Myricetin inhibits Micropterus salmoides rhabdovirus infection by damping inflammation through the NF-κB pathway by Zhiwen Wang, Ping Deng, Zemao Gu, Lijuan Li, Junfa Yuan

“…Micropterus salmoides Rhabdovirus (MSRV) is the causative agent of Micropterus salmoides Rhabdovirus disease, which mostly affects largemouth bass fry. By using experimental infection, transcriptome sequencing, and inhibitor treatment, the inflammatory response mediated by mitogen-activated protein kinase (MAPK), phosphatidylinositol3-kinase (PI3K), and nuclear factor kappa-B (NF-κB) pathways was verified as one of the pathological processes of MSRV infection. …”
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Genomewide analysis of the Class III peroxidase gene family in apple (Malus domestica) by Yao Lu, Rongqun Ma, Kunhao Wu, Jilu Sun, Yutong Li, Jiawei Zhao, Zhenbao Qi, Guangli Sha, Hongjuan Ge, Yanjing Shi

“…McSCAN analysis indicated that tandem duplication events played a dominant role in the expansion of Malus domestica peroxidases (MdPRXs), thus purifying selection maintained their function. Most MdPRX genes contained cis-elements responsive to light and plant hormones such as abscisic acid (ABA) and methyl jasmonate (MeJA), as well as various stress factors. …”
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Aspergillus galactosaminogalactan mediates adherence to host constituents and conceals hyphal β-glucan from the immune system. by Fabrice N Gravelat, Anne Beauvais, Hong Liu, Mark J Lee, Brendan D Snarr, Dan Chen, Wenjie Xu, Ilia Kravtsov, Christopher M Q Hoareau, Ghyslaine Vanier, Mirjam Urb, Paolo Campoli, Qusai Al Abdallah, Melanie Lehoux, Josée C Chabot, Marie-Claude Ouimet, Stefanie D Baptista, Jörg H Fritz, William C Nierman, Jean Paul Latgé, Aaron P Mitchell, Scott G Filler, Thierry Fontaine, Donald C Sheppard

“…Aspergillus fumigatus is the most common cause of invasive mold disease in humans. …”
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The candidate gene OLFML2A possibly contributed to the variation of total number of teats in Meishan and Erhualian pigs by influencing the formation of mammary placodes by C.X. Liu, R.H. Huang, W.D. Zhou, N.J. Jiang, Q. Liu, J.F. Ma, P.H. Li, Q.B. Zhao

“…Bayesian fine mapping was performed for the second most significant QTL in meta-analysis, which also was the most significant QTL in Erhualian pig GWAS, identifying its mapping at SSC5: 58 228 193 − 59 198 414 bp. …”
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Baseline predictors for 28-day COVID-19 severity and mortality among hospitalized patients: results from the IMPACC study by Jintong Hou, Benjamin Haslund-Gourley, Joann Diray-Arce, Annmarie Hoch, Nadine Rouphael, Patrice M. Becker, Alison D. Augustine, Al Ozonoff, Leying Guan, Steven H. Kleinstein, Bjoern Peters, Elaine Reed, Matt Altman, Charles R. Langelier, Holden Maecker, Seunghee Kim, Ruth R. Montgomery, Florian Krammer, Michael Wilson, Walter Eckalbar, Steven E. Bosinger, Ofer Levy, Hanno Steen, Lindsey B. Rosen, Lindsey R. Baden, Esther Melamed, Lauren I. R. Ehrlich, Grace A. McComsey, Rafick P. Sekaly, Joanna Schaenman, Albert C. Shaw, David A. Hafler, David B. Corry, Farrah Kheradmand, Mark A. Atkinson, Scott C. Brakenridge, Nelson I. Agudelo Higuita, Jordan P. Metcalf, Catherine L. Hough, William B. Messer, Bali Pulendran, Kari C. Nadeau, Mark M. Davis, Ana Fernandez Sesma, Viviana Simon, Monica Kraft, Chris Bime, Carolyn S. Calfee, David J. Erle, IMPACC Network, Lucy F. Robinson, Charles B. Cairns, Elias K. Haddad, Mary Ann Comunale

“…The study identifies SpO2/FiO2 ratio to be the most important predictor for both severity and mortality. …”
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Dissociation of mitochondrial and ribosomal biogenesis during thallium administration in rat kidney. by Sho Sugahara, Kana Unuma, Shuheng Wen, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura

“…To obtain insight into Tl toxicity in the kidney, rats were intraperitoneally administered Tl2SO4 (30 mg/kg), and the kidneys were removed 2 or 5 days later to examine the effects of Tl. Transcriptome analysis using DNA microarray of the rat kidney 2 and 5 days after Tl administration showed that cytoplasmic ribosomal proteins are the most upregulated category; many of the genes involved in ribosome biosynthesis were upregulated by Tl administration. …”
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The intratumoral microbiota heterogenicity is related to the prognosis and tumorigenesis of cervical cancer by Yi Guo, Yuhang Xiao, Changyi Zhang, Ying Wang, Guangxu Cao, Ka Yu Tse, Zhiqiang Han, Zhiqiang Han, Fang Li, Yong Zhi

“…Finally, the effect of the up-regulated Fibrinogen beta chain (FGB) expressed fragment peptide on the biological behavior of cancer was verified in vitro.ResultsWe found the composition heterogeneity of bacteria in CC tumors. Pseudomonas was most highly enriched in CC tissues and grouped according to the relative abundance level. …”
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Expression Profiling of Long Noncoding RNA and Messenger RNA in a Cecal Ligation and Puncture-Induced Colon Injury Mouse Model by Jinxiang Huang, Yuan Liu, Qingqiang Xie, Guorui Liang, Haifan Kong, Meiling Liu, Yujie Wang, Shanshan Zhang, Xuefeng Li

“…GO analysis showed that the altered lncRNAs were enriched and involved in multiple immune responses, which may be a response to sepsis stress. …”
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ALKBH5 modulation of ferroptosis in recurrent miscarriage: implications in cytotrophoblast dysfunction by Chuanmei Qin, Jiayi Wu, Xiaowei Wei, Xueqing Liu, Yi Lin

“…Background As one of the most common and abundant internal modifications of eukaryotic mRNA, N6-methyladenosine (m6A) modifications are closely related to placental development. …”
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The molecular subtyping and precision medicine in triple-negative breast cancer---based on Fudan TNBC classification by Lijuan Weng, Jianliang Zhou, Shenchao Guo, Nong Xu, Ruishuang Ma

“…Abstract Triple-negative breast cancer (TNBC) is widely recognized as the most aggressive form of breast cancer, occurring more frequently in younger patients and characterized by high heterogeneity, early distant metastases and poor prognosis. …”
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SEOR2 in Arabidopsis mediates Ca2+ dependent defense against phytoplasmas and reduction of plant growth by Keziah Omenge, Ottone Carmelo Viscardo, Fernando Rodrigo De Oliveira Cantao, Simonetta Santi, Aart Jan Eeuwe van Bel, Rita Musetti

“…In search for mechanism(s) underlying potential SEOR2-mediated defense responses the transcriptome of healthy wild type and Atseor1ko plants was disclosed by RNA sequencing. …”
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Multi-omics-Based Construction of ncRNA-Gene-Metabolite Networks Provides New Insights Into Metabolic Regulation Under Salt Stress in Rice by Haiyang Tong, Chao Wang, Xiaoqian Han, Qihao Sun, Enxi Luo, Chao Yang, Guo Xu, Xumin Ou, Shixuan Li, Jianing Zhang, Jun Yang

“…Abstract Rice (Oryza sativa L.), one of the most vital staple crops globally, suffers severe yield losses due to metabolic dysregulation under salt stress. …”
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From preneoplastic lesion to heterogenous tumor: recent insights into hepatoblastoma biology and therapeutic opportunities by Jun Yang, Andrew M. Davidoff, Andrew J. Murphy

“…Abstract Hepatoblastoma is the most common pediatric liver cancer, with the fastest rising incidence among childhood malignancies. …”
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A morning-specific phytohormone gene expression program underlying rhythmic plant growth. by Todd P Michael, Ghislain Breton, Samuel P Hazen, Henry Priest, Todd C Mockler, Steve A Kay, Joanne Chory

“…Most organisms use daily light/dark cycles as timing cues to control many essential physiological processes. …”
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Mapping naturally presented T cell antigens in medulloblastoma based on integrative multi-omics by Julia Velz, Lena K. Freudenmann, Gioele Medici, Marissa Dubbelaar, Malte Mohme, David R. Ghasemi, Jonas Scheid, Daniel J. Kowalewski, Angelica B. Patterson, Anna M. Zeitlberger, Katrin Lamszus, Manfred Westphal, Matthias Eyrich, Martina Messing-Jünger, Andreas Röhrig, Harald Reinhard, Kévin Beccaria, Rogeiro B. Craveiro, Beat M. Frey, Martin Sill, Sven Nahnsen, Marie Gauder, Konstantina Kapolou, Manuela Silginer, Tobias Weiss, Hans-Georg Wirsching, Patrick Roth, Michael Grotzer, Niklaus Krayenbühl, Oliver Bozinov, Luca Regli, Hans-Georg Rammensee, Elisabeth J. Rushing, Felix Sahm, Juliane S. Walz, Michael Weller, Marian C. Neidert

“…Abstract Medulloblastoma is the most frequent malignant primary brain tumor in children. …”
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Loss of function of MusaPUB genes in banana can provide enhanced resistance to bacterial wilt disease by Leena Tripathi, Valentine Otang Ntui, Samwel Muiruri, Trushar Shah, Jaindra Nath Tripathi

“…Gene edited plants exhibited mutations in both genes, with no significant growth penalties in most events. Several edited lines displayed complete resistance to Xvm infection, while others showed partial resistance, in contrast to the full susceptibility of wild-type controls. …”
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Epstein-Barr virus reactivation induces divergent abortive, reprogrammed, and host shutoff states by lytic progression. by Elliott D SoRelle, Lauren E Haynes, Katherine A Willard, Beth Chang, James Ch'ng, Heather Christofk, Micah A Luftig

“…Here, we have interrogated the host-pathogen dynamics following reactivation of Epstein-Barr virus (EBV). While benign in most people, EBV is responsible for infectious mononucleosis, up to 2% of human cancers, and is a trigger for the development of multiple sclerosis. …”
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Understanding adaptation to fluconazole: comparative insights into tolerance and resistance in Saccharomyces cerevisiae and Candida albicans by Lijun Zheng, Yubo Dong, Jing Wang, Yonghui Jia, Weifang Wang, Yi Xu, Yi Xu, Liangsheng Guo

“…Chemical induction of petite formation led to an increase in resistance accompanied by a decrease in tolerance.ConclusionTranscriptome analysis indicated that petites up-regulated efflux mechanisms while down-regulating most ERG genes. …”
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NF-κB RelA regulates temporal oligodendrocyte differentiation in the postnatal brains by Kamonrapat Sompub, Norihisa Bizen, Albert S. Baldwin, Albert S. Baldwin, Hirohide Takebayashi, Hirohide Takebayashi, Hirohide Takebayashi

“…The NF-κB signaling pathway responds to a diverse range of cytokines and extracellular stresses, regulating immune responses, inflammation, cell proliferation, and cell death. …”
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Impact of Acute Endurance Exercise on Alternative Splicing in Skeletal Muscle by Alexander Ahn, Jeongjin J. Kim, Aaron L. Slusher, Jeffrey Y. Ying, Eric Y. Zhang, Andrew T. Ludlow

“…Acute endurance exercise appears to transiently perturb AS in skeletal muscle, but transcriptome‐wide responses are not well defined. We aimed to better understand differential AS (DAS) and differential isoform expression (DIE) in skeletal muscle by comparing short‐read (SRS) and long‐read RNA sequencing (LRS) data. …”
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