hiPSC-neurons recapitulate the subtype-specific cell intrinsic nature of susceptibility to neurodegenerative disease-relevant aggregation by Ian Weidling, Christina N. Preiss, Sarah E. Chancellor, Gyan Srivastava, Lauren Gibilisco, Gen Lin, Melanie Shackett Brennan, Janice Lee, Lindsay M. Roth, Olga Morozova, Kyong Nyon Nam, Nehal R. Patel, Qing Liu, J. K. Thomas, Peter Reinhardt, Ruven Wilkens, Dagmar E. Ehrnhoefer, Andreas Striebinger, Stefan Barghorn, Christina Xanthopoulos, Marie-Theres Weil, Sandra Biesinger, Miroslav Cik, Nandini Romanul, Kiran Yanamandra, Alessandra M. Welker, Jessica Wu, Laura Gasparini, Jan Stöhr, Xavier Langlois, Justine D. Manos

“…Abstract Alzheimer’s disease (AD) is characterized by the accumulation and spread of Tau intraneuronal inclusions throughout most of the telencephalon, leaving hindbrain regions like the cerebellum and spinal cord largely spared. …”
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Single-cell RNA sequencing reveals immune microenvironment niche transitions during the invasive and metastatic processes of ground-glass nodules and part-solid nodules in lung ade... by Yi-Feng Ren, Qiong Ma, Xiao Zeng, Chun-Xia Huang, Jia-Li Ren, Fang Li, Jia-Jing Tong, Jia-Wei He, Yang Zhong, Shi-Yan Tan, Hua Jiang, Long-Fei Zhang, Heng-Zhou Lai, Ping Xiao, Xiang Zhuang, Peng Wu, Li-Ting You, Wei Shi, Xi Fu, Chuan Zheng, Feng-Ming You

“…Notably, CXCL9 + and TREM2 + tumor-associated macrophages (TAMs) exhibited the most significant enrichment changes. It was found that GGN–LUAD exhibited a stronger immune response than PSN–LUAD, with increased interaction between CXCL9 + TAMs and CD8 + tissue-resident memory T cells during invasion stage (MIA–IAC). …”
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Network analysis of the cerebrospinal fluid proteome reveals shared and unique differences between sporadic and familial forms of amyotrophic lateral sclerosis by Adam N. Trautwig, Edward J. Fox, Eric B. Dammer, Anantharaman Shantaraman, Lingyan Ping, Duc M. Duong, Caroline M. Watson, Fang Wu, Seneshaw Asress, Qi Guo, Allan I. Levey, James J. Lah, Federico Verde, Alberto Doretti, Antonia Ratti, Nicola Ticozzi, Cindy V. Ly, Timothy M. Miller, Mark A. Garret, James D. Berry, Eleanor V. Thomas, Christina N. Fournier, Zachary T. McEachin, Nicholas T. Seyfried, Jonathan D. Glass

“…., C9orf72 hexanucleotide repeat expansion or SOD1 mutation), the cause(s) of most cases are unknown. Consequently, there is a critical need for biomarkers that reflect disease onset and progression across ALS subgroups. …”
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Aspartame increases the risk of liver cancer through CASP1 protein: A comprehensive network analysis insights by Ni-ren Li, Yi-xuan Zeng, Yu-feng Gu, Pai Xie, Bing-ying Deng, Si-fan Lu, Wang-an Li, Yi Liu

“…Additionally, the single-cell sequencing found that CASP1 is most highly expressed in endothelial cells. In summary, these findings suggested that aspartame may increase the possibility of liver cancer by modulating the CASP1 protein. …”
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Distribution of alkylamines in surface waters around the Antarctic Peninsula and Weddell Sea by A. Rocchi, A. Rocchi, M. F. Fitzsimons, P. Akenga, A. Sotomayor, E. L. Sà, Q. Güell-Bujons, M. Vila, Y. M. Castillo, M. Dall'Osto, D. Vaqué, C. Wohl, C. Wohl, C. Wohl, R. Simó, E. Berdalet

“…However, knowledge of the sea surface distribution patterns and factors modulating alkylamines remain limited due to their high reactivity and low concentrations, which hamper accurate measurements. …”
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ISG15 as a Potent Immune Adjuvant in MVA-Based Vaccines Against Zika Virus and SARS-CoV-2 by Juan García-Arriaza, Michela Falqui, Patricia Pérez, Rocío Coloma, Beatriz Perdiguero, Enrique Álvarez, Laura Marcos-Villar, David Astorgano, Irene Campaña-Gómez, Carlos Óscar S. Sorzano, Mariano Esteban, Carmen Elena Gómez, Susana Guerra

“…<b>Background:</b> Vaccines represent one of the most affordable and efficient tools for controlling infectious diseases; however, the development of efficacious vaccines against complex pathogens remains a major challenge. …”
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Macrogenome-based study on the mechanism of Bacillus velezensis SX13 in regulating rhizophere environment and cucumber growth under different cultivation environments by Junzheng Wang, Mingfei Yang, Jing Wang, Peng Wang, Jiaqi Pan, Fei Ma, Xiaohui Hu

“…The results of the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis showed that the metabolic pathway with the highest abundance of enriched genes was also the pathway with the most enriched differential genes caused by reducing substrate supply or inoculation of B. velezensis SX13. …”
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Fermented strawberry pomace enhances carcass characteristics and meat quality by regulating plasma biochemical indices and antioxidant capacity in aged laying hens by Wei Lan, Wei Lan, Wei Lan, Ting Chen, Ting Chen, Binghua Qin, Binghua Qin, Md. Abul Kalam Azad, Md. Abul Kalam Azad, Zhihua Li, Yadong Cui, Yadong Cui, Xiangfeng Kong, Xiangfeng Kong, Xiangfeng Kong

“…The low-dose FSP level showed the most favorable outcomes.…”
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Wound Healing Properties of Plant-Based Hydrogel and Oleogel Formulations in a Rat Scald Burn Model by Oana Janina Roșca, Alexandru Nistor, Georgeta Hermina Coneac, Ioana Viorica Olariu, Ana-Maria Cotan, Roxana Racoviceanu, Elena Rodica Heredea, Adelin Ciudoiu, Gabriela Didea, Camelia Mihaela Lupou, Florin Borcan, Teodora Hoinoiu, Cristina Adriana Dehelean, Lavinia Lia Vlaia, Codruța Marinela Șoica

“…<b>Objective:</b> This study aimed to determine the most effective plant-based topical formulations for enhancing second-degree scald burn wound healing. …”
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MiR-147b-3p promotes osteogenesis by targeting NDUFA4 and PI3K/AKT pathway by Yuanyuan Guo, Kai Shen, Zhijie Li, Changchun Niu, Yang Luo

“…Among osteoporotic fractures, osteoporotic vertebral compression fractures (OVCF) are the most common and can significantly impact patients’ quality of life. …”
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Dynamic regulation of Rgs16 and its correlation with Neuregulin1 expression in acute and chronic nerve injury by Marina García-Bejarano, Marina García-Bejarano, Marina García-Bejarano, Riccardo Aucello, Riccardo Aucello, Federica Zen, Federica Zen, Marwa El Soury, Marwa El Soury, Francesca Cordero, Jesús M. de la Fuente, Isabelle Perroteau, Giulia Ronchi, Giulia Ronchi, Giovanna Gambarotta, Giovanna Gambarotta

“…Rgs16 emerged as the RGS member most highly expressed by Schwann cells after injury, suggesting its involvement in nerve degeneration. …”
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Targeting osteoarthritis with small extracellular vesicle therapy: potential and perspectives by Alba González-Rodríguez, F. Javier De Toro, F. Javier De Toro, F. Javier De Toro, Alberto Jorge-Mora, Pablo Fernandez-Pernas, Carlota Probaos Rivadulla, Carlota Probaos Rivadulla, Carlota Probaos Rivadulla, María Fraga, Juan A. Fafián-Labora, Juan A. Fafián-Labora, Juan A. Fafián-Labora, María C. Arufe, María C. Arufe, María C. Arufe

“…These nanosized vesicles facilitate intercellular communication, delivering bioactive molecules that can modulate the joint microenvironment, promote chondrogenesis, and alleviate pain. …”
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Synthesis and antitumoral activity of novel biaryl hydroxy-triazole and fluorene-triazole hybrids by David Chafi Zeitune, Marcelo Folhadella Martins Faria Azevedo, Mariane Senna Rangel, Robert de Sousa Bastos, José de Brito Vieira Neto, Claudia do Ó Pessoa, Camilla Djenne Buarque

“…However, structural rigidity did not consistently predict activity, as 1-(2,5-dibromophenyl)-4-(9H-fluoren-9-yl)-1H-1,2,3-triazole (LSO275), a rigid fluorene-triazole, was inactive. MOLM-13 was the most sensitive cell line, with compounds such as 4-(9H-fluoren-9-yl)-1-(4-(trifluoromethyl)phenyl)-1H-1,2,3-triazole (LSO259) and (1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)(4’-fluoro-[1,1’-biphenyl]-2-yl)methanol (LSO280), achieving maximum growth inhibition (MGI > 55%) despite not reaching IC50 values. …”
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THE ORGANIZATION WORKS TO IMPROVE THE CLINICAL AND ECONOMIC OUTCOMES OF CARE FOR PROSTATE CANCER by O. I. Apolikhin, A. V. Sivkov, I. V. Chernishov, M. I. Katibov, O. V. Zolotukhin, I. A. Shaderkin, S. A. Leonov, D. A. Vojtko, M. Y. Prosyannikov

“…During the realisation of the Programme on the territory of theVoronezh region they deployed 7 Interdistrict (ITC) and 1 regional centre. The most difficult clinical cases were sent to the Federal urology center - research Institute of urology. …”
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Annexin A8 deficiency delays atherosclerosis progression by Carmen Gutiérrez‐Muñoz, Rafael Blázquez‐Serra, Irene San Sebastián‐Jaraba, Sandra Sanz‐Andrea, Maria J. Fernández‐Gómez, Gonzalo Nuñez‐Moreno, Pablo Mínguez, Joan Carles Escolá‐Gil, Paula Nogales, Veronique Ollivier, Jose L. Martín‐Ventura, Benoit Ho‐Tin‐Noe, Ursula Rescher, Nerea Méndez‐Barbero, Luis M. Blanco‐Colio

“…Results RNA‐Seq unveiled AnxA8 as one of the most significantly upregulated genes in atherosclerotic aortas of ApoE−/− compared to wild‐type mice. …”
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Optimal allocation of STATCOM for multi-objective ORPD problem on thermal wind solar hydro scheduling using driving training based optimization by Tushnik Sarkar, Sabyasachi Gupta, Chandan Paul, Susanta Dutta, Provas Kumar Roy, Anagha Bhattacharya, Ghanshyam G. Tejani, Seyed Jalaleddin Mousavirad

“…Based on a range of studied cases, the experiment results show that the DTBO has a significantly stronger ability to solve ORPD challenges than the optimization methods discovered in the most recent ORPD literature. The usage of STATCOM improves power network performance for the ORPD issue, which is another significant finding. …”
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Integrative multi-omics and bioinformatics analysis of the effects of BaiRui YuPingFeng Powder on intestinal health in broilers by Haonan Xu, Fang Zhang, Yan Che, Yu Cui, Qisheng Yao, Yueqin Guan, Hao Chen, Hao Chen, Hao Chen, Yuying Huang

“…IntroductionIn recent years, global poultry consumption has increased rapidly, making chicken the most widely consumed meat worldwide by 2019. To increase livestock development, antibiotics are often added to animal feed as growth promoters. …”
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Identification of potential susceptibility loci for non-small cell lung cancer through whole genome sequencing in circadian rhythm genes by Xiaohang Xu, Luopiao Xu, Zeyong Lang, Gege Sun, Junlong Pan, Xue Li, Zilong Bian, Xifeng Wu

“…Abstract Lung cancer is a malignant tumor with a high morbidity and mortality rate worldwide, causing an increasing disease burden. Of these, the most common type is non-small cell lung cancer (NSCLC), which accounts for 80–85% of all lung cancer cases. …”
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Metabolomic Profiling of the Blood of Patients with Chronic Consciousness Disorders by A. A. Orlova, E. A. Kondrat'eva, Ya. A. Dubrovskii, N. V. Dryagina, E. V. Verbitskaya, S. A. Kondratev, A. A. Kostareva, A. N. Kondratev

“…Four major metabolites (at VIP &gt; 0.5), which content was most modulated depending on the study group, were identified including 4 (m/z 124.0867, Rt = 17.67, p &lt; 0.01), 33 (m/z 782.5722, Rt = 17.69, p &lt; 0.01), 6 (m/z 125.0904, Rt = 18.43, p &lt; 0.01) and 1 (m/z 463.2304, Rt = 15.78, p &lt; 0.01), with no significant differences between daytime and nighttime blood samples. …”
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A Novel Hypoxia-Related Gene Signature with Strong Predicting Ability in Non-Small-Cell Lung Cancer Identified by Comprehensive Profiling by Huajun Yang, Zhongan Wang, Ling Gong, Guichuan Huang, Daigang Chen, Xiaoping Li, Fei Du, Jiang Lin, Xueyi Yang

“…Non-small-cell lung cancer (NSCLC) is the most common malignant tumor among males and females worldwide. …”
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