The Transcriptional Signature of Active Tuberculosis Reflects Symptom Status in Extra-Pulmonary and Pulmonary Tuberculosis. by Simon Blankley, Christine M Graham, Jacob Turner, Matthew P R Berry, Chloe I Bloom, Zhaohui Xu, Virginia Pascual, Jacques Banchereau, Damien Chaussabel, Ronan Breen, George Santis, Derek M Blankenship, Marc Lipman, Anne O'Garra

“…<h4>Methods</h4>A novel cohort of patients with extra-pulmonary TB and sarcoidosis was recruited and the transcriptional response of these patients compared to those with pulmonary TB using a variety of transcriptomic approaches including testing a previously defined 380 gene meta-signature of active TB.…”
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Drought-induced molecular changes in crown of various barley phytohormone mutants by Anetta Kuczyńska, Martyna Michałek, Piotr Ogrodowicz, Michał Kempa, Natalia Witaszak, Michał Dziurka, Damian Gruszka, Agata Daszkowska-Golec, Iwona Szarejko, Paweł Krajewski, Krzysztof Mikołajczak

“…We verified the hypothesis that defects of gibberellins, brassinosteroids, and strigolactones action affect the transcriptomic, proteomic, and hormonal response of barley crown to the transitory drought influencing plant development under stress. …”
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Nitrate deficiency decreased photosynthesis and oxidation-reduction processes, but increased cellular transport, lignin biosynthesis and flavonoid metabolism revealed by RNA-Seq in... by Cai-Hong Shao, Cai-Fei Qiu, Yin-Fei Qian, Guang-Rong Liu

“…A total of 1635 genes showed differential expression in response to N deficiency revealed by Illumina sequencing. …”
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Gasdermin E in glioblastoma –pyroptosis resistance and tumor-promoting functions by Ege Solel, Egil Brudvik, Lars Andreas Rømo Ystaas, Yahaya A. Yabo, Emma Rigg, Romi Roy Choudhury, Halala Sdik Saed, Dieter Henrik Heiland, Rolf Bjerkvig, Jubayer Hossain, Hrvoje Miletic

“…Abstract Treatment of glioblastoma (GB), the most common and most aggressive malignant brain tumor, has made little progress over the past two decades. …”
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Mechanisms of Cannabis Growth Promotion by <i>Bacillus velezensis</i> S141 by Phirom Aunkam, Surachat Sibponkrung, Sirawich Limkul, Tuangrak Seabkongseng, Kanjana Mahanil, Kamolchanok Umnajkitikorn, Nantakorn Boonkerd, Neung Teaumroong, Shusei Sato, Panlada Tittabutr, Pakpoom Boonchuen

“…This study evaluated the effects of S141 on cannabis growth and utilized transcriptomic analysis to identify the responsive pathways. …”
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Species- and strain-specific microbial modulation of interferon, innate immunity, and epithelial barrier in 2D air–liquid interface respiratory epithelial cultures by Mian Horvath, Ruoyu Yang, Diana Cadena Castaneda, Megan Callender, Elizabeth S. Aiken, Anita Y. Voigt, Ryan Caldwell, José Fachi, Blanda Di Luccia, Zoe Scholar, Peter Yu, Andrew Salner, Marco Colonna, Karolina Palucka, Julia Oh

“…Results We found distinct species- and strain-level differences in host innate immunity and epithelial barrier response. Strikingly, we found that host interferon, an antiviral response, was one of the most variable host processes. …”
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The cardioprotective mechanisms of draconis sanguis: An integrated network pharmacology, bioinformatics, and experimental validation study by Keyan Wang, Rongxin Zhu, Junjun Li, Binhua Yuan, Xiang Li, Yunlin Li, Mingyue Huang, Fangfang Rui, Chun Li, Wei Wang

“…Transcriptomic and bioinformatic analyses identified Pla2g7 as the most critical target in the DS treatment of MI. …”
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Identification and expression analysis of NUDIX gene family in Rosa chinensis ‘Old Blush’ by FANG Huiyi, LIANG Yuwei, LI Xinyuan, Sun Fuhui, BI Bo, ZHANG Liangsheng

“…The chromosome localization results indicated that NUDIX genes of Rosa chinensis ‘Old Blush’ underwent multiple tandem duplication event, most of which went through purifying selection. Transcriptomic data analysis revealed that RcNUDIX1a/1b/1d/1e were specifically expressed in petals. …”
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Identification of StCCoAOMT gene family and analysis of resistance of StCCoAOMT1 and StCCoAOMT7 genes to drought, alkaline salt and combined stresses in potato by Yunyun Du, Ruyan Zhang, Yuan Lu, Yong Wang, Xingxing Wang, Weina Zhang, Yichen Kang, Yuhui Liu, Shuhao Qin

“…Lignin plays a key role in potato resistance to abiotic stresses, and most of the key enzymes in its synthetic pathway were involved in plant stress response. …”
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TRPV1 alleviates APOE4-dependent microglial antigen presentation and T cell infiltration in Alzheimer's disease by Jia Lu, Kexin Wu, Xudong Sha, Jiayuan Lin, Hongzhuan Chen, Zhihua Yu

“…APOE4, the most important genetic risk factor for sporadic AD, encodes apolipoprotein E4, which by itself is a potent modulator of immune response. …”
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High-rate mechano-stimulation alters proliferation- and maturation-related signaling of oligodendrocyte precursor cells in a 3D hydrogel by Ryosuke Yokosawa, Rachel A. Mazur, Kelsey A. Wilson, Jacob H. Lee, Noah W. Showalter, Kyle J. Lampe, Pamela J. VandeVord

“…In particular, mild TBI is the most common level of injury among TBI patients, and the reactivity of glial cells is a key mechanism in understanding mild TBI. …”
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Systems biology approach delineates critical pathways associated with papillary thyroid cancer: a multi-omics data analysis by Febby Payva, Santhy K. S., Remya James, Amrisa Pavithra E, Venketesh Sivaramakrishnan

“…Abstract Background Papillary thyroid cancer (PTC) is the most prevalent follicular cell-derived subtype of thyroid cancer. …”
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Neuropathology-based approach reveals novel Alzheimer's Disease genes and highlights female-specific pathways and causal links to disrupted lipid metabolism: insights into a viciou... by Yin Jin, Apostolia Topaloudi, Sudhanshu Shekhar, Guangxin Chen, Alicia Nicole Scott, Bryce David Colon, Petros Drineas, Chris Rochet, Peristera Paschou

“…Abstract Dementia refers to an umbrella phenotype of many different underlying pathologies with Alzheimer’s disease (AD) being the most common type. Neuropathological examination remains the gold standard for accurate AD diagnosis, however, most that we know about AD genetics is based on Genome-Wide Association Studies (GWAS) of clinically defined AD. …”
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Blood molecular subtypes to guide precision treatment strategies in systemic juvenile idiopathic arthritis by In-Woon Baek, Jung Woo Rhim, Kyung-Su Park, Ki-Jo Kim

“…Abstract Background Systemic juvenile idiopathic arthritis (sJIA) is the most severe subtype of JIA, with a combination of diverse clinical manifestations and a variable clinical course. …”
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SSR42 is a novel regulator of cytolytic activity in Staphylococcus aureus by Mary-Elizabeth Jobson, Brooke R. Tomlinson, Emilee M. Mustor, Emily A. Felton, Andy Weiss, Clayton C. Caswell, Lindsey N. Shaw

“…ABSTRACT SSR42 is the longest noncoding RNA in the Staphylococcus aureus cell and the second-most abundant transcript in the stationary-phase transcriptome, second only to RNAIII. …”
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Genome-Wide Identification and Expression Analysis of <i>UBP</i> Genes in Peppers (<i>Capsicum annuum</i> L.) by Xuerui Chang, Tiantian Wang, Jiaxin Huang, Jia Xu, Yangyang Ruan, Yanping Liang, Jing Wang

“…While most genes were not expressed in leaves, the expression of several genes (<i>CaUBP3/17/27/32/35/38</i>) in flowers was significantly altered. …”
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Identification of GiOMT gene family in Glycyrrhiza inflata bat and expression analysis under UV-B stresses by Caijuan Li, Hao Li, Yufan Liang, Rong Miao, Ziliang Liu, Sijin Chen, Dan Zhang, Cuiling Wang, Jiling Wu, Xiangyan Zhou, Mengfei Li

“…The basal sequence of GiOMT genes was highly conserved throughout the evolutionary history of G. inflata. Most of the GiOMT genes were highly expressed in roots and were involved in the response to UV-B stress. …”
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Multimodal AI/ML for discovering novel biomarkers and predicting disease using multi-omics profiles of patients with cardiovascular diseases by William DeGroat, Habiba Abdelhalim, Elizabeth Peker, Neev Sheth, Rishabh Narayanan, Saman Zeeshan, Bruce T. Liang, Zeeshan Ahmed

“…Our approach has the potential to uncover the intricate mechanisms underlying CVD, enabling patient-specific risk and response profiling. We sourced transcriptomic expression data and single nucleotide polymorphisms (SNPs) from both CVD patients and healthy controls. …”
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Biomarker analysis from CheckMate 214: nivolumab plus ipilimumab versus sunitinib in renal cell carcinoma by Jin Yao, Thomas Powles, David F McDermott, Toni K Choueiri, Petra Ross-MacDonald, Simon Papillon-Cavanagh, Robert J Motzer, M Brent McHenry, Megan Wind-Rotolo, Ron Ammar, Yann-Alexandre Vano, Saurabh Gupta, Celine Han, Shruti S Saggi

“…Background The phase 3 CheckMate 214 trial demonstrated higher response rates and improved overall survival with nivolumab plus ipilimumab versus sunitinib in first-line therapy for advanced clear-cell renal cell carcinoma (RCC). …”
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Single-Cell Transcriptional Analysis Reveals the Mechanism of AZD6738 in HCC Immunotherapy via EZH2 Targeting by Li RP, Wu GZ, Fang XD, Yang WW, Zhang HY, Yue HX, Zheng Y, Wang YP, Zhou YN

“…Additionally, we explore the specific effects of AZD6738 on the tumor microenvironment and its ability to regulate immune responses.Methods: We employed a combination of network pharmacology and transcriptomic analysis to identify specific molecules associated with HCC, including EZH2, CCNB1, PRKDC, CTSL, PSEN1, SLC6A3, and FKBP1A. …”
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