Cucurbitacin Profile and Metalloid Stress Response in Cucurbita pepo L. Upon Arsenic Exposure by Gerardo Flores‐Iga, Carlos Lopez‐Ortiz, Purushothaman Natarajan, Padma Nimmakayala, Umesh K. Reddy, Nagamani Balagurusamy, Aldo Almeida

“…WGCNA analysis reveals As‐specific gene co‐expression modules, indicating that low As levels induce adaptive responses in energy and allantoin metabolism, while higher levels trigger intensified oxidative stress responses, including upregulation of MYB transcription factors and heat shock proteins, which may support tolerance to the metalloid. …”
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The unfolded protein response influences therapy outcome and disease progression in chronic lymphocytic leukaemia by Umair Tahir Khan, Kim Clarke, Gina Eagle, Melanie Oates, Peter Hillmen, Sandrine Jayne, Martin J. S. Dyer, Alex Phipps, Francesco Falciani, Rosalind E. Jenkins, Andrew R Pettitt

“…One dataset compared pre-treatment samples associated with an optimal versus suboptimal response, while another compared paired samples collected before treatment and at disease progression. eIF2 signalling (pivotal to the unfolded protein response (UPR)), was identified as the most enriched pathway in both datasets (respective z-scores: − 6.245 and 3.317; p < 0.0001), as well as in a fludarabine-resistant CLL cell line established from HG3 cells (z-score: − 2.121; p < 0.0001). …”
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Versatile physiological functions of the Nudix hydrolase family in berry development and stress response in grapevine by Pei-pei WANG, Zhao-ke WANG, Le GUAN, Muhammad Salman HAIDER, Maazullah NASIM, Yong-bing YUAN, Geng-sen LIU, Xiang-peng LENG

“…Expression and phylogenetic analyses demonstrated that VvNUDX1 and VvNUDX3 might be involved in terpenoid biosynthesis in grapevine. Furthermore, most VvNUDX genes active toward the ADP-ribose/NADH showed different patterns in response to various abiotic and biotic stresses, such as salinity and drought, as well as different types of biotic treatments, such as Erysiphe necator, Bois Noir phytoplasma and leaf-roll-associated virus-3 (GLRaV-3). …”
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RNA N6-methyladenosine modulates endothelial atherogenic responses to disturbed flow in mice by Bochuan Li, Ting Zhang, Mengxia Liu, Zhen Cui, Yanhong Zhang, Mingming Liu, Yanan Liu, Yongqiao Sun, Mengqi Li, Yikui Tian, Ying Yang, Hongfeng Jiang, Degang Liang

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A comparison of the large‐scale gene expression patterns in summer and fall migratory Pantala flavescens (Fabricius) in northern China by Lingzhen Cao, Na Wang

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In Vitro Pollen Viability, Fluorescence Microscopy, and Transcriptomic Comparison of Self-Pollinated and Cross-Pollinated Inflorescence of <i>Artemisia annua</i> L. to Analyze Cand... by Yimei Zang, Shengrong Cui, Shugen Wei, Limei Pan, Lingyun Wan, Xiaojun Ma, Zuliang Luo, Jine Fu, Chongnan Wang

“…Using transcriptome analysis, we generated approximately 25.03 GB of data assembled into 69,498 genes and identified 620 differentially expressed genes (DEGs), including 10 classified as SI response genes. …”
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Age-dependent glial heterogeneity and traumatic injury responses in a vertebrate brain structure by Huiwen Qin, Shuguang Yu, Ruyi Han, Jie He

“…However, the influence of age on the glial dynamics and their TBI responses remains mostly unexplored. Here, we obtain a comprehensive single-cell transcriptome atlas of three major glial types under the physiological and TBI conditions across four post-embryonic life stages in the zebrafish midbrain optic tectum. …”
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Tumor-agnostic transcriptome-based classifier identifies spatial infiltration patterns of CD8+T cells in the tumor microenvironment and predicts clinical outcome in early-phase and... by Cláudia S Ferreira, Konstanty Korski, Michael A Cannarile, Irina Klaman, Petra C Schwalie, Iakov I Davydov, Andreas Roller, Martha L Serrano-Serrano, Astrid Heller, Nicolas Staedler, Gabriele Dietmann, Alberto Valdeolivas

“…Currently, patients’ immune status is mostly classified based on CD8+tumor-infiltrating lymphocytes. …”
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Herpes simplex virus-induced upregulation of inflammatory cytokines in human gingival fibroblasts by Yu Zhang, Kalam Lo, Chunmei Wang, Guoliang Zhou, Xiping Feng, Jing Ni, Xi Chen

“…Its periodic reactivation aligns with the most common course pattern of periodontal disease. …”
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Breed-Associated Differences in Differential Gene Expression Following Immunotherapy-Based Treatment of Canine High-Grade Glioma by Susan A. Arnold, Walter C. Low, Grace Elizabeth Pluhar

“…Given this breed-specific observation, we hypothesized that within the French bulldog breed, there are key transcriptomic differences when compared to other breeds, and that their tumors change differently in response to immunotherapy. …”
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Diurnal rhythms in durum wheat triggered by Rhopalosiphum padi (bird cherry-oat aphid) by Yoshiahu Goldstein, Jinlong Han, Daniel Kunk, Albert Batushansky, Vamsi Nalam, Vered Tzin

“…Abstract Wheat is a staple crop and one of the most widely consumed grains globally. Wheat yields can experience significant losses due to the damaging effects of herbivore infestation. …”
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Identification and Characterization of Flavonoid Biosynthetic Gene Families in <i>Paeonia</i> Species and Their Roles in Stamen Petalization of <i>Paeonia lactiflora</i> by Yanyi Zheng, Yongming Fan, Xiang Ji, Xiaopei Wu

“…Comparative and phylogenetic analysis revealed that most flavonoid biosynthesis-related genes experience lineage-specific expansion in <i>P. ludlowii.…”
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A Novel Research Paradigm for Sarcopenia of Limb Muscles: Lessons From the Perpetually Working Diaphragm's Anti‐Aging Mechanisms by Enhui Li, Rui Wang, Yanli Li, Xiang Zan, Shufen Wu, Yiru Yin, Xiaorong Yang, Litian Yin, Yu Zhang, Jianguo Li, Xin Zhao, Ce Zhang

“…ABSTRACT Background Skeletal muscle function and mass continuously decrease during aging. Most studies target limb muscles owing to their direct impact on mobility and falls risk. …”
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ER stress-driven unfolded protein response fuels aging-related tumor aggressiveness in gliomas by Xiaodong Shao, Shaolei Guo, Jia Yang, Junjie Dai, Kaihua Cao, Xia Cai, Tianshi Song, Shun Yao, Umar Raza, Kun Chen

“…BackgroundGliomas are the most prevalent and aggressive primary brain tumors. …”
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S. cerevisiae ERG5DeltaNTH1DeltaAMS1Delta construction enhancing stress tolerance for ethanol production increase in the presence of inhibitors and mechanism analysis based on the... by Peizhou Yang, Zhuanzhuan Lin, Jianchao Chen, Shuying Jiang, Zhi Zheng, Kanglin Wang

“…The ethanol concentration in S. cerevisiae SCENA reached 16.5 g/L, which was 1.23 folds compared with the control using rice bran hydrolysate. Further, the transcriptome analysis indicated down-regulated differential expression genes (DEGs) in S. cerevisiae SCENA were mainly from cellular response to glucose, cell periphery, and plasma membrane. …”
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A systems biology approach to the characterization of stress response in Dermacentor reticulatus tick unfed larvae. by Margarita Villar, Marina Popara, Nieves Ayllón, Isabel G Fernández de Mera, Lourdes Mateos-Hernández, Ruth C Galindo, Marina Manrique, Raquel Tobes, José de la Fuente

“…In this study, we used a systems biology approach to get an insight into the mechanisms active in D. reticulatus unfed larvae, with special emphasis on stress response.<h4>Principal findings</h4>The results support the use of paired end RNA sequencing and proteomics informed by transcriptomics (PIT) for the analysis of transcriptomics and proteomics data, particularly for organisms such as D. reticulatus with little sequence information available. …”
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PARP9-PARP13-PARP14 axis tunes colorectal cancer response to radiotherapy by Rimvile Prokarenkaite, Karolina Kuodyte, Greta Gudoityte, Elzbieta Budginaite, Daniel Naumovas, Egle Strainiene, Kristijonas Velickevicius, Audrius Dulskas, Ernestas Sileika, Jonas Venius, Virginijus Tunaitis, Augustas Pivoriunas, Vytaute Starkuviene, Vaidotas Stankevicius, Kestutis Suziedelis

“…Abstract Background Colorectal cancer (CRC) is the third most prevalent cancer worldwide. Despite substantial advancements in CRC therapy in recent years, ionizing radiation (IR) continues to be the predominant treatment for colon malignances. …”
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Identification of Gene Modules Associated with Low Temperatures Response in Bambara Groundnut by Network-Based Analysis. by Venkata Suresh Bonthala, Katie Mayes, Joanna Moreton, Martin Blythe, Victoria Wright, Sean Tobias May, Festo Massawe, Sean Mayes, Jamie Twycross

“…Modules of sub-optimal temperature stress are principally enriched with carbohydrate and lipid metabolic processes, while most of the modules of very sub-optimal temperature stress are significantly enriched with responses to stimuli and various metabolic processes. …”
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Fundamental changes in the antimicrobial resistance profile of Klebsiella quasipneumoniae ATCC 700603 in response to meropenem stress by Mai H. Elmahdy, Ahmed F. Azmy, Tarek Dishisha, Ahmed O. El-Gendy, Mohamed Sebak

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Machine learning explores the prognostic and immuno-oncological impact of mitochondrial unfolded protein response in CESC by Keh-Sen Liu, Yen-Hsiang Chang, Hsing-Ju Wu, Hung-Yu Lin

“…While the mitochondrial unfolded protein response (UPRmt) is known to influence cancer biology, its specific role in CESC remains unclear. …”
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