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The State of High‐Resolution Imaging of the Human Inner Ear: A Look Into the Black Box
Published 2025-07-01“…These cells are highly mechano‐ and chemo‐sensitive, and their death or dysfunction underlie the vast majority of hearing loss. …”
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The HOPS and vCLAMP protein Vam6 connects polyphosphate with mitochondrial function and oxidative stress resistance in Cryptococcus neoformans
Published 2025-04-01“…In particular, we found that mutants lacking the Vam6 protein had altered mitochondrial function, and that the mutants were perturbed for additional mitochondria and vacuole-related phenotypes (e.g., membrane composition, polyphosphate accumulation, and drug sensitivity). …”
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Modeling future sediment retention service in the Bagh-e-Shadi Forest protected area using InVEST and the ACCESS-ESM1-5 climate model
Published 2025-01-01“…IC0 and kb are calibration factors that shape the sigmoid function in the SDR–IC relationship. From 1997 to 2021, our findings indicated that the study area experienced an average annual soil loss of 77.1 t ha−1 year−1. …”
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Targeting DDX3 with a small molecule inhibitor for lung cancer therapy
Published 2015-03-01“…Mechanistically, loss of DDX3 function either by shRNA or by RK‐33 impaired Wnt signaling through disruption of the DDX3–β‐catenin axis and inhibited non‐homologous end joining—the major DNA repair pathway in mammalian somatic cells. …”
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Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats
Published 2025-05-01“…This is the first study to use MRI to follow functional changes in brain activity in response to different doses of psilocybin in fully awake, drug naive rats. …”
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Stability Analysis of a Fractional Epidemic Model Involving the Vaccination Effect
Published 2025-03-01“…The model differs from other <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>S</mi><mi>V</mi><mi>I</mi><mi>R</mi></mrow></semantics></math></inline-formula> models given in the literature in its progressive process with a distributed delay in the loss of the protective effect provided by the vaccine. …”
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Impact of an upper limb motion-driven virtual rehabilitation system on residual motor function in patients with complete spinal cord injury: a pilot study
Published 2025-03-01“…Due to the prolonged loss of motor control and peripheral sensory input, patients may struggle to effectively activate residual motor function during sEMG assessments. …”
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Screening and comprehensive evaluation of low nitrogen tolerance of Zhejiang photosensitive japonica rice cultivars
Published 2016-09-01“…Nitrogen is the most important mineral nutrient taken in from the soil by plants. …”
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Assessing the Performance of Daily Intake of a Homotaurine, Carnosine, Forskolin, Vitamin B2, Vitamin B6, and Magnesium Based Food Supplement for the Maintenance of Visual Function...
Published 2020-01-01“…At each check-up, patients were given a full eye test including perimetry, RNFL, and GCC using FD-OCT, PERG, contrast sensitivity, and QoL evaluation using the Glaucoma Symptom Scale questionnaire and National Eye Institute Visual Function Questionnaire 25. …”
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Assessments of prostate cancer cell functions highlight differences between a pan‐PI3K/mTOR inhibitor, gedatolisib, and single‐node inhibitors of the PI3K/AKT/mTOR pathway
Published 2025-01-01“…Metastatic castration‐resistant prostate cancer (mCRPC) is characterized by loss of androgen receptor (AR) sensitivity and oncogenic activation of the PI3K/AKT/mTOR (PAM) pathway. …”
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The RNA export factor, Nxt1, is required for tissue specific transcriptional regulation.
Published 2013-06-01“…We additionally find that transcripts from intron-less genes are more sensitive to loss of Nxt1 function than those from intron-containing genes and propose a mechanism in which transcript processing feeds back to increase activity of a tissue specific transcription complex.…”
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On shrinkage covariance estimators: how inefficient is 1/N strategy of covariance estimation for portfolio selection in foreign exchange market?
Published 2024-12-01“…This study challenges theoretically rigorous shrinkage covariance estimators using multiple evaluation metrics: systematic loss function, risk profile of minimum variance portfolios, Herfindahl index, financial efficiency, and concentration level. …”
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The essential clathrin adapter protein complex-2 is tumor suppressive specifically in vivo
Published 2025-03-01“…In tumors, alternative iron transport pathways allow pro-tumor effects of Adapter Protein complex-2 loss to manifest. In the most sensitive case, this is attributed to reprogramming the plasma membrane proteome, retaining integrins on the surface leading to Focal Adhesion Kinase phosphorylation and induction of proliferative signals. …”
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Suppression of the T-dependent antibody response following oral exposure to selected polycyclic aromatic compounds in B6C3F1/N mice
Published 2025-03-01“…Antibody suppression was associated with significant immune cell loss in the spleen; however, it was clear that the suppression of the TDAR was more sensitive than cell loss indicating that cell function impairments were involved. …”
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A road lane detection approach based on reformer model
Published 2025-03-01“…At present, road lane detection methods based on Transformer model are currently considered to be most effective and accurate; however, Transformer model-based road lane detection methods still have their own drawbacks, like high computational complexity of attention mechanisms and defects in activation function and loss functions. …”
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The Acinar Cage: Basement Membranes Determine Molecule Exchange and Mechanical Stability of Human Breast Cell Acini.
Published 2015-01-01“…Notably, an intact collagen IV mesh proved to be essential for this permeation function. Furthermore, we performed ultra-sensitive atomic force microscopy to quantify the response of native breast acini and of decellularized basement membrane shells against mechanical indentation. …”
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