Grazing exclusion significantly reduced soil organic carbon stocks but enhanced soil inorganic carbon stocks in desert steppe of northwest China by Guangxing Zhao, Zhihao Zhang, Akash Tariq, Rapkat Sabit, Jordi Sardans, Corina Graciano, Xiangyi Li, Yuhe Zhu, Josep Peñuelas, Dhafer A. Al-Bakre, Fanjiang Zeng

“…Grazing exclusion reduced SOCS and mineral-associated organic carbon (MAOC) stocks but promoted SICS and STCS. GE6 exerted the most detrimental impact on the STCS in this region. …”
Get full text

Precession-driven low-latitude hydrological cycle paced by shifting perihelion by H. Yang, X. Shi, X. Wang, Q. Liu, Y. Zhong, X. Liu, Y. Sun, Y. Cai, F. Liu, G. Lohmann, M. Werner, Z. Jian, T. M. L. Pinho, H. Cheng, L. Lu, L. Lu, J. Liu, J. Liu, C.-Y. Yang, Q. Yang, Q. Yang, Y. Hu, X. Cheng, J. Zhang, D. Chen

“…Classical theory suggests that precession modulates the inter-hemisphere summer insolation difference and hence controls the meridional displacement of the Intertropical Convergence Zone (ITCZ). …”
Get full text

Developability profiling of a panel of Fc engineered SARS-CoV-2 neutralizing antibodies by Andrew Dippel, Austin Gallegos, Vineela Aleti, Arnita Barnes, Xiaoru Chen, Elizabeth Christian, Jared Delmar, Qun Du, Reza Esfandiary, Erika Farmer, Andrew Garcia, Qing Li, Jia Lin, Weiyi Liu, LeeAnn Machiesky, Neil Mody, Arun Parupudi, Meagan Prophet, Keith Rickert, Kim Rosenthal, Song Ren, Harini Shandilya, Reena Varkey, Kevin Wons, Yuling Wu, Yueh-Ming Loo, Mark T. Esser, Nicole L. Kallewaard, Sarav Rajan, Melissa Damschroder, Weichen Xu, Gilad Kaplan

“…To combat the COVID-19 pandemic, potential therapies have been developed and moved into clinical trials at an unprecedented pace. Some of the most promising therapies are neutralizing antibodies against SARS-CoV-2. …”
Get full text

Natural products targeting AMPK signaling pathway therapy, diabetes mellitus and its complications by Min Li, Lu Ding, Lu Ding, Liyuan Cao, Zepeng Zhang, Xueyan Li, Zirui Li, Qinjing Xia, Kai Yin, Siyu Song, Zihan Wang, Haijian Du, Daqing Zhao, Xiangyan Li, Zeyu Wang, Zeyu Wang

“…Diabetes mellitus (DM) ranks among the most prevalent chronic metabolic diseases, characterized primarily by a persistent elevation in blood glucose levels. …”
Get full text

Dengue virus and Zika virus alter endoplasmic reticulum-mitochondria contact sites to regulate respiration and apoptosis by Wesley Freppel, Viviana Andrea Barragan Torres, Olus Uyar, Anaïs Anton, Zaynab Nouhi, Mathilde Broquière, Clément Mazeaud, Aïssatou Aïcha Sow, Alexanne Léveillé, Claudia Gilbert, Nicolas Tremblay, Jonathan Eintrez Owen, Cheyanne L. Bemis, Xavier Laulhé, Alain Lamarre, Christopher J. Neufeldt, Ian Gaël Rodrigue-Gervais, Andreas Pichlmair, Denis Girard, Pietro Scaturro, Laura Hulea, Laurent Chatel-Chaix

“…Furthermore, virus infection modulated the mitochondrial oxygen consumption rate. …”
Get full text

Induction chemotherapy plus camrelizumab combined with concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma in non-endemic areas: a phase 2 clinical tri... by Zhongqiu Wang, Yao Sun, Qingxin Wang, Yanlan Chai, Jian Sun, Ximei Zhang, Qi Wang, Wei Wang, Peiguo Wang

“…All patients received two 21-day cycles of camrelizumab (200 mg) plus docetaxel (75 mg/m2) and cisplatin (75 mg/m2), followed by intensity modulated radiotherapy and concurrent cisplatin (80 mg/m2 for two 21-day cycles). …”
Get full text

Epigenome-wide analysis across the development span of pediatric acute lymphoblastic leukemia: backtracking to birth by Akram Ghantous, Semira Gonseth Nusslé, Farah J. Nassar, Natalia Spitz, Alexei Novoloaca, Olga Krali, Eric Nickels, Vincent Cahais, Cyrille Cuenin, Ritu Roy, Shaobo Li, Maxime Caron, Dilys Lam, Peter Daniel Fransquet, John Casement, Gordon Strathdee, Mark S. Pearce, Helen M. Hansen, Hwi-Ho Lee, Yong Sun Lee, Adam J. de Smith, Daniel Sinnett, Siri Eldevik Håberg, Jill A. McKay, Jessica Nordlund, Per Magnus, Terence Dwyer, Richard Saffery, Joseph Leo Wiemels, Monica Cheng Munthe-Kaas, Zdenko Herceg

“…Causes of leukemia, the most common form, are largely unknown. Growing evidence points to an origin in-utero, when global redistribution of DNA methylation occurs driving tissue differentiation. …”
Get full text

Traffic-related ultrafine particles influence gene regulation in olfactory mucosa cells altering PI3K/AKT signaling by Laura Mussalo, Alexey M. Afonin, Tana Zavodna, Zdenek Krejcik, Katerina Honkova, Claire Fayad, Muhammad Ali Shahbaz, Juho Kalapudas, Elina Penttilä, Heikki Löppönen, Anne M Koivisto, Tarja Malm, Jan Topinka, Pasi Jalava, Riikka Lampinen, Katja M. Kanninen

“…Conclusively, traffic-related UFPs influence gene regulation of PI3K/AKT signaling to modulate OM cell survival, with existing AD pathology resulting in heightened vulnerability to UFP effects.…”
Get full text

Remodeling of the chromatin landscape in peripheral blood cells in patients with severe Delta COVID-19 by Vasiliy E. Akimov, Dmitriy I. Tychinin, Olga A. Antonova, Abusaid M. Shaymardanov, Maria D. Voronina, Kseniia A. Deinichenko, Oleg D. Fateev, Vladimir S. Yudin, Sergey M. Yudin, Vladimir E. Mukhin, Svetlana V. Romanova, Aleksandra I. Nekrasova, Anastasia S. Zhdanova, Anastasia V. Tsypkina, Ivan S. Vladimirov, Antonida V. Makhotenko, Anton A. Keskinov, Sergey A. Kraevoy, Ekaterina A. Snigir, Dmitry V. Svetlichnyy, Veronika I. Skvortsova

“…In severe cases, we discovered that regulome and chromatin co-accessibility modules were significantly altered across many cell types. …”
Get full text

Phase II study of nivolumab in patients with genetic alterations in DNA damage repair and response who progressed after standard treatment for metastatic solid cancers (KM-06) by Jae Ho Byun, Jeeyun Lee, Kyong Hwa Park, Eun Joo Kang, Sang Joon Shin, In Gyu Hwang, Ju Won Kim, Hyo Jin Lee, Ji Yoon Lee, Jason K Sa, Sook Ryun Park, Jung Sun Kim, Yu Jung Kim, Woo Kyun Bae, Won Jin Chang, Eun-Ok Kim

“…Background Immune-modulating antibodies targeting programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1) have demonstrated promising antitumor efficacy in various types of cancers, especially highly mutated ones. …”
Get full text

Role and mechanisms of exercise therapy in enhancing drug treatment for glioma: a review by Guanghui Wu, Guanghui Wu, Yisheng Chen, Yisheng Chen, Yisheng Chen, Yisheng Chen, Yisheng Chen, Yisheng Chen, Chong Chen, Jianling Liu, Qiaowu Wu, Yazhen Zhang, Runqiong Chen, Jianzhong Xiao, Yusheng Su, Haojun Shi, Chunsheng Yu, Miao Wang, Yifan Ouyang, Airong Jiang, Zhengzhou Chen, Xiao Ye, Chengwan Shen, Aikebaier Reheman, Xianjun Li, Ming Liu, Ming Liu, Jiancheng Shen, Jiancheng Shen

“…Gliomas, particularly glioblastoma (GBM), are among the most aggressive and challenging brain tumors to treat. …”
Get full text

Elucidation of the mechanism Underlying the promotion of ferroptosis and enhanced antitumor immunity by citrus polymethoxyflavones in CRC cells by Yingying Duan, Yingying Duan, Yu Wu, Jiaqi Tian, Jiaqi Tian, Yuqin Yin, Yuqin Yin, Zhongwen Yuan, Zhongwen Yuan, Wenting Zhu, Wenting Zhu, Suyue Zhou, Chen Li, Senling Feng, Senling Feng

“…Immunotherapy is one of the most commonly used anti-tumor modalities in a clinical setting. …”
Get full text

Differentially expressed microRNAs in pre-transplant lung biopsies target immune checkpoint proteins and can predict primary graft dysfunction in lung transplantation by Vitale Miceli, Pia Ferrigno, Claudio Centi, Claudia Carcione, Gioacchin Iannolo, Valentina Agnese, Giovanna Lo Iacono, Rosa Liotta, Pier Giulio Conaldi, Massimo Pinzani, Lavinia De Monte, Alessandro Bertani

“…However, primary graft dysfunction (PGD) remains one of the most relevant hurdles. Although PGD is attributed to ischemia-reperfusion injury (IRI), immune responses, primarily T cell-mediated, may play a pivotal role in its pathogenesis. …”
Get full text

Amblyostatin-1, the first salivary cystatin with host immunomodulatory and anti-inflammatory properties from the Neotropical tick Amblyomma sculptum, vector of Brazilian spotted fe... by Wilson Santos Molari, Mohamed Amine Jmel, Mohamed Amine Jmel, Josiane Betim Assis, Alan Frazão-Silva, Júlia Moura Bernardi, Gretta Huamanrayme, José María Medina, Eliane Esteves, Solange Cristina Antão, Gabriel Cerqueira Alves Costa, Aparecida Sadae Tanaka, Aparecida Sadae Tanaka, Andréa Cristina Fogaça, Andréa Cristina Fogaça, Zdenek Franta, Lucas Tirloni, Michalis Kotsyfakis, Michalis Kotsyfakis, Anderson Sá-Nunes, Anderson Sá-Nunes

“…Thus, this study aims to describe and characterize the most expressed member of the cystatin family identified in Amblyomma sculptum salivary transcriptome, named Amblyostatin-1. …”
Get full text

Fecal microbiota transplantation alters the proteomic landscape of inflammation in HIV: identifying bacterial drivers by Claudio Díaz-García, Elena Moreno, Alba Talavera-Rodríguez, Lucía Martín-Fernández, Sara González-Bodí, Laura Martín-Pedraza, José A. Pérez-Molina, Fernando Dronda, María José Gosalbes, Laura Luna, María Jesús Vivancos, Jaime Huerta-Cepas, Santiago Moreno, Sergio Serrano-Villar

“…Abstract Background Despite effective antiretroviral therapy, people with HIV (PWH) experience persistent systemic inflammation and increased morbidity and mortality. Modulating the gut microbiome through fecal microbiota transplantation (FMT) represents a novel therapeutic strategy. …”
Get full text

Quantum SWAP gate realized with CZ and iSWAP gates in a superconducting architecture by Christian Križan, Janka Biznárová, Liangyu Chen, Emil Hogedal, Amr Osman, Christopher W Warren, Sandoko Kosen, Hang-Xi Li, Tahereh Abad, Anuj Aggarwal, Marco Caputo, Jorge Fernández-Pendás, Akshay Gaikwad, Leif Grönberg, Andreas Nylander, Robert Rehammar, Marcus Rommel, Olga I Yuzephovich, Anton Frisk Kockum, Joonas Govenius, Giovanna Tancredi, Jonas Bylander

“…In particular, access to a gate set that includes support for the CZ-, iSWAP-, and SWAP-type families of gates renders conversions between these gate families unnecessary during compilation, as any two-qubit Clifford gate can be executed using at most one two-qubit gate from this set, plus additional single-qubit gates. …”
Get full text

Hemoglobin state-flux: A finite-state model representation of the hemoglobin signal for evaluation of the resting state and the influence of disease. by Randall L Barbour, Harry L Graber, San-Lian S Barbour

“…This assignment produces several classes of coefficient arrays, most with a dimension of 10×10.<h4>Biological motivation</h4>Motivating our approach is the understanding that effector mechanisms that modulate blood delivery to tissue operate on macroscopic scales, in a spatially and temporally varying manner. …”
Get full text

Dissecting the link between PD-1/PD-L1-based immunotherapy and cancer pain: mechanisms, research implications, and artificial intelligence perspectives by Marco Cascella, Brigida Miranda, Carmen Gagliardi, Lucia Santaniello, Milena Mottola, Alida Mancusi, Laura Ferrara, Federica Monaco, Francesca Gargano, Francesco Perri, Alessandro Ottaiano, Maurizio Capuozzo, Ornella Piazza, Stefano Pepe, Anna Crispo, Agostino Guida, Giovanni Salzano, Giustino Varrassi, Luigi Liguori, Francesco Sabbatino, The TRIAL Group

“…Cancer-related pain represents one of the most common complaints of cancer patients especially for those with advanced-stage of disease and/or bone metastases. …”
Get full text

Integrated multi-omics analysis and machine learning identify G protein-coupled receptor-related signatures for diagnosis and clinical benefits in soft tissue sarcoma by Duo Wang, Duo Wang, Duo Wang, Jihao Tu, Jihao Tu, Jianfeng Liu, Jianfeng Liu, Yuting Piao, Yuting Piao, Yiming Zhao, Yiming Zhao, Ying Xiong, Ying Xiong, Jianing Wang, Jianing Wang, Xiaotian Zheng, Xiaotian Zheng, Bin Liu, Bin Liu

“…Building up a GPR-TME classifier, low GPR combined with high TME exhibited the most favorable prognosis and immunotherapeutic efficacy, which was further performed for immune infiltration, functional enrichment, somatic mutation, immunotherapy response prediction, and scRNA-seq analyses.ConclusionsOur study constructed a GPRS that can serve as a promising tool for diagnosis and prognosis prediction, targeted prevention, and personalized medicine in STS.…”
Get full text

Partial depletion of circulating neutrophil granulocytes in mice exacerbates the inflammatory response and hypothermia during LPS induced severe systemic inflammation by Jessica Hernandez, Fabian Johannes Pflieger, Julia Schäffer, Leona Bähr, Jenny Schneiders, Thomas Reichel, Marita Meurer, Marita Meurer, Benjamin Lamp, Natali Bettina Bauer, Karsten Krüger, Lois Harden, Maren von Köckritz-Blickwede, Maren von Köckritz-Blickwede, Christoph Rummel, Christoph Rummel, Christoph Rummel

“…Neutrophil granulocytes (NG) are a crucial component of the immune system and modulate inflammation. Moreover, neutropenic fever is a severe condition for immunocompromised patients that can be life threatening. …”
Get full text