A phase I study of the CDK4/6 inhibitor ribociclib combined with gemcitabine in patients with advanced solid tumors by Aurora Norman, Mahesh Seetharam, Jacob Allred, Jianping Kong, Mateusz Opyrchal, Wen Wee Ma, Yanyan Lou, Grace K. Dy, Amit Mahipal, S. John Weroha, Andrea E. Wahner Hendrickson, Joel M. Reid, Alex A. Adjei

“…Eleven patients experienced Grade 3 adverse events (AE), the most common being neutropenia, thrombocytopenia, and anemia. …”
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Salicylic Acid-Induced Expression Profiles of LRR and LRR-RLK Candidate Genes Modulate <i>Mungbean Yellow Mosaic India Virus</i> Resistance in Blackgram and Its Two Wild Non-Progen... by Mansi Shukla, Priyanka Kaundal, Shalini Purwar, Mukul Kumar, Chandragupt Maurya, Chirag, Awdhesh Kumar Mishra, Kwang-Hyun Baek, Chandra Mohan Singh

“…R-genes, including gene families of leucine-rich repeats (LRRs) and leucine-rich repeat receptor-like kinases (LRR-RLKs), are known for modulating the resistance in plants against various biotic stresses. …”
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Detailed cytogenetic analysis of three duck species (the northern pintail, mallard, and common goldeneye) and karyotype evolution in the family Anatidae (Anseriformes, Aves) by V. R. Beklemisheva, K. V. Tishakova, S. A. Romanenko, D. A. Andreushkova, V. A. Yudkin, E. А. Interesova, F. Yang, M. A. Ferguson-Smith, A. S. Graphodatsky, A. A. Proskuryakova

“…Additionally, in this species, the presence of massive heterochromatic blocks in most macroautosomes and sex chromosomes was discovered. …”
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Obstructive Fecalomas in an Infant Treated with Successful Endoscopic Disimpaction by Risa Kanai, Kengo Nakaya, Koji Fukumoto, Masaya Yamoto, Hiromu Miyake, Akiyoshi Nomura, Susumu Yamada, Akihiro Makino, Hideto Iwafuchi, Naoto Urushihara

“…A fecaloma is a mass of accumulated feces with a consistency much harder than that of a fecal impaction. It is most frequently observed in the rectum and sigmoid area, and associated complications include colonic obstruction, ulceration, bleeding, and perforation. …”
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Modeling Parkinson’s Disease Using Induced Pluripotent Stem Cells by Xinchao Hu, Chengyuan Mao, Liyuan Fan, Haiyang Luo, Zhengwei Hu, Shuo Zhang, Zhihua Yang, Huimin Zheng, Huifang Sun, Yu Fan, Jing Yang, Changhe Shi, Yuming Xu

“…Parkinson’s disease (PD) is the second most common neurodegenerative disease. The molecular mechanisms of PD at the cellular level involve oxidative stress, mitochondrial dysfunction, autophagy, axonal transport, and neuroinflammation. …”
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RNA polymerase II-mediated rDNA transcription mediates rDNA copy number expansion in Drosophila. by George J Watase, Yukiko M Yamashita

“…Akin to telomere maintenance, rDNA maintenance is particularly important in cell types that proliferate for an extended time period, most notably in the germline that passes the genome through generations. …”
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Social inequalities in height: persisting differences today depend upon height of the parents. by Bruna Galobardes, Valerie A McCormack, Peter McCarron, Laura D Howe, John Lynch, Debbie A Lawlor, George Davey Smith

“…<h4>Background</h4>Substantial increases in height have occurred concurrently with economic development in most populations during the last century. In high-income countries, environmental exposures that can limit genetic growth potential appear to have lessened, and variation in height by socioeconomic position may have diminished. …”
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Unusual complication after laparoscopic left nephrectomy for renal tumour: a case report by Arantxa Arruabarrena, Juan Santiago Azagra, Jean Francoise Wilmart, Ioan Bachner, Dan Manzoni, Martine Goergen

“…So far, it is the first case describing an increasing subcapsularhaematoma of the spleen, most likely caused by the traction of firm adhesions to the organ. …”
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Determination of the Critical Phases of the Experimental Research Using Laboratory Animals: Risk Analysis by S. V. Khodko, M. N. Makarova, V. G. Makarov, S. S. Salynov, N. V. Rodionova

“…Russian and foreign standards require determination of the critical phases of each individual study by quality assurance staff based on checking the study protocol (plan).The aim of the study was to identify critical phases typical for most preclinical studies, and assess the potential risks during inspections.Materials and methods: the study was carried out by analysing the types and consequences of nonconformities. …”
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Revisiting low complications of VICRYL mesh in breast reconstruction: Insights from an updated systematic review by Allisa Barber, Aishu Ramamurthi, Madeline Ebert, Nelson Rodriguez-Unda

“…Background: Alloplastic breast reconstruction continues to be the most prevalent breast reconstruction performed in the United States. …”
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APPLICATION OF EXPECTED CREDIT LOSS MODEL AND MARKOV CHAIN TO CALCULATE NET SINGLE PREMIUM OF UNSECURED CREDIT INSURANCE by Hansen Juni Lieus, Devin Tedja, Vanessa Joewita, Agus Sofian Eka Hidayat, Alexander R. J Silalahi

“…Based on model sensitivity analysis, cash flow values were most sensitive to the variable used to construct the PDC model (). …”
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Persistent Health and Cognitive Impairments up to Four Years Post-COVID-19 in Young Students: The Impact of Virus Variants and Vaccination Timing by Ashkan Latifi, Jaroslav Flegr

“…The data further indicate that the ancestral SARS-CoV-2 variant may have the most significant long-term impact, while the Omicron variant appears to have the least. …”
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Pathomorphological characteristic of IgG4-related diseases by O. O. Dyadyk, M. D. Ivanova

“…Renal involvement in IgG4-related diseases most often occurs on the type of tubulointerstitial nephritis, with the further development of acute or chronic kidney injury. …”
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Probiotic Supplementation for Treatment of Infection: A Double-Blind Randomized Clinical Trial by Na Rae Lim, Soo Yeon Choi, Woo Chul Chung

“…This beneficial effect was most pronounced in patients with postprandial distress syndrome (P=0.02). …”
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Characteristics of heart changes in overweight and obese patients by S. V. Miklishanskaya, N. A. Mazur, V. V. Chigineva, E. A. Zolozova

“…The effect of obesity on the heart in most cases is associated with thickening of the LV myocardial wall due to lipid infiltration and mild cardiomyocyte hypertrophy. …”
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Schizophrenic Identity; Victorious Femininity and Defeated Masculinity: A Post-colonial study of The French Perfume by Amir Taj Alsir by faramarz mirzaei, boshra jazayerirad, khalil parvini, Hadi NazariMonazam

“…Arab writers have repeatedly referred to the encounter of the East and the West, and its reflection on post-colonial identity. …”
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Whole genome sequencing reveals the genetic diversity and structure of Leptosphaeria maculans populations from the Western Cape province of South Africa by Huibrecht Maria Schreuder, Beatrix Coetzee, Gerhardus Johannes van Coller, Diane Mostert

“…Analysis of molecular variance also indicated regions as the most important factor for population differentiation but suggested shallow population structure with only 3,71% of the total variation occurring between regions. …”
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Virology, epidemiology, transmissions, diagnostic tests, prophylaxis and treatments of human Mpox: Saudi Arabia perspective by Almonther Abdullah Hershan

“…Therefore, government health authorities of SA should continue to collaborate with various international health organizations including WHO to prevent, manage or monitor potential health risks at most of the entry points in SA including highways, seaports, and airports by ensuring adherence to hygiene protocols, vaccinations, and health screenings. …”
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Cost-effectiveness of Catheter Ablation Versus Antiarrhythmic Drug Therapy for the Treatment of Atrial Fibrillation: A Canadian Perspective by Yaariv Khaykin, Peter J. Mallow, John A. Rizzo, Atul Verma, Lauren Chun, Shelby Olesovsky, Matthew R. Reynolds

“…The 5-year probability of achieving cost-effectiveness was 0%, 0.9%, and 100% at the 3 cost per QALY thresholds. Results were most sensitive to time horizon, probability of repeat AF ablation, and stroke rate…”
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Increasing the prestige of local self-government bodies and the effectiveness of activities should begin in the process of studying at the university by E. S. Shugrina

“…The sociological methods include the method of expert survey and the method of content analysis, which makes it possible to reveal the real position of the respondent, if he wants to disguise it not only the positions expressed, but also the words actually used were analyzed. The most repeatable ones were identified with the help of special software products.The main results, scope of application. …”
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