Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol. by Fabrice E Graf, Philipp Ludin, Tanja Wenzler, Marcel Kaiser, Reto Brun, Patient Pati Pyana, Philippe Büscher, Harry P de Koning, David Horn, Pascal Mäser

“…The predominant mechanism of drug resistance in African trypanosomes is decreased drug uptake due to loss-of-function mutations in the genes for the transporters that mediate drug import. …”
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Global analysis of forest tipping points leading to changing water cycle dynamics by Marisol Domínguez-Tuda, Hugo A. Gutiérrez-Jurado

“…Critical thresholds were derived by fitting Richard’s Curve function to the observed relationship between growing sensitive area and tree cover loss. …”
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Medical foods in Alzheimer’s disease by Klaus W. Lange, Jianjun Guo, Shigehiko Kanaya, Katharina M. Lange, Yukiko Nakamura, Shiming Li

“…Improvements in symptomatology and regional brain atrophy in AD have been claimed for several medical foods, for example, those providing ketone bodies as alternative energy supply to neurons, those containing precursors believed to improve synaptic function, and those addressing oxidative stress related to memory loss. …”
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Leber hereditary optic neuropathy: utilities and carer burden from British and Irish participants by Claire Lawrence, Emma Williams, Andrew Mumford, Steve Bojakowski, Julio Benedicto, Andrew Lloyd

“…Abstract Background Leber hereditary optic neuropathy (LHON) is a rare, maternally inherited, mitochondrial disease resulting in sudden, progressive central vision loss. The condition affects numerous aspects of daily life, functioning and overall health-related quality of life (HRQL), which may spillover to carers. …”
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Recommendations for the diagnosis and treatment of alpha-1 antitrypsin deficiency by Paulo Henrique Ramos Feitosa, Maria Vera Cruz de Oliveira Castellano, Claudia Henrique da Costa, Amanda da Rocha Oliveira Cardoso, Luiz Fernando Ferreira Pereira, Frederico Leon Arrabal Fernandes, Fábio Marcelo Costa, Manuela Brisot Felisbino, Alina Faria França de Oliveira, Jose R Jardim, Marc Miravitlles

“…Although pulmonary densitometry appears to be the most sensitive measure of emphysema progression, it should not be used in routine clinical practice to monitor patients. …”
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Neuronal cell type specific roles for Nprl2 in neurodevelopmental disorder-relevant behaviors by Brianne Dentel, Lidiette Angeles-Perez, Abigail Y. Flores, Katherine Lei, Chongyu Ren, Andrea Pineda Sanchez, Peter T. Tsai

“…Loss of function in the subunits of the GTPase-activating protein (GAP) activity toward Rags-1 (GATOR1) complex, an amino-acid sensitive negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), is implicated in both genetic familial epilepsies and Neurodevelopmental Disorders (NDDs) (Baldassari et al., 2018). …”
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Private Data Protection with Machine Unlearning in Contrastive Learning Networks by Kongyang Chen, Zixin Wang, Bing Mi

“…The approach introduces a third-party dataset to ensure that the model’s outputs for forgotten data align with those of the third-party dataset, thereby removing identifiable training traces. A comprehensive loss function is designed, encompassing three objectives: preserving model accuracy, constraining gradients to make forgotten and third-party data indistinguishable, and reducing model confidence on the third-party dataset. …”
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Visual Electrodiagnostic Testing in Birdshot Chorioretinopathy by Radouil Tzekov, Brian Madow

“…Birdshot chorioretinopathy (BSCR) is a rare form of autoimmune posterior uveitis that can affect the visual function and, if left untreated, can lead to sight-threatening complications and loss of central vision. …”
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Modern solutions for maintaining of skin pH with dermatocosmetic care products by N. V. Zilberberg, A. I. Polishchuk

“…The article summarizes the clinical experience of the combined use of innovative cosmetic product line for the treatment of dry, sensitive, and prone to irritation skin. Results of assessment of morphofunctional and clinical state of skin (hydration level, dryness, transepidermal water loss), demonstrate the beneficial effects of using the line of specialized cosmetic products with pH 5.0 to restore the protective function of skin and maintain an optimal level of skin hydration.…”
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Brain-specific rescue of Clock reveals system-driven transcriptional rhythms in peripheral tissue. by Michael E Hughes, Hee-Kyung Hong, Jason L Chong, Alejandra A Indacochea, Samuel S Lee, Michael Han, Joseph S Takahashi, John B Hogenesch

“…Interestingly, the vast majority of core clock genes in liver were responsive to Clock expression in the SCN, suggesting that core clock genes in peripheral tissues are intrinsically sensitive to SCN cues. Nevertheless, most circadian output in the liver was absent or severely low-amplitude in Clock-rescue animals, demonstrating that the majority of peripheral transcriptional rhythms depend on a fully functional local circadian oscillator. …”
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MaskMyPy: python tools for performing and analyzing geographic masks by David Swanlund, Nadine Schuurman

“…Conclusion MaskMyPy makes it easy to apply a variety of geographic masks to a set of sensitive points and then measure which mask provided the most privacy while suffering the least information loss. …”
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The Short-Term Efficacy of Straw Incorporation on Soil Detachment in Sloping Farmland by Chong Yao, Songzhu Ye, Siyuan Chen, Zhijia Gu, Wei Yan, Ming Zhu, Li Song, Mingjun Zhang, Faqi Wu

“…The <i>Dc</i> exhibited a power function relationship with hydraulic parameters and stream power was the most appropriate hydraulic variable to express <i>Dc</i> for different straw incorporation rates. …”
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MYT1L deficiency impairs excitatory neuron trajectory during cortical development by Allen Yen, Simona Sarafinovska, Xuhua Chen, Dominic D. Skinner, Fatjon Leti, MariaLynn Crosby, Jessica Hoisington-Lopez, Yizhe Wu, Jiayang Chen, Zipeng A. Li, Kevin K. Noguchi, Robi D. Mitra, Joseph D. Dougherty

“…While MYT1L can both activate and repress gene expression, the repressive effects are most sensitive to haploinsufficiency, likely mediating MYT1L syndrome. …”
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Multiple drug resistance caused by germline mutation of exon 27 of BRCA2 gene in triple-negative breast cancer: a case report and literature review by Yuting Li, Guojie Xu, Liling Zhang, Kewei Zhao, Yanxia Zhao, Dan Han

“…Mutations in these genes lead to the loss of function of their respective proteins, resulting in HRD and the development of hereditary breast cancer. …”
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Evaluation of coagulation factors in fresh frozen plasma treated with riboflavin and ultraviolet light by Antić Ana, Stanojković Zoran, Mačukanović-Golubović Lana, Jelić Marija

“…Comparing the middle values of coagulation factors in the control and illuminated units we noticed their statistically significant decrease in illuminated units (p &lt; 0.001), but the activity of coagulation ones was still in the reference range. The most sensitive coagulation factors to photoinactivation were FVIII, FIX and FXI (21.99%, 20.54% and 17.26% loss, respectively). …”
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A compositional model for effort‐aware Just‐In‐Time defect prediction on android apps by Kunsong Zhao, Zhou Xu, Meng Yan, Lei Xue, Wei Li, Gemma Catolino

“…More specifically, KPIDL first exploits a feature learning technique to preprocess original data for obtaining better feature representation, and then introduces a state‐of‐the‐art cost‐sensitive cross‐entropy loss function into the deep neural network to alleviate the class imbalance issue by considering the prior probability of the two types of classes. …”
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Effects of chilling on photosynthesis citrus in different soil moisture conditions by ZHANG Fang, TANG Xiao-yun

“…Effects of chilling on photosynthesis could be a function of soil moisture conditions. For plants with adequate water supply, Pn and Gs of their leaves were significantly reduced by chilling. …”
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HarmGR13 mediates myo-inositol taste perception in Helicoverpa armigera larvae. by Yu-Sheng Tan, Bao-Tong Mo, Guo-Cheng Li, Yu-Ruo Guo, Jian-Zhen Zhang, Chen-Zhu Wang

“…Myo-inositol, a sugar alcohol produced by most plants, serves as a nutrient and feeding stimulant for many phytophagous insects. …”
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CGD-CD: A Contrastive Learning-Guided Graph Diffusion Model for Change Detection in Remote Sensing Images by Yang Shang, Zicheng Lei, Keming Chen, Qianqian Li, Xinyu Zhao

“…The network is trained with a carefully crafted contrastive loss function to effectively capture high-level structural information. …”
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Distinct Phenotypes Caused by Mutation of MSH2 in Trypanosome Insect and Mammalian Life Cycle Forms Are Associated with Parasite Adaptation to Oxidative Stress. by Viviane Grazielle-Silva, Tehseen Fatima Zeb, Jason Bolderson, Priscila C Campos, Julia B Miranda, Ceres L Alves, Carlos R Machado, Richard McCulloch, Santuza M R Teixeira

“…<h4>Conclusions/significance</h4>Taken together, these results indicate MSH2 displays conserved, dual roles in MMR and in the response to oxidative stress. Loss of the latter function results in life cycle dependent differences in phenotypic outcomes in T. brucei MSH2 mutants, most likely because of the greater burden of oxidative stress in the insect stage of the parasite.…”
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