Evaluating present-day and future impacts of agricultural ammonia emissions on atmospheric chemistry and climate by M. Beaudor, M. Beaudor, D. Hauglustaine, J. Lathière, M. Van Damme, M. Van Damme, L. Clarisse, N. Vuichard

“…Future agricultural emissions under the most increased level (SSP4-3.4) have been further exploited to evaluate the impact of enhanced ammonia emissions combined with future contrasting aerosol precursor emissions (SSP1-2.6 – low emissions; SSP3-7.0 – regionally contrasted emissions). …”
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Neuronal expression of S100B triggered by oligomeric Aβ peptide contributes to protection against cytoskeletal damage and synaptic loss by Joana Saavedra, Joana Saavedra, Joana Saavedra, Mariana Nascimento, Mariana Nascimento, Mariana Nascimento, António J. Figueira, António J. Figueira, Marina I. Oliveira da Silva, Marina I. Oliveira da Silva, Tiago Gião, Tiago Gião, Tiago Gião, João Oliveira, João Oliveira, João Oliveira, Márcia A. Liz, Márcia A. Liz, Márcia A. Liz, Márcia A. Liz, Márcia A. Liz, Cláudio M. Gomes, Cláudio M. Gomes, Isabel Cardoso, Isabel Cardoso, Isabel Cardoso

“…The S100 family is a group of calcium-binding proteins with intra- and extracellular functions, that are important modulators of inflammatory responses. S100B, which is upregulated in AD patients and the most abundant member of this family, was shown to inhibit in vitro the aggregation and toxicity of Aβ42, acting as a neuroprotective holdase-type chaperone. …”
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The N-6 methyladenosine dynamics in STEMI and the effect of IL-6 inhibition - a hypothesis generating sub-study of the ASSAIL-MI trial by Tuva B. Dahl, Tuva B. Dahl, Ana Quiles-Jiménez, Kaspar Broch, Kaspar Broch, Anne Kristine Anstensrud, Anne Kristine Anstensrud, Lars Gullestad, Lars Gullestad, Lars Gullestad, Geir Ø. Andersen, Geir Ø. Andersen, Ola Kleveland, Jonas Øgaard, Jonas Øgaard, Vigdis Bjerkeli, Vigdis Bjerkeli, Azita Rashidi, Kuan Yang, Kirsten B. Holven, Kirsten B. Holven, Pål Aukrust, Magnar Bjørås, Magnar Bjørås, Camilla Huse, Camilla Huse, Camilla Huse, Bente Halvorsen, Bente Halvorsen

“…BackgroundEpitranscriptomics, with m6A as the most prevalent in mammals, is a novel treatment target for inflammatory diseases, including cardiovascular diseases. …”
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The microbiota metabolite, phloroglucinol, confers long-term protection against inflammation by Janire Castelo, Sarai Araujo-Aris, Diego Barriales, Samuel Tanner Pasco, Iratxe Seoane, Ainize Peña-Cearra, Ainhoa Palacios, Carolina Simó, Virginia Garcia-Cañas, Muthita Khamwong, Itziar Martín-Ruiz, Monika Gonzalez-Lopez, Laura Barcena, José Ezequiel Martín Rodríguez, José Luís Lavín, Naiara Gutiez, Raquel Marcos, Estibaliz Atondo, Arantza Cobela, Laura Plaza-Vinuesa, Adrián Plata, Eneko Santos-Fernandez, Alberto Fernandez-Tejada, Mari Carmen Villarán, José Miguel Mancheño, Juana Maria Flores, Ana María Aransay, Aize Pellón, Blanca de las Rivas, Rosario Muñoz, Abelardo Margolles, Patricia Ruas-Madiedo, Maria Victoria Selma, Mercedes Gomez de Agüero, Leticia Abecia, Juan Anguita, Héctor Rodríguez

“…Phloroglucinol induces alterations in metabolic and epigenetic pathways that are most prevalent in upstream progenitors as hallmarks of central trained immunity. …”
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Response of Water-Sediment Structure to Three-dimensional Baroclinic Effects in Yangtze River Estuary by ZHU Xian-bo, LU Chuan-teng, LUO Xiao-feng, ZHANG Gong-jin

“…Key components of the model included hydrodynamic module, salinity transport module, sediment module, and density calculation. …”
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AGW-YOLO-Based UAV Remote Sensing Approach for Monitoring Levee Cracks by HU Weibo, ZHOU Shaoliang, ZHAO Erfeng, ZHAO Xueqiang

“…Firstly, a lightweight ADown module was incorporated to replace the conventional stride-2 convolution. …”
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Current Status of Cystic Fibrosis in Türkiye: Data from the National Registry by Dilber Ademhan Tural, Tuğba Şişmanlar Eyüboğlu, Güzin Cinel, Erkan Çakır, Sevgi Pekcan, Uğur Özçelik, Nagehan Emiralioğlu Ordukaya, Ebru Yalçın, Halime Nayır Büyükşahin, Mahir Serbes, Derya Ufuk Altıntaş, Mina Hizal, Gaye İnal, Özlem Keskin, Sanem Eryılmaz Polat, Suat Savaş, Fatma Nur Ayman, Meltem Erdal, Havva İpek Demir, Hasan Yüksel, Demet Polat Uluğ, Ali Özdemir, Gökçen Dilşa Tuğcu, Ezgi Demirdöğen, Merve Korkmaz, Yakup Canıtez, Handan Kekeç, Ayşe Tana Aslan, Koray Harmancı, Velat Şen, Hadice Selimoğlu Şen, Ayşe Ayzıt Kılınç, Azer Kılıç Başkan, Berrak Öztosun, Ebru Damadoğlu, Oğuz Karcıoğlu, Gökçen Kartal Öztürk, Figen Gülen, Fazılcan Zirek, Ece Ocak, Nilay Baş İkizoğlu, Eylül Pınar Çakır, Erdem Topal, Mehmet Kılıç, Gönül Çaltepe, Pelin Asfuroğlu, Nazan Çobanoğlu, Melih Hangül, Erdi Çağrı Dağdelen, Mehmet Köse, Ali Ersoy, Ayşen Bingöl, Abdurrahman Erdem Başaran, Beste Özsezen, Tuğba Ramaslı Gürsoy, Pervin Korkmaz, Zeynep Gökçe Gayretli Aydın, Deniz Doğru

“…Genetic analyses were completed in 97.3% of patients. The most common variant, F508del, had a total variant frequency of 22.1%. …”
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A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons by Benedikt V. Hölbling, Yashica Gupta, Paolo M. Marchi, Magda L. Atilano, Michael Flower, Enric Ureña, Rajkumar A. Goulden, Hannah K. Dobbs, Eszter Katona, Alla Mikheenko, Ashling Giblin, Ali Raza Awan, Chloe L. Fisher-Ward, Niamh O'Brien, Deniz Vaizoglu, Liam Kempthorne, Katherine M. Wilson, Lauren M. Gittings, Mireia Carcolé, Marc-David Ruepp, Sarah Mizielinska, Linda Partridge, Pietro Fratta, Sarah J. Tabrizi, Bhuvaneish T. Selvaraj, Siddharthan Chandran, Emma Armstrong, Paul Whiting, Adrian M. Isaacs

“…Summary: Repeat expansions in C9orf72 are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia. …”
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BIOSPHERE measurement campaign from January 2024 to March 2024 and in May 2024: Effects of the solar events on the radiation belts, UV radiation and ozone in the atmosphere by Viviane Pierrard, David Bolsée, Alexandre Winant, Amer Al-Qaaod, Faton Krasniqi, Maximilien Péters de Bonhome, Edith Botek, Lionel Van Laeken, Danislav Sapundjiev, Roeland Van Malderen, Alexander Mangold, Iva Ambrozova, Marek Sommer, Jakub Slegl, Styliani A Geronikolou, Alexandros G Georgakilas, Alexander Dorn, Benjamin Rapp, Jaroslav Solc, Lukas Marek, Cristina Oancea, Lionel Doppler, Ronald Langer, Sarah Walsh, Marco Sabia, Marco Vuolo, Alex Papayannis, Carlos Granja

“…They also modified the cosmic ray injections, mainly at high latitudes, creating Forbush decrease for the most intense ones. SEP events injected energetic protons in the atmosphere that could penetrate deeper in the atmosphere because they had more energy than the electrons. …”
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Menisoxoisoaporphine A, a novel oxoisoaporphine alkaloid from Menispermi Rhizoma, inhibits inflammation by targeting PDE4B by Xin Qiao, Xin Qiao, Xin Qiao, Xiaojuan Cao, Xiaojuan Cao, Xiaojuan Cao, Shuang Xu, Shuang Xu, Shuang Xu, Cunlin Wang, Cunlin Wang, Cunlin Wang, Rui Guo, Rui Guo, Rui Guo, Xiaojuan Yao, Xiaojuan Yao, Xiaojuan Yao, Qiong Zhang, Qiong Zhang, Qiong Zhang

“…BackgroundDysregulated and excessive inflammatory reactions can lead to tissue damage, which is the underlying cause of most human diseases. Menisoxoisoaporphine A (MA), a novel oxoisoaporphine alkaloid, was obtained from Menispermi Rhizoma, a traditional Chinese medicinal herb used in the treatment of inflammatory conditions in clinical practice. …”
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Application of the Sponge Model Implants in the Study of Vaccine Memory in Mice Previously Immunized with LBSap by Mariana Ferreira Lanna, Lucilene Aparecida Resende, Paula Mello De Luca, Wanessa Moreira Goes, Maykelin Fuentes Zaldívar, André Tetzl Costa, Walderez Ornelas Dutra, Alexandre Barbosa Reis, Olindo Assis Martins-Filho, Kenneth Jhon Gollob, Sandra Aparecida Lima de Moura, Edelberto Santos Dias, Érika Michalsky Monteiro, Denise Silveira-Lemos, Rodolfo Cordeiro Giunchetti

“…Consequently, these results may inform the selection of the most suitable experimental model for biomolecule testing, taking into account how the unique characteristics of each mouse strain affect the immune response dynamics.…”
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Bioprospection of rattlesnake venom peptide fractions with anti-adipose and anti-insulin resistance activity in vitro by David Meléndez-Martínez, Erika Ortega-Hernández, Edwin Estefan Reza-Zaldívar, Alejandro Carbajal-Saucedo, Gustavo Arnaud-Franco, Ana Gatica-Colima, Luis Fernando Plenge-Tellechea, Marilena Antunes-Ricardo, Daniel A. Jacobo-Velázquez, Karla Mayolo-Deloisa, Omar Lozano, Marco Rito-Palomares, Jorge Benavides

“…Moreover, other toxins such as Phospholipases A2 and Disintegrins have shown their potential to modulate insulin secretion in vitro. This suggests an unexplored diversity of venom peptides with a potential anti-obesogenic in Mexican rattlesnake venoms. …”
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TFE3-mediated lysosomal biogenesis and homeostasis alleviates arsenic-induced lysosomal and immune dysfunction in macrophages by Guowei Xu, Haiyang Chen, Zheng Cong, Ling Zhou, Ning Zhao, Yuqing Yang, Ting Li, Xuping Liu, Yi Wang, Bing Li

“…The MiT/TFE family plays a crucial role in maintaining lysosomal biogenesis and homeostasis, with TFE3 being ubiquitously expressed across most immune cell types, however, its specific role in immune function remains largely unexplored and controversial. …”
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Sympathetic hyperinnervation drives abdominal aortic aneurysm development by promoting vascular smooth muscle cell phenotypic switching by Zhenquan Tang, Jingfang Xie, Ming Jin, Guoquan Wei, Ziwei Fu, Xiajing Luo, Chuling Li, Xiaoqian Jia, Hao Zheng, Lintao Zhong, Xinzhong Li, Junfen Wang, Guojun Chen, Yanmei Chen, Wangjun Liao, Yulin Liao, Jianping Bin, Senlin Huang

“…Results: We observed sympathetic hyperinnervation, the most important form of sympathetic neural remodeling, in both mouse AAA models and AAA patients. …”
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Uncovering the role of Gpr45 in obesity regulation by Eva O. Karolczak, Chia Li, Ivan C. Alcantara, Isabel M. Cohen, Claire Gao, Cuiying Xiao, Abigail I. Goldschmidt, Cynthia A. Pinkus, Junjie Li, Monica M. Li, Ryan M. Esquejo, Jean-Philippe Fortin, Kendra K. Bence, Marc L. Reitman, Michael J. Krashes

“…Objectives: G protein-coupled receptors (GPCRs) are the most druggable targets in biology due to their cell-type specificity, ligand binding, and cell surface accessibility. …”
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Sexual dimorphism in lung transcriptomic adaptations in fetal alcohol spectrum disorders by Vishal D. Naik, Dylan J. Millikin, Daniel Moussa, Hong Jiang, Alexander L. Carabulea, Joseph D. Janeski, Jiahui Ding, Kang Chen, Marta Rodriguez-Garcia, Sunil Jaiman, Stephen A. Krawetz, Gil Mor, Jayanth Ramadoss

“…Samples with RNA Integrity Numbers (RINs) > 8 were prepared using the NEBNext Poly(A) mRNA Magnetic Isolation Module (NEB), xGen Broad-range RNA Library Prep (IDT), and xGen Normalase UDI Primer Plate 2 (IDT). …”
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Future projections of Siberian wildfire and aerosol emissions by R. K. Nurrohman, R. K. Nurrohman, T. Kato, H. Ninomiya, L. Végh, N. Delbart, T. Miyauchi, H. Sato, T. Shiraishi, R. Hirata

“…<p>Wildfires are among the most influential disturbances affecting ecosystem structure and biogeochemical cycles in Siberia. …”
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Caveolin-1 inhibits the proliferation and invasion of lung adenocarcinoma via EGFR degradation by Jiahui Dong, Ruiping Du, Yani Zhang, Bo Hong, Gengyun Sun

“…Abstract Lung adenocarcinoma (LUAD) has become the most common pathological pattern of lung cancer in recent decades. …”
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The Study of Farnesyl Diphosphate and Squalene Synthase Gene Expression Levels in Artemisia absinthium Exposed to Environmental Gamma Radiation by Sadegh Rahbarnejad, Ali Asghari, Noraddin Hosseinpour Azad, Ehsan Shokri

“…During the evolutionary process, plants have developed mechanisms that not only allow them to survive under the most severe radiation doses but also respond effectively to small changes in radiation intensity through physiological adjustments. …”
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Development and validation of the Global Adolescent and Child Physical Activity Questionnaire (GAC-PAQ) in 14 countries: study protocol by Tom Loney, Yang Liu, Justin Richards, Mark S Tremblay, Adewale L Oyeyemi, John J Reilly, Dale W Esliger, Karen Roberts, Melody Smith, Valerie Carson, Anuradha Khadilkar, Marie Löf, S H Wong, Diego Augusto Santos Silva, Jasmin Bhawra, Narayan Subedi, Javier Brazo-Sayavera, Alejandra Jauregui, Piyawat Katewongsa, Dyah Anantalia Widyastari, Leigh M Vanderloo, Olga Lucia Sarmiento, Taru Manyanga, Richard Larouche, Mahdi Rostami Haji Abadi, Salomé Aubert, Rachel C Colley, Christine Delisle Nyström, Ryan Harper-Brown, Silvia Alejandra Gonzalez Cifuentes, Geoff Kira, Nicholas Kuzik, Tawonga W Mwase-Vuma, Oliver W A Wilson

“…To assess convergent validity, subsamples (50 adolescents/country) will simultaneously complete the PA module from existing international surveys.Ethics and dissemination Approvals from research ethics boards and relevant organisations will be obtained in all participating countries. …”
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