C-terminal binding protein-2 triggers CYR61-induced metastatic dissemination of osteosarcoma in a non-hypoxic microenvironment by Laura Di Patria, Nadia Habel, Robert Olaso, Romain Fernandes, Catherine Brenner, Bojana Stefanovska, Olivia Fromigue

“…Abstract Background Osteosarcoma is the most prevalent cancer-related bone disease diagnosed in the pediatric age group. …”
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Genome-wide identification of pyrabactin resistance 1-like (PYL) gene family under phytohormones and drought stresses in alfalfa (Medicago sativa) by Kun Wang, Jiao Cheng, Jing-Ru Chen, Yan-Yan Luo, Yu-Heng Yao, Li-Li Nan

“…MsPYL genes contains cis-acting elements that has functions in plant growth and development, hormone regulation, and stress response. Furthermore, transcriptome data showed that drought stress affected the MsPYL genes’ expression levels in alfalfa. …”
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Analysis of the underlying mechanism of Ziziphi Spinosae Semen for treating anxiety disorder in a zebrafish sleep deprivation model by Jian Zhang, Junli Feng, Chenyu Feng

“…Anxiety and depression are the most prevalent psychiatric disorders in the world, and they are highly comorbid with each other. …”
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Dual function of Gasdermin E: pyroptosis-mediated pan-cancer suppression versus HCC-specific oncogenic activity by Gulijiamali Kahaer, Sirun Pan, Chengcheng Yang, Wenchen Xie, Yan Lu

“…Due to promoter hypermethylation, GSDME is epigenetically silenced in most solid tumors, including gastric, colorectal, and breast cancers. …”
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Selenium exposure on breast cancer risk and progression: Comprehensive analysis identifies MSRB1 as a novel therapeutic target by Jingsong Cheng, Diyuan Zhang, Ningxi Wang, Ziheng Zheng, Cong Zhang, Nanting Chen, Yuanyuan Wan, Xue Chen, Qingyao Yin, Xinyi Zhu, Yu Zhao, Liming Yi, Na Sun

“…Background: Breast cancer (BRCA) is the most common malignancy in women worldwide. Selenium (Se), a crucial trace element, significantly impacts BRCA patient survival, although its roles in tumorigenesis, the tumor immune microenvironment (TIME), and precision therapy remain unclear. …”
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A plasmid-chromosome crosstalk in multidrug resistant enterobacteria by Laura Toribio-Celestino, Alicia Calvo-Villamañán, Cristina Herencias, Aida Alonso-del Valle, Jorge Sastre-Dominguez, Susana Quesada, Didier Mazel, Eduardo P. C. Rocha, Ariadna Fernández-Calvet, Alvaro San Millan

“…Combining genetic engineering, transcriptomics, and CRISPRi gene silencing, we show that a pOXA-48-encoded LysR regulator is responsible for the plasmid-chromosome crosstalk. …”
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The Porphyromonas gingivalis RNA-binding protein is required for growth in high levels of zinc and persistence with host cells by Sai Yanamandra, Holly Marsh, Romana Cvitkovic, Qin Gui, Benjamin R. Belvin, Janina P. Lewis, Janina P. Lewis, Janina P. Lewis

“…We have determined that both the transcriptome and proteome are affected by the deletion of RbpPg1 and found that the major group of proteins with elevated expression were the ones associated with response to environmental stress changes, while proteins mediating metabolic processes were downregulated. …”
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A novel computational approach for predicting complex phenotypes in Drosophila (starvation-sensitive and sterile) by deriving their gene expression signatures from public data. by Dobril K Ivanov, Gerrit Bostelmann, Benoit Lan-Leung, Julie Williams, Linda Partridge, Valentina Escott-Price, Janet M Thornton

“…These data records often include phenotypic characteristics following genetic and environmental perturbations, with the aim of discovering underlying molecular mechanisms leading to the phenotypic responses. A constrained set of phenotypic characteristics is usually recorded and these are mostly hypothesis driven of possible to record within financial or practical constraints. …”
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Gene Expression Profiling and Biofunction Analysis of HepG2 Cells Targeted by Crocetin by Yi-Ling Wen, Yong Li, Guangcheng Zhu, Zhibing Zheng, Meng Shi, Si Qin

“…Crocetin is a carotenoid extracted from Gardenia jasminoides, one of the most popular traditional Chinese medicines, which has been used in the prevention and treatment of various diseases. …”
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Active poly‐GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model by Qihui Zhou, Nikola Mareljic, Meike Michaelsen, Samira Parhizkar, Steffanie Heindl, Brigitte Nuscher, Daniel Farny, Mareike Czuppa, Carina Schludi, Alexander Graf, Stefan Krebs, Helmut Blum, Regina Feederle, Stefan Roth, Christian Haass, Thomas Arzberger, Arthur Liesz, Dieter Edbauer

“…Abstract The C9orf72 repeat expansion is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD). …”
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Redefining the role of IL-18 in post-surgical recovery and sepsis: a key mediator of inflammation resolution by Ioanna Papatheodorou, Gabriela Blažková, Veronika Bosáková, Zuzana Tomášiková, Erin Spearing, Robin Klieber, Pavel Ostašov, Julie Štíchová, Martina Dvončová, Alexandra Mýtniková, Jan Emmer, Kamila Bendíčková, Tomáš Tomáš, Vladimír Šrámek, Petros Kolovos, Monika Holubová, Martin Helán, Marcela Vlková, Jan Frič, Marcela Hortová-Kohoutková

“…Abstract Background Timely resolution of innate immune responses activated by surgical intervention is crucial for patient recovery. …”
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A novel HVEM-Fc recombinant protein for lung cancer immunotherapy by Yuanshan Yao, Bin Li, Jing Wang, Chunji Chen, Wen Gao, Chunguang Li

“…Moreover, the combination of HVEM-Fc with a PD-1 inhibitor yields the most effective anti-tumor outcomes.…”
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RAB5B: explore its carcinogenic potential and understand its role, prognostic value and biological significance in pan-cancer by Jing Zhu, Chun Yu, Xin Xu, Chu Zou, Jiaqi Li, Rui Wang, Xinchao Li, Aijun Sun, Shiyan Wang, Chao Jiang

“…It also correlated significantly with immunotherapy biomarkers and responses. ESTIMATE and immune infiltration analyses highlighted RAB5B’s link to immunosuppression, emphasizing its role in immune regulation. …”
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Secretome enriched with small extracellular vesicles derived from human gingiva-derived mesenchymal stem cells enhances rat tongue muscle regeneration by Qunzhou Zhang, Puhan He, Shihong Shi, Qilin Xu, Eric J. Granquist, Beth A. Winkelstein, Rabie M. Shanti, Anh D. Le

“…Abstract Background Accumulating evidence demonstrates that the therapeutic effects of stem cells are most likely attributed to their secretome, composed of a myriad of bioactive factors, including small extracellular vesicles (EVs). …”
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Development and characterization of high-efficiency cell-adapted live attenuated vaccine candidate against African swine fever by Min Ho Kim, Ashan Subasinghe, Yongkwan Kim, Hyeok-Il Kwon, Yehjin Cho, Kiramage Chathuranga, Ji-Won Cha, Ji-Yoon Moon, Ji-Hyeon Hong, Jin Kim, Seung-Chul Lee, Niranjan Dodantenna, Nuwan Gamage, W. A. Gayan Chathuranga, Yeonji Kim, In-Joong Yoon, Joo Young Lee, In Pil Mo, Weonhwa Jheong, Sung-Sik Yoo, Jong-Soo Lee

“…Global transcriptome analysis showed that ASFV-MEC-01 lacking 12 genes triggered stronger innate antiviral responses than the parental virus, as exemplified by high levels of mRNA encoding interferon regulatory and inflammatory genes in PAM cells. …”
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Transcriptions of ACO and ACS genes are involved in nitrate-dependent root growth of maize seedlings by Guoqi Yao, Zhenwei Yan, Shijun Ma, Xia Liu, Juan Shan, Bing Cao, Xiaole Chen, Bingying Leng, Chunhua Mu

“…In this research, we performed Gene Set Enrichment Analysis (GSEA) of maize transcriptomes in response to nitrate and found that the ethylene action pathway might participate in nitrate signaling. …”
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Genome-wide identification and expression analysis of growth-regulating factor (GRF) and GRF-interacting factor (GIF) gene families in Castanea mollissima by WANG Xiangyu, TIAN Yujuan, LI Yun, WANG Dongsheng, WANG Xuan, GUO Chunlei, LIU Jing, ZHANG Hai’e, ZHANG Jingzheng, YU Liyang

“…Under drought stress, CmGRFs in Yanshanzaofeng and Dabanhong were almost not expressed, indicating that they may not be related to the response of Chinese chestnuts to drought stress. The infection of Drycosmusk kuriphilus significantly induced the expression of CmGRF2, CmGRF3, CmGRF7, and Cm-GIF1, indicating that they may be related to the response of Chinese chestnuts to D. kuriphilus infection. …”
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Differential gene expression of tumor-infiltrating CD8+ T cells in advanced versus early-stage colorectal cancer and identification of a gene signature of poor prognosis by Reem Saleh, Varun Sasidharan Nair, Salman M Toor, Rowaida Z Taha, Khaled Murshed, Mahmood Al-Dhaheri, Mahwish Khawar, Mahir Abdulla Petkar, Mohamed Abu Nada, Fares Al-Ejeh, Eyad Elkord

“…Background Cytotoxic CD8+ T cell-mediated response is the most important arm of adaptive immunity, which dictates the capacity of the host immune response in eradicating tumor cells. …”
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Essential Role for endogenous siRNAs during meiosis in mouse oocytes. by Paula Stein, Nikolay V Rozhkov, Fan Li, Fabián L Cárdenas, Olga Davydenko, Lee E Vandivier, Brian D Gregory, Gregory J Hannon, Richard M Schultz

“…The transcriptome of these oocytes is widely perturbed and shows a highly significant correlation with the transcriptome of Dicer null and Ago2 null oocytes. …”
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Genome-Wide Analysis of PAPS1-Dependent Polyadenylation Identifies Novel Roles for Functionally Specialized Poly(A) Polymerases in Arabidopsis thaliana. by Christian Kappel, Gerda Trost, Hjördis Czesnick, Anna Ramming, Benjamin Kolbe, Son Lang Vi, Cláudia Bispo, Jörg D Becker, Cornelia de Moor, Michael Lenhard

“…Here, we have estimated poly(A)-tail lengths on a transcriptome-wide scale in wild-type and paps1 mutants. …”
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