Curcumin induces tumor suppression in ameloblastoma by promoting apoptotic mechanism via MiR-9 expression: A narrative review by Hilmy Irsyadi Hanif, Reisca Tiara Hardiyani, Intan Dzahabiyah Septiani, Heni Susilowati

“…Curcumin, as one of the most common well-described compounds, remarkably has a potential antitumor agent. …”
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New Insights on Human Polyomavirus JC and Pathogenesis of Progressive Multifocal Leukoencephalopathy by Anna Bellizzi, Elena Anzivino, Donatella Maria Rodio, Anna Teresa Palamara, Lucia Nencioni, Valeria Pietropaolo

“…Until the human immunodeficiency virus (HIV) pandemic, PML was rare: in fact HIV-induced immunodeficiency is the most common predisposing factor accounting for 85% of all instances of PML. …”
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Screen for mitochondrial DNA copy number maintenance genes reveals essential role for ATP synthase by Atsushi Fukuoh, Giuseppe Cannino, Mike Gerards, Suzanne Buckley, Selena Kazancioglu, Filippo Scialo, Eero Lihavainen, Andre Ribeiro, Eric Dufour, Howard T Jacobs

“…To identify novel components of this machinery, plus other cellular pathways required for mtDNA viability, we implemented a genome‐wide RNAi screen in Drosophila S2 cells, assaying for loss of fluorescence of mtDNA nucleoids stained with the DNA‐intercalating agent PicoGreen. In addition to previously characterized components of the mtDNA replication and transcription machineries, positives included many proteins of the cytosolic proteasome and ribosome (but not the mitoribosome), three proteins involved in vesicle transport, some other factors involved in mitochondrial biogenesis or nuclear gene expression, > 30 mainly uncharacterized proteins and most subunits of ATP synthase (but no other OXPHOS complex). …”
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Increased level of extracellular ATP at tumor sites: in vivo imaging with plasma membrane luciferase. by Patrizia Pellegatti, Lizzia Raffaghello, Giovanna Bianchi, Federica Piccardi, Vito Pistoia, Francesco Di Virgilio

“…Extracellular ATP may be crucial for the tumour not only as a stimulus for growth but also as a source of an immunosuppressive agent such as adenosine. Our approach offers a new tool for the investigation of the biochemical composition of tumour milieu and for development of novel therapies based on the modulation of extracellular purine-based signalling.…”
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Infinity war: Trichomonas vaginalis and interactions with host immune response by Giulia Bongiorni Galego, Tiana Tasca

“…Trichomonas vaginalis is the pathological agent of human trichomonia-sis. The incidence is 156 million cases worldwide. …”
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Ameliorative effects of Berberine chloride against 5-fluorouracil-induced cardiotoxicity in Sprague Dawley rats by Mirna Akram Labib, Omar S. Saeed, Samar H. ElSharkawy, Marwa S. Khattab, Hesham Y. El-Zorba, Khaled Abo-EL-Sooud

“…Abstract 5-Fluorouracil (5-FU) is the most commonly used chemotherapeutic agent for solid malignancies. …”
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Effects of Glucocorticoids on Apoptosis and Clearance of Apoptotic Cells by Aisleen McColl, Sylwia Michlewska, Ian Dransfield, Adriano G. Rossi

“…The glucocorticoid (GC) drugs are one of the most commonly prescribed and effective anti-inflammatory agents used for the treatment of many inflammatory disorders through their ability to attenuate phlogistic responses. …”
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CTSS in the tumor microenvironment links immune escape and immunotherapy sensitivity in kidney renal clear cell carcinoma by Hanjing Zhou, Jun Ying, Xuchun Xu, Jian Huang

“…Through single-cell RNA sequencing and high-dimensional weighted gene co-expression network analysis (hdWGCNA), we identified a crucial IE-related gene module most strongly associated with KIRC progression. …”
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Modern aspects of external application and prospects of using the secretome of mesenchymal stem cells (review) by E. O. Bakhrushina, I. V. Gravel, O. S. Filippova, V. N. Tychinin, A. A. Popova, O. B. Dobrovolsky

“…The secretome of mesenchymal stem cells (SMSC) is widely used in medicine. It is most often used due to its immune-modulating and regenerative properties in the treatment of autoimmune, immuno-mediated and other diseases due to its anti-inflammatory, neuroprotective and regenerating action. …”
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Effect of High Selective Serotonin-Reuptake Inhibitor Doses on the Development and Treatment of Sarcoid-Like Reaction by Badr Rashed Al-Ghamdi

“…Sarcoidosis is a systemic disorder characterized by the presence of noncaseating granulomas that are most commonly observed in the lungs. Sarcoid-like reaction has been reported to develop in response to several immune modulator agents and antidepressants. …”
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Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review by Cristina M. Uritu, Cosmin T. Mihai, Gabriela-Dumitrita Stanciu, Gianina Dodi, Teodora Alexa-Stratulat, Andrei Luca, Maria-Magdalena Leon-Constantin, Raluca Stefanescu, Veronica Bild, Silvia Melnic, Bogdan I. Tamba

“…The data highlighted in this review paper provide valuable scientific information for the specific implications of Lamiaceae plants in pain modulation that might be used for isolation of potentially active compounds from some of these medicinal plants in future and formulation of commercial therapeutic agents.…”
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Bacterial Toxin-Antitoxin Systems and New Strategies for Creating Antibacterial Preparations by B. G. Andryukov, N. N. Besednova, T. S. Zaporozhets, M. P. Bynina

“…Intensive research of bacterial toxin-antitoxin systems (TAS) in recent decades has significantly expanded and deepened knowldge about them. As TAS modules were first discovered in the plasmids and later in the chromosomes of bacteria, and after subsequent study of their specific regulation of activation and functions, their image has changed from simple curious genetic objects to one of the most important tools. …”
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An Overview of the Bioactivity of Spontaneous Medicinal Plants Suitable for the Improvement of Lung Cancer Therapies by Lidia-Ioana Virchea, Adina Frum, Cecilia Georgescu, Bence Pecsenye, Endre Máthé, Monica Mironescu, Mihai-Tudor Crăciunaș, Maria Totan, Ciprian Tănăsescu, Felicia-Gabriela Gligor

“…Lung cancer is the second cause of death in the world, being the most common type of cancer. Conventional therapies are not always recommended due to the particularities of patients. …”
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Amplification-Free Electrochemiluminescent Biosensor for Ultrasensitive Detection of Fusobacterium nucleatum Using Tetrahedral DNA-Based CRISPR/Cas12a by Xindan Zhang, Minkang Wu, Haoran Shi, Soochan Kim, Shixiang Lu, Ping Wang, Jieling Qin

“…Different from the conventional 1- or 2-dimensional probes, the platform was constructed by tetrahedral DNA nanostructure (TDN) probes conjugated with quenchers and coralliform gold (CFAu) functionalized with luminescent agents. The TDN serves as an exceptional scaffold to modulate the recognition unit, substantially enhancing the recognition and cleavage efficiency of AsCas12a toward the probes. …”
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Synergistic Effect of Combined Antibiotic and Methanolic Extracts of Withania somnifera and Catharanthus roseus against MDR Salmonella enterica Serovar Typhi by Neha Chauhan, Azhar Khan, Umar Farooq

“…Typhoid has become the most neglected and majorly affecting disease of tropical and subtropical countries, including India, and is among the most important global health problems, as the emergence of multidrug resistance has shut down the effect of antimicrobial agents and makes it difficult to control the bacteria inside the host. …”
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Potential targets of phytochemical immunomodulatory therapy in periodontitis immunopathogenesis: A narrative review by Andari Sarasati, Alma Linggar Jonarta

“…Introduction: Periodontitis is one of the most prevalent diseases occurring worldwide, and is caused by an imbalance of host immunological defenses and microbiome profile which occurs in the oral cavity. …”
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Unlocking the Interactions Between the Whole-Body Microbiome and HPV Infection: A Literature Review by Myrto Papamentzelopoulou, Vassiliki C. Pitiriga

“…However, dysbiotic microbial communities may cause disruption of the symbiotic relationship between the host and the local microbiota, leading to the pathogenesis of various diseases, including viral infections and cancers. One of the most common infectious agents causing cancer is the human papilloma virus (HPV), which accounts for more than 90% of cervical cancers. …”
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The Roles of AMPK in Revascularization by Ming-Hong Chen, Qiong-Mei Fu

“…Coronary heart disease (CHD) is the most common and serious illness in the world and has been researched for many years. …”
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Advances in research on biomaterials and stem cell/exosome-based strategies in the treatment of traumatic brain injury by Wenya Chi, Yingying He, Shuisheng Chen, Lingyi Guo, Yan Yuan, Rongjie Li, Ruiyao Liu, Dairan Zhou, Jianzhong Du, Tao Xu, Yuan Yu

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Validation of <i>Monilinia fructicola</i> Putative Effector Genes in Different Host Peach (<i>Prunus persica</i>) Cultivars and Defense Response Investigation by Lucia Landi, Annamaria Lucrezia D’Ortenzio, Sarah Mojela Makau, Rita Milvia De Miccolis Angelini, Gianfranco Romanazzi

“…<i>Monilinia fructicola</i> is the most common and destructive brown rot agent on peaches. …”
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