Comparative transcriptomics in B73-teosinte near-isogenic maize lines reveals key defense signaling and phytoalexins in response to Cercospora zeina infection by Xiaomeng Sun, Xiaomeng Sun, Ruiyu Zhang, Ruiyu Zhang, Zongping Wang, Zongping Wang, Haotian Zhang, Haotian Zhang, Hairun Wen, Hairun Wen, Junli Zhang, Naibin Yu, Naibin Yu, Zhe Wang, Zhe Wang, Huanhuan Tai, Huanhuan Tai, Qin Yang, Qin Yang

“…The URGs in Qgls8-R were significantly enriched in metabolic processes, phytohormone signaling, and response to biotic stress, while the URGs in Qgls8-S were mostly involved in plant growth and developmental processes. …”
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In-vitro effect of aflibercept and dexamethasone on the expression level of genes associated with epithelial-mesenchymal transition in retinal pigment epithelial cells by M. Hossein Nowroozzadeh, Hajar Farvardin, Seyed Ali Nabavizadeh, Fatemeh Sanie-Jahromi

“…Aflibercept plus dexamethasone combination led to a gene expression profile mostly similar to dexamethasone alone. The combination treatment also had a significant increase in β-catenin gene expression. …”
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Comprehensive characterization of high-risk coding and non-coding single nucleotide polymorphisms of human CXCR4 gene. by Bonoshree Sarkar, Muhammad Safiul Alam Mondal, Taibur Rahman, Md Ismail Hosen, Atiqur Rahman

“…Furthermore, RegulomeDB databases were employed to assess the regulatory potential of these non-coding SNPs based on chromatin state and protein binding regulation. In the mostly annotated variant (ENSP00000241393) of the CXCR4 gene, we found 23 highly deleterious and pathogenic nsSNPs and these were selected for in-depth analysis. …”
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Voices from the frontline: findings from a thematic analysis of a rapid online global survey of maternal and newborn health professionals facing the COVID-19 pandemic by Lenka Benova, Aduragbemi Banke-Thomas, Emma Radovich, Francesca L Cavallaro, Andrea Pembe, Oona Maeve Renee Campbell, Thomas van den Akker, Bouchra Assarag, Thérèse Delvaux, Mitsuaki Matsui, Alexandre Delamou, Wendy Jane Graham, Bosede Afolabi, Annettee Nakimuli, Louise Tina Day, Aline Semaan, Constance Audet, Elise Huysmans, Hannah Blencowe, Séverine Caluwaerts, Leonardo Chavane, Giorgia Gon, Peter Kascak, Sarah Moxon

“…Overall, 47% of participants in LMICs and 69% in HICs felt mostly or completely knowledgeable in how to care for COVID-19 maternity patients. …”
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Exploring Bone Morphogenetic Protein-2 and -4 mRNA Expression and Their Receptor Assessment in a Dynamic <i>In Vitro</i> Model of Vascular Calcification by Manuela Cabiati, Federico Vozzi, Elisa Ceccherini, Letizia Guiducci, Elisa Persiani, Ilaria Gisone, Agnese Sgalippa, Antonella Cecchettini, Silvia Del Ry

“…Thus, our findings provide insights into the mechanisms by which dynamic co-culture modulates the <i>BMP</i> system activation in an environment mimicking <i>in vivo</i> VC’s cellular and mechanical characteristics.…”
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Unveiling the mechanism of amelioration of adjuvant-induced rheumatoid arthritis by Drynaria quercifolia rhizome extract using network pharmacology and gene expression-based studie... by Debabrata Modak, Subhajit Ghosh, Sourav Sarkar, Sudipta K. Roy, Ayan Chakraborty, Arpita Ray, Chirag N. Patel, John J. Georrge, Subarna Thakur, Soumen Bhattacharjee

“…Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis indicated that key target genes were mostly enriched in the inflammatory response associated with multiple signalling pathways. …”
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Nanoparticles in Plant Cryopreservation: Effects on Genetic Stability, Metabolic Profiles, and Structural Integrity in Bleeding Heart (Papaveraceae) Cultivars by Kulus D, Tymoszuk A, Kulpińska A, Dębska B, Michalska A, Nowakowska J, Wichrowska D, Wojnarowicz J, Szałaj U

“…In ‘Gold Heart’, the majority (94%) of genetic variation detected was within populations, while 6% was attributed to nanoparticle treatments (mostly the application of 15 ppm ZnONPs). The application of nanoparticles significantly influenced the metabolic profile of bleeding heart plants, particularly affecting the synthesis of phenolic acids and aldehydes, as well as the antioxidant mechanisms in both ‘Gold Heart’ and ‘Valentine’ cultivars. …”
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Genetically predicted plasma metabolites mediate the causal relationship between gut microbiota and osteosarcoma by Xiuyu Qin, Zhuming Fan, Shaopeng Qiao, Jian Li, Jia Lv

“…Generally speaking, GM play a role in human health mostly through metabolites. However, the causal relationship between GM, plasma metabolites, and OS remains unclear. …”
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Pancreatic cancer cell-intrinsic transglutaminase-2 promotes T cell suppression through microtubule-dependent secretion of immunosuppressive cytokines by Anton Wellstein, Thomas Seufferlein, Alexander Kleger, Tim Eiseler, Anton Lahusen, Nora Minhöfer, Kim-André Lohse, Christine Blechner, Jessica Lindenmayer, Sabine Windhorst, Yuan-Na Lin

“…Background Pancreatic ductal adenocarcinoma (PDAC) is mostly refractory to immunotherapy due to immunosuppression in the tumor microenvironment and cancer cell-intrinsic T cell tolerance mechanisms. …”
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Modelling the air quality impacts of a zero emission zone scenario in the city of Milan by Andrea Piccoli, Valentina Agresti, Marco Bedogni, Giovanni Lonati, Guido Pirovano

“…Again, the reduction introduced by the ZEZ are low and are mostly included within the ZEZ area (maximum 2% and 0.6 % for NO2 and PM2.5 respectively). …”
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3D culturing as a promising strategy to enhance the angiogenic potential of adipose stem cell-derived secretome: insights into the role of miR-145-5p/ANGPT2 axis by G. Gerini, E. Mari, P. Pontecorvi, S. Camero, E. Romano, D. Ranieri, F. Megiorni, P. Fioramonti, A. Angeloni, C. Marchese, S. Ceccarelli

“…Abstract Background Adipose-derived mesenchymal stem cells (ASCs) represent a valid therapeutic option for clinical application in several diseases, mostly due to the paracrine activity of their secretome, exerting pro-angiogenic, antinflammatory and immunosuppressive effects. …”
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The Development and Implementation of a Simulated Patient Resource for Teaching and Assessment in Optometry Low Vision Rehabilitation by Karas M, Lucas N, Ryan B

“…Even though feedback suggested that the method is mostly acceptable to both assessors and students, we have concluded that having access to a readily available pool of real patients is the more credible option for teaching and assessing this accredited level of low vision practice. …”
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Study of NO₂ and HCHO vertical profile measurement based on fast synchronous multi-axis differential optical absorption spectroscopy (FS MAX-DOAS) by J. Xu, J. Xu, A. Li, Z. Hu, H. Zhang, H. Zhang, M. Qin

“…Compared with the differential slant column densities (dSCDs) at each elevation angle measured by the MAX-DOAS system, the Pearson correlation coefficient of NO<span class="inline-formula">₂</span> reached 0.9, while for HCHO it ranged mostly between 0.76 and 0.85. The results of the slant column concentration inversion indicate that the root mean square (rms) of the FS MAX-DOAS spectrum inversion can consistently be lower than that of MAX-DOAS over an extended period. …”
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Soil organic carbon mineralization is controlled by the application dose of exogenous organic matter by O. Mendoza, S. De Neve, H. Deroo, H. Li, A. Françoys, A. Françoys, S. Sleutel

“…In sum, this experiment and our previous research suggest that EOM mineralization is mostly independent of EOM dose, but EOM dose modulates the mineralization of native SOC. …”
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Responses of field-grown maize to different soil types, water regimes, and contrasting vapor pressure deficit by T. H. Nguyen, T. Gaiser, J. Vanderborght, A. Schnepf, F. Bauer, A. Klotzsche, L. Lärm, H. Hüging, F. Ewert, F. Ewert

“…Our analysis is based on a comprehensive dataset measured along the soil–plant–atmosphere pathway at field scale in two growing seasons (2017 and 2018) with contrasting climatic conditions (low and high vapor pressure deficit). Roots were observed mostly in the topsoil (10–20 cm) of the stony soil, while more roots were found in the subsoil (60–80 cm) of the silty soil. …”
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