Overcoming multi-drug resistance in SCLC: a synergistic approach with venetoclax and hydroxychloroquine targeting the lncRNA LYPLAL1-DT/BCL2/BECN1 pathway by Shuxin Li, Jianyi Lv, Zhihui Li, Qiuyu Zhang, Jing Lu, Xueyun Huo, Meng Guo, Xin Liu, Changlong Li, Jinghui Wang, Hanping Shi, Li Deng, Zhenwen Chen, Xiaoyan Du

“…Results Our findings revealed that LYPLAL1-DT is upregulated in chemoresistant SCLC cell lines. Gain- and loss-of-function assays demonstrated that LYPLAL1-DT impairs sensitivity to cDDP, VP-16, or PTX both in vitro and in vivo. …”
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Weight bias in mental health settings: a scoping review by Samantha R. Philip, Erin C. Standen, Jordan Schueler, Sherecce A. Fields, Sean M. Phelan, Sean M. Phelan

“…IntroductionWeight bias is a pervasive form of prejudice, most deeply and directly harming individuals in larger bodies. …”
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Analisis Status Keberlanjutan Sumber Mata Air Senjoyo pada Dimensi Ekologi dengan Metode RAP-WARES (Rapid Appraissal for Water Resources) by Anggia Agatha Reza, Desti Christian Cahyaningrum, Susanti Pudji Hastuti

“…Also, the analysis process that is repeated is stable and errors in data entry and loss can be avoided. Based on the sensitivity analysis, there are two most sensitive attributes, namely the attribute of protection against rivers and springs (change in RMS 3.50%), and attributes of tourism activities (change in RMS 3.20%). …”
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Improving the conditions of regional hemodinamics of the eyes as a method of treatment in optic neuropathy at short-sightedness of high degree. by N. G. Zavgorodnyaya, O. O. Denisova, N. A. Vesnina, N. A. Kudinova- Savchenko

“…Patients in the control group in most cases achieved stabilization of the process, there was a negative trend of visual function during long-term follow-up. …”
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Effectiveness assessment of the bifidobacteria encapsulation when enriching juice-containing beverages with probiotics by O. P. Neverova, O. V. Zinina, Ch. Li, Zh. Liang, M. B. Rebezov, E. A. Vishnyakova, E. S. Barykina

“…Beverages are among the most popular types of products that attract attention of researchers for enrichment with functional ingredients. …”
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Identification of Selection Signatures Related to Johne\'s Disease in Iranian Holstein Cows using Genomic Data by Fateme Navoshki, Hossein Moradi shahr babak, Ali Sadeghi Sefid Mazgi, johann soelkner

“…The economic consequences of Johne's disease include reduced production, loss of genetic value, increased sensitivity to other diseases, increased interval between calving, weight loss, reduced carcass value, reduced fertility (due to reduced serum progesterone formation and corpus luteum), decreased quality and quantity of milk (decreasing fat and protein and increasing somatic cells in milk), and premature elimination. …”
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Determining the Cost-Effective Methods for Heat Exchanger Maintenance Using Extreme Value Analysis (EVA) Ask ChatGPT by Anne Ting Ai Nee, Ainul Akmar Mokhtar, Noor Hazliza A Latip, Farah Nur Faizul, Nurul Hazwani Azmi

“…The mean remaining helpful life was calculated using the best-fit life data analysis distribution, and the estimated number of tubes approaching 40% wall loss was also determined. This evaluation is critical for forecasting the functional lifespan of the heat exchangers and deciding whether tube plugging, retubing, or replacement is the most cost-effective option against operational risk during the upcoming planned shutdown or turnaround phase. …”
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Application of Glucomannan by Sonia Sharma, Neeraj Wadhwa

“…It may also be useful in treatment of chronic constipation, decreasing serum cholesterol, and increasing insulin sensitivity. As a food supplement it could play a significant role in weight loss. …”
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BCDCNN: breast cancer deep convolutional neural network for breast cancer detection using MRI images by D. E. Martina Jaincy, V. Pattabiraman

“…Afterwards, feature extraction is done and finally, BCD is conducted employing BCDCNN, wherein the loss function is newly designed based on an adaptive error similarity. …”
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Auditory processing and its cognitive correlates in older adults with mild cognitive impairment by Leelavathi Thamizhmani, Kanaka Ganapathy, Hari Prakash Palaniswamy, Arivudai Nambi Pitchaimuthu, Prabha Adhikari M. R.

“…While studies indicate that all auditory processing domains are impacted, it remains unclear which domain most significantly correlates with cognitive functions in MCI, warranting further investigation into these relationships. …”
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GES-YOLO: A Light-Weight and Efficient Method for Conveyor Belt Deviation Detection in Mining Environments by Hongwei Wang, Ziming Kou, Yandong Wang

“…Finally, to improve the detection capability for small objects such as conveyor rollers, we introduce the Scaled Intersection over Union (SIoU) loss function, enabling the algorithm to sensitively detect rollers and provide a precise localization for deviation detection. …”
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Is colloidal oat an effective emollient ingredient for the prevention and treatment of atopic dermatitis in infants? by Joseph F. Fowler, Lin Ma, James Bergman, Paul Horowitz, Tina Lavender, Lawrence F. Eichenfield, Zoe Draelos, Simon G. Danby, Michael J. Cork

“…Concerns about oat sensitization remain unsubstantiated in most studies.Conclusion Colloidal oat emollients are effective, well-tolerated, and cost-efficient for pediatric AD management. …”
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Optimal power flow using recent red-tailed hawk optimization algorithm by Ahmed M Nassef, Mohammad Ali Abdelkareem, Mohamed Louzazni

“…The optimal power flow (OPF) solution determines the most efficient and secure operating point by considering certain objective functions and ensuring the system's operational restrictions are met. …”
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Omega-3 Polyunsaturated Fatty Acids Effect on Neuropathy of the Peripheral Nervous System in Dietary Obese Rats: Is the Source of These Fatty Acids Important for Outcome? by Davidson E, Obrosov O, Coppey L, Yorek M

“…Eric Davidson,1 Oleksandr Obrosov,1 Lawrence Coppey,1 Mark Yorek1– 4 1Department of Internal Medicine, University of Iowa, Iowa City, IA, USA; 2Department of Veterans Affairs Iowa City Health Care System, Iowa City, IA, USA; 3Veterans Affairs Center for the Prevention and Treatment of Visual Loss, Iowa City, IA, USA; 4Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA, USACorrespondence: Mark Yorek, Department of Veteran Affairs Iowa City Health Care System, Building 41, Room 127, Iowa City, IA, 52246, Tel +1-319-338-0581 ext. 637696, Fax +1-319-339-7162, Email mark-yorek@uiowa.eduObjective: To answer the question what is the best source or composition of omega-3 polyunsaturated fatty acids (PUFA) that will provide the most favorable and safe outcome for peripheral neuropathy (PN) in an animal model of obesity? …”
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Effect of foliar spray of Spermine and Spermidine on growth and some physiological characteristics of chickpea (Cicer arietinum L) under salt stress by Ali Ashori, Manoochehr Gholipoor, Mostafa Heidari

“…Salt stress, resulted from salts accumulation in soil solution is one the limiting factors for chickpea cultivation in arid and semiarid areas. Chickpea is a salt sensitive plant and yield loss is one of the most potential impacts of salinity on chickpea. …”
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Identification of SURF4 and RALGAPA1 as promising therapeutic targets in glioblastoma and pan-cancer through integrative multi-omics, CRISPR-Cas9 screening and prognostic meta-anal... by Fei Wang, Yuxuan Chen, Run Huang, Dengfeng Lu, Juyi Zhang, Yanbo Yang, Hanhan Dang, Meirong Liu, Zhouqing Chen, Xiaoou Sun, Zhong Wang

“…GBM multi-omics data from public and in-house cohorts validated that CD44 and SURF4 might be synthetic lethal partners of loss-of-function tumor suppressor genes. Analysis for immune-related pathway activity revealed complex regulation relationships of the four hub genes in tumor microenvironment (TME). …”
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Exploring the Role of p53 in Radiosensitivity: A Key Player in Cancer Therapy by Tusher- Al-Arafat, Aihong Mao, Takanori Katsube, Bing Wang

“…Its efficacy, however, is frequently challenged by the heterogeneous sensitivity of tumors and surrounding tissues to radiation. …”
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Unraveling the association and regulatory role of miR-146b-5p in coronary artery disease by Xiaozhu Ma, Shuai Mei, Yi He, Qidamugai Wuyun, Li Zhou, Ziyang Cai, Qiushi Luo, Yi Wen, Jiangtao Yan

“…Furthermore, gain- and loss-of-function experiments in THP-1 cells showed that miR-146b-5p inhibited inflammation, cell proliferation, and migration. …”
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RAU-Net for precise lung cancer GTV segmentation in radiation therapy planning by Huai-wen Zhang, Bo Hu, Jun Yang, Liang-li Xiong, Huan-huan Shi, Qi-liang Xiong, Chen Yi, Shao-feng Jiang

“…Ablation studies further confirmed the crucial role of the ROI extraction phase, attention mechanism, SE-Res module, and Combined Loss Function (CLoss) in enhancing segmentation performance. …”
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A novel approach to skin disease segmentation using a visual selective state spatial model with integrated spatial constraints by Yu Bai, Hai Zhou, Hongjie Zhu, Shimin Wen, Binbin Hu, Haotian Li, Huazhang Wang, Daji Ergu, Fangyao Liu

“…Additionally, we introduce a spatially-constrained loss function that mitigates gradient stability issues by considering the distance between label and prediction boundaries. …”
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