Functions and Therapeutic Potentials of Long Noncoding RNA in Skeletal Muscle Atrophy and Dystrophy by Yidi Zhang, Teng Wang, Ziang Wang, Xin'e Shi, Jianjun Jin

“…ABSTRACT Skeletal muscle is the most abundant tissue in the human body and is responsible for movement, metabolism, energy production and longevity. …”
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The role of bile acid metabolism-related genes in prognosis assessment of hepatocellular carcinoma and identification of NPC1 as a biomarker by Maosen Xu, Maosen Xu, Yu Zhang, Yan Tie, Yiqiao Luo, Yang Wang, Ziqi Zhang

“…Hepatocellular carcinoma (HCC) is one of the most prevalent and deadly cancers worldwide, with a high recurrence rate and poor prognosis. …”
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Artificial intelligence-assisted RNA-binding protein signature for prognostic stratification and therapeutic guidance in breast cancer by Yunxia Zhao, Li Li, Shuqi Yuan, Zixin Meng, Jiayi Xu, Zhaogen Cai, Yijing Zhang, Xiaonan Zhang, Tao Wang

“…Low AIRS scores predicted better responses to immune checkpoint inhibitors, while drug sensitivity analysis highlighted panobinostat and paclitaxel as potential therapies for high-risk patients.ConclusionsThe AIRS model offers a robust tool for BC prognosis and treatment stratification, integrating genomic, transcriptomic, and single-cell data. …”
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The human STING agonist E7766 induces immunogenic tumor clearance, independent of tumor-intrinsic STING expression in the KRASG12D/+ Trp53−/− murine model of sarcoma by Karys M. Hildebrand, Kurt N. Hildebrand, Carolina Salazar Arcila, Kayla Marritt, Jahanara Rajwani, Golpira Elmi Assadzadeh, Antoine Dufour, Frank R. Jirik, Michael J. Monument

“…All STING agonists significantly increased survival time, however, only E7766 resulted in durable tumor clearance, inducing CD8+ T-cell infiltration and activated lymphocyte transcriptomic signatures in the TME. Antibody depletion was used to assess the dependency of treatment responses on CD8+ T-cells, showing that in their absence, tumor clearance did not occur following E7766 therapy. …”
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Exploration of shared biomarkers and mechanisms in systemic lupus erythematous and lung cancer via bioinformatics analysis by Chueh-Hsuan Hsu, Shuo-Chueh Chen, Yung-Luen Yu

“…These findings are particularly meaningful in SLE, where most patients are female and smoking is a known risk factor. …”
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Safety, tolerability, pharmacokinetics, and pharmacodynamics of the oral allosteric TYK2 inhibitor ESK‐001 using a randomized, double‐blind, placebo‐controlled study design by Sibel Ucpinar, Joyce K. Kwan, Joshua D. Hoffman, Mera K. Tilley, Jeffrey A. Douglas, Roman G. Rubio, Ruixiao Lu, Philip A. Nunn, Claire L. Langrish

“…ESK‐001 inhibited the downstream TYK2 pathway as shown by inhibition of pSTAT1 expression. Transcriptomic analysis of unstimulated whole blood samples confirmed dose‐dependent inhibition of Type I IFN‐induced genes and SIGLEC1, a novel TYK2‐responsive biomarker. …”
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CXCL12/CXCR4 axis mediates CD8 + T cell overactivation in the progression of viral myocarditis by Li Zhang, Keyu Liu, Xiuyun Duan, Shan Zhou, Hailin Jia, Yingnan You, Bo Han

“…Abstract Background Myocarditis is a common inflammatory heart disease in children and young adults, with fulminant myocarditis (FM) being the most severe form due to its rapid onset and high mortality rate. …”
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Vascular-type heterogeneity is associated with differential gene expression profiles of endothelial cells under shear stress by Allaura A. Cox, Christopher James Ng

“…While several genes were differentially expressed by all 3 vascular EC types (44.2%), most differentially expressed genes were limited to 1 or 2 of the vascular types. …”
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Omics-Based Interaction Analysis Reveals Interplay of Chemical Pollutant (Ozone) and Photoradiation (UVSSR) Stressors in Skin Damage by Hong Zhang, Yiying Dong, Xue Xiao, Xiao Cui, Xuelan Gu

“…Conventional differential expression analysis showed that, among exposure groups, co-exposure dysregulated the most genes, followed by ozone and UVSSR alone. Omics-based interaction framework (OBIF) analysis showed that most interactive genes following ozone and UVSSR exposure displayed a cooperative effect and had functions related to the skin barrier; these genes with synergistic effects were enriched in biological pathways such as the chronic inflammatory response and the apoptotic signaling pathway. …”
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Genome-wide identification of castor bean class III peroxidase genes and analysis of expression patterns under abiotic stresses by Jiayu Li, Mubo Fan, Shuqi Yang, Hongyan Huo, Weiquan Fan, Shiyou Lü, Jixing Zhang

“…Abstract Background The peroxidase (PRX) gene family plays important roles in plant growth and development, antioxidant defense, immune response, cell wall synthesis, and environmental stress response. …”
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A Series of Novel Alleles of <i>Ehd2</i> Modulating Heading and Salt Tolerance in Rice by Peng Xu, Shulei Hao, Xiaoxia Wen, Guifang Ma, Qinqin Yang, Ling Liu, Galal Bakr Anis, Yingxin Zhang, Lianping Sun, Xihong Shen, Qunen Liu, Daibo Chen, Yongbo Hong, Yuyu Chen, Xiaodeng Zhan, Shihua Cheng, Liyong Cao, Weixun Wu

“…Salinity stress significantly hampers rice growth and productivity. Transcriptomic analysis of <i>elh10</i> and ZH8015 seedlings exposed to salt stress for 24 h identified 5150 differentially expressed genes (DEGs) at the seedling stage, predominantly linked to stress response pathways. …”
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Effects of high-temperature stress on gene expression related to photosynthesis in two jujube (Ziziphus jujuba Mill.) varieties by Lei Yang, Xiaojuan Yang, Bingqi Shen, Juan Jin, Lili Li, Dingyu Fan, Subina Xiaokelaiti, Qing Hao, Jianxin Niu

“…Elevated temperatures critically impact crop growth, development, and yield, with photosynthesis being the most temperature-sensitive physiological process in plants. …”
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AmMADS47 of Agropyron mongolicum negatively regulates drought tolerance in rice by Bobo Fan, Bobo Fan, Hushuai Nie, Xiaolei Li, Yu Ma, Ersuo Lv, Jing Wu, Xiuxiu Yan, Yongqing Zhai, Yan Zhao, Jie Liu, Xiaohong Du, Yanhong Ma

“…Gene regulation in response to osmotic stress was analyzed in the three pathways, showing that, compared to WTD, OED exhibited up-regulation of a few drought-sensitive genes, while most genes positively regulating drought in WTD were down-regulated in OED. …”
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Identification and expression analysis of bHLH transcription factors family in Rhododendron delavayi by WANG Hongfei1, OU Jing1*, WANG Xiaojing2, KE Ke3, FAN Yu1, ZHOU Yumei1, FAN Xinyue1

“…Water deficiency is a critical factor that restricts the utilization of Rhododendron delavayi in landscaping. bHLH transcription factors are pivotal regulators of plant growth, development, and stress responses. This study aimed to identify members of the R. delavayi bHLH transcription factor(RdbHLH)family by utilizing the R. delavayi genome file and transcriptome data. …”
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Blood-based detection of MMP11 as a marker of prostate cancer progression regulated by the ALDH1A1-TGF-β1 signaling mechanism by Ielizaveta Gorodetska, Vasyl Lukiyanchuk, Marta Gawin, Myroslava Sliusar, Annett Linge, Fabian Lohaus, Tobias Hölscher, Kati Erdmann, Susanne Fuessel, Angelika Borkowetz, Anna Wojakowska, Daniel Fochtman, Mark Reardon, Ananya Choudhury, Yasmin Antonelli, Aldo Leal-Egaña, Ayse Sedef Köseer, Uğur Kahya, Jakob Püschel, Andrea Petzold, Daria Klusa, Claudia Peitzsch, Romy Kronstein-Wiedemann, Torsten Tonn, Lukasz Marczak, Christian Thomas, Piotr Widłak, Monika Pietrowska, Mechthild Krause, Anna Dubrovska

“…Abstract Background Prostate cancer (PCa) is the second most common type of tumor diagnosed in men and the fifth leading cause of cancer-related death in male patients. …”
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Comprehensive molecular profiling of FH-deficient renal cell carcinoma identifies molecular subtypes and potential therapeutic targets by Xingming Zhang, Junjie Zhao, Xiaoxue Yin, Jiayu Liang, Yongquan Wang, Linmao Zheng, Ping Tan, Yifei Lin, Nanwei Xu, Sha Zhu, Junru Chen, Jinge Zhao, Xu Hu, Xiuyi Pan, Ling Nie, Mengni Zhang, Yuntian Chen, Yaowen Zhang, Haoyang Liu, Jindong Dai, Zhipeng Wang, Haolin Liu, Yuchao Ni, Niels J. Rupp, Holger Moch, Xinan Sheng, Kan Gong, Xiaodong Liu, Zhibin Chen, Zhengyu He, Yaodong Wang, Lijing Xu, Mingsheng Liu, Hongqing Zhou, Bo Tang, Rui Huang, Qiang Wei, Xiang Li, Jiyan Liu, Jin Yao, Banghua Liao, Zhenhua Liu, Pengfei Shen, Ni Chen, Hao Zeng, Guangxi Sun

“…Tumors in C2 display moderate response to this therapeutic approach. In contrast, tumors in C3 exhibit an unfavorable response to anti-angiogenic monotherapy and its combination with ICB. …”
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SEC24D depletion induces osteogenic differentiation deficiency by inactivating the ATF6/TGF-β/Runx2 regulatory loop by Jing Zhang, Kai Yang, Wen-qi Chen, Dong-lan Sun, Hua-ying Hu, Qian Li, You-sheng Yan, Ya-zhou Li, Cheng-hong Yin, Qing Guo

“…In silico analysis suggested that the missense R313H mutation most likely affects protein stability and secondary structure. …”
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Predictive prioritization of genes significantly associated with biotic and abiotic stresses in maize using machine learning algorithms by Anjan Kumar Pradhan, Prasad Gandham, Kanniah Rajasekaran, Niranjan Baisakh

“…Identifying genes and associated networks underlying stress resistance responses in maize is paramount. A meta-transcriptome approach was undertaken to interrogate 39,756 genes differentially expressed in response to biotic and abiotic stresses in maize were interrogated for prioritization through seven machine learning (ML) models, such as support vector machine (SVM), partial least squares discriminant analysis (PLSDA), k-nearest neighbors (KNN), gradient boosting machine (GBM), random forest (RF), naïve bayes (NB), and decision tree (DT) to predict top-most significant genes for stress conditions. …”
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Expression patterns and clinical significance of vasculogenic mimicry-related genes in patients with head and neck squamous cell carcinoma by Rui Lai, Xuanyu Gu, Yueyue Cai, Qiang Li

“…In recent years, vasculogenic mimicry has become one of the most studied mechanisms that promote cancer incidence and progression. …”
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IrSPI, a tick serine protease inhibitor involved in tick feeding and Bartonella henselae infection. by Xiang Ye Liu, Jose de la Fuente, Martine Cote, Ruth C Galindo, Sara Moutailler, Muriel Vayssier-Taussat, Sarah I Bonnet

“…Ixodes ricinus is the most widespread and abundant tick in Europe, frequently bites humans, and is the vector of several pathogens including those responsible for Lyme disease, Tick-Borne Encephalitis, anaplasmosis, babesiosis and bartonellosis. …”
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