T-cell immune checkpoint inhibition plus hypomethylation for locally advanced HER2-negative breast cancer: a phase 2 neoadjuvant window trial of decitabine and pembrolizumab follow... by Monique Williams, Patrick Dillon, Harry D Bear, Andrew S Poklepovic, Maciej Kmieciak, Kandace P McGuire, Xiaoyan Deng, Dipankar Bandyopadhyay, Michael Idowu, Taylor M Jenkins, Giovanni Archer, Lindsey Gwaltney, Daniel Flora, Daniel Stover, Mary Hackney, Masey Ross, Hetal Vachhani, Raphael Louie, Amelia Grover, Tasnim Rahman, Amber Hendrix

“…Biopsies before and after window immunotherapy quantified TILs and programmed death-ligand 1 (PD-L1) expression. Patients proceeded to NCT and tumor resection per standard of care. …”
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Dissecting the link between PD-1/PD-L1-based immunotherapy and cancer pain: mechanisms, research implications, and artificial intelligence perspectives by Marco Cascella, Brigida Miranda, Carmen Gagliardi, Lucia Santaniello, Milena Mottola, Alida Mancusi, Laura Ferrara, Federica Monaco, Francesca Gargano, Francesco Perri, Alessandro Ottaiano, Maurizio Capuozzo, Ornella Piazza, Stefano Pepe, Anna Crispo, Agostino Guida, Giovanni Salzano, Giustino Varrassi, Luigi Liguori, Francesco Sabbatino, The TRIAL Group

“…Cancer-related pain represents one of the most common complaints of cancer patients especially for those with advanced-stage of disease and/or bone metastases. …”
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Adoptive cell therapy with tumor-infiltrating lymphocytes in combination with nivolumab in patients with advanced melanoma by D. König, B. Kasenda, M. Sandholzer, A. Chirindel, A. Zingg, R. Ritschard, H. Thut, K. Glatz, E.A. Kappos, D. Schaefer, C. Kettelhack, J. Passweg, K. Baur, A. Holbro, A. Buser, D. Lardinois, L.T. Jeker, N. Khanna, F. Stenner, M.S. Matter, N. Rodrigues Mantuano, M. Binder, A. Zippelius, H. Läubli

“…All patients had hematologic adverse events (AEs). Most common non-hematologic AEs were fever and cytokine release syndrome. …”
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Real-World Outcomes in Patients with Advanced Penile Squamous Cell Carcinoma Receiving Immune Checkpoint Inhibitors: A Single Institution Experience by Tony Z. Zhuang, Subir Goyal, Katherine B. Case, T. Anders Olsen, Shalini Vemuru, Ahmet Yildirim, Rohit V. Goswamy, Jacqueline T. Brown, Bradley C. Carthon, Omer Kucuk, Mehmet Asim Bilen, Viraj A. Master, Bassel Nazha

“…Human papillomavirus (HPV)/p16+ status was determined by immunohistochemistry. Programmed death-ligand 1 (PD-L1) positivity was defined as >1%. …”
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dCas9-SPO11-1 locally stimulates meiotic recombination in rice by Léo Herbert, Aurore Vernet, Aurore Vernet, Julien Frouin, Julien Frouin, Anne Cécile Meunier, Anne Cécile Meunier, Jeremy Di Mattia, Minghui Wang, Gaganpreet K. Sidhu, Luc Mathis, Alain Nicolas, Alain Nicolas, Emmanuel Guiderdoni, Emmanuel Guiderdoni, Ian Fayos

“…However, the potential to recover all the combinations of the parental alleles remains limited in most organisms, including plants, by the occurrence of only few crossovers per chromosome and a prominent bias in their spatial distribution. …”
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Perception of Medical and Nursing Students Plus Clinical Instructors Towards Objective Structured Clinical Examination: A Case Study of Five Health Training Institutions in Sub-Sah... by Kibuuka R, Mpasa F, Kanyike AM, Ndikom CM, Kaminga AC, Owusu-Sekyere S, Ogah A, Kusi Amponsah A, Kiyimba K, Obakiro SB, Munthali G, Msowoya WK, Kibuule D, Phiri EC, Baluwa M, Phiri T, Katuramu R

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Studying the Role of Urban Female Activity in Achieving Sustainable Rural Development in Rural district of Ashaghabad, Neyshabour by Masoomeh Mollanorozi, Seid Eskandar Seidaiy, Nasibe hosseini

“…Clearly, identifying the less-considered rural groups in rural development programs is more important. According to most rural development experts rural women are one of the groups that have been less considered by rural development planners and decision makers because of various economic, social and cultural reasons (Mirlotfi et al. 2013). …”
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A Comparative Analysis of Energy Efficiency of Two Sprinkler Irrigation Systems for Wheat Cultivation (Case Study: Dehgolan Plains, Kurdistan) by P. Tahmasbi, F. Dalvand, S.A. Hosseini, B. Karimi, H. Ghadrshnas

“…These key inputs play a crucial role in ensuring food security and economic stability for the country. One of the most important agricultural development programs in the country should be to increase efficiency of energy consumption in the agricultural sector. …”
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Genetic Diversity and Relationship Analysis of Different Local and International Cultivars and some Strawberry Clones (Fragaria× ananassa Duch) by Masume Abedi, Mehdi Hadadinejad, Kamran Ghasemi, Ghafar Kiani

“…Extended Abstract Background: Strawberry (Fragaria × ananassa) is a perennial shrub of the Rosaceae family that has become one of the most significant fruits globally due to its unique characteristics, ease of care, and delicious flavor. …”
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Educació superior i societat a Mèxic: els reptes del segle XXI Higher education and society in Mexico: 21st century challenges Educación superior y sociedad en México: los retos de... by Hugo Casanova Cardiel

“…After a historical overview of the origin and development of Mexican university, he analyses the different factors that define higher education in that country. Although most universities in Mexico are public, in recent decades the presence of the private sector has increased. …”
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The triple-helix model as foundation of innovative entrepreneurial ecosystems by Klaus Bruno Schebesch, Horațiu Florin Șoim, Radu Lucian Blaga

“…City-centered, EESs tend to be most expressive in their projects but also subject to a stronger long tail-effect. …”
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HER2-positive breast cancer with invasive micropapillary carcinoma component shows immunosuppressive microenvironment and resistance to neoadjuvant therapy by Lulu Zhang, Lijia Zhou, Anli Yang, Shaoquan Zheng, Keming Chen, Yutian Zou, Qingru Zhou, Daining Wang, Fei Xu, Jiajia Huang, Zhongyu Yuan, Shusen Wang, Yanxia Shi, Peng Sun, Xin An

“…Bioinformatics analysis revealed that the CTNNB1 gene, which encodes the β-catenin protein, was the most highly upregulated gene in IMPC patients. Immune profiling demonstrated reduced infiltration of CD4+ and CD8+ T cells, along with increased macrophage levels in the IMPC tumor microenvironment (TME). …”
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Phase 2 study of cemiplimab in patients with metastatic cutaneous squamous cell carcinoma: primary analysis of fixed-dosing, long-term outcome of weight-based dosing by Dirk Schadendorf, Ralf Gutzmer, Thomas Eigentler, Israel Lowy, Vladimir Jankovic, Elizabeth Stankevich, Anna C Pavlick, Danny Rischin, Michael R Migden, Annette M Lim, Chrysalyne D Schmults, Nikhil I Khushalani, Brett G M Hughes, Lara A Dunn, Leonel Hernandez-Aya, Anne Lynn S Chang, Badri Modi, Axel Hauschild, Claas Ulrich, Brian Stein, Jessica L Geiger, Murad Alam, Emmanuel Okoye, Melissa Mathias, Jocelyn Booth, Siyu Li, Matthew G Fury, Alexander Guminski

“…Background Cemiplimab, a high-affinity, potent human immunoglobulin G4 monoclonal antibody to programmed cell death-1 demonstrated antitumor activity in a Phase 1 advanced cutaneous squamous cell carcinoma (CSCC) expansion cohort (NCT02383212) and the pivotal Phase 2 study (NCT02760498). …”
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Disruption to diabetes and hypertension care during the COVID-19 pandemic in Latin America and the Caribbean and mitigation approaches: a scoping review by Oluwabunmi Ogungbe, Samira Barbara Jabakhanji, Roopa Mehta, John McCaffrey, David Byrne, Sinéad Hurley, Lori Rosman, Eyram Cyril Bansah, Folahan Ibukun, Irene Afua Quarshie, Katherine Lord, Yidan Lu, Yunzhi Wang, Asma Rayani, Hairong Liu, Ann Joseph, Alejandro Escobosa, Ivy Nyamuame, Jieun Lee, Ning Meng, Ibrahim Jehanzeb, Temitope Akinyemi, Shoichiro Nohara, Mauro F. F. Mediano, Yvette Yeboah-Kordieh, Cecilia de Sousa, Juliana Farhat, Renato Bandeira de Mello, Tara Taeed, Lawrence J. Appel, Sonia Y. Angell, Edward W. Gregg, Kunihiro Matsushita

“…., due to financial constraints). The most reported interventions included remote care strategies (e.g., smartphone applications, virtual meeting platforms) and mental health programs for healthcare workers. …”
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Efficacy and safety of neoadjuvant sintilimab, oxaliplatin and capecitabine in patients with locally advanced, resectable gastric or gastroesophageal junction adenocarcinoma: early... by Yan Wang, Ning Li, Jing Zhang, Ying Liu, Zhongqi Li, Nong Xu, Zhimin Ma, Yafei Zhang, Haiping Jiang, Xiongfei Yu, Mei Kong, Donghui Zhou, Weibin Wang, Haohao Wang, Haiyong Wang, Kuifeng He, Yimin Lu, Kui Zhao, Ziran Li, Yisen Wang, Lisong Teng

“…However, the role of anti-programmed cell death protein-1 treatment in the neoadjuvant setting remains unclear. …”
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Comparing newly developed SNP barcode panels with microsatellites to explore population genetics of malaria parasites in the Peruvian Amazon by Luis Cabrera-Sosa, Luis Cabrera-Sosa, Luis Cabrera-Sosa, Mahdi Safarpour, Johanna Helena Kattenberg, Roberson Ramirez, Joseph M. Vinetz, Joseph M. Vinetz, Joseph M. Vinetz, Anna Rosanas-Urgell, Dionicia Gamboa, Dionicia Gamboa, Dionicia Gamboa, Dionicia Gamboa, Christopher Delgado-Ratto, Christopher Delgado-Ratto

“…IntroductionMalaria molecular surveillance (MMS) can provide insights into transmission dynamics, guiding national control programs. We previously designed AmpliSeq assays for MMS, which include different traits of interest (resistance markers and pfhrp2/3 deletions), and SNP barcodes to provide population genetics estimates of Plasmodium vivax and Plasmodium falciparum parasites in the Peruvian Amazon. …”
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Pediatric to adult care transfer in rare liver diseases: Recommendations based on insights from a European omnistakeholder event by Karsten Vanden Wyngaert, Janne Suykens, Deirdre Kelly, Isabel Goncalves, Ena Lindhart Thomsen, Jose Willemse, Zoe Mariño, João Madaleno, Jemma Day, Marianne Samyn, Mohamed Ali, Marianne Hørby Jørgensen, Eva Goossens, Johan De Munter, Anneloes Van Staa, Jo Wray, Panayiota Protopapa, Ansgar Lohse, Ruth De Bruyne

“…Our results also underscored the importance of peer mentorship programs (100%), informing young people about the transfer process (85%), and implementing joint consultations (93%). …”
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Research on chemical control of peach shoot blight and the association between phloem volatile compounds and resistance by HU Zhu, WANG Li, ZHAO Hongyue

“…In recent years, peach shoot blight caused by Diaporthe amygdali has been one of the most prevalent fungal diseases in major peachproducing regions of southern China. …”
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Genetic analysis of citrus fruit-related traits in the progeny of HB Pomelo × Huagan No.4 hybrids by CHENG Hanyuan, ZHENG Jierong, XU Chenyu, YI Hualin, WU Juxun

“…Additionally, they displayed a variety of skin and flesh colors, with orange and yellow being the most common. The majority of the hybrid progenies matured later than their parents, with the majority matured in January and February. …”
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Characterization and application of flow heterogeneity in high water cut reservoirs by ZHANG Min, JIN Zhongkang, FENG Xubo

“…Additionally, flow velocity, as the most intuitive representation of the flow field, was chosen as the computational indicator to develop a method for evaluating heterogeneity. …”
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