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  1. 141
    Sustainable forest management: success and challenges in Ethiopia

    Sustainable forest management: success and challenges in Ethiopia by Rusha Begna Wakweya

    Published 2025-05-01
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  2. 142
    Aspectos neurológicos e eletromiograficos da hanseniase: estudo de 100 casos Neurological and electromiographic aspects of leprosy: study of 100 cases

    Aspectos neurológicos e eletromiograficos da hanseniase: estudo de 100 casos Neurological and electromiographic aspects of leprosy: study of 100 cases by Plínio Garcez de Sena

    Published 1976-03-01
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  3. 143
    Open-source electrophilic fragment screening platform to identify chemical starting points for UCHL1 covalent inhibitors

    Open-source electrophilic fragment screening platform to identify chemical starting points for UCHL1 covalent inhibitors by Scott B. Ficarro, Zachary H. Marto, Nicholas M. Girardi, Dingyu Deng, Isabella Jaen Maisonet, Guillaume Adelmant, Laura E. Fleming, Mona Sharafi, Isidoro Tavares, Andrew Zhao, HyoJeon Kim, Hyuk-Soo Seo, Sirano Dhe-Paganon, Sara J. Buhrlage, Jarrod A. Marto

    Published 2024-12-01
    “…The system enables primary screening of ∼10,000 covalent fragments per day in pooled format. In a proof-of-concept study we executed primary and secondary screens to identify 27 hit fragments against UCHL1, a deubiquitinating enzyme that is emerging as a drug target of interest across multiple clinical indications. …”
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