Impact on the Leishmania mexicana transcriptome due to knockout of genes encoding orthologs of methyltransferases involved in m1A and m5C mRNA modifications by Angela Moreira Bezerra, Ariely Barbosa Leite, Christian Robson de Souza Reis, João Luiz de Lemos Padilha Pitta, Suellen Rodrigues Maran, Nilmar Silvio Moretti, Danielle Maria Nascimento Moura, Antonio Mauro Rezende

“…For the NSUN2 genes, enrichment analysis indicated impacts on biological processes mostly related to nucleotide metabolism and DNA binding. …”
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Study on physiological changes and response mechanism of Cerasus humilis under alkali stress by Meitong Pan, Shan Jiang, Lengleng Ma, Junbai Ma, Chenzhuo Yue, Lingyang Kong, Danli Wang, Wei Ma, Xiubo Liu, Weichao Ren

“…IntroductionCerasus humilis has high economic and nutritional value, but at the molecular level, there are few studies on salt-alkali stress of C. humilis, and no one has reported the response mechanism of the oxidation system of C. humilis under abiotic stress.Methods and resultsIn this research, transcriptomic and metabolomic analysis showed that C. humilis had a wide range of metabolic activities under alkali stress, and antioxidant enzymes played an important role in response to alkali stress. …”
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Identification and Characterization of bZIP Gene Family Combined Transcriptome Analysis Revealed Their Functional Roles on Abiotic Stress and Anthocyanin Biosynthesis in Mulberry (... by Qinghua Liu, Haowen Fang, Hong Zhou, Xiling Wang, Zhiwei Hou

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Tick innate immune responses to hematophagy and Ehrlichia infection at single-cell resolution by Abdulsalam Adegoke, Jose M. C. Ribeiro, Ryan C. Smith, Shahid Karim

“…IntroductionTicks rely on robust cellular and humoral responses to control microbial infection. However, several aspects of the tick's innate immune system remain uncharacterized, most notably that of the immune cells (called hemocytes), which are known to play a significant role in cellular and humoral responses. …”
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A myeloid IFN gamma response gene signature correlates with cancer prognosis by Yuchao Zhang, Asma Khanniche, Yizhe Li, Zhenchuan Wu, Hailong Wang, Hongyu Zhang, Xiaoxue Li, Landian Hu, Xiangyin Kong

“…Its influence on prognosis and therapeutic responses across cancer types remains unclear. Objective This study aimed to perform a pan‐cancer analysis of IFN‐γ response genes to determine their prognostic significance and evaluate their impact on clinical outcomes and anti‐PD1 immunotherapy responses. …”
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Discovering molecular signatures in kidney transplant biopsies with borderline changes and isolated V-lesions: single-cell RNA-sequencing analysis of human blood and tissue Spatial... by Jeongin Song, Minji Kang, Yunyoung Jang, Christine Suh-Yun Joh, Ha Yeon Shin, Julia Young Baik, Hyun Seung Choi, Kyu Hong Kim, Seong Min Lee, Seung-Min Cha, Hyunah Ku, Ahram Han, Sang Il Min, Jongwon Ha, Kyung Chul Moon, Sehoon Park, Seung Seok Han, Hajeong Lee, Dong Ki Kim, Kook Hwan Oh, Kwon Wook Joo, Ji Hwan Moon, Chung-Gyu Park, Yon Su Kim, Seung Hee Yang, Hyun Je Kim, Yong Chul Kim

“…Abstract Acute T cell-mediated rejection (TCMR) is one of the most important causes of kidney graft injury and loss; however, in-depth transcriptomic analyses of relevant tissues and circulating immune cells are limited. …”
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Integration of histopathology, transcriptomics and non-targeted metabolomics reveals toxic effects of thiamethoxam under acute stress in mirror carp (Cyprinus carpio var. Longke-11... by Dongchang Guo, Wenyang Song, Manhong Liu, Haixia Jiang, Xiaolong Wang, Zhiying Jia, Bin Xu

“…Genes related to immune response and antioxidant stress were mostly downregulated, while genes related to inflammation and apoptosis were predominantly upregulated. …”
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Exploring Potential Causal Links: How Parkinson’s Disease Brain Damage Impacts Liver Health–A Mendelian Randomization and Transcriptomic Study by Liu T, Chen Q, Wu H, Li J, Xian M, Lu K, Zhu C, Wei J

“…Clinical studies have demonstrated a close association between PD and liver disease, but most research has focused on the impact of liver disorders on brain damage in PD, and further exploration is needed to understand the pathways and mechanisms underlying liver damage in patients with PD.Methods: This study employs Mendelian Randomization (MR) and transcriptomic analysis to investigate the causal impact of PD-related brain damage on liver health, identifying serum metabolites (eg, cysteine) and shared immune-inflammatory pathways as mediators.Results: The study indicates that PD-related brain damage does indeed have an impact on liver metabolic function. …”
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Between Two Extremes: Tripsacum dactyloides Root Anatomical Responses to Drought and Waterlogging by Joel F. Swift, Desi Thimesch, Lucas Bengfort, Shahzaib Asif, Maggie R. Wagner

“…These findings highlight spatial variation in root anatomical responses to water stress and provide a framework that can inform sampling protocols for various other data types where sampling effort is limiting (e.g., microbiome, transcriptome, proteome).…”
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RNA-Seq analysis reveals the long noncoding RNAs associated with immunity in wild Myotis myotis bats by Sebastien Riquier, Samuel Carthy, Graham M. Hughes, Frederic Touzalin, Wilfried Haerty, Zixia Huang, Emma C. Teeling

“…From these variations, we identified lncRNAs most likely associated with immune response in bats. …”
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Deep spatial sequencing revealing differential immune responses in human hepatocellular carcinoma by Yan-Ping Yu, Caroline Obert, Bao-Guo Ren, Marielle Krivit, Kyle Metcalfe, Jia-Jun Liu, Jia-Jun Liu, Tuval Ben-Yehezkel, Silvia Liu, Silvia Liu, Jian-Hua Luo

“…Hepatocellular carcinoma (HCC) is one of the most lethal cancers for humans. HCC is highly heterogeneous. …”
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Air particles from 31 Chinese cities induced differential cellular responses by Zhang Lu, Liu Huaying, Xing Qisong, Chen Haoxuan, Yao Maosheng

“…Results from cell-released volatile organic compounds (VOCs), transcriptome, and proteome showed large variations in responses of the cells with the exposure. …”
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Single-cell analysis of arthritogenic alphavirus-infected human synovial fibroblasts links low abundance of viral RNA to induction of innate immunity and arthralgia-associated gene... by Fabian Pott, Dylan Postmus, Richard J. P. Brown, Emanuel Wyler, Elena Neumann, Markus Landthaler, Christine Goffinet

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Behavioral, physiological and genetic responses of the Yesso scallop Mizuhopecten yessoensis to the predation of sea star by Xuetao Li, Xuetao Li, Xuetao Li, Xian Li, Xian Li, Danyang Li, Danyang Li, Dandan Zhang, Xingyue Zhai, Xubo Wang, Xubo Wang, Junxia Mao, Junxia Mao, Ying Tian, Ying Tian, Ming Liu, Yaqing Chang, Yaqing Chang, Zhenlin Hao, Zhenlin Hao

“…Enzyme assays indicated significant changes in superoxide dismutase (SOD), catalase (CAT), arginine kinase (AK), and octopine dehydrogenase (ODH) across different tissues and size groups, with the most pronounced responses observed in medium - sized individuals. …”
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The seminal vesicle is a juvenile hormone-responsive tissue in adult male Drosophila melanogaster by Yoshitomo Kurogi, Yosuke Mizuno, Ryosuke Hayashi, Krystal Goyins, Naoki Okamoto, Lacy Barton, Ryusuke Niwa

“…Starting from published transcriptomic and proteomics datasets, we next identified Lactate dehydrogenase as a JH-response gene expressed in the seminal vesicle epithelium, suggesting insect seminal vesicles undergo metabolic regulation by JH. …”
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Molecular mechanisms of ageing in cancer development and therapeutic response: Translational implications for precision oncology by Laiba Husain

“…Abstract Background The intricate relationship between cellular ageing processes and cancer development represents one of the most significant challenges in contemporary oncology. …”
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Evolutionary responses of Escherichia coli to phage pressure: insights into mucoidy and colanic acid overexpression by Laurie C. Piché, Sophie Bories, Viacheslav Liato, Valérie E. Paquet, Linda Saucier, Marie-Pierre Létourneau-Montminy, Steve J. Charette, Rodrigue Dubar, Simon J. Labrie, Patrick Lagüe, Antony T. Vincent

“…Results In most cases, phage resistance resulted in a significant increase in mucoidy. …”
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Combined multi-omics and physiological approaches to elucidate drought-response mechanisms of durum wheat by Osvin Arriagada, Claudio Meneses, Romina Pedreschi, Romina Pedreschi, Gerardo Núñez-Lillo, Carlos Maureira, Samantha Reveco, Valentina Villarroel, Úrsula Steinfort, Francisco Albornoz, Patricia Cabas-Lühmann, Manuela Silva, Iván Matus, Andrés R. Schwember

“…IntroductionDurum wheat is the most important cereal in the Mediterranean regions, where drought negatively affects grain yield. …”
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Identification of Differentially Expressed Drought-Responsive Genes in Guar [Cyamopsis tetragonoloba (L.) Taub] by Aref Alshameri, Fahad Al-Qurainy, Abdel-Rhman Gaafar, Salim Khan, Mohammad Nadeem, Saleh Alansi, Hassan O. Shaikhaldein, Abdalrhaman M. Salih

“…Drought remains one of the most serious environmental stresses because of the continuous reduction in soil moisture, which requires the improvement of crops with features such as drought tolerance. …”
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The Peptide-Encoding <i>CLE25</i> Gene Modulates Drought Response in Cotton by Dayong Zhang, Qingfeng Zhu, Pu Qin, Lu Yu, Weixi Li, Hao Sun

“…CLAVATA3 (CLV3)/endosperm surrounding region (CLE) peptides have been reportedly involved in plant growth and development, as well as responses to abiotic stresses. However, the stress resilience of most <i>CLE</i> genes in cotton remains largely unknown. …”
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