Intermittent Supplementation with Far-Red Light Accelerates Leaf and Bud Development and Increases Yield in Lettuce by Yanke Liu, Rong Ye, Xinying Gao, Rongcheng Lin, Yang Li

“…Additionally, dynamic expression analysis showed genes involved to far-red photoreception, response, and hormone metabolism and transport exhibited optimal rhythmic responses only under 30 min intermittent far-red light supplementation. …”
Get full text

Exploring IRGs as a Biomarker of Pulmonary Hypertension Using Multiple Machine Learning Algorithms by Jiashu Yang, Siyu Chen, Ke Chen, Junyi Wu, Hui Yuan

“…Methods: We conducted a comprehensive analysis of a large transcriptome dataset, including PAH and inflammatory response genes (IRGs), integrated with 113 machine learning models to assess diagnostic potential. …”
Get full text

Prognostic value of circadian rhythm-associated genes in breast cancer by Ling Wang, Xiang Gao, Ximeng Zuo, Tangshun Wang, Xiaoguang Shi

“…Abstract Objective Breast cancer (BC) remains the most prevalent malignancy among women. Clinical evidence indicates that genetic variations related to circadian rhythms, as well as the timing of therapeutic interventions, influence the response to radiation therapy and the toxicity of pharmacological treatments in women with BC. …”
Get full text

Hepatitis B virus modulates store-operated calcium entry to enhance viral replication in primary hepatocytes. by Jessica C Casciano, Nicholas J Duchemin, R Jason Lamontagne, Laura F Steel, Michael J Bouchard

“…Many viruses modulate calcium (Ca2+) signaling to create a cellular environment that is more permissive to viral replication, but for most viruses that regulate Ca2+ signaling, the mechanism underlying this regulation is not well understood. …”
Get full text

Exon level machine learning analyses elucidate novel candidate miRNA targets in an avian model of fetal alcohol spectrum disorder. by Abrar E Al-Shaer, George R Flentke, Mark E Berres, Ana Garic, Susan M Smith

“…We address these limitations with a novel approach and implemented an unsupervised machine learning model, which we applied to an exon-level analysis to reduce data complexity to the most likely functionally relevant exons, without loss of novel information. …”
Get full text

A haplotype-phased genome characterizes the genomic architecture and causal variants for RXf1 conferring resistance to Xanthomonas fragariae in strawberry (F. × ananassa) by Jin-Hee Kim, Vance M. Whitaker, Seonghee Lee

“…The 1.62 Gbp genome containing two haplotypes, 56 chromosomes and 193,072 annotated genes. Transcriptome analysis in response to the ALS pathogen identified a candidate gene, Resistance gene analogue 3 (RGA3), associated with the RXf1 resistance. …”
Get full text

GLN2 as a key biomarker and therapeutic target: evidence from a comprehensive pan-cancer study using molecular, functional, and bioinformatic analyses by Shuang Gao, Lei Zhang, Guoping Sun

“…GNL2 may be involved in the regulation of cell cycle progression and remodeling of the tumor microenvironment and is associated with poor prognosis as a risk factor in most tumors. The potential of GNL2-based cancer therapies is emphasized, assisting in predicting the response to chemotherapy.…”
Get full text

Elucidation of the role of stress-induced DNA polymerase II in the pathogenesis of uropathogenic Escherichia coli by Dr Damian Gawel, M.Sc. Anna Betkowska, MD Marcin Rozwadowski, Dr Marlena Godlewska, Prof Roel Schaaper

“…Introduction: Uropathogenic Escherichia coli (UPEC) strains are responsible for most registered urinary tract infections (UTIs) in humans. …”
Get full text

Epigenetic modulation of the NLRP6 inflammasome sensor as a therapeutic modality to reduce necroptosis-driven gastrointestinal mucosal dysfunction in HIV/SIV infection by Lakmini S. Premadasa, Marina McDew-White, Luis Romero, Beverly Gondo, Jade A. Drawec, Binhua Ling, Chioma M. Okeoma, Mahesh Mohan

“…From a clinical standpoint, low-dose phytocannabinoids in combination with ART could safely and successfully reduce/reverse persistent GI inflammatory responses via modulating DNA methylation.…”
Get full text

Identification and functional characterization of the RPP13 gene family in potato (Solanum tuberosum L.) for disease resistance by Baoqi Yuan, Chuang Li, Qingfeng Wang, Qi Yao, Xiaowei Guo, Yuhang Zhang, Zhongwei Wang

“…Expression pattern analysis showed that StRPP13-8, StRPP13-10, and StRPP13-23 are highly expressed in various tissues, indicating their involvement in basic physiological functions, whereas StRPP13-6 and StRPP13-25 are mainly induced under specific pathogen infection conditions. Transcriptome and qRT-PCR analyses further revealed functional divergence of the RPP13 gene family in response to potato scab disease. …”
Get full text

lncRNA IL-17RA-1 Attenuates LPS-Induced Sepsis via miR-7847-3p/PRKCG-Mediated MAPK Signaling Pathway by Yuanxiu Gan, Jie Long, Yan Zeng, Yan Zhang, Yang Tao

“…Sepsis represents a syndrome of systemic inflammatory response, which is mostly a result of infection with various pathogenic microorganisms, characterized by an uncontrolled infection response of the organism leading to life-threatening organ dysfunction. …”
Get full text

Kir6.1, a component of an ATP-sensitive potassium channel, regulates natural killer cell development by Natalie Samper, Lilja Hardardottir, Delphine M. Depierreux, Soomin C. Song, Ayano Nakazawa, Ivan Gando, Tomoe Y. Nakamura, Andrew M. Sharkey, Carla R. Nowosad, Stefan Feske, Francesco Colucci, William A. Coetzee, William A. Coetzee, William A. Coetzee

“…Kcnj8 expression is highest in the most mature subset of splenic NK cells (CD27-/CD11b+) and in NKG2A+ or Ly49C/I+ educated uterine NK cells. …”
Get full text

Data‐Driven Molecular Typing: A New Frontier in Esophageal Cancer Management by Yue Du, Bianli Gu, Linlin Shi, Yong She, Qi Zhao, Shegan Gao

“…Despite advancements, most patients are diagnosed at advanced stages, limiting effective treatment options. …”
Get full text

Genome‑wide identification of the cotton FAR gene family reveals GhFAR3 as a positive regulator of Verticillium dahliae resistance by Wenhan Cheng, Siqi Gao, Zhaojie He, Nurimanguli Aini, Zengqiang Zhao, Xianpeng Xiong, Ning Wang, Rui Chen, Keyun Feng

“…Promoter cis-element analysis and transcriptome profiling revealed that while most FAR genes were downregulated under abiotic stress, many were notably upregulated in response to hormone treatments and Verticillium dahliae infection. …”
Get full text

Oligo-dT anchored cDNA-SRAP and cDNA-SCoT aided identification of transcripts differentially expressed during the early stages of recovery of resurrection plant Haberlea rhodopensi... by Elena Kumanova, Gergana Mihailova, Elena Georgieva Todorovska, Katya Georgieva, Stefan Tsonev, Nikolai Kirilov Christov

“…The results of this study will contribute to obtaining new information on the defence mechanisms in the recovery process of H. rhodopensis, especially at the early stages of recovery, which is the most vulnerable period for plants.…”
Get full text

Novel marker genes and small molecule drugs for radiotherapy resistance in cervical cancer identified based on single-cell multi-omics analysis by Yang Liu, Xin Pan, Xu Zhang, Bo Tan, Rui Ran, Li Liu, Lin Yang, Zhiliang Wang

“…Abstract Radiotherapy is the cornerstone of treatment for cervical cancer, yet the variability of patient response demands a deeper understanding of the molecular determinants of radioresistance. …”
Get full text

Genome-wide identification and expression analysis of the JMJ-C gene family in melon (Cucumis melo L.) reveals their potential role in fruit development by Wuyun Jin, Wei Yan, Ming Ma, Agula Hasi, Gen Che

“…We investigated the expression profile of 17 CmJMJ genes in different lateral organs and four developmental stages of fruit by RNA-seq transcriptome analysis and RT-qPCR. The results revealed that most CmJMJ genes were prominently expressed in female flowers, ovaries, and developing fruits, suggesting their active role in melon fruit development. …”
Get full text

Integrative Proteomics and Genomics Identify Novel Biomarkers and Therapeutic Targets in Vitiligo via Mendelian Randomization by Chenjue Yan, Ling Jiang, Yibo Hu, Ting You, Jing Chen, Songjiang Wu

“…Of these, three proteins (KLF4, TNFRSF13C, and TNFSF10) were high priority with the most convincing evidence. Bioinformatics analysis and model prediction of genes associated with vitiligo progression showed these three protein-coding genes were significantly associated with vitiligo occurrence, and their functions were related to cell cycle, apoptosis, oxidative stress, inflammatory response, and immune infiltration. …”
Get full text

The tissue-specific RNA binding protein T-STAR controls regional splicing patterns of neurexin pre-mRNAs in the brain. by Ingrid Ehrmann, Caroline Dalgliesh, Yilei Liu, Marina Danilenko, Moira Crosier, Lynn Overman, Helen M Arthur, Susan Lindsay, Gavin J Clowry, Julian P Venables, Philippe Fort, David J Elliott

“…T-STAR protein was most highly concentrated in forebrain-derived structures like the hippocampus, which also showed maximal Neurexin1-3 AS4 splicing repression. …”
Get full text

Comparative Analysis of Proximal Tubule Cell Sources for In Vitro Studies of Renal Proximal Tubule Toxicity by Courtney Sakolish, Han-Hsuan D. Tsai, Hsing-Chieh Lin, Piyush Bajaj, Remi Villenave, Stephen S. Ferguson, Jason P. Stanko, Richard A. Becker, Philip Hewitt, Weihsueh A. Chiu, Ivan Rusyn

“…<b>Results:</b> Gene expression data showed that the primary kidney cells most closely matched the transcriptome of the human kidney medulla, followed by the TERT1 and ciPTEC lines, with the HEK lines showing the lowest similarity. …”
Get full text