20‐Year Trajectories of Substance‐Use Service Utilization by Ontario's Muslim‐Majority Country Immigrants by Ahmed N. Hassan, Fardowsa Ahmed, Haley Golding, Luke Mondor, Taaha Muhammad, Marwa Azab, Jibran Khokhar, Heba Ragheb, Allie Ali, Nazila Isgandarova, Abd Alfatah Tawakkal, Refik Saskin

“…Methods A population‐based, repeated measures cross‐sectional study was conducted. …”
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European standard clinical practice recommendations for primary pediatric low-grade gliomas by Kleoniki Roka, Katrin Scheinemann, Shivaram Avula, John H. Maduro, Ulrich W. Thomale, Astrid Sehested, A.Y.N. Schouten-Van Meeteren

“…Pediatric low-grade gliomas are the most common brain tumours in childhood and adolescence. …”
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Measurement Matters: A Metrological Approach to Renal Preimplantation Biopsy Evaluation to Address Uncertainty in Organ Selection by John O.O. Ayorinde, MD (UK), Xavier Loizeau, PhD, Victoria Bardsley, MBBS (UK), Spencer Angus Thomas, PhD, Marina Romanchikova, PhD, Alex Samoshkin, PhD, Gavin J. Pettigrew, MD (UK)

“…Core biopsies yielded inadequate slides most frequently. Repeat biopsy of the same kidney led to marked variation in biopsy scores. …”
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A Biomechanical Analysis of Weighted Lifting With an Active Knee Exoskeleton by Margaret A. Meagher, Grace R. Hunt, Brendon Ortolano, Rosemarie Murray, Lukas Gabert, Kenneth Bo Foreman, Tommaso Lenzi

“…Manual material handlers experience some of the highest injury rates among professions monitored by the Bureau of Labor Statistics. Most of these injuries are musculoskeletal strains, sprains, and tears linked to repeated lifting and lowering of heavy objects. …”
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G‐quadruplex‐binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo by Roberto Simone, Rubika Balendra, Thomas G Moens, Elisavet Preza, Katherine M Wilson, Amanda Heslegrave, Nathan S Woodling, Teresa Niccoli, Javier Gilbert‐Jaramillo, Samir Abdelkarim, Emma L Clayton, Mica Clarke, Marie‐Therese Konrad, Andrew J Nicoll, Jamie S Mitchell, Andrea Calvo, Adriano Chio, Henry Houlden, James M Polke, Mohamed A Ismail, Chad E Stephens, Tam Vo, Abdelbasset A Farahat, W David Wilson, David W Boykin, Henrik Zetterberg, Linda Partridge, Selina Wray, Gary Parkinson, Stephen Neidle, Rickie Patani, Pietro Fratta, Adrian M Isaacs

“…Abstract Intronic GGGGCC repeat expansions in C9orf72 are the most common known cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), which are characterised by degeneration of cortical and motor neurons, respectively. …”
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Sleep-Disordered Breathing and Central Respiratory Control in Children: A Comprehensive Review by Marco Zaffanello, Angelo Pietrobelli, Luana Nosetti, Giuliana Ferrante, Erika Rigotti, Stefania Ganzarolli, Giorgio Piacentini

“…Research suggests that repeated oxygen drops during sleep—common in SDB—may harm the brainstem’s breathing control centres. …”
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Active peptides of TSP-1 inhibit retinal angiogenesis through the CD36 pathway in a rat model of choroidal neovascularization. by Yadi Li, Aiping Deng, Kangwei Jiao, Jie Yan, Wandong Zuo, Yujie Dong, Wenrong Xu, Yuting Li, Chunming Guo, Maorong Chen, Run Tian, Zhulin Hu

“…<h4>Results</h4>According to the wound-healing and CCK-8 assays, VR-13 was the most effective in inhibiting the proliferation and migration of endothelial cells. …”
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Functional analysis of African Xanthomonas oryzae pv. oryzae TALomes reveals a new susceptibility gene in bacterial leaf blight of rice. by Tuan T Tran, Alvaro L Pérez-Quintero, Issa Wonni, Sara C D Carpenter, Yanhua Yu, Li Wang, Jan E Leach, Valérie Verdier, Sébastien Cunnac, Adam J Bogdanove, Ralf Koebnik, Mathilde Hutin, Boris Szurek

“…Most Xanthomonas species translocate Transcription Activator-Like (TAL) effectors into plant cells where they function like plant transcription factors via a programmable DNA-binding domain. …”
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Comparative analysis of the mobilome yields new insights into its diversity, dynamics and evolution in parasites of the Trypanosomatidae family by Percy Omar Tullume-Vergara, Adriana Ludwig, Vyacheslav Yurchenko, Adriano Cappellazzo Coelho, Elizabeth Magiolo Coser, Marco Aurélio Krieger, Marta M.G. Teixeira, Jeffrey Jon Shaw, Joao M.P. Alves

“…We found evidence of recent transposon activity in most species, with notable bursts in the Vickermania, Lafontella, Porcisia and Angomonas spp., along with Leishmania (Mundinia) chancei, L. …”
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PACT prevents aberrant activation of PKR by endogenous dsRNA without sequestration by Sadeem Ahmad, Tao Zou, Jihee Hwang, Linlin Zhao, Xi Wang, Anton Davydenko, Ilana Buchumenski, Patrick Zhuang, Alyssa R. Fishbein, Diego Capcha-Rodriguez, Aaron Orgel, Erez Y. Levanon, Sua Myong, James Chou, Matthew Meyerson, Sun Hur

“…We show that PACT directly suppresses PKR activation by endogenous dsRNA ligands, such as inverted-repeat Alu RNAs, which robustly activate PKR in the absence of PACT. …”
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The function and properties of common food packaging materials and their suitability for reusable packaging: The transition from a linear to circular economy by Ronan Farrell, Yvonne J. Cortese, Declan M. Devine, Noel Gately, Margarita Rueda, Lorena Rodriguez, Romina Pezzoli

“…One design aspect often neglected is the influence of repeated use on the properties of the packaging material. …”
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Transcutaneous and transcranial electrical stimulation for enhancing military performance: an update and systematic review by Onno van der Groen, Sara A. Rafique, Nick Willmot, Margaret G. Murphy, Margaret G. Murphy, Eulalia Tisnovsky, Tad T. Brunyé, Tad T. Brunyé

“…We focused on whether the studies addressed key questions about the generalizability of lab findings to military tasks, the frequency and intensity of adverse effects, the impact of repeated ES administration, and the ethical and regulatory considerations for its use in potentially vulnerable military populations.ResultsEleven studies met the inclusion criteria; most demonstrated overall low to some concerns, however, two of these had overall high risk of bias. …”
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Self-sampling and self-testing for HIV at a commercial and community-based test provider in the Netherlands: user preferences and usability by I. J. M. Willemstein, O. Shobowale, A. M. Żakowicz, H. Bos, E. L. M. Op de Coul

“…Twenty-two percent of the study participants experienced some problems performing the HIVSS/ST, the most reported problem was obtaining sufficient blood through the finger prick (71%). …”
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Inflammatory response of cultured macrophages in treatment-naive patients with systemic sclerosis by E. V. Gerasimova, A. I. Bogatyreva, T. V. Kirichenko, T. V. Popkova, R. U. Shayakhmetova, L. P. Ananyeva, Yu. V. Markina, A. M. Markin, A. N. Orekhov

“…Macrophages activated via a proinflammatory pathway can be considered as major participants in the maintaining of system chronic lowgrade inflammation.The aim of this study was to evaluate the inflammatory response and of macrophages in patients with systemic sclerosis to reveal the most significant inflammatory mediators in pathogenesis of this disease.Materials and methods. …”
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Effect of Low dose Isotretinoin on Lipid Profile and Liver enzymes in Acne Patients: A Cross Sectional Study by Ayush Jha, Rima Shrestha, Anupa Khadka, Ashmita Wagle

“… Introduction: Oral isotretinoin remains the most clinically effective anti-acne therapy. However, a myriad of adverse effects are associated with isotretinoin use. …”
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Endoscopic Prophylaxis and Treatment of Portal-Genesis Oesophageal Haemorrhage by B. Kh. Bebezov, R. A. Sultangaziev, T. A. Abdykadyrov

“…Portal hypertension-triggered oesophageal and gastric variceal bleeding is the most dangerous and threatening complication, with an up to 50–70 % mortality at first episode. …”
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Safety assessment of mixtures of 1,9‐nonanediamine (NMDA) and 2‐methyl‐1,8‐octanediamine (MODA), for use in food contact materials by EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Claude Lambré, José Manuel Barat Baviera, Claudia Bolognesi, Andrew Chesson, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Inger‐Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Ronan Cariou, Laurence Castle, Emma Di Consiglio, Roland Franz, Nicole Hellwig, Maria Rosaria Milana, Eric Barthélémy, Daniele Comandella, Gilles Rivière

“…The polyamide material is also intended to be used for repeated use up to 121°C with short contact (up to 30 min). …”
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Lake Baikal amphipods and their genomes, great and small by P. B. Drozdova, E. V. Madyarova, A. N. Gurkov, A. E. Saranchina, E. V. Romanova, J. V. Petunina, T. E. Peretolchina, D. Y. Sherbakov, M. A. Timofeyev

“…While genome sizes vary within one order of magnitude, the karyotypes are relatively stable (2n = 52 for most species studied). Moreover, analysis of the diversity of repeated sequences in nuclear genomes showed significant between­species differences.  …”
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MOLECULAR STRUCTURE OF AMYOTROPHIC LATERAL SCLEROSIS IN RUSSIAN POPULATION by N. Yu. Abramycheva, E. V. Lysogorskaya, Yu. S. Shpilyukova, A. S. Vetchinova, M. N. Zakharova, S. N. Illarioshkin

“…Total rate of the identified mutations in the examined ALS cohort was 9.5 %. The most frequently observed defects were mutations in the SOD1 (24.0 % in familial ALS and 4.6 % in sporadic ALS) and C9orf72 (pathological hexanucleotide repeat expansion was identified in 1.8 % cases of ALS, all sporadic) genes. …”
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Effect of Low dose Isotretinoin on Lipid Profile and Liver enzymes in Acne Patients: A Cross Sectional Study by Ayush Jha, Rima Shrestha, Anupa Khadka, Ashmita Wagle

“… Introduction: Oral isotretinoin remains the most clinically effective anti-acne therapy. However, a myriad of adverse effects are associated with isotretinoin use. …”
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