Genomic signatures of SnRKs highlighted conserved evolution within orchids and stress responses through ABA signaling in the Cymbidium ensifolium by Ruiyue Zheng, Kai Zhao, Jiemin Chen, Xuanyi Zhu, Yukun Peng, Mingli Shen, Zhong-Jian Liu, Donghui Peng, Yuzhen Zhou

“…Abstract Sucrose non-fermenting 1-related protein kinases (SnRKs) are crucial for modulating plant responses to abiotic stresses, linking metabolism with stress signaling pathways. …”
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Radiation dose escalation in locally advanced oesophageal cancer: a systematic review and hierarchical Bayesian meta-analysisResearch in context by Yang-Hong Dai, Po-Huang Chen, Yi-Jhih Huang, Ding-Jie Lee, Po-Chien Shen, Cheng-Hsiang Lo, Yu-Guang Chen, Yu-Fu Su, Jen-Fu Yang, Ying-Fu Wang, Wen-Yen Huang, Chun-Shu Lin, Chih-Cheng Tsao, Katherine A. Vallis

“…Modern techniques like intensity-modulated or volumetric-modulated radiotherapy were associated with higher complete response rate and a trend toward reduced toxicity. …”
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A novel anxiety-associated SNP identified in LYNX2 (LYPD1) is associated with decreased protein binding to nicotinic acetylcholine receptors by Kristin R. Anderson, Wenpeng Cao, Hui Sun Lee, Mark A. Crenshaw, Talulla B. Palumbo, Ethan Fisher-Perez, Amanda DeGraaf, Peter Rogu, Maria A. Beatty, Gabrielle M. Gracias, Gabrielle M. Gracias, Avani V. Pisapati, Katie Hoffman, Krystle J. McLaughlin, Almut Hupbach, Wonpil Im, Wonpil Im, X. Frank Zhang, Julie M. Miwa

“…IntroductionAnxiety disorders are among the most common mental illnesses in the US. An estimated 31.1% of U.S. adults experience any anxiety disorder at some time in their lives. …”
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Presentation, calibration and testing of the DCESS II Earth system model of intermediate complexity (version 1.0) by E. Fernández Villanueva, G. Shaffer

“…</p> <p>Model calibration was carried out for the pre-industrial climate, and model steady-state solutions were compared against available modern-day observations. For the most part, calibration results agree well with observed data, including excellent agreement with ocean carbon species. …”
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How Does Nature Create the Painting “Gradient Coloration of ‘Manicure Finger’ Grape”? Integrated Omics Unveil the Pigments Basis and Metabolism Networks of Its Formation by Shihan Bao, Jianing Li, Jiaqi Wang, Tian Lan, Mengyuan Wei, Xiangyu Sun, Yulin Fang, Tingting Ma

“…Novel transcription factors VvbHLH148, VvMYBA22, and VvMYBA3 were also most probably involved in this regulatory process. …”
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A New Heteroleptic Zn(II) Complex with Schiff Bases Sensitizes Triple-Negative Breast Cancer Cells to Doxorubicin and Paclitaxel by Raiane Aparecida dos Santos Machado, Raoni Pais Siqueira, Fernanda Cardoso da Silva, André Carlos Pereira de Matos, Dayanne Silva Borges, Gislaine Gonçalves Rocha, Thais Cristina Prado de Souza, Rafael Aparecido Carvalho Souza, Clayton Rodrigues de Oliveira, Antônio G. Ferreira, Pedro Ivo da Silva Maia, Victor Marcelo Deflon, Carolina Gonçalves Oliveira, Thaise Gonçalves Araújo

“…<b>Background/Objectives</b>: Triple-negative breast cancer (TNBC) is the most challenging molecular subtype of breast cancer (BC) in clinical practice, associated with a worse prognosis due to limited treatment strategies and its insensitivity to conventional drugs. …”
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Unraveling gut microbiome alterations and metabolic signatures in hereditary transthyretin amyloidosis by Hanyu Li, Zeyuan Wang, Shan He, Xinyue Zhao, Qingyang Wu, Yueshen Sun, Yue Fan, Xiaomin Hu, Zhuang Tian, Shuyang Zhang

“…Notably, the serum levels of gamma-aminobutyric acid (GABA) and taurine were markedly decreased in the hATTR group, with the most pronounced reduction in those exhibiting hATTR-related cardiac amyloidosis. …”
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Vaginal microbiome dysbiosis and sexually transmitted infections correlate with concentrations of immunoglobulin isotypes in human cervicovaginal mucus: insights into HIV-1 transmi... by Matrona M. Akiso, Matrona M. Akiso, Israel Abook, Marianne W. Mureithi, Marianne W. Mureithi, Janet Kombo, Janet Kombo, Print Koi, Print Koi, Joel Musando, Ruth J. Chirchir, Michael D. McRaven, Ann M. Carias, Sarah Joseph, Omu Anzala, Omu Anzala, Thomas J. Hope

“…IntroductionLittle is known about the relationship between antibody isotype in cervicovaginal mucus (CVM) and the local microenvironment and how this impacts HIV-1 transmission at the female genital mucosa.MethodsIn a cohort of 139 adult women in Kenya, we measured antibody isotypes in CVM and describe their associations with local pH, serum concentrations of estrogen and progesterone, and sexually transmitted infections (STIs), including HIV-1.ResultsWe found that immunoglobulin G2 (IgG2) was the most abundant and IgG4 was the least abundant in the CVM. …”
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Research progress on the application of Lacticaseibacillus rhamnosus GG in pediatric respiratory diseases by Yang Liu, Yang Liu, Yang Liu, Yang Liu, Yan Chen, Yan Chen, Yan Chen, Huijuan Liao, Huijuan Liao, Huijuan Liao, Shijie Sun, Shijie Sun, Shijie Sun, Xiaohu Zhang, Xiaohu Zhang, Xiaohu Zhang, Xiaohu Zhang, Liang Xie, Liang Xie, Liang Xie, Liang Xie, Hanmin Liu, Hanmin Liu, Hanmin Liu, Hanmin Liu, Hanmin Liu

“…Lacticaseibacillus rhamnosus GG (LGG), one of the most extensively studied probiotics, has gained attention as a potential adjunct therapies due to their ability to modulate the gut microbiota and immune responses. …”
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Effects of chlorogenic acid on growth performance, immunity, antioxidant capacity, intestinal microbiota, and liver transcriptome in Mauremys mutica by Hongyao Zhang, Jingu Shi, Zike Yan, Mingzuo Gao, Kaijie Lin, Yutian Zhan, Yuhan Li, Jingzhen Liang, Shuyu Han

“…Notably, the 200 mg/kg CGA treatment exhibited the most significant improvements in growth performance, digestive enzyme activity, intestinal morphology, villus length, immunity, and antioxidant capacity. …”
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Expression Profile of Human Cytomegalovirus <i>UL111A</i> cmvIL-10 and LAcmvIL-10 Transcripts in Primary Cells and Cells from Renal Transplant Recipients by Giovana W. C. Almeida, Martha T. Oliveira, Isabella G. L. Martines, Giuliano C. Fiori, Michael M. Nevels, Ian J. Groves, John Sinclair, José Medina-Pestana, Rayra Sampaio da Silva, Monica Nakamura, Lucio Requião-Moura, Emma Poole, Maria C. Carlan da Silva

“…HCMV has a variety of strategies to modulate host antiviral responses, and one important player is a viral homolog of the cellular interleukin-10 (cIL-10). …”
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HC-Pro inhibits HEN1 methyltransferase activity, leading to autophagic degradation of AGO1 by Zhao-Jun Pan, Wei-Lun Wei, Phuong-Anh Tran, Ru-Ying Fang, Thanh Ha Pham, John L. Bowman, Chao-Tzu Chung, Bing-Nan Shen, Ju-Ting Yang, Han-Han Chang, Wann-Neng Jane, Chiung-Hsiang Cheng, Chia-Chi Wang, Hsin-Yi Wu, Syuan-Fei Hong, Qian-Wen Shang, Sin-Fen Hu, Pin-Chun Lin, Fu-Hui Wu, Choun-Sea Lin, Yu-Ling Hung, Tang-Long Shen, Shih-Shun Lin

“…P1/HC-Pro from turnip mosaic virus (P1/HC-ProTu) exhibited the most potent inhibition of HEN1, followed by P1/HC-Pro from zucchini yellow mosaic virus (P1/HC-ProZy), while P1/HC-Pro from tobacco etch virus (P1/HC-ProTe) showed the weakest inhibitory effect. …”
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Inhibition of EPAC1 signaling pathway alters atrial electrophysiology and prevents atrial fibrillation by Bastien Guillot, Bastien Guillot, Arthur Boileve, Arthur Boileve, Richard Walton, Richard Walton, Alexandre Harfoush, Alexandre Harfoush, Caroline Conte, Caroline Conte, Yannis Sainte-Marie, Yannis Sainte-Marie, Sabine Charron, Sabine Charron, Olivier Bernus, Olivier Bernus, Alice Recalde, Alice Recalde, Laurent Sallé, Laurent Sallé, Fabien Brette, Fabien Brette, Fabien Brette, Frank Lezoualc’h, Frank Lezoualc’h

“…IntroductionAtrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with increased mortality and morbidity. …”
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Distinct mRNA expression profiles and miRNA regulators of the PI3K/AKT/mTOR pathway in breast cancer: insights into tumor progression and therapeutic targets by Tomasz Sirek, Tomasz Sirek, Katarzyna Król-Jatręga, Katarzyna Król-Jatręga, Przemysław Borawski, Nikola Zmarzły, Dariusz Boroń, Dariusz Boroń, Dariusz Boroń, Dariusz Boroń, Piotr Ossowski, Olga Nowotny-Czupryna, Kacper Boroń, Dominika Janiszewska-Bil, Elżbieta Mitka-Krysiak, Beniamin Oskar Grabarek, Beniamin Oskar Grabarek

“…This study provides a foundation for targeted therapies aimed at modulating this critical pathway to improve breast cancer outcomes.…”
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The cost effectiveness of a multidomain intervention on physical, cognitive, vascular, dietary and psychosocial outcomes among community dwelling older adults with cognitive frailt... by Pavapriya Ponvel, Suzana Shahar, Devinder Kaur Ajit Singh, Arimi Fitri Mat Ludin, Ponnusamy Subramaniam, Norhayati Ibrahim, Hasnah Haron, Aniza Ismail, Chin Ai-Vyrn, Mazlyfarina Mohamad, Hidayah Fadzil, Norhayati Mustafa Khalid, A’isyah Mohammad Safien, Jamilah Mohammad Hanipah, Azyana Ibrahim, Jenni Lehtisalo, Miia Kivipelto, Francesca Mangialasche

“…The ICER computation indicated the 2-min step test as the most cost-effective measure (ICER RM 149.19 ≈USD33.26). …”
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Development of a latency model for HIV-1 subtype C and the impact of long terminal repeat element genetic variation on latency reversal by Shreyal Maikoo, Robert-Jan Palstra, Krista L. Dong, Tokameh Mahmoudi, Thumbi Ndung'u, Paradise Madlala

“…However, HIV-1 subtype B (HIV-1B), prevalent in Europe and North America, has been the focus of most cure research and testing despite making up only 12 % of HIV-1 infections globally. …”
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Functional and quality of life outcomes after partial glossectomy: a multi-institutional longitudinal study of the head and neck research network by Agnieszka Dzioba, Daniel Aalto, Georgina Papadopoulos-Nydam, Hadi Seikaly, Jana Rieger, Johan Wolfaardt, Martin Osswald, Jeffrey R. Harris, Daniel A. O’Connell, Cathy Lazarus, Mark Urken, Ilya Likhterov, Raymond L. Chai, Erika Rauscher, Daniel Buchbinder, Devin Okay, Risto-Pekka Happonen, Ilpo Kinnunen, Heikki Irjala, Tero Soukka, Juhani Laine, Head and Neck Research Network

“…Anderson Dysphagia Inventory (MDADI)] and quality of life [European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Head and Neck Module (EORTC-H&N35)]. Outcome measures were completed pre-operatively and at 1-, 6-, and 12-months post-operatively. …”
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Epigenomic analysis identifies DTP subpopulation using HOPX to develop targeted therapy resistance in lung adenocarcinoma by Yang Tian, Reshmee Bhattacharya, Seungyeul Yoo, Feng Jiang, Eric Park, Genesis Lara Granados, Yudao Shen, Kwang-Su Park, Husnu Umit Kaniskan, Jian Jin, Benjamin D. Hopkins, Jun Zhu, Hideo Watanabe

“…The integrative network and pathway analysis revealed that one subpopulation is associated with cell cycle, while the other is enriched in developmental pathways. HOPX was the most enriched alveolar signature gene in the latter. …”
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BLH3 Regulates the ABA Pathway and Lignin Synthesis Under Salt Stress in <i>Lilium pumilum</i> by Wenhao Wan, Lingshu Zhang, Xingyu Liu, Huitao Cui, Miaoxin Shi, Hao Sun, Wei Yang, Xinran Wang, Fengshan Yang, Shumei Jin

“…RT-qPCR analysis revealed that <i>LpBLH3</i> is most highly expressed in the leaves of <i>L. pumilum</i>. …”
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Deep behavioral phenotyping tracks functional recovery following tibia fracture in mice by Jonathan E. Layne, Dustin M. Snapper, Dustin M. Snapper, Molly E. Czachor, Charles Lam, Jacob D. Matityahu, Dane R. G. Lind, Matthieu Huard, Johnny Huard, Kazuhito Morioka, Julian C. Motzkin, Julian C. Motzkin, Allan I. Basbaum, Jarret A. P. Weinrich, Jarret A. P. Weinrich, Chelsea S. Bahney, Chelsea S. Bahney

“…Our goals were to identify and characterize metrics most indicative of fracture-induced behavioral impairment and to use these metrics to quantify how functional recovery is altered in mice with pin stabilized versus non-stabilized fractures. …”
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