HIV persistence in lymph node B cell follicles by Andrea O. Papadopoulos, Leonard Mvaya, Trevor Khaba, Namani Ngema, Werner Smidt, Sibongiseni Msipa, Bongiwe Mahlobo, Thandekile Ngubane, Krista Dong, Ismail Jajbhay, Johan Pansegrouw, Kondwani Jambo, Zaza Ndhlovu

“…Immune regulatory mechanisms hindering cytolytic CD8+ responses at these sites are poorly characterized, likely enabling HIV persistence. …”
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Assessment of the histone mark-based epigenomic landscape in human myometrium at term pregnancy by San Pin Steve Wu, Elvis Quiroz, Tianyuan Wang, Skylar G Montague Redecke, Xin Xu, Lin Lin, Matthew L Anderson, Francesco J DeMayo

“…Putative myometrial super enhancers are mostly colocalized with progesterone receptor-occupying sites and preferentially associated with highly expressing genes, suggesting a conserved role of PGR in regulating the myometrial transcriptome between species. …”
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