Long‐Term High‐Fat Diet Affected Bone Marrow Microenvironment During Aging at Single‐Cell Resolution by Yidan Pang, Siyuan Zhu, Peng Ding, Senyao Zhang, Yi Zhang, Fang Ye, Changqing Zhang, Junjie Gao, Jimin Yin

“…Single‐cell transcriptomics of bone marrow cells highlighted LHA‐driven perturbations in immune cell populations with distinct metabolic adaptations to LHA. …”
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Dynamic Alterations in DNA Methylation of CD4+ T Cells and Macrophages in a Murine Model of Tuberculous Pleural Infection Induced by BCG Vaccination by Ming‐Ming Shao, Qing‐Yu Chen, Xin Zhang, Shu‐Feng Dong, Rui‐Qi Wei, Huan‐Zhong Shi, Feng‐Shuang Yi

“…Notably, macrophages exhibited the most pronounced differences in DNA methylation profiles on Day 1, while CD4+ T cells demonstrated gradual changes over time. …”
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Genome-wide identification, phylogenetic and expression pattern analysis of GATA gene family in Cerasus humilis by Meitong Pan, Chenzhuo Yue, Shan Jiang, Junbai Ma, Lengleng Ma, Lingyang Kong, Yang Ling, Wei Ma, Weichao Ren, Xiubo Liu

“…Moreover, the promoter region of the ChGATA gene family contained cis-acting elements linked to stress, hormones, and plant growth. The transcriptome heatmap showed that the expression of the ChGATA was specific under alkali stress, and ChGATAs in the same subpopulation would also show different expression patterns. qPCR analysis showed that most of the screened ChGATAs first decreased and then increased with time. …”
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Integrated multi-omics analysis and machine learning identify G protein-coupled receptor-related signatures for diagnosis and clinical benefits in soft tissue sarcoma by Duo Wang, Duo Wang, Duo Wang, Jihao Tu, Jihao Tu, Jianfeng Liu, Jianfeng Liu, Yuting Piao, Yuting Piao, Yiming Zhao, Yiming Zhao, Ying Xiong, Ying Xiong, Jianing Wang, Jianing Wang, Xiaotian Zheng, Xiaotian Zheng, Bin Liu, Bin Liu

“…Building up a GPR-TME classifier, low GPR combined with high TME exhibited the most favorable prognosis and immunotherapeutic efficacy, which was further performed for immune infiltration, functional enrichment, somatic mutation, immunotherapy response prediction, and scRNA-seq analyses.ConclusionsOur study constructed a GPRS that can serve as a promising tool for diagnosis and prognosis prediction, targeted prevention, and personalized medicine in STS.…”
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Therapy of genomic unstable solid tumours (WHO grade 3/4）in clinical stage III/IV using individualised neoantigen tumour peptides-INP trial (individualised neoantigen tumour peptid... by Ling Wang, Xia Chen, Juan Zhao, Jiaxi Tang, Wanyan Tang, Bin Liao, Weiqi Nian

“…Tumour neoantigens have been studied in a wide range of tumours. Most of research on neoantigens has focused just on a unique tumour and a single mutated gene. …”
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Why do we age? The main signs of aging by Ugіs Kletnieks, Audrius Butkevichius, V. V. Hladyshev, S. S. Sоkolovskyi

“…Although modern medical advances have made a certain contribution to human health and greatly extended life expectancy, along with the aging of society, various chronic diseases are gradually emerging, which are the most important causes of disability and death of the elderly. …”
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Identification of neoantigen epitopes in cervical cancer by multi-omics analysis by Jing Yuan, Na Xu, Xueqi Gong, Jihui Ai, Kezhen Li, Yingyan Han

“…Although most cervical cancer cells express HPV-related oncoproteins, some do not. …”
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Increased nuclear factor I-mediated chromatin access drives transition to androgen receptor splice variant dependence in prostate cancer by Larysa Poluben, Mannan Nouri, Jiaqian Liang, Shaoyong Chen, Andreas Varkaris, Betul Ersoy-Fazlioglu, Olga Voznesensky, Irene I. Lee, Xintao Qiu, Laura Cato, Ji-Heui Seo, Matthew L. Freedman, Adam G. Sowalsky, Nathan A. Lack, Eva Corey, Peter S. Nelson, Myles Brown, Henry W. Long, Joshua W. Russo, Steven P. Balk

“…AR activity in VCaP16 is driven by ARv7, independently of full-length AR (ARfl), and its cistrome and transcriptome mirror those of ARfl in VCaP cells. ARv7 expression increases rapidly in response to ENZ, but there is a delay in gaining chromatin binding and transcriptional activity, which is associated with increased chromatin accessibility. …”
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Mosaic loss of the Y chromosome in human neurodegenerative and oncological diseases by I. L. Kuznetsova, L. I. Uralsky, T. V. Tyazhelova, T. V. Andreeva, E. I. Rogaev

“…The development of new biomarkers for prediction and early detection of human diseases, as well as for monitoring the response to therapy is one of the most relevant areas of modern human genetics and genomics. …”
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Systematic screening of metabolic pathways to identify two breast cancer subtypes with divergent immune characteristics by Xiangshu Cheng, Shuhao Zhang, Xin Meng, Rui Chen, Hao Tang, Jiacheng Wang, Yongshuai Jiang, Ruijie Zhang

“…Abstract Due to the high heterogeneity among breast cancer (BRCA) patients, most individuals show a limited response rate to one specific treatment. …”
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The translatome of glioblastoma by Fleur M. G. Cornelissen, Zhaoren He, Edward Ciputra, Richard R. deHaas, Ammarina Beumer‐Chuwonpad, David Noske, W. Peter Vandertop, Sander R. Piersma, Connie R. Jiménez, Cornelis Murre, Bart A. Westerman

“…Glioblastoma (GB), the most common and aggressive brain tumor, demonstrates intrinsic resistance to current therapies, resulting in poor clinical outcomes. …”
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A Mitochondria‐Related Signature in Diffuse Large B‐Cell Lymphoma: Prognosis, Immune and Therapeutic Features by Zhen‐Zhong Zhou, Jia‐Chen Lu, Song‐Bin Guo, Xiao‐Peng Tian, Hai‐Long Li, Hui Zhou, Wei‐Juan Huang

“…ABSTRACT Background Distinctive heterogeneity characterizes diffuse large B‐cell lymphoma (DLBCL), one of the most frequent types of non‐Hodgkin's lymphoma. Mitochondria have been demonstrated to be closely involved in tumorigenesis and progression, particularly in DLBCL. …”
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Identification of ZNF652 as a Diagnostic and Therapeutic Target in Osteoarthritis Using Machine Learning by Chen Y, Liang R, Zheng X, Fang D, Lu WW, Chen Y

“…Nevertheless, its role in OA has not been elucidated.Methods: The search term “osteoarthritis” was utilized to procure transcriptome data relating to OA patients and healthy people from the Gene Expression Omnibus (GEO) database. …”
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A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the Drosophila ventral nerve cord by Jelly HM Soffers, Erin Beck, Daniel J Sytkowski, Marianne E Maughan, Devasri Devarakonda, Yi Zhu, Beth A Wilson, Yu-Chieh David Chen, Ted Erclik, James W Truman, James B Skeath, Haluk Lacin

“…Lastly, we documented behaviors elicited in response to optogenetic activation of individual neuronal lineages and generated a comprehensive lineage-behavior map of the entire fly VNC. …”
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Sex-specific attenuation of photoreceptor degeneration by reserpine in a rhodopsin P23H rat model of autosomal dominant retinitis pigmentosa by Hyun Beom Song, Laura Campello, Anupam Mondal, Holly Y Chen, Milton A English, Michael Glen, Phillip Vanlandingham, Rafal Farjo, Anand Swaroop

“…The female rats demonstrate better preservation of both rod and cone photoreceptors following reserpine treatment. Retinal transcriptome analysis reveals sex-specific responses to reserpine, with significant upregulation of phototransduction genes and proteostasis-related pathways, and notably, genes associated with stress response. …”
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Changes in goose hypothalamus under different photocycles: RNA-Seq reveals new pathways and molecules by Yuyan FENG, Jie LIU, Xiaojing CHEN, Binbin GUO, Mingming LEI, Huanxi ZHU, Yingdong NI

“…Reproduction in avian species is regulated by light, and the hypothalamus is the most important regulator of the response to light signals. …”
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Impact of ITH on PRAD patients and feasibility analysis of the positive correlation gene MYLK2 applied to PRAD treatment by Chuanyu Ma, Chuanyu Ma, Guandu Li, Xiaohan Song, Xiaochen Qi, Tao Jiang

“…IntroductionProstate adenocarcinoma (PRAD) is an extremely widespread site of urological malignancy and is the second most common male cancer in the world. Currently, research progress in immunotherapy for prostate treatment is slower compared to other tumours, which is mainly considered to be caused by the low rate of immune response in prostate cancer as a cold tumour. …”
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Identification of SMYD2 as a candidate diagnostic and prognostic biomarker for gastric cancer by Sichao Wang, Chuanxi Zhao, Dongmei Li, Qingzhi Liu, Cuiping Mao, Shanshan Ding, Shujun Zhang, Wenjing Shang

“…BackgroundHistone modification enzymes (HMEs) are associated with cancer development, treatment response, and prognosis. However, the potential roles of HMEs in gastric cancer (GC) remain unclear. …”
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Myocardial Proteome in Human Heart Failure With Preserved Ejection Fraction by Vivek P. Jani, Edwin J. Yoo, Aleksandra Binek, Alina Guo, Julie S. Kim, Jennifer Aguilan, Mohammad Keykhaei, Sydney R. Jenkin, Simone Sidoli, Kavita Sharma, Jennifer E Van Eyk, David A. Kass, Virginia S. Hahn

“…Recent human myocardial transcriptomics and metabolomics have identified major differences between HFpEF and controls. …”
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Analysis of Alternative Splicing Events and Identification of Key Genes in <i>Brassica napus</i> Leaves Infected by <i>Leptosphaeria biglobosa</i> by Xinning Ma, Lin Yuan, Jiuru Huangfu, Mengjiao Yan, Chen Guo, Lili Zhao, Hongxia Sun, Xiaoqing Jia, Ziqin Li, Haiyan Huangfu

“…Here, we used the Illumina Novaseq sequencing platform to conduct transcriptome sequencing on canola (<i>Brassica napus</i>) leaves infected with the blackleg pathogen (<i>Leptosphaeria biglobosa</i> strain nm⁻¹) at 0 h, 72 h, 120 h, and 168 h post-inoculation to investigate the mechanism of AS coordination with transcriptional regulation in canola’s response to blackleg disease. …”
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