Dysosmia syndrome in COVID-19, сlinic, treatment and prevention by V. V. Skvortsov, V. B. Petrunicheva, D. I. Rodin

“…Since the olfactory function plays a large role in the life of every person, its loss can lead to discomfort, stress and limitation of various kinds of pleasures associated with the perception of smells, etc. …”
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The putative protein methyltransferase LAE1 of Trichoderma atroviride is a key regulator of asexual development and mycoparasitism. by Razieh Karimi Aghcheh, Irina S Druzhinina, Christian P Kubicek

“…In darkness, Δ lae1 strains did not sporulate, and the OElae1 strains produced as much spores as the parent strain. Loss-of-function of lae1 also abolished sporulation triggered by mechanical injury of the mycelia. …”
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Bio-inspired biomaterial coating for enzyme responsive release of antimicrobial peptides by Dennis A. Böhner, Karin Mörl, Annette G. Beck-Sickinger

“…Biofilm formation and implant-associated infections, potentially leading to periprosthetic bone loss and subsequent loss of osseointegration, remain high-risk factors for failure of implants. …”
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Lower reclamation of coastal lagoon conserves higher waterbird assemblage phylogenetic diversity by Xianli Che, Min Zhang, Wangming Li, YanYan Zhao, Xuebing Zhao, Yisheng Peng, Alexandra Ashley Grossi, Zhaohui Pang, Fasheng Zou

“…Natural habitat loss caused by wetland reclamation is one of the most important causation for waterbird decline worldwide. …”
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Spotlight on the Mechanism of Action of Semaglutide by Ilias Papakonstantinou, Konstantinos Tsioufis, Vasiliki Katsi

“…Initially intended to control blood glucose levels in patients with type 2 diabetes, semaglutide, a potent glucagon-like peptide 1 analogue, has been established as an effective weight loss treatment by controlling appetite. Integrating the latest clinical trials, semaglutide in patients with or without diabetes presents significant therapeutic efficacy in ameliorating cardiometabolic risk factors and physical functioning, independent of body weight reduction. …”
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The neurochemistry of peripheral nerve regeneration by Andreea Benga, Fatih Zor, Ahmet Korkmaz, Bogdan Marinescu, Vijay Gorantla

“…Peripheral nerve injuries (PNIs) can be most disabling, resulting in the loss of sensitivity, motor function and autonomic control in the involved anatomical segment. …”
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Long-Term Moderate-Level Noise Exposure Caused Hyperexcitability in the Central Auditory System by Fei Xu, Guangdi Chen, Li Li, Wei Sun

“…Noise exposure is one of the most common causes of hearing loss and hyperacusis. …”
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SBDS-Deficient Cells Have an Altered Homeostatic Equilibrium due to Translational Inefficiency Which Explains their Reduced Fitness and Provides a Logical Framework for Interventio... by Piera Calamita, Annarita Miluzio, Arianna Russo, Elisa Pesce, Sara Ricciardi, Farhat Khanim, Cristina Cheroni, Roberta Alfieri, Marilena Mancino, Chiara Gorrini, Grazisa Rossetti, Ivana Peluso, Massimiliano Pagani, Diego L Medina, Johanna Rommens, Stefano Biffo

“…Ribosomopathies are a family of inherited disorders caused by mutations in genes necessary for ribosomal function. Shwachman-Diamond Bodian Syndrome (SDS) is an autosomal recessive disease caused, in most patients, by mutations of the SBDS gene. …”
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Multiple mechanisms of aminoglycoside ototoxicity are distinguished by subcellular localization of action by Patricia Wu, Patricia Wu, Francisco Barros-Becker, Francisco Barros-Becker, Roberto Ogelman, Roberto Ogelman, Esra D. Camci, Esra D. Camci, Tor H. Linbo, Tor H. Linbo, Julian A. Simon, Edwin W. Rubel, David W. Raible, David W. Raible, David W. Raible

“…Conversely delayed death is associated with lysosomal accumulation and is reduced by altering endolysosomal function, while acute death is not sensitive to lysosomal manipulations. …”
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Patterns of obesity development before the diagnosis of type 2 diabetes: the Whitehall II cohort study. by Dorte Vistisen, Daniel R Witte, Adam G Tabák, Christian Herder, Eric J Brunner, Mika Kivimäki, Kristine Færch

“…They experienced an initial beta cell compensation followed by loss of beta cell function, whereas insulin sensitivity was relatively stable. …”
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High-resolution mapping of substantia nigra in Parkinson’s disease using 7 tesla magnetic resonance imaging by Christopher F. Madelung, Annemette Løkkegaard, Søren A. Fuglsang, Marta M. Marques, Vincent O. Boer, Kristoffer H. Madsen, Anne-Mette Hejl, David Meder, Hartwig R. Siebner

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The relevance of creating a new combined ophthalmic drug with anti-inflammatory and antibacterial effects by L. I. Kucherenko, D. V. Okolzin

“…These injuries often lead to serious consequences, including loss of vision or a significant decrease in its functions. …”
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p53 Immunohistochemistry Patterns Are Surrogate Biomarkers for TP53 Mutations in Gastrointestinal Neuroendocrine Neoplasms by Junjie Li, Jing Wang, Dan Su, Xiu Nie, Yueping Liu, Lianghong Teng, Junyi Pang, Huanwen Wu, Zhiyong Liang

“…Most cases with pattern A harboured loss-of-function (LOF) mutations, whereas patterns B and C tended to indicate wild-type TP53 and gain-of-function (GOF) mutations, respectively. …”
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The complete chloroplast genome sequence of Podocarpus lambertii: genome structure, evolutionary aspects, gene content and SSR detection. by Leila do Nascimento Vieira, Helisson Faoro, Marcelo Rogalski, Hugo Pacheco de Freitas Fraga, Rodrigo Luis Alves Cardoso, Emanuel Maltempi de Souza, Fábio de Oliveira Pedrosa, Rubens Onofre Nodari, Miguel Pedro Guerra

“…These results reinforce the apparently loss of rps16 gene in Podocarpaceae cp genome. In addition, several SSRs in the P. lambertii cp genome are likely intraspecific polymorphism sites, which may allow highly sensitive phylogeographic and population structure studies, as well as phylogenetic studies of species of this genus.…”
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Modelling of Regional Economy Growth Strategy by I. S. Mezhov, E. V. Kletskova

“…The argument in favor of this approach is that the development of most regions is experiencing a deficit of investment resources from year to year, the need for subsidies of regional budgets, the loss of production and jobs. …”
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qBiCo: a method to assess global DNA conversion performance in epigenetics via single-copy genes and repetitive elements by Faidra Karkala, Roy B. Simons, Floor Claessens, Vivian Kalamara, Manfred Kayser, Athina Vidaki

“…Abstract Background Human DNA methylation profiling offers great promises in various biomedical applications, including ageing, cancer and even forensics. So far, most DNA methylation techniques are based on a chemical process called sodium bisulfite conversion, which specifically converts non-methylated cytosines into uracils. …”
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Crop classification with deep convolutional neural network based on crop feature by Mohamad Reza Gili, Davoud Ashourloo, Hosein Aghighi, Ali Akbar Matkan, Alireza SHakiba

“…Then the algorithm was implemented using these feature channels in the test area and the overall accuracy was upgraded to 86% and the kappa coefficient to 0.82 compared to which indicated a significant improvement in the results compared to the previous case.Conclusion:The deep convolutional neural network is very sensitive to the type of input channels for detecting agricultural crops and selecting the channels with suitable tempo-spectral characteristics for different types of crops, has a great impact on the accuracy of network training and can reduce the loss of training network and increase its efficiency in the classification of various crops.…”
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The role of p53-microRNA 200-Moesin axis in invasion and drug resistance of breast cancer cells by Farheen Alam, Fatima Mezhal, Hussain EL Hasasna, Vidhya A Nair, SR Aravind, Maha Saber Ayad, Ahmed El-Serafi, Wael M Abdel-Rahman

“…After Moesin silencing, the p53-mutant cells 1001 reverted from mesenchymal-to-epithelial phenotype and showed subtle reduction in migration and invasion and loss of ZEB1 and SNAIL expression. Interestingly, Moesin silencing restored the 1001 sensitivity to Doxorubicin. …”
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Health economic evaluation of risdiplam in patients with spinal muscular atrophy by А. S. Kolbin, А. А. Kurylev, Yu. Е. Balykina, М. А. Proskurin, S. А. Mishinova

“…Spinal muscular atrophies (SMA) are clinically and genetically heterogenous inherited orphan diseases leading to progressive spinal motoneurons degeneration and loss of function. Risdiplam and nusinersen are both authorized in Russia for pathogenic SMA treatment and included in the list of vital and essential drugs.Objective: health economic evaluation of risdiplam (Evrysdi®) in patients with spinal muscular atrophy.Material and methods. …”
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