A telomere-associated molecular landscape reveals immunological, microbial, and therapeutic heterogeneity in colorectal cancer by Yinmeng Zhang, Jiawei Fan, Jiahui Zhao, He Zhu, Yan Xia, Hong Xu

“…BackgroundColorectal cancer (CRC) ranks among the most prevalent malignancies of the gastrointestinal tract and remains a leading cause of cancer-related mortality worldwide. …”
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Anti-PD1 based precision induction therapy in unresectable stage III non-small cell lung cancer: a phase II umbrella clinical trial by Chengxiang Yi, Dongliang Bian, Jue Wang, Shiqi Hu, Liangdong Sun, Yilv Yan, Suyu Wang, Ziyun Shen, Huansha Yu, Yong Yang, Yirui Zhou, Xiaogang Liu, Nan Song, Yuming Zhu, Deping Zhao, Gening Jiang, Liang Duan, Wenxin He, Dong Xie, Jie Dai, Lele Zhang, Peng Zhang

“…The median event-free survival is 29.9 months (95% CI: 17.0-42.7). Most common adverse event is anemia (49.0%). Exploratory transcriptomic analyses reveal Bone Marrow Stromal Cell Antigen 1 (BST1) as a promising biomarker for response to chemoimmunotherapy. …”
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Genome-Wide Identification of Superoxide Dismutase (<i>SOD</i>) Gene Family in <i>Cymbidium</i> Species and Functional Analysis of <i>CsSOD</i>s Under Salt Stress in <i>Cymbidium s... by Ruyi Li, Songkun Lin, Yin Yan, Yuming Chen, Linying Wang, Yuzhen Zhou, Shuling Tang, Ning Liu

“…<i>Cis</i>-element prediction showed that stress-responsive elements were identified in most <i>SOD</i>s. …”
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Establishment of a Novel in vitro Model of Sepsis-Induced Myocardial Injury Using Septic Serum: A Comprehensive Comparative Study by Yang H, Feng L, Jiang Z, Deng R, Wu X, Zeng K

“…However, the precise mechanisms underlying sepsis-induced myocardial injury remain unclear, and the most appropriate in vitro model for its investigation remains to be established. …”
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Unveiling the role of TGF-β signaling pathway in breast cancer prognosis and immunotherapy by Yifan Zheng, Yifan Zheng, Li Li, Wenqian Cai, Lin Li, Rongxin Zhang, Wenbin Huang, Wenbin Huang, Yulun Cao

“…Nonetheless, the connection between genes associated with the TSP and the clinical outcomes of breast cancer, as well as their impact on the tumor microenvironment and immunotherapeutic responses, remains elusive.MethodsBreast cancer transcriptomic and single-cell sequencing data were obtained from the The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases. …”
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The Genome Assembly of Vitis vinifera cv. Shiraz by Cristobal A. Onetto, Christopher M. Ward, Anthony R. Borneman

“…Shiraz (Syrah) is a dark-skinned cultivar of the wine grape Vitis vinifera that forms the basis of some of the world’s most iconic wines. Worldwide, Shiraz is the fourth most planted grapevine cultivar; however, it represents the most planted cultivar in Australia. …”
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Integrating Bulk RNA and Single-Cell Sequencing Data Reveals Genes Related to Energy Metabolism and Efferocytosis in Lumbar Disc Herniation by Lianjun Yang, Jinxiang Li, Zhifei Cui, Lihua Huang, Tao Chen, Xiang Liu, Hai Lu

“…<b>Background/Objectives</b>: Lumbar disc herniation (LDH) is the most common condition associated with low back pain, and it adversely impacts individuals’ health. …”
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Prolonged heat stress in Brassica napus during flowering negatively impacts yield and alters glucosinolate and sugars metabolism by Mariam Kourani, Maria Anastasiadi, John P. Hammond, Fady Mohareb

“…In this study, we investigated the transcriptomic and metabolomic responses to heat stress in B. napus plants exposed to a gradual increase in temperature reaching 30°C in the day and 24°C at night for a period of 6 days. …”
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Deciphering the mechanisms for preferential tolerance of Escherichia coli BL21 to Cd(II) over Cu(II) and Ni(II): A combined physiological, biochemical, and multiomics perspective by Jackson Nkoh Nkoh, Ting Ye, Chenjing Shang, Chunyuan Li, Jianguang Tu, Sihui Li, Zuping Wu, Pengyu Chen, Quaid Hussain, Seraphine Nkie Esemu

“…Escherichia coli is one of the most studied life forms, and its response to oxidative stress is driven by a complex ensemble of mechanisms driven by transcriptomic-level adjustments. …”
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Genome-wide identification and functional characterization of the LBD transcription factor gene family in Zanthoxylum armatum DC. reveal its potential role in leaf variation by Yifei Deng, Chong Sun, Xueqian Fu, Yuan Guo, Yongxing Zhu, Chongyu Liu, Ruxin Xu, Han Liu, Qiang Li, Ning Tang, Mi Kuang, Wenying Yang, Xia Liu, Zexiong Chen

“…By mediating the regulation of leaf morphology, these genes may play important roles in the response to abiotic stress and adaptation to ecological changes. …”
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New insights into the evolution analysis of trihelix gene family in eggplant (Solanum melongena L.) and expression analysis under abiotic stress by Yanhong Lan, Fangyi Gong, Chun Li, Feng Xia, Yifan Li, Xiaojun Liu, Duchen Liu, Genyun Liang, Chao Fang, Peng Cai

“…Abstract Background Trihliex transcription factors (TFs) play crucial roles in plant growth and development, stress response, and plant hormone signaling network transmission. …”
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Integrative analysis of T cell-mediated tumor killing-related genes reveals KIF11 as a novel therapeutic target in esophageal squamous cell carcinoma by Xinxin Cheng, Huihui Zhao, Zhangwang Li, Liping Yan, Qingjie Min, Qingnan Wu, Qimin Zhan

“…Therefore, selecting candidate patients who will benefit the most from these drugs is critical. However, validated biomarkers for predicting immunotherapy response and overall survival are lacking. …”
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Genome-wide identification, evolutionary expansion and expression divergence of the AP2/ERF gene family in loquat (Eriobotrya japonica) by Yumeng Liu, Linqi Cai, Xiurun Fan, Huiling Zhang, Minghui Chen, Yue Lin, Junwei Chen, Kai Xu, Boping Wu

“…Cis-element analysis showed that most of the AP2/ERF genes in loquat had multiple cis-elements related to stress response, plant hormone signal transduction, and plant growth and development. …”
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QTL mapping provides new insights into emamectin benzoate resistance in salmon lice, Lepeophtheirus salmonis by Armin Sturm, Greta Carmona-Antoñanzas, Joseph L. Humble, Claudia Croton, Sally Boyd, Rapule Mphuti, John B. Taggart, David I. Bassett, Ross D. Houston, Karim Gharbi, James E. Bron, Michaël Bekaert

“…The aim of the present work was to obtain insights into potential EMB resistance mechanisms by identifying genetic and transcriptomic markers associated with EMB resistance. …”
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Tangeretin Suppresses Fumonisin Production by Modulating an NmrA- and HSCARG-like Protein in <i>Fusarium verticillioides</i> by Liuqing Wang, Wenlei Zhai, Dongmei Jiang, Nan Jiang, Jiaqi Yan, Haoyun Jiang, Meng Wang

“…Among these, fumonisin B₁ (FB₁) is the most prevalent mycotoxin, primarily produced by <i>Fusarium verticillioides</i>, especially in maize and its derived products. …”
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Pancreatic cancer cell-intrinsic transglutaminase-2 promotes T cell suppression through microtubule-dependent secretion of immunosuppressive cytokines by Anton Wellstein, Thomas Seufferlein, Alexander Kleger, Tim Eiseler, Anton Lahusen, Nora Minhöfer, Kim-André Lohse, Christine Blechner, Jessica Lindenmayer, Sabine Windhorst, Yuan-Na Lin

“…A combination of transcriptomic analyses, cytometric and immunohistochemistry techniques allowed us to validate the underlying T cell response phenotypes of PDAC cells. …”
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The Maltase Involved in Starch Metabolism in Barley Endosperm Is Encoded by a Single Gene. by Vasilios M E Andriotis, Gerhard Saalbach, Robbie Waugh, Robert A Field, Alison M Smith

“…Multiple forms of the enzyme most likely arise from proteolysis and other post-translational modifications.…”
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Cbf11 and Mga2 function together to activate transcription of lipid metabolism genes and promote mitotic fidelity in fission yeast. by Anna Marešová, Michaela Grulyová, Miluše Hradilová, Viacheslav Zemlianski, Jarmila Princová, Martin Převorovský

“…Deletion of either gene results in a similar array of defects, including slow growth, dysregulated lipid homeostasis, impaired cell cycle progression (cut phenotype), abnormal cell morphology, perturbed transcriptomic and proteomic profiles, and compromised response to the stressors camptothecin and thiabendazole. …”
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MYB/AKT3 axis is a key driver of ovarian cancer growth, aggressiveness, and chemoresistance by Kunwar Somesh Vikramdeo, Orlandric Miree, Shashi Anand, Amod Sharma, Sanjeev Kumar Srivastava, Seema Singh, Rodney P Rocconi, Ajay Pratap Singh

“…Abstract Background Ovarian cancer (OC) remains the most lethal gynecologic malignancy in the United States due to its late diagnosis, aggressive nature, and poor responsiveness to existing therapies. …”
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Identification of WRKY gene family and analysis of drought stress expression in Poncirus polyandra by ZHANG Shanshan, RUAN Sunmei, YANG Wenzhong

“…The genes clustered on chromosome one were the most, with a total of nine genes. But there was only one gene distributed on chromosome four. …”
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