BRCA loss of function including BRCA1 DNA-methylation, but not BRCA-unrelated homologous recombination deficiency, is associated with platinum hypersensitivity in high-grade ovaria... by Heidelinde Fiegl, Simon Schnaiter, Daniel U. Reimer, Katharina Leitner, Petra Nardelli, Irina Tsibulak, Verena Wieser, Katharina Wimmer, Esther Schamschula, Christian Marth, Alain G. Zeimet

“…Here we tested the hypothesis that BRCA loss of function (LOF) due to epigenetic or genetic aberrations is a better predictor for the clinical outcome than HRD. …”
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Impact on Metabolism Generated by Surgical and Pharmacological Interventions for Weight Loss in Women with Infertility by Paulo César Gete Palacios, Alberto Moscona-Nissan, Renata Saucedo, Aldo Ferreira-Hermosillo

“…On the other hand, pharmacological treatments such as glucagon-like-peptide 1 receptor agonists offer non-invasive alternatives with promising results in body weight, improving insulin sensitivity and restoring ovarian function. However, their use must be discontinued before conception due to potential fetal risks. …”
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A Surrogate Piecewise Linear Loss Function for Contextual Stochastic Linear Programs in Transport by Qi Hong, Mo Jia, Xuecheng Tian, Zhiyuan Liu, Shuaian Wang

“…Traditional two-stage frameworks separate prediction and optimization, which can lead to suboptimal decisions, as minimizing prediction error does not necessarily minimize decision loss. To address this limitation, inspired by the smart predict-then-optimize framework, we introduce a novel tunable piecewise linear loss function (PLLF). …”
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The effect of fasciolosis invasion on the protein-synthesizing function of the liver in cows sensitized by atypical mycobacteria and the influence of corrective fac-tors by O. V. Kuljaba, V. V. Stybel, D. F. Gufrij, B. V. Gutyj, V. S. Pykaliuk, U. M. Vus, Kh. Ya. Leskiv, T. О. Pundiak, T. V. Martyshuk

“…Among the most common parasitic pathologies in ruminants, trematode diseases, particularly fascioliasis, occupy a leading position in terms of severity and the economic losses they cause. …”
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Environmental stressors drive fungal community homogenization and diversity loss in plateau freshwater lakes by Kai Fang, Zheng-Quan Zhang, Hong-Wei Shen, Yong-Zhong Lu, Lin Yang, Zong-Long Luo

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Characterization and drug sensitivity of a novel human ovarian clear cell carcinoma cell line genomically and phenotypically similar to the original tumor by Miriam Franklin, Lucy Gentles, Elizabeth Matheson, Nick Bown, Paul Cross, Angela Ralte, Connor Gilkes‐Immeson, Alice Bradbury, Maryam Zanjirband, John Lunec, Yvette Drew, Rachel O'Donnell, Nicola J. Curtin

“…They have a very high degree of loss of heterozygosity (LOH) affecting approximately 85% of the genome, mostly copy neutral and almost identical to the original tumor. …”
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Clinical and functional characterization of the GABRB3 p.Met80Val variant in early-onset epilepsy with long-term follow-up by Ran Hua, Junhong Jiang, Baotian Wang, Zihao Zhu, Juan Wang, De Wu, Li Yang

“…Noteworthy, GABRB3 variants can result in both gain-of-function and loss-of-function effects. However, their precise functional and clinical implications remain unknown. …”
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Ribosomal DNA copy number loss and sequence variation in cancer. by Baoshan Xu, Hua Li, John M Perry, Vijay Pratap Singh, Jay Unruh, Zulin Yu, Musinu Zakari, William McDowell, Linheng Li, Jennifer L Gerton

“…Ribosomal DNA is one of the most variable regions in the human genome with respect to copy number. …”
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Association between the number of pregnancies and hearing loss: NHANES 1999–2018 by Haohong Lai, Juntao Wu, ZhuoYi Chen, Minqian Gao, Haidi Yang

“…Sensitivity analyses, including alternative definitions of hearing loss and multiple imputation for missing covariates, confirmed the robustness of the results. …”
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Ovarian cancer: new accents treatment of patients with platinum-sensitive relapses by A. G. Kedrova, A. G. Nikitin, V. V. Kosyy, M. V. Yurova

“…The commonality of these tumors is caused by the same type of coelomic epithelium of mesodermal origin of the rudiments of Müllerian ducts, as well as similarities in the ways of carcinogenesis: the loss or inactivation of the tumor suppressor TP53, loss of function of proteins BRCA1 and BRCA2 – the controllers of DNA repair and genome integrity. …”
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Ultra-sensitive terahertz photonic crystal fiber sensor for detection of tuberculosis by Md. Safiul Islam, A.H.M. Iftekharul Ferdous, Abdullah Al Mamun, Md. Shamim Anower, Md. Jakir Hossen, Syed Udoy Ahmed

“…The sensor that has been designed exhibits a high relative sensitivity (ranging from 99.72 % to 99.95 %) and minimal losses when compared to previous detectors incorporating PCF. …”
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MicroRNA: sex steroids, hormonal carcinogenesis, hormonal sensitivity of tumor tissue by A. V. Malek, L. M. Bershtein

“…Malignant transformation leads to a distortion of the regulatory effects of sex hormones that crucially influence the system of microRNA-regulated post-transcriptional control of gene expression. The most established and clinically significant example of such phenomenon is the loss of sensitivity of cells to the regulatory action of these hormones. …”
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Machine learning algorithm based on combined clinical indicators for the prediction of infertility and pregnancy loss by Rui Zhang, Yuanbing Guo, Xiaonan Zhai, Juan Wang, Xiaoyan Hao, Liu Yang, Lei Zhou, Jiawei Gao, Jiayun Liu

“…Three methods were used for screening 100+ clinical indicators, and five machine learning algorithms were used to develop and evaluate diagnostic models based on the most relevant indicators.ResultsMultivariate analysis revealed significant differences in several factors between the patients and the control group. 25-hydroxy vitamin D3 (25OHVD3) was the factor exhibiting the most prominent difference, and most patients presented deficiency in the levels of this vitamin. 25OHVD3 is associated with blood lipids, hormones, thyroid function, human papillomavirus infection, hepatitis B infection, sedimentation rate, renal function, coagulation function, and amino acids in patients with infertility. …”
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YOLOGX: an improved forest fire detection algorithm based on YOLOv8 by Caixiong Li, Yue Du, Xing Zhang, Peng Wu

“…Finally, the proposed Focal-SIoU loss function replaces the original loss function, effectively reducing directional errors by combining angle, distance, shape, and IoU losses, thus optimizing the model training process. …”
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Skin Barrier-Improving and Skin-Soothing Effects of Autophagy-Activating Peptide on Sensitive Skin by Sohee Eun, Minhye Lim, Juyeon Jung, Kayoung Shin, Sungwoo Kim, Yeonjae Kim, Gaewon Nam, Sekyoo Jeong, Hyunjung Kim

“…Among the complex and diverse triggering and aggravating factors for sensitive skin syndrome, potential defects in skin barrier function are considered one of the most important ones. …”
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Loss of VHL-mediated pRb regulation promotes clear cell renal cell carcinoma by Mercy Akuma, Minjun Kim, Chenxuan Zhu, Ellis Wiljer, Antoine Gaudreau-Lapierre, Leshan D. Patterson, Lars Egevad, Simon Tanguay, Laura Trinkle-Mulcahy, William L. Stanford, Yasser Riazalhosseini, Ryan C. Russell

“…Concordantly, VHL-inactivation results in pRb hyperstabilization. Functionally, loss of pRb in ccRCC led to increased cell death, transcriptional changes, and loss of oncogenic properties in vitro and in vivo. …”
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Central Contrast Sensitivity as an Outcome Measure in Randomized Controlled Trials in Glaucoma—A Systematic Review by Alexander Sverstad, Jens Riis Møller, Gianni Virgili, Augusto Azuara-Blanco, Josefine Freiberg, Simone Ahrensberg, Olav Kristianslund, Goran Petrovski, Miriam Kolko

“…<b>Purpose</b>: Standard automated perimetry (SAP) remains the gold standard functional test in glaucoma, used primarily for evaluating peripheral vision loss. …”
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High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes by Tiffany K. Miles, Tiffany K. Miles, Angela K. Odle, Stephanie D. Byrum, Stephanie D. Byrum, Stephanie D. Byrum, Alex N. Lagasse, Anessa C. Haney, Victoria G. Ortega, Ashley K. Herdman, Melanie C. MacNicol, Melanie C. MacNicol, Angus M. MacNicol, Gwen V. Childs

“…Ingenuity Pathway Analysis indicated that the DEGs included targets of critical upstream regulators important for pituitary cell function and plasticity (CREB, Fox01, cAMP, STAT3, insulin, TRH, GnRH, and leptin signaling pathways), with most pathways predicted to be downregulated by the HFD. …”
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Sex-specific loss of mitochondrial membrane integrity in the auditory brainstem of a mouse model of Fragile X Syndrome by Claire Caron, Elizabeth Anne McCullagh, Giulia Bertolin

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Noise-induced ribbon synapse loss in the mouse basal cochlear region does not reduce inner hair cell exocytosis by David Oestreicher, David Oestreicher, Alfonso Mauro Malpede, Alfonso Mauro Malpede, Annalena Reitmeier, Annalena Reitmeier, Carolin Paula Bräuer, Carolin Paula Bräuer, Laura Schoch, Laura Schoch, Nicola Strenzke, Nicola Strenzke, Tina Pangrsic, Tina Pangrsic, Tina Pangrsic

“…Noise-induced hearing loss is one of the most common forms of hearing loss in adults and also one of the most common occupational diseases. …”
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